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References from P7C3: A novel multi-target therapeutic strategy to combat disuse-related bone loss in space and on earth. Local targets link to admitted publications; unresolved targets remain external evidence.
The molecular basis of bone mechanotransduction
2016 · External reference
Receptor-mediated cell mechanosensing
10.1091/mbc.e17-04-0228 · 2017 · External reference
The effect of space travel on bone metabolism: considerations on today’s major challenges and advances in pharmacology
10.3390/ijms22094585 · 2021 · External reference
Changes in interstitial fluid flow, mass transport and the bone cell response in microgravity and normogravity
10.1038/s41413-022-00234-9 · 2022 · External reference
Unresolved reference
2006 · External reference
Disuse osteoporosis: clinical and mechanistic insights
10.1007/s00223-021-00836-1 · 2022 · External reference
Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance
10.1359/jbmr.041222 · 2005 · External reference
Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
10.1210/jc.2010-0067 · 2010 · External reference
Osteoporosis: now and the future
10.1016/s0140-6736(10)62349-5 · 2011 · External reference
The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects
10.1359/jbmr.1998.13.10.1594 · 1998 · External reference
Rehabilitation: neurogenic bone loss after spinal cord injury
10.3390/biomedicines11092581 · 2023 · External reference
Neuromuscular diseases and bone
2019 · External reference
Immobilization osteoporosis
2021 · External reference
Disuse osteoporosis
2001 · External reference
A systematic review and meta-analysis of bone loss in space travelers
10.1038/s41526-020-0103-2 · 2020 · External reference
Cortical and trabecular bone microstructure did not recover at weight-bearing skeletal sites and progressively deteriorated at non-weight-bearing sites during the year following international space station missions
10.1002/jbmr.3188 · 2017 · External reference
Skeletal health in long-duration astronauts: nature, assessment, and management recommendations from the NASA Bone Summit
10.1002/jbmr.1948 · 2013 · External reference
Unresolved reference
2023 · External reference
Human health during space travel: state-of-the-art review
10.3390/cells12010040 · 2022 · External reference
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars
2023 · External reference
The crewed journey to Mars and its implications for the human microbiome
10.1186/s40168-021-01222-7 · 2022 · External reference
The influence of disuse on bone microstructure and mechanics assessed by HR-PQCT
10.1016/j.bone.2014.02.014 · 2014 · External reference
Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight
10.1038/s41598-022-13461-1 · 2022 · External reference
Hormone therapy: short-term relief, long-term consequences
10.1016/s0140-6736(14)62458-2 · 2015 · External reference
Hormone replacement therapy – where are we now?
10.1080/13697137.2020.1851183 · 2021 · External reference
Estrogen therapy for osteoporosis in the modern era
10.1007/s00198-018-4414-z · 2018 · External reference
Bisphosphonates: mechanism of action and role in clinical practice
10.4065/83.9.1032 · 2008 · External reference
Duration of bisphosphonate drug holidays in osteoporosis patients: a narrative review of the evidence and considerations for decision-making
10.3390/jcm10051140 · 2021 · External reference
American Society for Bone and Mineral Research. Bisphosphonate-Associated Osteonecrosis of the Jaw: report of a task force of the American Society for Bone and Mineral Research
10.1359/jbmr.0707onj · 2007 · External reference
Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-ΚB signaling pathways
10.18632/aging.103976 · 2020 · External reference
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT extension study
10.1016/s2213-8587(19)30346-8 · 2019 · External reference
Discontinuation of denosumab therapy for osteoporosis: a systematic review and position statement by ECTS
10.1016/j.bone.2017.08.003 · 2017 · External reference
Romosozumab or alendronate for fracture prevention in women with osteoporosis
10.1056/nejmoa1708322 · 2017 · External reference
The current state of bone loss research: data from spaceflight and microgravity simulators
10.1002/jcb.24454 · 2013 · External reference
Animal model of simulated microgravity: a comparative study of hindlimb unloading via tail versus pelvic suspension
10.1002/phy2.12 · 2013 · External reference
Unresolved reference
2019 · External reference
