Research graph
References from Type 1 diabetes aetiology and pathogenesis – A new hypothesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Anti-pancreatic cellular hypersensitivity in diabetes mellitus
10.2337/diab.20.6.424 · 1971 · External reference
Unresolved reference
1980 · External reference
Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon
2025 · External reference
Pathologic anatomy of the pancreas in juvenile diabetes mellitus
10.2337/diab.14.10.619 · 1965 · External reference
HL-A antigens and diabetes mellitus
10.1016/s0140-6736(74)91201-x · 1974 · External reference
Thyroid, gastric and adrenal auto-immunity in diabetes mellitus
1973 · External reference
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
10.1016/s0140-6736(74)90140-8 · 1974 · External reference
Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease
10.1016/s0140-6736(74)90281-5 · 1974 · External reference
Islet-cell-surface antibodies in juvenile diabetes mellitus
10.1056/nejm197808242990802 · 1978 · External reference
Insulin antibodies in insulin-dependent diabetics before insulin treatment
10.1126/science.6362005 · 1983 · External reference
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
10.1038/298167a0 · 1982 · External reference
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
10.1038/347151a0 · 1990 · External reference
Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
10.1073/pnas.88.19.8337 · 1991 · External reference
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
10.1089/dna.1994.13.505 · 1994 · External reference
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
10.1073/pnas.0705894104 · 2007 · External reference
Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies
10.1111/pedi.12093 · 2014 · External reference
Clinical characteristics in Swedish children with and without autoantibodies at the time of type 1 diabetes diagnosis
10.2337/dc25-0840 · 2025 · External reference
Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset
10.3389/fimmu.2024.1427349 · 2024 · External reference
Next-generation sequencing reveals that HLA-DRB3, -DRB4, and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes
10.2337/db15-1115 · 2016 · External reference
Reversion of β-cell autoimmunity changes risk of type 1 diabetes: TEDDY study
10.2337/dc16-0181 · 2016 · External reference
The incidence of diabetes among 0-34 year olds in Sweden: new data and better methods
10.1007/s00125-014-3225-9 · 2014 · External reference
Diabetes and gender
10.1007/s001250051573 · 2001 · External reference
10.1007/bf00265396
10.1007/bf00265396 · 1989 · External reference
Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children
10.2337/dc12-0445 · 2013 · External reference
Genetic overlap between type 1 diabetes and other autoimmune diseases
10.1007/s00281-021-00885-6 · 2022 · External reference
Unresolved reference
1994 · External reference
Neonatal diabetes mellitus
10.1056/nejm199601043340118 · 1996 · External reference
Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease
10.2337/dc15-0144 · 2015 · External reference
Endocrine pancreas development: effects of metabolic and intergenerational programming caused by a protein-restricted diet
10.1097/mpa.0b013e3182236320 · 2012 · External reference
The rise and fall of a paradigm and conceiving a new hypothesis for type 1 diabetes
10.1007/s00125-025-06610-4 · 2026 · External reference
Activation pathways that drive CD4(+) T cells to break tolerance in autoimmune diseases
10.1111/imr.13071 · 2022 · External reference
Geospatial clustering of type 1 diabetes in Sweden: a cohort study based on all residential locations from birth to diagnosis
10.1007/s00125-026-06675-9 · 2026 · External reference
Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats
10.1006/jaut.1996.0105 · 1997 · External reference
NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice
10.2337/db09-0120 · 2009 · External reference
Pancreatic beta-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis
10.1371/journal.pone.0022485 · 2011 · External reference
Loss of insulin-positive cell clusters precedes the decrease in islet frequency and beta-cell area in type 1 diabetes
10.2337/db25-0326 · 2025 · External reference
Illuminating the complete ss-cell mass of the human pancreas- signifying a new view on the islets of Langerhans
10.1038/s41467-024-47686-7 · 2024 · External reference
Anti-adrenal cellular hypersensitivity in Addison's disease. II. Correlation with clinical and serological findings
1969 · External reference
Heritability of Addison's disease and prevalence of associated autoimmunity in a cohort of 112,100 Swedish twins
10.1007/s12020-017-1441-z · 2017 · External reference
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
10.1038/s41467-021-21015-8 · 2021 · External reference
The postnatal maternal environment influences diabetes development in nonobese diabetic mice
10.1016/j.jaut.2006.11.006 · 2007 · External reference
Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
10.2337/diabetes.48.5.989 · 1999 · External reference
The effect of maternal diabetes on pancreatic islets in newborn rats: a quantitative and immunocytochemical study
2006 · External reference
The NOD mouse beyond autoimmune diabetes
10.3389/fimmu.2022.874769 · 2022 · External reference
Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes
10.1016/0896-8411(95)90004-7 · 1995 · External reference
Actual distribution of the number and volume of the islets of Langerhans in different size classes in non-diabetic humans of varying ages
10.1038/1841498a0 · 1959 · External reference
Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
