References

Unresolved reference

2025 · External reference

Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

10.1016/s0140-6736(25)00355-1 · 2025 · External reference

Metabolic dysfunction-associated steatotic liver disease (MASLD): a state-of-the-art review

10.7570/jomes23052 · 2023 · External reference

The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review

10.1097/hep.0000000000000004 · 2023 · External reference

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

10.1016/s2468-1253(22)00165-0 · 2022 · External reference

Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis

10.1016/s2468-1253(22)00317-x · 2023 · External reference

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

10.1210/endrev/bnz009 · 2020 · External reference

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

10.1002/hep.27368 · 2015 · External reference

Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease

10.1053/j.gastro.2019.12.054 · 2020 · External reference

An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

10.1016/j.jhep.2023.01.024 · 2023 · External reference

Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity

10.1016/j.bbadis.2013.05.029 · 2014 · External reference

Androgens and the regulation of adiposity and body fat distribution in humans

10.1002/j.2040-4603.2018.tb00043.x · 2018 · External reference

5α-reductase type 2 regulates glucocorticoid action and metabolic phenotype in human hepatocytes

10.1210/en.2015-1149 · 2015 · External reference

Hepatic sexual dimorphism - implications for non-alcoholic fatty liver disease

10.1038/s41574-021-00538-6 · 2021 · External reference

Association of Bariatric Surgery with major adverse liver and cardiovascular outcomes in patients with biopsy-proven nonalcoholic steatohepatitis

10.1001/jama.2021.19569 · 2021 · External reference

The change in the percent of android and gynoid fat mass correlated with increased testosterone after laparoscopic sleeve gastrectomy in Chinese obese men: a 6-month follow-up

10.1007/s11695-018-3116-0 · 2018 · External reference

Five-year changes in body composition in type 2 diabetes mellitus patients with a BMI <32.5 kg/m

10.1007/s11695-021-05430-w · 2021 · External reference

EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

10.1016/j.jhep.2024.04.031 · 2024 · External reference

Effects of intestine-specific deletion of FGF15 on the development of fatty liver disease with vertical sleeve gastrectomy

10.1097/hc9.0000000000000444 · 2024 · External reference

Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats

10.1038/s41366-019-0420-2 · 2020 · External reference

Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD

10.1016/j.metabol.2023.155663 · 2023 · External reference

Comparison of hormonal response to a mixed-meal challenge in hypoglycemia after sleeve gastrectomy vs gastric bypass

10.1210/clinem/dgac455 · 2022 · External reference

Plasma concentration of gastrointestinal hormones and subjective appetite ratings after diet or bariatric surgery: 1-year results from the DISGAP study

10.1038/s41366-024-01658-5 · 2025 · External reference

Bariatric-metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trial

10.1016/s0140-6736(23)00634-7 · 2023 · External reference

Role of estrogens in the regulation of liver lipid metabolism

10.1007/978-3-319-70178-3_12 · 2017 · External reference

Sex differences in nonalcoholic fatty liver disease: state of the art and identification of research gaps

10.1002/hep.30626 · 2019 · External reference

AlphaPept: a modern and open framework for MS-based proteomics

10.1038/s41467-024-46485-4 · 2024 · External reference

DEqMS: a method for accurate variance estimation in differential protein expression analysis

10.1074/mcp.tir119.001646 · 2020 · External reference

limma powers differential expression analyses for RNA-sequencing and microarray studies

10.1093/nar/gkv007 · 2015 · External reference

Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity

10.1371/journal.pgen.1009975 · 2022 · External reference

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients

10.1016/j.jhep.2013.09.012 · 2014 · External reference

The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after roux-en-Y gastric bypass and sleeve gastrectomy surgery

10.2337/db22-0568 · 2023 · External reference

Proteomic changes upon treatment with semaglutide in individuals with obesity

10.1038/s41591-024-03355-2 · 2025 · External reference

Integrated proteomic and metabolomic profiling identifies distinct molecular signatures and metabolic pathways associated with obesity and potential targets for anti-obesity therapies

2025 · External reference

Multi-omics profiling reveals altered mitochondrial metabolism in adipose tissue from patients with metabolic dysfunction-associated steatohepatitis

10.1016/j.ebiom.2024.105532 · 2025 · External reference

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

10.1038/nature09968 · 2011 · External reference

Proteome and phosphoproteome characterization of liver in the postprandial state from diet-induced obese and lean mice