Unresolved reference
2005 · External reference
Approaching gravity as a continuum using the rat partial weight-bearing model
10.3390/life10100235 · 2020 · External reference
Interdependence of muscle atrophy and bone loss induced by mechanical unloading
10.1002/jbmr.2113 · 2014 · External reference
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
10.1016/s0092-8674(00)81569-x · 1998 · External reference
Soluble RANKL exaggerates hindlimb suspension-induced osteopenia but not muscle protein balance
10.1002/jor.24917 · 2021 · External reference
The RANKL/RANK/OPG pathway
10.1007/s11914-007-0024-y · 2007 · External reference
Functions of RANKL/RANK/OPG in bone modeling and remodeling
10.1016/j.abb.2008.03.018 · 2008 · External reference
Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse
10.1016/j.bone.2016.02.005 · 2016 · External reference
Bisphosphonate conjugation for bone specific drug targeting
10.1016/j.bonr.2018.06.007 · 2018 · External reference
Muscle atrophy and bone loss after 90 days’ bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study
10.1016/j.bone.2004.11.014 · 2005 · External reference
Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis
10.1359/jbmr.041010 · 2005 · External reference
Medical Advisory Council of the British Menopause Society. Prevention and treatment of osteoporosis in women
10.1177/20533691221139902 · 2023 · External reference
Administration of denosumab preserves bone mineral density at the knee in persons with subacute spinal cord injury: findings from a randomized clinical trial
10.1002/jbm4.10375 · 2020 · External reference
Efficacy and safety of denosumab vs. bisphosphonates in postmenopausal women previously treated with oral bisphosphonates
10.1007/s00198-019-05233-x · 2020 · External reference
Comparison of denosumab and zoledronic acid in postmenopausal women with osteoporosis: bone mineral density (BMD) and trabecular bone score (TBS)
10.3346/jkms.2022.37.e68 · 2022 · External reference
Denosumab treatment of severe disuse osteoporosis in a boy with spinal muscular atrophy
2017 · External reference
A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss
10.1038/s41413-023-00273-w · 2023 · External reference
Long-term consequences of osteoporosis therapy with denosumab
10.20945/2359-3997000000560 · 2022 · External reference
Effects of teriparatide and vibration on bone mass and bone strength in people with bone loss and spinal cord injury: a randomized, controlled trial
10.1002/jbmr.3525 · 2018 · External reference
Combination therapy of PTH and antiresorptive drugs on osteoporosis: a review of treatment alternatives
2021 · External reference
Teriparatide for osteoporosis: importance of the full course
10.1007/s00198-016-3534-6 · 2016 · External reference
Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243
10.1167/iovs.14-15468 · 2014 · External reference
Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury
10.1089/neu.2013.3135 · 2014 · External reference
P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury
10.1016/j.celrep.2014.08.030 · 2014 · External reference
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
10.1073/pnas.1213956109 · 2012 · External reference
P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo
10.1038/cddis.2017.250 · 2017 · External reference
(−)-P7C3-S243 protects a rat model of Alzheimer’s disease from neuropsychiatric deficits and neurodegeneration without altering amyloid deposition or reactive glia
10.1016/j.biopsych.2017.10.023 · 2018 · External reference
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage
10.1016/j.cell.2014.07.040 · 2014 · External reference
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
10.1038/s41392-020-00311-7 · 2020 · External reference
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
10.1016/j.cmet.2018.02.011 · 2018 · External reference
Age-related NAD+ decline
10.1016/j.exger.2020.110888 · 2020 · External reference
Why NAD(+) declines during aging: it’s destroyed
10.1016/j.cmet.2016.05.022 · 2016 · External reference
A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging
10.1038/s41514-021-00058-7 · 2021 · External reference
AMPK phosphorylates NAMPT to regulate NAD + homeostasis under ionizing radiation
10.1098/rsob.220213 · 2022 · External reference
A multifunctional therapeutic strategy using P7C3 as a countermeasure against bone loss and fragility in an ovariectomized rat model of postmenopausal osteoporosis
2024 · External reference
An update on neuroaging on earth and in spaceflight
