Research graph
References from Direct effects of glucagon-like Peptide-1 receptor agonists on mitochondrial function in human-derived in vitro models: A systematic review and meta-analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Evaluation of an oral small-molecule glucagon-like peptide-1 receptor agonist, lotiglipron, for type 2 diabetes and obesity: a dose-ranging, phase 2, randomized, placebo-controlled study
10.1111/dom.16005 · 2025 · External reference
Weight loss and maintenance related to the mechanism of action of glucagon-like peptide 1 receptor agonists
10.1007/s12325-021-01710-0 · 2021 · External reference
Curbing the appetites and restoring the capacity for satisfaction: the impact of GLP-1 agonists on the reward circuitry
10.1016/j.nsa.2025.105512 · 2025 · External reference
Glucagon-like Peptide-1 and hypothalamic regulation of satiation: cognitive and neural insights from human and animal studies
10.4093/dmj.2025.0106 · 2025 · External reference
What is food noise? A conceptual model of food cue reactivity
10.3390/nu15224809 · 2023 · External reference
Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations
10.1016/j.lfs.2013.10.006 · 2013 · External reference
Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats
10.1093/gerona/glt006 · 2013 · External reference
Sex-specific mitochondrial dysregulation and metformin response in Wilson disease
10.1038/s41598-026-58720-7 · 2026 · External reference
Maternal plasma metabolic profile demarcates a role for neuroinflammation in non-typical development of children
10.3390/metabo11080545 · 2021 · External reference
Brain atrophy and white matter damage linked to peripheral bioenergetic deficits in the neurodegenerative disease FXTAS
10.3390/ijms22179171 · 2021 · External reference
Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?
10.1210/endrev/bnaa005 · 2020 · External reference
Glucagon-like peptide-1 receptor agonist stimulates mitochondrial bioenergetics in human adipocytes
10.18388/abp.2017_1634 · 2017 · External reference
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
10.1172/jci.insight.134221 · 2020 · External reference
Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells
10.1111/jnc.13736 · 2016 · External reference
Role of Exendin-4 in brain insulin resistance, mitochondrial function, and neurite outgrowth in neurons under palmitic acid-induced oxidative stress
2021 · External reference
Unresolved reference
2022 · External reference
Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes
10.1016/j.redox.2023.102849 · 2023 · External reference
Incretin mimetics restore the ER-Mitochondrial axis and switch cell fate towards survival in LUHMES dopaminergic-like neurons: implications for novel therapeutic strategies in Parkinson's disease
10.3233/jpd-230030 · 2023 · External reference
Exendin-4 protects against high glucose-induced mitochondrial dysfunction and oxidative stress in SH-SY5Y neuroblastoma cells through GLP-1 receptor/Epac/Akt signaling
10.1016/j.ejphar.2023.175896 · 2023 · External reference
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy
10.1016/j.ejphar.2019.172715 · 2019 · External reference
Liraglutide prevents high glucose induced HUVECs dysfunction via inhibition of PINK1/Parkin-dependent mitophagy
10.1016/j.mce.2022.111560 · 2022 · External reference
Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro
10.1016/j.diabres.2023.110635 · 2023 · External reference
The protective effects of lixisenatide against inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes
10.1016/j.intimp.2019.105732 · 2019 · External reference
The impact of glucagon and exenatide on oxidative stress levels and antioxidative enzyme expression in in vitro induced steatosis in HepG2 cell culture
10.5603/ep.99891 · 2024 · External reference
Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in Alzheimer's disease
10.1016/j.neuropharm.2019.107813 · 2020 · External reference
Incretin-Based multi-agonist peptides are neuroprotective and anti-inflammatory in cellular models of neurodegeneration
10.3390/biom14070872 · 2024 · External reference
Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells
10.1016/j.neuro.2022.08.007 · 2022 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews
2021 · External reference
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research
2020 · External reference
SYRCLE's risk of bias tool for animal studies
10.1186/1471-2288-14-43 · 2014 · External reference
Systematic review and evidence integration for literature-based environmental health science assessments
10.1289/ehp.1307972 · 2014 · External reference
GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables
10.1016/j.jclinepi.2010.04.026 · 2011 · External reference
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
10.1136/bmj.39489.470347.ad · 2008 · External reference
GRADE: assessing the quality of evidence in environmental and occupational health
10.1016/j.envint.2016.01.004 · 2016 · External reference
Mechanisms of action and therapeutic application of glucagon-like Peptide-1
10.1016/j.cmet.2018.03.001 · 2018 · External reference
Glucagon-like peptide 1 (GLP-1)
10.1016/j.molmet.2019.09.010 · 2019 · External reference
Assessing mitochondrial dysfunction in cells
10.1042/bj20110162 · 2011 · External reference