Research graph
References from Immunometabolic regulation of macrophage function in cardio–hepatic–renal comorbidities: Mechanisms and therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Advanced oxidation protein products contribute to chronic-kidney-disease-induced adipose inflammation through macrophage activation
10.3390/toxins15030179 · 2023 · External reference
From lipid switch to tissue repair: how resolvins reprogram macrophage polarization and function
10.1097/in9.0000000000000076 · 2026 · External reference
SGLT2 inhibitors: multifaceted therapeutic agents in cardiometabolic and renal diseases
10.3390/metabo15080536 · 2025 · External reference
Cenicriviroc suppresses and reverses steatohepatitis by regulating macrophage infiltration and M2 polarization in mice
10.1210/endocr/bqae069 · 2024 · External reference
hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery
10.1186/s13287-025-04521-0 · 2025 · External reference
TREM2 as a regulator of obesity-induced cardiac remodeling: mechanisms and therapeutic insights
10.1152/ajpheart.00075.2025 · 2025 · External reference
Attenuation of adipose tissue inflammation by pro-resolving lipid mediators
2024 · External reference
Timing-dependent anti-inflammatory effects of empagliflozin in monocyte-derived macrophages from post-myocardial infarct patients with type 2 diabetes
10.1186/s12933-025-03042-7 · 2026 · External reference
GABA ameliorates diet-induced hepatic steatosis and insulin resistance by inhibiting macrophage activation
10.1111/dom.16556 · 2025 · External reference
More than glucose elimination: additional benefits of SGLT2 inhibitors in glomerular diseases
10.1007/s40265-026-02286-1 · 2026 · External reference
Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization
10.1016/j.jep.2023.116810 · 2023 · External reference
Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy
10.1016/j.lfs.2020.118808 · 2021 · External reference
Incidence and risk factors of new clinical disorders in patients with COVID-19 hyperinflammatory syndrome
10.1038/s41598-025-04070-9 · 2025 · External reference
Increased macrophage activation marker soluble CD163 is associated with graft dysfunction and metabolic derangements in renal transplant recipients
2021 · External reference
The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease
10.1016/j.kint.2022.08.026 · 2022 · External reference
Early changes in cardiac macrophage subsets in heart failure with preserved ejection fraction
10.3390/ijms262010196 · 2025 · External reference
Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease
2021 · External reference
The metabolic and molecular mechanisms of α-mangostin in cardiometabolic disorders
10.3892/ijmm.2022.5176 · 2022 · External reference
Macrophage activation marker sCD163 is associated with liver injury and hepatic insulin resistance in obese patients before and after Roux-en-Y gastric bypass
2022 · External reference
High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
10.1038/s41467-020-20500-w · 2021 · External reference
Btk knockout attenuates the liver inflammation in STZ-induced diabetic mice by suppressing NLRP3 inflammasome activation
10.1016/j.bbrc.2021.02.094 · 2021 · External reference
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
10.7554/elife.83075 · 2023 · External reference
Y4 RNA fragments from cardiosphere-derived cells ameliorate diabetic myocardial ischemia‒reperfusion injury by inhibiting protein kinase C β-mediated macrophage polarization
10.1186/s12933-024-02247-6 · 2024 · External reference
The effect of miR-471-3p on macrophage polarization in the development of diabetic cardiomyopathy
10.1016/j.lfs.2020.118989 · 2021 · External reference
Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote periodontal regeneration
10.1089/ten.tea.2020.0141 · 2021 · External reference
Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy
10.1016/j.biopha.2022.113947 · 2022 · External reference
Chemerin as a mediator of hypertension and cardiometabolic diseases (A comprehensive review)
10.1007/s11906-025-01354-3 · 2025 · External reference
Regulation of Monocytes/Macrophages by the renin-angiotensin system in diabetic nephropathy: state of the art and results of a pilot study
10.3390/ijms22116009 · 2021 · External reference
Impact of breaking up of sitting time on anti-inflammatory response induced by extracellular vesicles