10.3390/ijms26041738 · 2025 · External reference
Mesenchymal stem cells arouse myocardial NAD+ metabolism to alleviate microgravity-induced cardiac dysfunction
10.1016/j.bbrc.2024.150623 · 2024 · External reference
<scp>P7C3</Scp> ameliorates bone loss by inhibiting osteoclast differentiation and promoting osteogenesis
10.1002/jbm4.10811 · 2023 · External reference
Estrogens protect bone mass by inhibiting NAD + metabolism in osteoclasts
2025 · External reference
Poly(ADP-Ribose) polymerase-1-induced NAD+ depletion promotes nuclear factor-ΚB transcriptional activity by preventing P65 de-acetylation
10.1016/j.bbamcr.2013.04.005 · 2013 · External reference
A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme
2023 · External reference
The Nf-Core framework for community-curated bioinformatics pipelines
10.1038/s41587-020-0439-x · 2020 · External reference
Nextflow enables reproducible computational workflows
10.1038/nbt.3820 · 2017 · External reference
STAR: ultrafast universal RNA-Seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Twelve years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
RSeQC: quality control of RNA-Seq experiments
10.1093/bioinformatics/bts356 · 2012 · External reference
Qualimap: evaluating next-generation sequencing alignment data
10.1093/bioinformatics/bts503 · 2012 · External reference
Predicting the molecular complexity of sequencing libraries
10.1038/nmeth.2375 · 2013 · External reference
DupRadar: a bioconductor package for the assessment of PCR artifacts in RNA-Seq data
10.1186/s12859-016-1276-2 · 2016 · External reference
FeatureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
In osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
10.4067/s0716-97602012000300009 · 2012 · External reference
New insights into osteoporosis: the bone–fat connection
10.1111/j.1365-2796.2012.02564.x · 2012 · External reference
The subunit composition and function of mammalian cytochrome c oxidase
10.1016/j.mito.2015.07.002 · 2015 · External reference
Mitochondrial genetics and therapeutic overview of Leber’s hereditary optic neuropathy
10.4103/ijo.ijo_358_17 · 2017 · External reference
Exploring the oncogenic impact of heteroplasmic de novo MT-ND5 truncating mutations
10.1016/j.mitoco.2025.03.001 · 2025 · External reference
Extracellular matrix and integrin composition of the normal bladder wall
10.1007/bf00182062 · 1996 · External reference
Emerging functions of thrombospondin-1 in immunity
10.1016/j.semcdb.2023.05.008 · 2024 · External reference
MALAT1 long non-coding RNA: functional implications
10.3390/ncrna6020022 · 2020 · External reference
Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
10.1073/pnas.1007293108 · 2011 · External reference
Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency
10.1128/mcb.24.4.1608-1613.2004 · 2004 · External reference
Specialized roles for actin in osteoclasts: unanswered questions and therapeutic opportunities
10.3390/biom9010017 · 2019 · External reference
Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153
10.1038/s41413-022-00218-9 · 2022 · External reference
Surface chemistry of biologically-active reducible oxide nanozymes
2023 · External reference
Osteoclasts secrete osteopontin into resorption lacunae during bone resorption
10.1007/s00418-019-01770-y · 2019 · External reference
Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene
10.1111/nyas.12709 · 2016 · External reference
Mitochondrial function in pluripotent stem cells and cellular reprogramming
10.1159/000355050 · 2014 · External reference
Mitochondrial transfer regulates cell fate through metabolic remodeling in osteoporosis
10.1002/advs.202204871 · 2023 · External reference
The collagenolytic activity of cathepsin K is unique among mammalian proteinases
10.1074/jbc.273.48.32347 · 1998 · External reference
HNGF6A inhibits oxidative stress-induced MC3T3-E1 cell apoptosis and osteoblast phenotype inhibition by targeting Circ_0001843/MiR-214 pathway
10.1007/s00223-020-00660-z · 2020 · External reference
Humanin suppresses receptor activator of nuclear factor-ΚB ligand-induced osteoclast differentiation via AMP-activated protein kinase activation
10.4196/kjpp.2019.23.5.411 · 2019 · External reference
Role of MOTS-c in the regulation of bone metabolism
2023 · External reference
MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway
2018 · External reference
MOTS-c inhibits osteolysis in the mouse calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation
10.1016/j.phrs.2019.104381 · 2019 · External reference
Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation
10.1016/j.bbrc.2016.05.135 · 2016 · External reference
Mitochondrial complex I subunit MT-ND1 mutations affect disease progression
10.1016/j.heliyon.2024.e28808 · 2024 · External reference
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model
10.1073/pnas.1119577109 · 2012 · External reference
Dynamics of human mitochondrial complex I assembly: implications for neurodegenerative diseases
2016 · External reference
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
10.1038/s41467-024-46602-3 · 2024 · External reference
Oxidative phosphorylation in bone cells
10.1016/j.bonr.2023.101688 · 2023 · External reference
Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes
10.1371/journal.pone.0107447 · 2014 · External reference
Mitochondrial morphology and function impaired by dimethyl sulfoxide and dimethyl formamide
10.1007/s10863-018-9759-7 · 2018 · External reference
Unresolved reference
2025 · External reference
Molecular pathways in mitochondrial disorders due to a defective mitochondrial protein synthesis
2024 · External reference
Neurotherapeutic capacity of P7C3 agents for the treatment of traumatic brain injury
10.1016/j.neuropharm.2018.09.024 · 2019 · External reference
Decorin modulates collagen matrix assembly and mineralization
10.1016/j.matbio.2008.11.003 · 2009 · External reference
Fibulin-1 is required for bone formation and bmp-2-mediated induction of osterix
10.1016/j.bone.2014.07.038 · 2014 · External reference
The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling
10.1074/jbc.m112.440370 · 2013 · External reference
Regulation of matrix metalloproteinase-9 protein expression by 1α,25-(OH) 2 D 3 during osteoclast differentiation
10.4142/jvs.2014.15.1.133 · 2014 · External reference
Matrix metalloproteinase-9 enhances osteoclastogenesis: insights from transgenic rabbit bone marrow models and in vitro studies
10.3390/ijms26073194 · 2025 · External reference
Cryptotanshinone inhibits osteoclast differentiation by targeting LCP1 to suppress diabetic osteoporosis
10.1016/j.intimp.2025.116115 · 2026 · External reference
Significance analysis of microarrays applied to the ionizing radiation response
10.1073/pnas.091062498 · 2001 · External reference
Reg3α and Reg3β expressions followed by JAK2/STAT3 activation play a pivotal role in the acceleration of liver hypertrophy in a rat ALPPS model
10.3390/ijms21114077 · 2020 · External reference
JAK/STAT3-dependent activation of the RalGDS/Ral pathway in M1 mouse myeloid leukemia cells
10.1074/jbc.m105749200 · 2001 · External reference
An overview of mammalian P38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling
10.12688/f1000research.22092.1 · 2020 · External reference
LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages
10.1084/jem.20062611 · 2007 · External reference
Myostatin promotes osteoclastogenesis by regulating Ccdc50 gene expression and RANKL-induced NF-ΚB and MAPK pathways
2020 · External reference
The role of Glypican-3 in regulating Wnt, YAP, and hedgehog in liver cancer
2019 · External reference
The loss of Glypican-3 induces alterations in Wnt signaling
10.1074/jbc.m410090200 · 2005 · External reference
Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the Α6β4 integrin and MT1-MMP
10.1593/neo.111450 · 2012 · External reference
Reversible photoregulation of cell-cell adhesions with Opto-E-cadherin
10.1038/s41467-023-41932-0 · 2023 · External reference
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17
10.1515/bc.2008.121 · 2008 · External reference
Dysregulation of TCTP in biological processes and diseases
10.3390/cells9071632 · 2020 · External reference
E-cadherin expression increases cell proliferation by regulating energy metabolism through nuclear factor-κB in <scp>AGS</Scp> cells
10.1111/cas.13321 · 2017 · External reference
FABP3 deficiency exacerbates metabolic derangement in cardiac hypertrophy and heart failure via PPARα pathway
2021 · External reference
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing
10.3390/ijms10041729 · 2009 · External reference
Dual role of mitochondrial porin in metabolite transport across the outer membrane and protein transfer to the inner membrane
10.1016/j.molcel.2018.12.014 · 2019 · External reference
Receptor serine/threonine kinases
2005 · External reference
Serine/threonine kinases play important roles in regulating polyunsaturated fatty acid biosynthesis in Synechocystis Sp. PCC6803
2021 · External reference
