Research graph
References from Empagliflozin inhibits the apoptosis of pancreatic β-cells through amelioration of endoplasmic reticulum (ER) stress. Local targets link to admitted publications; unresolved targets remain external evidence.
Beta cell dysfunction and insulin resistance
10.3389/fendo.2013.00037 · 2013 · External reference
Chronic hyperglycemia and glucose toxicity: pathology and clinical sequelae
10.3810/pgm.2012.11.2615 · 2012 · External reference
Mechanisms of beta-cell apoptosis in type 2 diabetes-prone situations and potential protection by GLP-1-Based therapies
10.3390/ijms22105303 · 2021 · External reference
Natural history of beta-cell adaptation and failure in type 2 diabetes
10.1016/j.mam.2014.12.002 · 2015 · External reference
Beta cells operate collectively to help maintain glucose homeostasis
10.1016/j.bpj.2020.04.005 · 2020 · External reference
Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)
10.1002/jcb.30247 · 2022 · External reference
Islet beta cell failure in type 2 diabetes
10.1172/jci29103 · 2006 · External reference
The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth
10.4161/cbt.5.7.2967 · 2006 · External reference
Regulated translation initiation controls stress-induced gene expression in mammalian cells
10.1016/s1097-2765(00)00108-8 · 2000 · External reference
Perk is essential for translational regulation and cell survival during the unfolded protein response
10.1016/s1097-2765(00)80330-5 · 2000 · External reference
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
10.1038/35014014 · 2000 · External reference
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
10.1016/s1534-5807(02)00203-4 · 2002 · External reference
Endoplasmic Reticulum stress and autophagy in the pathogenesis of non-alcoholic fatty liver disease (NAFLD): current evidence and perspectives
10.1007/s13679-021-00431-3 · 2021 · External reference
The major molecular mechanisms mediating the renoprotective effects of SGLT2 inhibitors: an update
10.1016/j.biopha.2019.109526 · 2019 · External reference
The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
10.1007/s00228-023-03586-1 · 2024 · External reference
Empagliflozin Attenuates non-alcoholic fatty liver disease (NAFLD) in high fat diet Fed ApoE((-/-)) mice by activating autophagy and reducing ER stress and apoptosis
10.3390/ijms22020818 · 2021 · External reference
The effects of empagliflozin, an SGLT2 inhibitor, on pancreatic beta-cell mass and glucose homeostasis in type 1 diabetes
2016 · External reference
Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic beta cells in diabetic db/db mice
10.1038/s41598-021-94896-w · 2021 · External reference
Diabetes and beta cell function: from mechanisms to evaluation and clinical implications
10.11613/bm.2013.033 · 2013 · External reference
Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
10.1111/dom.12073 · 2013 · External reference
Pharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor
10.1007/s40262-013-0126-x · 2014 · External reference
Orexin-A exerts equivocal role in atherosclerosis process depending on the duration of exposure: in vitro Study
10.3390/nu12010053 · 2019 · External reference
Estrogen receptor subtypes elicit a distinct gene expression profile of endothelial-derived factors implicated in atherosclerotic plaque vulnerability
10.3390/ijms231810960 · 2022 · External reference
Human beta cell mass and function in diabetes: recent advances in knowledge and technologies to understand disease pathogenesis
10.1016/j.molmet.2017.06.019 · 2017 · External reference
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
10.2337/diabetes.50.6.1290 · 2001 · External reference
Apoptosis in pancreatic beta-islet cells in Type 2 diabetes
2016 · External reference
Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis
10.2337/db07-0178 · 2007 · External reference
beta-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency
10.2337/db10-0522 · 2011 · External reference
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic beta-cells: protective role of p62-positive cytoplasmic inclusions
10.1038/cdd.2010.111 · 2011 · External reference
The molecular mechanisms of pancreatic beta-cell glucotoxicity: recent findings and future research directions
10.1016/j.mce.2012.08.003 · 2012 · External reference
Correction: proteasome dysfunction mediates high glucose-induced apoptosis in rodent Beta cells and human islets
2014 · External reference
Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
10.2353/ajpath.2010.090532 · 2010 · External reference
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
10.2337/db07-0197 · 2007 · External reference
RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
10.2337/db13-1383 · 2014 · External reference
Combined transcriptome and proteome profiling of the pancreatic beta-cell response to palmitate unveils key pathways of beta-cell lipotoxicity
10.1186/s12864-020-07003-0 · 2020 · External reference
The proapoptotic BH3-only proteins bim and puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
10.1038/cddis.2014.88 · 2014 · External reference
SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans
10.1016/j.molmet.2020.101071 · 2020 · External reference
The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves beta-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat
10.1124/jpet.114.213454 · 2014 · External reference
Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic beta cells: in vitro and in vivo studies
10.1080/21655979.2021.2001240 · 2021 · External reference
Early treatment with empagliflozin and GABA improves beta-cell mass and glucose tolerance in Streptozotocin-Treated mice
10.1155/2019/2813489 · 2019 · External reference
Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese type 2 diabetic db/db mice
10.1016/j.bbrc.2015.10.109 · 2016 · External reference
Early administration of dapagliflozin preserves pancreatic beta-cell mass through a legacy effect in a mouse model of type 2 diabetes
10.1111/jdi.12945 · 2019 · External reference
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells
10.1007/s00210-023-02607-1 · 2024 · External reference
Effect of empagliflozin on tacrolimus-induced pancreas islet dysfunction and renal injury
10.1111/ajt.14316 · 2017 · External reference
Empagliflozin treatment is associated with improved beta-cell function in type 2 diabetes mellitus
10.1210/jc.2017-01838 · 2018 · External reference
Effects of SGLT2 inhibitors on insulin secretion and insulin Resistance—results from a cross-sectional study
10.2337/db18-1187-p · 2018 · External reference
Single cell transcriptomic analysis of SGLT2 expression supports an indirect or off-target role for the cardioprotective benefits of empagliflozin in heart failure
10.1038/s41598-025-93144-9 · 2025 · External reference
SGLT2 inhibitors therapy protects glucotoxicity-induced beta-cell failure in a mouse model of human KATP-induced diabetes through mitigation of oxidative and ER stress
10.1371/journal.pone.0258054 · 2022 · External reference
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation
10.1074/jbc.m110.216093 · 2011 · External reference
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
10.1016/s1097-2765(03)00105-9 · 2003 · External reference