10.2174/0113816128244442231018070639 · 2023 · External reference
Single-cell RNA sequencing reveals metabolic stress-dependent activation of cardiac macrophages in a model of dyslipidemia-induced diastolic dysfunction
10.1161/circulationaha.122.062984 · 2024 · External reference
GLP-1 RAs vs. SGLT2is: divergent pathways of cardiovascular inflammation control in obesity-associated diabetes
10.1016/j.ando.2026.102494 · 2026 · External reference
Pleiotropic effects of SGLT2 inhibitors: a focus on macrophage-mediated action
10.1016/j.phrs.2025.108046 · 2025 · External reference
Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures
10.1016/j.isci.2022.104602 · 2022 · External reference
Obesity/cardiometabolic phenotype of heart failure with preserved ejection fraction: mechanisms to recent trials
10.1097/hco.0000000000001113 · 2024 · External reference
Sex differences in the impact of obesity on immunity
10.1111/imr.70101 · 2026 · External reference
MCC950, a selective NLRP3 inhibitor, attenuates adverse cardiac remodeling following heart failure through improving the cardiometabolic dysfunction in Obese mice
2022 · External reference
ETS1-THBS1 axis regulates macrophage polarization and exacerbates myocardial injury in diabetic cardiomyopathy
10.1097/fjc.0000000000001720 · 2025 · External reference
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
10.1038/s41467-020-20315-9 · 2021 · External reference
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway
10.1016/j.atherosclerosis.2025.119109 · 2025 · External reference
Macrophage energy metabolism in cardiometabolic disease
10.1007/s11010-024-05099-6 · 2025 · External reference
Inhibition of SGLT1 alleviates the glycemic variability-induced cardiac fibrosis via inhibition of activation of macrophage and cardiac fibroblasts
10.1128/mcb.00282-21 · 2022 · External reference
Dehydration accelerates cytogenesis and cyst growth in Pkd1(-/-) mice by regulating macrophage M2 polarization
10.1007/s10753-023-01806-5 · 2023 · External reference
RasGRP4 exacerbates diabetic kidney fibrosis via Aloxe3-Mediated oxidative stress and scar-associated macrophage activation
10.1096/fj.202501964r · 2025 · External reference
Marein alleviates the development of atherosclerosis through targeting miR-126/lipoprotein-associated phospholipase A(2) axis
10.1096/fj.202402378r · 2025 · External reference
Mesenchymal stem cells attenuate podocyte injury in diabetic nephropathy through the promotion of type 2 macrophage polarization
10.1089/scd.2025.0038 · 2025 · External reference
Dehydration accelerates cytogenesis and cyst growth in Pkd1(-/-) mice by regulating macrophage M2 polarization
10.1007/s10753-023-01806-5 · ExternalCitation · doi-reference
Macrophage energy metabolism in cardiometabolic disease
10.1007/s11010-024-05099-6 · ExternalCitation · doi-reference
Chemerin as a mediator of hypertension and cardiometabolic diseases (A comprehensive review)
10.1007/s11906-025-01354-3 · ExternalCitation · doi-reference
More than glucose elimination: additional benefits of SGLT2 inhibitors in glomerular diseases
10.1007/s40265-026-02286-1 · ExternalCitation · doi-reference
GLP-1 RAs vs. SGLT2is: divergent pathways of cardiovascular inflammation control in obesity-associated diabetes
10.1016/j.ando.2026.102494 · ExternalCitation · doi-reference
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway
10.1016/j.atherosclerosis.2025.119109 · ExternalCitation · doi-reference
Btk knockout attenuates the liver inflammation in STZ-induced diabetic mice by suppressing NLRP3 inflammasome activation
10.1016/j.bbrc.2021.02.094 · ExternalCitation · doi-reference
Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy
10.1016/j.biopha.2022.113947 · ExternalCitation · doi-reference
Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures
10.1016/j.isci.2022.104602 · ExternalCitation · doi-reference
Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization
10.1016/j.jep.2023.116810 · ExternalCitation · doi-reference
The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease
10.1016/j.kint.2022.08.026 · ExternalCitation · doi-reference
Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy
10.1016/j.lfs.2020.118808 · ExternalCitation · doi-reference
The effect of miR-471-3p on macrophage polarization in the development of diabetic cardiomyopathy
10.1016/j.lfs.2020.118989 · ExternalCitation · doi-reference
