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References from Discovery of bacterial biofilm inhibitors against catheter-associated urinary tract infections using computational approaches. Local targets link to admitted publications; unresolved targets remain external evidence.
Hybrid N-Acylcysteines as dual-acting matrix disruptive and anti-quorum sensing agents fighting Pseudomonas aeruginosa biofilms: design, synthesis, molecular docking studies, and in vitro assays
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2021 · External reference
A cross-sectional assessment of urinary tract infections among geriatric patients: prevalence, medication regimen complexity, and factors associated with treatment outcomes
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Integrative machine learning, virtual screening, and molecular modeling for BacA-targeted anti-biofilm drug discovery against staphylococcal infections
10.3390/cryst14121057 · 2024 · External reference
Reduction of biofilm formation of Escherichia coli by targeting quorum sensing and adhesion genes using the CRISPR/Cas9-HDR approach, and its clinical application on urinary catheter
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Unresolved reference
2026 · External reference
Elucidating novel antibacterial compounds from the NPASS database against the FimH lectin domain for the treatment of urinary tract infections: an in-silico study
10.1080/07391102.2022.2059009 · 2023 · External reference
Silicone Foley catheters impregnated with microbial indole derivatives inhibit crystalline biofilm formation by Proteus mirabilis
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An overview of biological and computational methods for designing mechanism-informed anti-biofilm agents
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In vivo, in vitro and molecular docking studies reveal the anti-virulence property of hispidulin against Pseudomonas aeruginosa through the modulation of quorum sensing
10.1016/j.ibiod.2022.105487 · 2022 · External reference
DeepGEEP: data-driven prediction of bacterial biofilm gene expression profiles
2023 · External reference
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Antimicrobial and antibiofilm activity and machine learning classification analysis of essential oils from different mediterranean plants against Pseudomonas aeruginosa
10.3390/molecules23020482 · 2018 · External reference
Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: a systematic review and meta-analysis
10.1371/journal.pone.0308946 · 2024 · External reference
Mathematical pharmacodynamic modeling for antimicrobial assessment of ceftazidime/colistin versus gentamicin/meropenem combinations against carbapenem-resistant Pseudomonas aeruginosa biofilm
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Research advances of molecular docking and molecular dynamic simulation in recognizing interaction between muscle proteins and exogenous additives
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Structure based virtual screening and molecular dynamics of natural anti-biofilm compounds against SagS response regulator/sensor kinase in Pseudomonas aeruginosa
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Unresolved reference
2023 · External reference
Using machine learning to predict antibiotic resistance to support optimal empiric treatment of urinary tract infections
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Different factors control long-term versus short-term outcomes for bacterial colonisation of a urinary catheter
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Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates
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Unresolved reference
2004 · External reference
Unresolved reference
2021 · External reference
TargIDe: a machine-learning workflow for target identification of molecules with antibiofilm activity against Pseudomonas aeruginosa
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Quantitative structure-activity relationships (QSARs) in medicinal chemistry
2023 · External reference
Genome editing fidelity in the context of DNA sequence and chromatin structure
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The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix
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The CroRS two-component regulatory system is required for intrinsic β-lactam resistance in Enterococcus faecalis
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A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms
10.1073/pnas.0807717105 · 2008 · External reference
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10.3390/microorganisms11092141 · 2023 · External reference
Phytochemicals from the fruit and foliage of cranberry (Vaccinium macrocarpon)-potential benefits for human health
2012 · External reference
Quorum quenching approaches against bacterial-biofilm-induced antibiotic resistance
10.3390/antibiotics13070619 · 2024 · External reference
The role of physicochemical and topological parameters in drug design
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2024 · External reference
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10.1139/cjm-2024-0155 · External reference
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2024 · External reference
Novel antimicrobial peptides against Pseudomonas aeruginosa: in silico design and experimental validation
2025 · External reference
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10.1080/08927014.2023.2294763 · 2023 · External reference
Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors
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Unresolved reference
2023 · External reference
