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References from Caloric restriction mimetics rewire the AMPK–mTOR–ULK1 signaling nexus to restore autophagic proteostasis in the aging brain. Local targets link to admitted publications; unresolved targets remain external evidence.
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2026 · External reference
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Resveratrol derivatives as potential treatments for Alzheimer’s and Parkinson’s disease
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2024 · External reference
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Calorie restriction: is AMPK as a key sensor and effector?
2011 · External reference
The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity
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AMPK/SIRT1/PGC-1α signaling pathway: molecular mechanisms and targeted strategies from energy homeostasis regulation to disease therapy
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Resveratrol as a calorie restriction mimetic: therapeutic implications
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Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications
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Resveratrol stimulates AMP kinase activity in neurons
10.1073/pnas.0610068104 · 2007 · External reference
The cellular phase of Alzheimer’s disease
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Unlocking the potential: caloric restriction, caloric restriction mimetics, and their impact on cancer prevention and treatment
10.3390/metabo14080418 · 2024 · External reference
Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process
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Calorie restriction for enhanced longevity: the role of novel dietary strategies in the present obesogenic environment
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10.1016/j.intimp.2023.109986 · 2023 · External reference
Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells
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The multifaceted role of nutrient sensing and mTORC1 signaling in physiology and aging
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PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons
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Metformin-induced mitochondrial complex I inhibition: facts, uncertainties, and consequences
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Metformin: from mechanisms of action to therapies
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TFEB; beyond its role as an autophagy and lysosomes regulator
10.3390/cells11193153 · 2022 · External reference
Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential
10.1186/s12933-024-02566-8 · 2025 · External reference
mTOR/AMPK signaling in the brain: cell metabolism, proteostasis and survival
10.1016/j.cotox.2018.05.002 · 2018 · External reference
Metformin: activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action
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Metabolic adaptation to calorie restriction
10.1126/scisignal.abb2490 · 2020 · External reference
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
10.1038/nn.3512 · 2013 · External reference
AMPK: a nutrient and energy sensor that maintains energy homeostasis
10.1038/nrm3311 · 2012 · External reference
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Calorie restriction mimetics: can you have your cake and eat it, too?
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Calorie restriction mimetics: an emerging research field
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Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy
10.1073/pnas.2317945121 · 2024 · External reference
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2015 · External reference
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mTOR inhibitor therapy and metabolic consequences: where do we stand?
10.1155/2018/2640342 · 2018 · External reference
mTOR as a central hub of nutrient signalling and cell growth
10.1038/s41556-018-0205-1 · 2019 · External reference
Anti-aging effects of calorie restriction (CR) and CR mimetics based on the senoinflammation concept
2020 · External reference
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2023 · External reference
Caloric restriction and its mimetics
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2026 · External reference
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10.1038/nrd4391 · 2014 · External reference
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Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
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10.1016/j.cmet.2018.05.011 · 2018 · External reference
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10.1242/jcs.146365 · 2016 · External reference
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10.1038/nm.3232 · 2013 · External reference
Autophagy, aging, and age-related neurodegeneration
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The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
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2020 · External reference
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Autophagy–proteasome crosstalk in neurodegenerative diseases: cellular proteostasis, neural interactions, and therapeutic implications
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The positive effect of spermidine in older adults suffering from dementia after 1 year
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AMPK: the energy sensor at the crossroads of aging and cancer
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Nanodelivery strategies for caloric restriction mimetics in age-associated neurodegeneration
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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
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Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson’s disease model
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2025 · External reference
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mTOR: more targets of resveratrol?
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Urolithin A in health and diseases: prospects for Parkinson’s disease management
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Autophagy gone awry in neurodegenerative diseases
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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation
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The effects of caloric restriction and its mimetics in Alzheimer’s disease through autophagy pathways
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2025 · External reference
MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
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2025 · External reference
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2025 · External reference
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