Research graph
References from Fibronectin's tensional state as a mechanical signature of fibrotic extracellular matrix in idiopathic pulmonary fibrosis models. Local targets link to admitted publications; unresolved targets remain external evidence.
Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases
10.1183/16000617.0076-2018 · 2018 · External reference
What’s in a name? That which we call IPF, by any other name would act the same
10.1183/13993003.00692-2018 · 2018 · External reference
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
10.1164/rccm.2009-040gl · 2011 · External reference
Global incidence and prevalence of idiopathic pulmonary fibrosis
10.1186/s12931-021-01791-z · 2021 · External reference
Incidence and prevalence of idiopathic pulmonary fibrosis: a systematic literature review and meta-analysis
10.1186/s12890-025-03836-1 · 2025 · External reference
Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001-11
10.1016/s2213-2600(14)70101-8 · 2014 · External reference
What do we need to know about rising rates of idiopathic pulmonary fibrosis? A narrative review and update
10.1007/s12325-022-02395-9 · 2023 · External reference
Current and future treatment landscape for idiopathic pulmonary fibrosis
10.1007/s40265-023-01950-0 · 2023 · External reference
Trials and treatments: an update on pharmacotherapy for idiopathic pulmonary fibrosis
2023 · External reference
Novel therapeutic approaches for pulmonary fibrosis
10.1111/j.1476-5381.2011.01247.x · 2011 · External reference
Matrix biomechanics and dynamics in pulmonary fibrosis
10.1016/j.matbio.2017.12.004 · 2018 · External reference
Pulmonary fibrosis: pathogenesis, etiology and regulation
10.1038/mi.2008.85 · 2009 · External reference
Idiopathic pulmonary fibrosis
10.1056/nejmra1705751 · 2018 · External reference
Genetics of idiopathic pulmonary fibrosis: from mechanistic pathways to personalised medicine
10.1136/jmedgenet-2016-103973 · 2017 · External reference
Idiopathic pulmonary fibrosis: disease mechanisms and drug development
10.1016/j.pharmthera.2020.107798 · 2021 · External reference
Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast
10.2174/092986709787846497 · 2009 · External reference
Substrate stiffness regulates extracellular matrix deposition by alveolar epithelial cells
2011 · External reference
The mechanical memory of lung myofibroblasts
10.1039/c2ib00149g · 2012 · External reference
TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?
2000 · External reference
The extracellular matrix: an active or passive player in fibrosis?
10.1152/ajpgi.00132.2011 · 2011 · External reference
Design and evaluation of a polypeptide that mimics the integrin binding site for EDA fibronectin to block profibrotic cell activity
2021 · External reference
Role of collagen in airway mechanics
2021 · External reference
Mechanisms of tissue repair: from wound healing to fibrosis
10.1016/s1357-2725(96)00115-x · 1997 · External reference
Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs
10.1371/journal.pone.0180751 · 2017 · External reference
Matrix abnormalities in pulmonary fibrosis
10.1183/16000617.0033-2018 · 2018 · External reference
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
10.1016/j.ceb.2008.06.008 · 2008 · External reference
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix
10.1038/ncomms9026 · 2015 · External reference
Unraveling the mechanobiology of extracellular matrix
10.1146/annurev-physiol-021317-121312 · 2018 · External reference
Cell niche properties as tuned by physical factors: ECM proteins as mechanochemical switches
2025 · External reference
Mechanical stretching of fibronectin fibers upregulates binding of Interleukin-7
10.1021/acs.nanolett.7b01617 · 2018 · External reference
Detection of an integrin-binding mechanoswitch within fibronectin during tissue formation and fibrosis
10.1021/acsnano.7b02755 · 2017 · External reference
Fibronectin Fiber extension decreases cell spreading and migration
10.1002/jcp.25271 · 2016 · External reference
Fibrosis: cross-organ biology and pathways to development of innovative drugs
10.1038/s41573-025-01158-9 · 2025 · External reference
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
10.1038/s41580-024-00716-0 · 2024 · External reference
Peeling back the layers of the bleomycin model of lung fibrosis: lessons learned, factors to consider, and future directions
2025 · External reference
The importance of interventional timing in the bleomycin model of pulmonary fibrosis
10.1183/13993003.01105-2019 · 2020 · External reference
Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
10.1038/s41467-017-01846-0 · 2017 · External reference
Loss of fibronectin fiber tension in glioblastoma is associated with microvascular proliferations and immune cell infiltration
10.1002/advs.202416526 · 2025 · External reference
Fibronectin fibers progressively lose their tension in invasive human breast carcinoma while being tensed in DCIS and healthy breast tissue
2025 · External reference
Untensed fibronectin fibers: a novel hallmark of microthrombi
10.3389/fcvm.2025.1627917 · 2025 · External reference
Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope
10.1038/ncomms1135 · 2010 · External reference
Engineering mechanosensitive multivalent receptor-ligand interactions: why the nanolinker regions of bacterial adhesins matter
10.1021/nl302153h · 2012 · External reference
Fibers with integrated mechanochemical switches: minimalistic design principles derived from fibronectin
10.1016/j.bpj.2012.09.028 · 2012 · External reference