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10.1098/rsif.2019.0042 · 2019 · External reference
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10.1371/journal.pgen.1006816 · 2017 · External reference
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10.3390/ph16091263 · 2023 · External reference
Virulence factors of uropathogenic Escherichia coli
10.1016/s0924-8579(03)00236-x · 2003 · External reference
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10.1089/jmf.2010.0312 · 2012 · External reference
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Quorum quenching: role in nature and applied developments
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10.3389/fmicb.2016.00949 · 2016 · External reference
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10.1128/9781555817466.ch15 · 2015 · External reference
The Enterococcus faecalis fsr two-component system controls biofilm development through production of gelatinase
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2022 · External reference
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10.1128/iai.01652-13 · 2014 · External reference
Structural bases for F plasmid conjugation and F pilus biogenesis in Escherichia coli
10.1073/pnas.1904428116 · 2019 · External reference
Ultrasonic strategies for mitigating microbial adhesion and biofilm formation on medical surfaces: a mini review
10.3389/fmicb.2025.1558035 · 2025 · External reference
Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease
10.1128/mbio.02164-24 · 2024 · External reference
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Synthesis, antimicrobial, molecular docking against bacterial and fungal proteins and in silico studies of glucopyranoside derivatives as potent antimicrobial agents
10.1002/cbdv.202400932 · 2024 · External reference
Proteus mirabilis biofilms and catheter-associated urinary tract infections
10.4161/viru.2.5.17783 · 2011 · External reference
Mannose-resistant Proteus-like fimbriae are produced by most Proteus mirabilis strains infecting the urinary tract, dictate the in vivo localization of bacteria, and contribute to biofilm formation
10.1128/iai.72.12.7294-7305.2004 · 2004 · External reference
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10.1128/jb.00286-11 · 2011 · External reference
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10.1111/j.1574-6968.2006.00587.x · 2007 · External reference
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2022 · External reference
Aggregatibacter actinomycetemcomitans dispersin B: the quintessential antibiofilm enzyme
10.3390/pathogens13080668 · 2024 · External reference
An updated review on chemical compositions, biological capabilities, and clinical benefits of cranberries
10.1016/j.fbio.2023.102877 · 2023 · External reference
Unresolved reference
2024 · External reference
Hiring of the anti-quorum sensing activities of hypoglycemic agent linagliptin to alleviate the Pseudomonas aeruginosa pathogenesis
10.3390/microorganisms10122455 · 2022 · External reference
Ginger extract inhibits biofilm formation by Pseudomonas aeruginosa PA14
10.1371/journal.pone.0076106 · 2013 · External reference
UafB is a serine-rich repeat adhesin of Staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells
10.1099/mic.0.047639-0 · 2011 · External reference
Antigen 43 from Escherichia coli induces inter-and intraspecies cell aggregation and changes in colony morphology of Pseudomonas fluorescens
10.1128/jb.182.17.4789-4796.2000 · 2000 · External reference
Bacterial adhesins: function and structure
10.1016/s1438-4221(00)80102-2 · 2000 · External reference
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10.1016/j.ijmm.2005.10.002 · 2006 · External reference
Biofilms of clinical strains of Staphylococcus that do not contain polysaccharide intercellular adhesin
10.1111/j.1574-6968.2005.00043.x · 2006 · External reference
A data-driven machine learning approach for discovering potent LasR inhibitors
10.1080/21655979.2023.2243416 · 2023 · External reference
GC-MS unveils monosaccharide D-Allose in Terminalia arjuna bark extract acting against biofilm regulatory proteins (SrtA and SarA) of Staphylococcus aureus: a drug discovery approach
10.1016/j.ijms.2025.117527 · 2025 · External reference
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2025 · External reference
Role of epaQ, a previously uncharacterized Enterococcus faecalis gene, in biofilm development and antimicrobial resistance
10.1128/jb.00078-19 · 2019 · External reference
Antibiofilm activity of trans-cinnamaldehyde, p-coumaric, and ferulic acids on uropathogenic Escherichia coli
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2022 · External reference
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10.3390/md20080488 · 2022 · External reference
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10.1038/emi.2014.1 · 2014 · External reference
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10.1016/j.wneu.2022.11.046 · 2023 · External reference
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Unveiling the neem (Azadirachta indica) effects on biofilm formation of food-borne bacteria and the potential mechanism using a molecular docking approach
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The Rcs phosphorelay: a complex signal transduction system
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Powerful antibiotics discovered using AI
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Investigating Polypyrrole/silver-based composite for biofilm prevention on silicone surfaces for urinary catheter applications
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A molecular description of cellulose biosynthesis