10.1016/j.jprot.2020.104072 · 2021 · External reference

Regional differences in subcutaneous adipose tissue gene expression

10.1038/oby.2012.117 · 2012 · External reference

Effect of distinct lifestyle interventions on mobilization of fat storage pools: CENTRAL magnetic resonance imaging randomized controlled trial

10.1161/circulationaha.117.030501 · 2018 · External reference

Distinct abdominal and gluteal adipose tissue transcriptome signatures are altered by exercise training in African women with obesity

10.1038/s41598-020-66868-z · 2020 · External reference

Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES)

10.1371/journal.pone.0119941 · 2015 · External reference

Further evidence supporting a potential role for ADH1B in obesity

10.1038/s41598-020-80563-z · 2021 · External reference

A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women

10.1038/s41598-019-40992-x · 2019 · External reference

Epigenetic regulation of diabetogenic adipose morphology

10.1016/j.molmet.2019.04.009 · 2019 · External reference

ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis

10.1073/pnas.2319301121 · 2024 · External reference

Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease

10.1038/s41588-023-01497-6 · 2023 · External reference

Lumican, a small leucine-rich proteoglycan

10.1002/iub.131 · 2008 · External reference

2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

10.1530/joe-13-0010 · 2013 · External reference

Lumican modulates adipocyte function in obesity-associated type 2 diabetes

10.1080/21623945.2022.2154112 · 2022 · External reference

Adipose tissue depot-specific intracellular and extracellular cues contributing to insulin resistance in obese individuals

10.1096/fj.201902703r · 2020 · External reference

Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis

10.1016/j.molmet.2018.10.007 · 2019 · External reference

Multi-omics analysis of bariatric surgery’s impact on type 2 diabetes and prediabetes

10.1038/s41598-025-14577-w · 2025 · External reference

Effect of bariatric surgery on non-alcoholic fatty liver disease: an exploratory metabolomics and validation study

10.1007/s11695-025-08031-z · 2025 · External reference

Metabolomic alterations in patients with obesity and the impact of metabolic bariatric surgery: insights for future research

10.3390/metabo15070434 · 2025 · External reference

Dynamics of the human bile acid metabolome during weight loss

10.1038/s41598-024-75831-1 · 2024 · External reference

Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss

10.1002/oby.21686 · 2016 · External reference

Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)

10.1210/jc.2014-4120 · 2015 · External reference

Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss

10.2337/db08-0094 · 2008 · External reference

Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process

10.1016/s0140-6736(26)00717-8 · 2026 · External reference

AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome

10.1210/jc.2017-00947 · 2017 · External reference

Longitudinal analyses of the steroid metabolome in obese PCOS girls with weight loss

10.1530/ec-17-0051 · 2017 · External reference

Metabolomic architecture of obesity implicates metabolonic lactone sulfate in cardiometabolic disease

10.1016/j.molmet.2021.101342 · 2021 · External reference

The metabolomic profile associated with clustering of cardiovascular risk factors-a multi-sample evaluation

10.1371/journal.pone.0274701 · 2022 · External reference

Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways

10.1111/liv.15575 · 2023 · External reference

Effects of uremic toxin p-cresol on proliferation, apoptosis, differentiation, and glucose uptake in 3T3-L1 cells

10.1111/aor.12252 · 2014 · External reference

The natural metabolite 4-cresol improves glucose homeostasis and enhances β-cell function

10.1016/j.celrep.2020.01.066 · 2020 · External reference

Roux-en-Y gastric bypass, adjustable gastric banding, or sleeve gastrectomy for severe obesity (By-Band-Sleeve): a multicentre, open label, three-group, randomised controlled trial

10.1016/s2213-8587(25)00025-7 · 2025 · External reference

Effect of gastric bypass versus sleeve gastrectomy on the remission of type 2 diabetes, weight loss, and cardiovascular risk factors at 5 years (Oseberg): secondary outcomes of a single-centre, triple-blind, randomised controlled trial

10.1016/s2213-8587(24)00396-6 · 2025 · External reference

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management

10.1016/j.jhep.2014.11.034 · 2015 · External reference

Obesity surgery makes patients healthier and more functional: real world results from the United Kingdom National Bariatric Surgery Registry

10.1016/j.soard.2018.02.012 · 2018 · External reference

Sex differences in prevalence and prognosis of steatotic liver disease phenotypes: biological sex matters

10.1016/j.jhep.2023.08.013 · 2024 · External reference