Research graph
References from CHAC1 aggravates aldosterone-induced glomerular mesangial cell ferroptosis in diabetic kidney disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Increased glucocorticoid metabolism in diabetic kidney disease
10.1371/journal.pone.0269920 · 2022 · External reference
Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages
10.1096/fj.201901038rr · 2019 · External reference
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease
10.1038/s41581-018-0001-y · 2018 · External reference
Metformin rescues osteoblast fate in Glucocorticoid-associated osteonecrosis of the femoral head via PERK/CHAC1/GSH-mediated reprogramming of glutathione homeostasis
10.1016/j.freeradbiomed.2026.08.013 · 2026 · External reference
ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR
10.1152/ajprenal.00112.2007 · 2007 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
The role of iron and reactive oxygen species in cell death
10.1038/nchembio.1416 · 2014 · External reference
CHAC1 mediates endoplasmic reticulum stress-dependent ferroptosis in calcium Oxalate kidney Stone Formation
2025 · External reference
Diabetic nephropathy: pathogenesis, mechanisms, and therapeutic strategies
10.1055/a-2435-8264 · 2025 · External reference
Mesangial cells in diabetic kidney disease: from mechanisms to therapeutic implications
10.7150/ijbs.114907 · 2025 · External reference
Single-cell RNA profiling of glomerular cells shows dynamic changes in experimental diabetic kidney disease
10.1681/asn.2018090896 · 2019 · External reference
Systemic immune-inflammation index is associated with diabetic kidney disease in type 2 diabetes mellitus patients: evidence from NHANES 2011-2018
10.3389/fendo.2022.1071465 · 2022 · External reference
Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists
10.1021/jm2011645 · 2011 · External reference
A lactic acid-Chac1 axis regulates ferroptosis-associated cell death and tumor progression
10.1016/j.prp.2026.156665 · 2026 · External reference
Insights into the cell type-specific susceptibility of kidney cells to ferroptosis
10.1016/j.drudis.2026.104598 · 2026 · External reference
Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression
10.1210/en.2009-0442 · 2009 · External reference
Ang II-induced oscillation of clock genes can attenuate phenotypic transformation in vascular smooth muscle cells by activating the AT1R/PLC/Ca(2+)/PKC/p-CREB pathway
10.1080/07420528.2025.2523515 · 2025 · External reference
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells
10.1172/jci117251 · 1994 · External reference
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis
10.1126/scitranslmed.adn3079 · 2025 · External reference
Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase
10.1042/bj20141154 · 2015 · External reference
Ferroptosis in diabetes mellitus and its complications: overview of clinical and preclinical research
10.1038/s41420-025-02780-7 · 2025 · External reference
Hepatic glutathione depletion ameliorates MASLD through selective protein oxidation and inhibition of lipogenesis
10.1172/jci197556 · 2026 · External reference
Reshaping cell fate: recent advances in CHAC1-mediated pathways of programmed cell death in disease and prognosis
10.1016/j.bbrc.2025.152849 · 2025 · External reference
Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes
10.1172/jci.insight.96968 · 2018 · External reference
Pathophysiological analysis of uninephrectomized db/db mice as a model of severe diabetic kidney disease
10.33549/physiolres.934784 · 2022 · External reference
Renin-angiotensin-aldosterone system-mediated redox effects in chronic kidney disease
10.1016/j.trsl.2008.12.008 · 2009 · External reference
The role of ferroptosis in diabetes pathogenesis: therapeutic implications of hydrogen sulfide and its reactive metabolites
10.3390/antiox15030369 · 2026 · External reference
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis
10.1038/s41401-024-01228-5 · 2024 · External reference
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition
10.1016/j.diabres.2019.107843 · 2019 · External reference
Glucose area under the curve during oral glucose tolerance test as an index of glucose intolerance
10.1007/s13340-015-0212-4 · 2016 · External reference
Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation
10.1186/s13036-022-00299-4 · 2022 · External reference
Diabetic kidney disease
2015 · External reference
Diabetic kidney disease: a report from an ADA Consensus Conference
10.1053/j.ajkd.2014.08.001 · 2014 · External reference
HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose
10.1042/bsr20202924 · 2021 · External reference
Development of albuminuria and glomerular lesions in normoglycemic B6 recipients of db/db mice bone marrow: the role of mesangial cell progenitors
10.2337/diabetes.53.9.2420 · 2004 · External reference
The role of ferroptosis in the development of acute and chronic kidney diseases
10.1002/jcp.30901 · 2022 · External reference