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Antibacterial potential of Bacopa monnieri (L.) Wettst. and its bioactive molecules against uropathogens—an in silico study to identify potential lead molecule (s) for the development of new drugs to treat urinary tract infections
10.3390/molecules27154971 · 2022 · External reference
In silico selection and experimental validation of FDA-approved drugs as anti-quorum sensing agents
10.3389/fmicb.2019.02355 · 2019 · External reference
N-alkylimidazole derivatives as potential inhibitors of quorum sensing in Pseudomonas aeruginosa
10.1016/j.heliyon.2022.e12581 · 2022 · External reference
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In-silico and in-vitro assessment of the antibiofilm potential of azo dye, carmoisine against Pseudomonas aeruginosa
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A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing
10.1128/jb.00249-23 · 2023 · External reference
Artificial intelligence-driven analysis of antimicrobial-resistant and biofilm-forming pathogens on biotic and abiotic surfaces
2024 · External reference
Biofilm models for the practitioner
10.2166/wst.2000.0486 · 2000 · External reference
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Anti-biofilms' activity of garlic and thyme essential oils against Salmonella typhimurium
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2026 · External reference
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Unresolved reference
2017 · External reference
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10.1038/nrmicro.2016.89 · 2016 · External reference
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2024 · External reference
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Cranberry juice components act against development of urinary tract infections
2009 · External reference
Archaeal type IV pili and their involvement in biofilm formation
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Role of biofilm in bacterial infection and antimicrobial resistance
10.31729/jnma.7580 · 2022 · External reference
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2015 · External reference
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The two-component system GrvRS (EtaRS) regulates ace expression in Enterococcus faecalis OG1RF
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Cyclic di-GMP: the first 25 years of a universal bacterial second messenger
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Urinary tract infection in older adults
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Combating biofilm of ESKAPE pathogens from ancient plant-based therapy to modern nanotechnological combinations
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Computational modeling of synthetic microbial biofilms
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Towards improved biofilm models
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2023 · External reference
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Three-dimensional cellular automaton for modeling of self-similar evolution in biofilm-forming bacterial populations
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Role of type 1 and type 3 fimbriae in Klebsiella pneumoniae biofilm formation
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The application of machine learning techniques to innovative antibacterial discovery and development
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Cellulose as an architectural element in spatially structured Escherichia coli biofilms
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Escherichia coli biofilm: development and therapeutic strategies
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Targeting the Pseudomonas aeruginosa quorum sensing system to inhibit virulence factors and eradicate biofilm formation using AHL-analogue phytochemicals
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Vanillin derivative inhibits quorum sensing and biofilm formation in Pseudomonas aeruginosa: a study in a Caenorhabditis elegans infection model
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7295 elderly hospitalized patients with catheter-associated urinary tract infection: a case-control study
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Biofilms: understanding the structure and contribution towards bacterial resistance in antibiotics
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Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition
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Unveiling the potential of marine compounds as quorum sensing inhibitors targeting Pseudomonas aeruginosa's LasI: a computational study using molecular docking and molecular dynamics
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Structural analysis and architectural principles of the bacterial amyloid curli
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The production of curli amyloid fibers is deeply integrated into the biology of Escherichia coli
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Tarragon essential oil as a source of bioactive compounds with anti-quorum sensing and anti-proteolytic activity against Pseudomonas spp. isolated from fish–in vitro, in silico and in situ approaches
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Virulence factors associated with coagulase negative staphylococci isolated from human infections
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Bacterial biofilms in patients with indwelling urinary catheters
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Modulation of crystalline Proteus mirabilis biofilm development on urinary catheters
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In silico and in vivo methods for designing antibiofilm agents against Pseudomonas aeruginosa and Staphylococcus aureus
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