Pleiotropic effects of SGLT2 inhibitors: a focus on macrophage-mediated action
10.1016/j.phrs.2025.108046 · ExternalCitation · doi-reference
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
10.1038/s41467-020-20315-9 · ExternalCitation · doi-reference
High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
10.1038/s41467-020-20500-w · ExternalCitation · doi-reference
Incidence and risk factors of new clinical disorders in patients with COVID-19 hyperinflammatory syndrome
10.1038/s41598-025-04070-9 · ExternalCitation · doi-reference
Mesenchymal stem cells attenuate podocyte injury in diabetic nephropathy through the promotion of type 2 macrophage polarization
10.1089/scd.2025.0038 · ExternalCitation · doi-reference
Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote periodontal regeneration
10.1089/ten.tea.2020.0141 · ExternalCitation · doi-reference
Marein alleviates the development of atherosclerosis through targeting miR-126/lipoprotein-associated phospholipase A(2) axis
10.1096/fj.202402378r · ExternalCitation · doi-reference
RasGRP4 exacerbates diabetic kidney fibrosis via Aloxe3-Mediated oxidative stress and scar-associated macrophage activation
10.1096/fj.202501964r · ExternalCitation · doi-reference
ETS1-THBS1 axis regulates macrophage polarization and exacerbates myocardial injury in diabetic cardiomyopathy
10.1097/fjc.0000000000001720 · ExternalCitation · doi-reference
Obesity/cardiometabolic phenotype of heart failure with preserved ejection fraction: mechanisms to recent trials
10.1097/hco.0000000000001113 · ExternalCitation · doi-reference
From lipid switch to tissue repair: how resolvins reprogram macrophage polarization and function
10.1097/in9.0000000000000076 · ExternalCitation · doi-reference
GABA ameliorates diet-induced hepatic steatosis and insulin resistance by inhibiting macrophage activation
10.1111/dom.16556 · ExternalCitation · doi-reference
Sex differences in the impact of obesity on immunity
10.1111/imr.70101 · ExternalCitation · doi-reference
Inhibition of SGLT1 alleviates the glycemic variability-induced cardiac fibrosis via inhibition of activation of macrophage and cardiac fibroblasts
10.1128/mcb.00282-21 · ExternalCitation · doi-reference
TREM2 as a regulator of obesity-induced cardiac remodeling: mechanisms and therapeutic insights
10.1152/ajpheart.00075.2025 · ExternalCitation · doi-reference
Single-cell RNA sequencing reveals metabolic stress-dependent activation of cardiac macrophages in a model of dyslipidemia-induced diastolic dysfunction
10.1161/circulationaha.122.062984 · ExternalCitation · doi-reference
Y4 RNA fragments from cardiosphere-derived cells ameliorate diabetic myocardial ischemia‒reperfusion injury by inhibiting protein kinase C β-mediated macrophage polarization
10.1186/s12933-024-02247-6 · ExternalCitation · doi-reference
Timing-dependent anti-inflammatory effects of empagliflozin in monocyte-derived macrophages from post-myocardial infarct patients with type 2 diabetes
10.1186/s12933-025-03042-7 · ExternalCitation · doi-reference
hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery
10.1186/s13287-025-04521-0 · ExternalCitation · doi-reference
Cenicriviroc suppresses and reverses steatohepatitis by regulating macrophage infiltration and M2 polarization in mice
10.1210/endocr/bqae069 · ExternalCitation · doi-reference
Impact of breaking up of sitting time on anti-inflammatory response induced by extracellular vesicles
10.2174/0113816128244442231018070639 · ExternalCitation · doi-reference
Regulation of Monocytes/Macrophages by the renin-angiotensin system in diabetic nephropathy: state of the art and results of a pilot study
10.3390/ijms22116009 · ExternalCitation · doi-reference
Early changes in cardiac macrophage subsets in heart failure with preserved ejection fraction
10.3390/ijms262010196 · ExternalCitation · doi-reference
SGLT2 inhibitors: multifaceted therapeutic agents in cardiometabolic and renal diseases
10.3390/metabo15080536 · ExternalCitation · doi-reference
Advanced oxidation protein products contribute to chronic-kidney-disease-induced adipose inflammation through macrophage activation
10.3390/toxins15030179 · ExternalCitation · doi-reference
The metabolic and molecular mechanisms of α-mangostin in cardiometabolic disorders
10.3892/ijmm.2022.5176 · ExternalCitation · doi-reference
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
10.7554/elife.83075 · ExternalCitation · doi-reference
