Research graph
References from ATF6 contributes to cardiac macrophage polarization and metabolic reprogramming following myocardial ischemia/reperfusion injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
2023 · External reference
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
10.1038/s41569-021-00511-w · 2021 · External reference
Mechanisms of substrate processing during ER-associated protein degradation
10.1038/s41580-023-00633-8 · 2023 · External reference
Reshaping endoplasmic reticulum quality control through the unfolded protein response
10.1016/j.molcel.2022.03.025 · 2022 · External reference
Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease
10.1161/circresaha.110.227819 · 2010 · External reference
Mechanisms, regulation and functions of the unfolded protein response
10.1038/s41580-020-0250-z · 2020 · External reference
The unfolded protein response and cell fate control
10.1016/j.molcel.2017.06.017 · 2018 · External reference
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
10.1038/nrm3270 · 2012 · External reference
Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival
10.1158/0008-5472.can-19-1116 · 2019 · External reference
GRINA alleviates hepatic ischemia–reperfusion injury-induced apoptosis and ER-phagy by enhancing HRD1-mediated ATF6 ubiquitination
10.1016/j.jhep.2025.01.012 · 2025 · External reference
Proteostasis and beyond: ATF6 in ischemic disease
10.1016/j.molmed.2019.03.005 · 2019 · External reference
Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
10.1186/s11658-023-00491-4 · 2023 · External reference
Macrophage polarization in myocardial ischemia–reperfusion injury: pathophysiology and therapeutic targets
10.2147/dddt.s516001 · 2025 · External reference
Estrogen signaling and cardiovascular disease
10.1161/circresaha.110.236687 · 2011 · External reference
The G protein-coupled oestrogen receptor GPER in health and disease: an update
10.1038/s41574-023-00822-7 · 2023 · External reference
Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury
10.1186/s13020-022-00616-5 · 2022 · External reference
The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1’s phosphorylation dependent SUMOylation
10.7150/ijbs.60459 · 2021 · External reference
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
10.1126/science.aan6733 · 2017 · External reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · 2015 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Uniform manifold approximation and projection (UMAP) reveals composite patterns and resolves visualization artifacts in microbiome data
10.1128/msystems.00691-21 · 2021 · External reference
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
10.1038/s41590-018-0276-y · 2019 · External reference
Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes
10.1016/j.envint.2022.107393 · 2022 · External reference
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
10.1016/j.immuni.2023.01.011 · 2023 · External reference
Epigenetic blockade of SOD2 boosts mitochondria ROS and cytoskeleton remodelling in cardiac fibrosis
10.1093/cvr/cvaf257 · 2026 · External reference
Identification of diagnostically relevant biomarkers in patients with coronary artery disease by comprehensive analysis
10.2147/jir.s494438 · 2024 · External reference
Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a
10.1186/s12964-022-00842-2 · 2022 · External reference
HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes
10.1016/s0378-4274(97)00098-2 · 1997 · External reference
Endoplasmic reticulum chaperone GRP78 protects heart from ischemia/reperfusion injury through Akt activation
10.1161/circresaha.117.312641 · 2018 · External reference
ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in severe acute pancreatitis
10.7150/thno.46934 · 2020 · External reference
Cardiac macrophages and emerging roles for their metabolism after myocardial infarction
10.1172/jci171953 · 2023 · External reference
Cardiac macrophage metabolism in health and disease
10.1016/j.tem.2023.10.011 · 2024 · External reference
Resident cardiac macrophages: heterogeneity and function in health and disease
10.1016/j.immuni.2022.08.009 · 2022 · External reference
The human heart contains distinct macrophage subsets with divergent origins and functions
10.1038/s41591-018-0059-x · 2018 · External reference
Macrophages in cardiac remodelling after myocardial infarction
10.1038/s41569-022-00823-5 · 2023 · External reference
Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair
10.3390/cells10010051 · 2020 · External reference
Dual inhibition of endoplasmic reticulum stress and oxidation stress manipulates the polarization of macrophages under hypoxia to sensitize immunotherapy
10.1021/acsnano.1c04068 · 2021 · External reference
Precisely regulating M2 subtype macrophages for renal fibrosis resolution
10.1021/acsnano.3c05998 · 2023 · External reference
Natural melanin/alginate hydrogels achieve cardiac repair through ROS scavenging and macrophage polarization
2021 · External reference
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages
10.1038/cr.2013.75 · 2013 · External reference
Obesity, hypertension, and cardiac dysfunction: novel roles of Immunometabolism in macrophage activation and inflammation
10.1161/circresaha.119.312321 · 2020 · External reference