Galectin-1: a traditionally immunosuppressive protein displays context-dependent capacities
10.3390/ijms24076501 · 2023 · External reference
Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice
10.1038/s41467-023-39715-8 · 2023 · External reference
Soluble CD163 is associated with CD163 MRNA expression in adipose tissue and with insulin sensitivity in steady-state condition but not in response to calorie restriction
10.1210/jc.2013-3348 · 2014 · External reference
Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice
10.2337/db11-1116 · 2013 · External reference
Growth hormone regulates the balance between bone formation and bone marrow adiposity
10.1359/jbmr.091015 · 2010 · External reference
Transforming growth factor-Β3 regulates adipocyte number in subcutaneous white adipose tissue
10.1016/j.celrep.2018.09.069 · 2018 · External reference
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation
2013 · External reference
SPARC functions as an inhibitor of adipogenesis
10.1007/s12079-009-0064-4 · 2009 · External reference
Glycosaminoglycan modification of decorin depends on MMP14 activity and regulates collagen assembly
10.3390/cells9122646 · 2020 · External reference
Adiponectin: role in physiology and pathophysiology
2020 · External reference
Follistatin-like 1 suppresses osteoblast differentiation of bone marrow mesenchymal cells during inflammation
10.1016/j.archoralbio.2022.105345 · 2022 · External reference
The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia
10.1186/1742-2094-11-116 · 2014 · External reference
Matrix metalloproteinases/tissue inhibitors of metalloproteinases ratio: a biomarker of bone resorption in geriatric osteoporosis?
10.4235/agmr.23.0024 · 2023 · External reference
Unresolved reference
2016 · External reference
Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis
10.1038/s12276-019-0220-8 · 2019 · External reference
Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism
2022 · External reference
Insulin-like growth factor binding proteins in femoral and vertebral bone marrow stromal cells: expression and regulation by thyroid hormone and dexamethasone
10.1002/1097-4644(20010501)81:2<229::aid-jcb1038>3.0.co;2-c · 2001 · External reference
Prolactinoma and bone
10.1016/j.coemr.2018.02.006 · 2018 · External reference
Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption
10.1016/s0021-9258(18)98430-9 · 1993 · External reference
The role of BMPs in the regulation of osteoclasts resorption and bone remodeling: from experimental models to clinical applications
2022 · External reference
Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF
10.1186/1476-4598-6-71 · 2007 · External reference
RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts
10.1038/s41423-022-00959-x · 2022 · External reference
Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment
10.1111/acel.13936 · 2023 · External reference
A comparison of bone microarchitectural and transcriptomic changes in murine long bones in response to hindlimb unloading and aging
10.1016/j.bone.2023.116973 · 2024 · External reference
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2022 · External reference
Infrared assessment of bone quality: a review
10.1007/s11999-010-1751-4 · 2011 · External reference
Lipid bands of approx. 1740 cm−1 as spectral biomarkers and image of tissue oxidative stress
10.1016/j.saa.2022.121926 · 2023 · External reference
Long-term immobilization in elderly females causes a specific pattern of cortical bone and osteocyte deterioration different from postmenopausal osteoporosis
10.1002/jbmr.3970 · 2020 · External reference
Different impact of short-term and long-term hindlimb disuse on bone homeostasis
10.1016/j.gene.2024.148457 · 2024 · External reference
Matrix/mineral ratio and domain size variation with bone tissue age: a photothermal infrared study
10.1016/j.jsb.2022.107878 · 2022 · External reference
Influence of remodeling on the mineralization of bone tissue
10.1007/s00198-009-0861-x · 2009 · External reference
Mechanomics: an emerging field between biology and biomechanics
10.1007/s13238-014-0057-9 · 2014 · External reference
Loading and skeletal development and maintenance
10.4061/2011/786752 · 2011 · External reference
Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli
10.1016/s1359-6446(01)01872-4 · 2001 · External reference
The role of mechanical stimulation in recovery of bone loss—high versus low magnitude and frequency of force
10.3390/life4020117 · 2014 · External reference
Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells
10.1111/j.1365-2184.2007.00461.x · 2007 · External reference
Simulated microgravity suppresses osteogenic differentiation of mesenchymal stem cells by inhibiting oxidative phosphorylation
10.3390/ijms21249747 · 2020 · External reference
Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis
10.1210/en.2003-1156 · 2004 · External reference
Space microgravity drives transdifferentiation of human bone marrow-derived mesenchymal stem cells from osteogenesis to adipogenesis
10.1096/fj.201700208rr · 2018 · External reference
Bone marrow adiposity modulation after long duration spaceflight in astronauts
10.1038/s41467-023-40572-8 · 2023 · External reference
Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the women international space simulation for exploration study
10.1152/japplphysiol.91530.2008 · 2009 · External reference
Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation
10.1038/npjmgrav.2016.16 · 2016 · External reference
Increased bone marrow adiposity in murine femoro-tibial epiphyses exposed to 30 days of microgravity
10.19185/matters.201904000010 · 2019 · External reference
Resistive exercises, with or without whole body vibration, prevent vertebral marrow fat accumulation during 60 days of head-down tilt bed rest in men
10.1152/japplphysiol.00029.2012 · 2012 · External reference
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
10.1038/s41421-024-00689-6 · 2024 · External reference
PPAR-γ and Wnt regulate the differentiation of MSCs into adipocytes and osteoblasts respectively
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Polarity as a physiological modulator of cell function
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The WNT signaling pathway in development and disease
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Transcriptional regulation of frizzled-1 in human osteoblasts by Sp1
10.1371/journal.pone.0163277 · 2016 · External reference
E2F1 effects on osteoblast differentiation and mineralization are mediated through up-regulation of frizzled-1
10.1016/j.bone.2013.06.019 · 2013 · External reference
AP2 suppresses osteoblast differentiation and mineralization through down-regulation of frizzled-1
10.1042/bj20140668 · 2015 · External reference
MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines
10.1182/blood-2006-10-051060 · 2007 · External reference
Insulin-like growth factor binding protein (IGFBP-6) as a novel regulator of inflammatory response in cystic fibrosis airway cells
2022 · External reference
Human follistatin-related protein: a structural homologue of follistatin with nuclear localization
10.1210/endo.142.8.8319 · 2001 · External reference
Follistatin-like 1 promotes osteoclast formation via RANKL-mediated NF-ΚB activation and M-CSF-induced precursor proliferation
10.1016/j.cellsig.2016.05.018 · 2016 · External reference
Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-β1-regulated genes, one of which seems to encode a Follistatin-related polypeptide
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Identifying pathogenic variants in the follistatin-like 1 gene (FSTL1) in patients with skeletal and atrioventricular valve disorders
10.1002/mgg3.567 · 2019 · External reference
The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects
2018 · External reference
Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5
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GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells
10.1530/joe-15-0012 · 2015 · External reference
Growth hormone receptor controls adipogenic differentiation of chicken bone marrow mesenchymal stem cells by affecting mitochondrial biogenesis and mitochondrial function
2022 · External reference
Growth hormone reprograms macrophages toward an anti-inflammatory and reparative profile in an MAFB-dependent manner
10.4049/jimmunol.1901330 · 2020 · External reference
Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
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Adiponectin: friend or foe in obesity and inflammation
10.1515/mr-2022-0002 · 2022 · External reference
Adipose-tissue plasticity in health and disease
10.1016/j.cell.2021.12.016 · 2022 · External reference
Adiponectin and lipid metabolism in skeletal muscle
10.1016/j.apsb.2012.06.008 · 2012 · External reference
Adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells
10.1002/stem.144 · 2009 · External reference
Effects of adiponectin on osteoclastogenesis from mouse bone marrow-derived monocytes
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