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References from Metabolic signature across Life's Essential 8 profiles is heterogenous and may predict cardiovascular disease and mortality. Local targets link to admitted publications; unresolved targets remain external evidence.
Heart disease and stroke statistics: a report of US and global data from the American heart association
10.1161/cir.0000000000001303 · 2025 · External reference
Life's essential 8: updating and enhancing the American heart association's construct of cardiovascular health: a presidential advisory from the American heart association
10.1161/cir.0000000000001078 · 2022 · External reference
Metabolomic pattern predicts incident coronary heart disease
10.1161/atvbaha.118.312236 · 2019 · External reference
Metabolic predictors of incident coronary heart disease in women
10.1161/circulationaha.117.029468 · 2018 · External reference
A metabolomic profile is associated with the risk of incident coronary heart disease
10.1016/j.ahj.2014.01.019 · 2014 · External reference
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts
10.1161/circulationaha.114.013116 · 2015 · External reference
Metabolomics and cardiovascular biomarker discovery
10.1373/clinchem.2011.169573 · 2012 · External reference
Mid-life anti-inflammatory metabolites are inversely associated with long-term cardiovascular disease events
10.1016/j.ebiom.2024.105551 · 2025 · External reference
Metabolite profiles and the risk of developing diabetes
10.1038/nm.2307 · 2011 · External reference
Biological age predictors
10.1016/j.ebiom.2017.03.046 · 2017 · External reference
Low prevalence of "ideal cardiovascular health" in a community-based population: the heart strategies concentrating on risk evaluation (Heart SCORE) study
10.1161/circulationaha.110.980151 · 2011 · External reference
Impact of life's essential eight and inflammatory markers on long-term cardiovascular disease risk and all-cause mortality: insights from the Heart SCORE study
10.1016/j.hrtlng.2025.102710 · 2026 · External reference
The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research
10.1016/0165-1781(89)90047-4 · 1989 · External reference
Diagnosis and classification of diabetes: standards of care in Diabetes-2025
2025 · External reference
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American college of cardiology/American Heart association task force on clinical practice guidelines
2019 · External reference
10.1161/hyp.0000000000000066
10.1161/hyp.0000000000000066 · 2018 · External reference
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American college of cardiology/american heart association task force on practice guidelines
10.1016/j.jacc.2013.11.005 · 2014 · External reference
Sphingolipids contribute to human atherosclerotic plaque inflammation
10.1161/atvbaha.116.305675 · 2016 · External reference
Sphingolipid metabolites in inflammatory disease
10.1038/nature13475 · 2014 · External reference
Lipidomic risk score to enhance cardiovascular risk stratification for primary prevention
10.1016/j.jacc.2024.04.060 · 2024 · External reference
Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysis
10.2174/092986709788682164 · 2009 · External reference
Ethanolamine plasmalogens prevent the oxidation of cholesterol by reducing the oxidizability of cholesterol in phospholipid bilayers
10.1194/jlr.m200340-jlr200 · 2003 · External reference
Plasmalogens: a potential therapeutic target for neurodegenerative and cardiometabolic disease
10.1016/j.plipres.2019.04.003 · 2019 · External reference
The Framingham heart study and the epidemiology of cardiovascular disease: a historical perspective
10.1016/s0140-6736(13)61752-3 · 2014 · External reference
Association of environmental injustice and cardiovascular diseases and risk factors in the United States
10.1161/jaha.123.033428 · 2024 · External reference
Genetic risk, adherence to a healthy lifestyle, and coronary disease
10.1056/nejmoa1605086 · 2016 · External reference
The accuracy of cardiovascular pooled cohort risk estimates in U.S. older adults
10.1007/s11606-019-05361-4 · 2020 · External reference
Metabolite signature of life's essential 8 and risk of coronary heart disease among low-income black and white Americans
10.1161/circgen.123.004230 · 2023 · External reference
Polygenic risk scores for cardiovascular disease: a scientific statement from the American heart association
2022 · External reference
Short-term global cardiovascular disease risk prediction in older adults
10.1016/j.jacc.2018.02.050 · 2018 · External reference
Effects of sample handling and storage on quantitative lipid analysis in human serum
10.1007/s11306-009-0174-2 · 2009 · External reference