Fibronectin fibers are highly tensed in healthy organs in contrast to tumors and virus-infected lymph nodes
10.1016/j.mbplus.2020.100046 · 2020 · External reference
Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers
10.1016/j.matbio.2023.01.002 · 2023 · External reference
Metformin attenuates lung fibrosis development via NOX4 suppression
10.1186/s12931-016-0420-x · 2016 · External reference
Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis
10.1186/s12931-020-01369-1 · 2020 · External reference
Exploring animal models that resemble idiopathic pulmonary fibrosis
10.3389/fmed.2017.00118 · 2017 · External reference
Simple method of estimating severity of pulmonary fibrosis on a numerical scale
10.1136/jcp.41.4.467 · 1988 · External reference
Immune mechanisms of pulmonary fibrosis with bleomycin
10.3390/ijms24043149 · 2023 · External reference
Molecular and tissue alterations of collagens in fibrosis
10.1016/j.matbio.2018.02.004 · 2018 · External reference
Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension
10.1073/pnas.072650799 · 2002 · External reference
Disentangling the multifactorial contributions of fibronectin, collagen and cyclic strain on MMP expression and extracellular matrix remodeling by fibroblasts
10.1016/j.matbio.2014.09.001 · 2014 · External reference
Mechanisms of force generation and transmission by myofibroblasts
10.1016/j.copbio.2003.08.006 · 2003 · External reference
Identification of transcriptomic markers for developing idiopathic pulmonary fibrosis: an integrative analysis of gene expression profiles
2020 · External reference
Identification of hub genes and pathways associated with idiopathic pulmonary fibrosis via bioinformatics analysis
10.3389/fmolb.2021.711239 · 2021 · External reference
Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis
10.7150/ijms.61309 · 2021 · External reference
Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis
10.1124/jpet.104.082099 · 2005 · External reference
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
10.1038/s41467-019-10839-0 · 2019 · External reference
Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1
10.1165/rcmb.2010-0338oc · 2011 · External reference
Inactivation of anthracyclines by serum heme proteins
10.1021/tx700002f · 2007 · External reference
Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-β1/Smad2/Smad3 pathway
10.1016/j.acthis.2020.151600 · 2020 · External reference
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
10.1183/09031936.00174914 · 2015 · External reference
Dasatinib
10.1038/nrd2135 · 2006 · External reference
Inhibition of Src family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors
10.1158/1078-0432.ccr-10-2616 · 2011 · External reference
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors
10.1016/j.phrs.2015.01.003 · 2015 · External reference
Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF pathway
10.1016/j.ejphar.2015.11.008 · 2015 · External reference
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
10.1183/13993003.02367-2016 · 2017 · External reference
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
10.1016/j.ebiom.2018.12.052 · 2019 · External reference
Relaxed fibronectin: a potential novel target for imaging endometriotic lesions
10.1186/s13550-024-01070-0 · 2024 · External reference
Loss of fibronectin fiber tension is inherent to ECM remodeling in human myocarditis and post-inflammatory fibrosis
10.1016/j.mbplus.2025.100182 · 2025 · External reference
The scar-in-a-jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well
10.1111/j.1476-5381.2009.00387.x · 2009 · External reference
Cell-extracellular matrix mechanotransduction in 3D
10.1038/s41580-023-00583-1 · 2023 · External reference
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
10.1186/s12943-023-01744-8 · 2023 · External reference
Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers
10.1016/j.bpj.2014.09.044 · 2014 · External reference
Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis
10.1039/c2ib20059g · 2012 · External reference
Strain-induced alignment in collagen gels
10.1371/journal.pone.0005902 · 2009 · External reference
Hot and cold fibrosis: the role of serum biomarkers to assess immune mechanisms and ECM-cell interactions in human fibrosis
10.1016/j.jhep.2025.02.039 · 2025 · External reference
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
10.1038/s41467-018-07858-8 · 2019 · External reference
Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF
10.1136/thoraxjnl-2015-207429 · 2016 · External reference
An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis
10.1165/rcmb.2017-0096st · 2017 · External reference
Shared and distinct mechanisms of fibrosis
10.1038/s41584-019-0322-7 · 2019 · External reference
Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis
2011 · External reference
Evaluation of (99m)Tc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis
10.1186/s13075-018-1681-1 · 2018 · External reference
Orbit image analysis: an open-source whole slide image analysis tool
10.1371/journal.pcbi.1007313 · 2020 · External reference
A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model
10.1371/journal.pone.0193057 · 2018 · External reference
(18)F-AzaFol for detection of folate receptor-β positive macrophages in experimental interstitial lung disease-a proof-of-concept study
10.3389/fimmu.2019.02724 · 2019 · External reference
Purification of human plasma fibronectin using immobilized gelatin and Arg affinity chromatography
10.1038/nprot.2008.12 · 2008 · External reference