10.2337/db07-1369 · 2008 · External reference
The pathogenic "symphony" in type 1 diabetes: a disorder of the immune system, beta cells, and exocrine pancreas
10.1016/j.cmet.2023.06.018 · 2023 · External reference
Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats
10.1006/jaut.1996.0105 · ExternalCitation · doi-reference
10.1007/bf00265396
10.1007/bf00265396 · ExternalCitation · doi-reference
The incidence of diabetes among 0-34 year olds in Sweden: new data and better methods
10.1007/s00125-014-3225-9 · ExternalCitation · doi-reference
The rise and fall of a paradigm and conceiving a new hypothesis for type 1 diabetes
10.1007/s00125-025-06610-4 · ExternalCitation · doi-reference
Geospatial clustering of type 1 diabetes in Sweden: a cohort study based on all residential locations from birth to diagnosis
10.1007/s00125-026-06675-9 · ExternalCitation · doi-reference
Diabetes and gender
10.1007/s001250051573 · ExternalCitation · doi-reference
Genetic overlap between type 1 diabetes and other autoimmune diseases
10.1007/s00281-021-00885-6 · ExternalCitation · doi-reference
Heritability of Addison's disease and prevalence of associated autoimmunity in a cohort of 112,100 Swedish twins
10.1007/s12020-017-1441-z · ExternalCitation · doi-reference
Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes
10.1016/0896-8411(95)90004-7 · ExternalCitation · doi-reference
The pathogenic "symphony" in type 1 diabetes: a disorder of the immune system, beta cells, and exocrine pancreas
10.1016/j.cmet.2023.06.018 · ExternalCitation · doi-reference
The postnatal maternal environment influences diabetes development in nonobese diabetic mice
10.1016/j.jaut.2006.11.006 · ExternalCitation · doi-reference
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
10.1016/s0140-6736(74)90140-8 · ExternalCitation · doi-reference
Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease
10.1016/s0140-6736(74)90281-5 · ExternalCitation · doi-reference
HL-A antigens and diabetes mellitus
10.1016/s0140-6736(74)91201-x · ExternalCitation · doi-reference
Actual distribution of the number and volume of the islets of Langerhans in different size classes in non-diabetic humans of varying ages
10.1038/1841498a0 · ExternalCitation · doi-reference
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
10.1038/298167a0 · ExternalCitation · doi-reference
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
10.1038/347151a0 · ExternalCitation · doi-reference
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
10.1038/s41467-021-21015-8 · ExternalCitation · doi-reference
Illuminating the complete ss-cell mass of the human pancreas- signifying a new view on the islets of Langerhans
10.1038/s41467-024-47686-7 · ExternalCitation · doi-reference
Islet-cell-surface antibodies in juvenile diabetes mellitus
10.1056/nejm197808242990802 · ExternalCitation · doi-reference
Neonatal diabetes mellitus
10.1056/nejm199601043340118 · ExternalCitation · doi-reference
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
10.1073/pnas.0705894104 · ExternalCitation · doi-reference
Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
10.1073/pnas.88.19.8337 · ExternalCitation · doi-reference
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
10.1089/dna.1994.13.505 · ExternalCitation · doi-reference
Endocrine pancreas development: effects of metabolic and intergenerational programming caused by a protein-restricted diet
10.1097/mpa.0b013e3182236320 · ExternalCitation · doi-reference
Activation pathways that drive CD4(+) T cells to break tolerance in autoimmune diseases
10.1111/imr.13071 · ExternalCitation · doi-reference
Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies
10.1111/pedi.12093 · ExternalCitation · doi-reference
Insulin antibodies in insulin-dependent diabetics before insulin treatment
10.1126/science.6362005 · ExternalCitation · doi-reference
Pancreatic beta-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis
10.1371/journal.pone.0022485 · ExternalCitation · doi-reference
Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
10.2337/db07-1369 · ExternalCitation · doi-reference
NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice
10.2337/db09-0120 · ExternalCitation · doi-reference
Next-generation sequencing reveals that HLA-DRB3, -DRB4, and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes
10.2337/db15-1115 · ExternalCitation · doi-reference
Loss of insulin-positive cell clusters precedes the decrease in islet frequency and beta-cell area in type 1 diabetes
10.2337/db25-0326 · ExternalCitation · doi-reference
Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children
10.2337/dc12-0445 · ExternalCitation · doi-reference
Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease
10.2337/dc15-0144 · ExternalCitation · doi-reference
Reversion of β-cell autoimmunity changes risk of type 1 diabetes: TEDDY study
10.2337/dc16-0181 · ExternalCitation · doi-reference
Clinical characteristics in Swedish children with and without autoantibodies at the time of type 1 diabetes diagnosis
10.2337/dc25-0840 · ExternalCitation · doi-reference
Pathologic anatomy of the pancreas in juvenile diabetes mellitus
10.2337/diab.14.10.619 · ExternalCitation · doi-reference
Anti-pancreatic cellular hypersensitivity in diabetes mellitus
10.2337/diab.20.6.424 · ExternalCitation · doi-reference
Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
10.2337/diabetes.48.5.989 · ExternalCitation · doi-reference
The NOD mouse beyond autoimmune diabetes
10.3389/fimmu.2022.874769 · ExternalCitation · doi-reference
Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset
10.3389/fimmu.2024.1427349 · ExternalCitation · doi-reference
