Research graph
References from From Retina to Brain: Viral Tools for Targeting Retinal Cells and Mapping Visual Circuits. Local targets link to admitted publications; unresolved targets remain external evidence.
"Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors
10.1128/jvi.01327-07 · 2007 · External reference
"Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model
10.1093/hmg/10.26.3075 · 2001 · External reference
"Restoration of Visual Function by Enhancing Conduction in Regenerated Axons
10.1016/j.cell.2015.11.036 · 2016 · External reference
"Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo
10.3389/fncir.2013.00011 · 2013 · External reference
"Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial
10.1016/s0140-6736(16)30371-3 · 2016 · External reference
"Projection targeting with phototagging to study the structure and function of retinal ganglion cells
2026 · External reference
"The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina
10.1089/hum.2012.125 · 2012 · External reference
"Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
10.1016/j.neuron.2019.05.044 · 2019 · External reference
"Transneuronal circuit tracing with neurotropic viruses
10.1016/j.conb.2009.03.007 · 2008 · External reference
"Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses
10.1523/jneurosci.0409-15.2015 · 2015 · External reference
"Design and Characterization of a Novel Intravitreal Dual-Transgene Genetic Medicine for Neovascular Retinopathies
10.1167/iovs.65.14.1 · 2024 · External reference
"Different patterns of neuronal infection after intracerebral injection of two strains of pseudorabies virus
10.1128/jvi.72.5.4434-4441.1998 · 1998 · External reference
"Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport, and pathogenesis
10.1523/jneurosci.13-06-02515.1993 · 1993 · External reference
"Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system
10.1128/jvi.66.5.3032-3041.1992 · 1992 · External reference
"Two alpha-herpesvirus strains are transported differentially in the rodent visual system
10.1016/0896-6273(91)90236-s · 1991 · External reference
"Overexpression of growth-associated proteins in the neurons of adult transgenic mice
10.1016/s0165-0270(96)00121-5 · 1997 · External reference
"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
10.1038/nn.4593 · 2017 · External reference
"AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes
10.1038/s41434-023-00436-8 · 2024 · External reference
"Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons
10.1038/s41593-018-0091-7 · 2018 · External reference
"Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter
10.15252/emmm.201404077 · 2014 · External reference
"AI-engineered AAV capsid enables intravitreal delivery for the treatment of diverse retinal degenerations
10.1016/j.omta.2026.201806 · 2026 · External reference
"In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous
10.1126/scitranslmed.3005708 · 2013 · External reference
"Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
10.1038/mt.2009.181 · 2009 · External reference
"Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
10.1038/nbt.3440 · 2016 · External reference
"Defining spatial nonuniformities of all ipRGC types using an improved Opn4(cre) recombinase mouse line."
2024 · External reference
"Transneuronal Circuit Analysis with Pseudorabies Viruses
10.1002/cpz1.841 · 2023 · External reference
"VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family
10.1074/jbc.m609517200 · 2007 · External reference
"Architecture of retinal projections to the central circadian pacemaker
10.1073/pnas.1523629113 · 2016 · External reference
"Distinct representation and distribution of visual information by specific cell types in mouse superficial superior colliculus
10.1523/jneurosci.2768-14.2014 · 2014 · External reference
"Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity
10.1038/mt.2015.121 · 2015 · External reference
"Human blue-opsin promoter preferentially targets reporter gene expression to rat s-cone photoreceptors
10.1167/iovs.05-1670 · 2006 · External reference
"Machine-guided design of cell-type-targeting cis-regulatory elements
10.1038/s41586-024-08070-z · 2024 · External reference
"Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects
10.1371/journal.pone.0075666 · 2013 · External reference
"Multiple Retinal Axons Converge onto Relay Cells in the Adult Mouse Thalamus
10.1016/j.celrep.2015.08.003 · 2015 · External reference
"A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors
10.3389/fnins.2017.00521 · 2017 · External reference
"Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors
10.1006/mcne.2002.1168 · 2002 · External reference
"Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection
10.1038/gt.2008.178 · 2009 · External reference
"Adeno-Associated Virus Vectors in Retinal Gene Therapy: Challenges, Innovations, and Future Directions
10.3390/biom15070940 · 2025 · External reference
"Strategies for Targeting Neural Circuits: How to Manipulate Neurons Using Virus Vehicles
10.3389/fncir.2022.882366 · 2022 · External reference
"Empowering Retinal Gene Therapy with a Specific Promoter for Human Rod and Cone ON-Bipolar Cells
10.1016/j.omtm.2020.03.003 · 2020 · External reference
"Pseudorabies virus membrane proteins gI and gE facilitate anterograde spread of infection in projection-specific neurons in the rat
10.1128/jvi.74.23.10975-10983.2000 · 2000 · External reference
"Next-generation replication-defective HSV vectors for delivery of large DNA payloads
10.1016/j.ymthe.2025.03.055 · 2025 · External reference
"Third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency
2023 · External reference
"Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans
10.1038/s41593-019-0431-2 · 2019 · External reference
"AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter
10.1167/iovs.07-0257 · 2007 · External reference
"AAV2-Retro-Mediated Gene Transfer Selectively Targets Outer Retinal Cells Following Intravitreal Injection
10.1167/iovs.67.3.54 · 2026 · External reference
"A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Muller cells
10.1371/journal.pone.0007467 · 2009 · External reference
"AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery
10.3389/fddev.2023.1148795 · 2023 · External reference
"Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration
10.1038/nn.2117 · 2008 · External reference
"Pathway-specific inputs to the superior colliculus support flexible responses to visual threat
10.1126/sciadv.ade3874 · 2023 · External reference
"Engineering adeno-associated virus vectors for gene therapy
10.1038/s41576-019-0205-4 · 2020 · External reference
"Directed evolution of adeno-associated virus for efficient gene delivery to microglia
10.1038/s41592-022-01547-7 · 2022 · External reference
"Tracing inputs to inhibitory or excitatory neurons of mouse and cat visual cortex with a targeted rabies virus
10.1016/j.cub.2013.07.033 · 2013 · External reference
"A Cre-dependent, anterograde transsynaptic viral tracer for mapping output pathways of genetically marked neurons
10.1016/j.neuron.2011.12.002 · 2011 · External reference
"Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
10.1038/s41591-018-0327-9 · 2019 · External reference
"Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
10.1016/j.omtm.2021.09.006 · 2021 · External reference
"Diverse Central Projection Patterns of Retinal Ganglion Cells
10.1016/j.celrep.2017.01.075 · 2017 · External reference
"Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms
10.1002/cne.23761 · 2015 · External reference
"Gene therapy returns to centre stage
10.1038/nature15818 · 2015 · External reference
"Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors
10.1016/j.neuroscience.2009.03.032 · 2009 · External reference
"AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury
10.1167/iovs.17-22634 · 2017 · External reference
"Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters
10.1038/s41434-022-00380-z · 2023 · External reference
"Advances in AAV capsid engineering: Integrating rational design, directed evolution and machine learning
10.1016/j.ymthe.2025.03.056 · 2025 · External reference
"AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy
2020 · External reference
"scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution
10.7554/elife.64175 · 2021 · External reference
"Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders
10.15252/emmm.202013392 · 2021 · External reference
"Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits
10.1523/jneurosci.22-07-02701.2002 · 2002 · External reference
"Vectors and Gene Delivery to the Retina
10.1146/annurev-vision-102016-061413 · 2017 · External reference
"Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
10.1038/s41592-020-0799-7 · 2020 · External reference
"Rabies Virus CVS-N2c(DeltaG) Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability
10.1016/j.neuron.2016.01.004 · 2016 · External reference
"A projection specific logic to sampling visual inputs in mouse superior colliculus
10.7554/elife.50697 · 2019 · External reference
"Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing
10.1016/j.neuron.2017.01.028 · 2017 · External reference
"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
10.1016/s0140-6736(17)31868-8 · 2017 · External reference
"Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye
10.1002/cne.20030 · 2004 · External reference
"Pseudorabies virus expressing enhanced green fluorescent protein: A tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits
10.1073/pnas.97.16.9264 · 2000 · External reference
"Anterograde, transneuronal transport of herpes simplex virus type 1 strain H129 in the murine visual system
10.1128/jvi.70.8.5405-5413.1996 · 1996 · External reference
"Neuritin1 Cis-Regulatory Elements Enable Gene Expression Preferentially in Retinal Ganglion Cells
10.1167/iovs.67.4.18 · 2026 · External reference
"Retrograde AAV-mediated gene modulation reveals chloride intracellular channel proteins as potent regulators of retinal ganglion cell death
10.1016/j.expneurol.2024.114810 · 2024 · External reference
"A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons
10.1016/j.neuron.2016.09.021 · 2016 · External reference
"Quantitative analysis of rabies virus-based synaptic connectivity tracing
10.1371/journal.pone.0278053 · 2023 · External reference
"Seeing the Light after 25 Years of Retinal Gene Therapy
10.1016/j.molmed.2018.06.006 · 2018 · External reference
"Vector platforms for gene therapy of inherited retinopathies
10.1016/j.preteyeres.2014.08.001 · 2014 · External reference
"Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
10.1038/s41593-022-01068-8 · 2022 · External reference
"Adeno-associated virus vector as a platform for gene therapy delivery
10.1038/s41573-019-0012-9 · 2019 · External reference
"Recombinant adeno-associated virus as a delivery platform for ocular gene therapy: A comprehensive review
10.1016/j.ymthe.2024.10.017 · 2024 · External reference
"Mouse gamma-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells
10.1523/jneurosci.0102-20.2020 · 2020 · External reference
"Deep learning-guided design of cell type-specific AAV promoters
2026 · External reference
"Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development
10.1038/s41598-020-63559-7 · 2020 · External reference
"Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons
10.1016/j.neuron.2007.01.033 · 2007 · External reference
"Similarities and differences among inner retinal neurons revealed by the expression of reporter transgenes controlled by Brn-3a, Brn-3b, and Brn-3c promotor sequences
10.1017/s0952523800009184 · 1996 · External reference
"MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression
10.1038/mt.2010.279 · 2011 · External reference
"An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing
10.1038/s41467-022-35355-6 · 2022 · External reference
"Virus-Based Neural Circuit Tracing
10.1007/978-3-031-69188-1_5 · 2024 · External reference
"Strategies of AAV capsid engineering for targeted delivery to brain, muscle, and retina
2025 · External reference
"Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers
10.1016/j.neuron.2020.07.010 · 2020 · External reference
"Effective gene therapy with nonintegrating lentiviral vectors
10.1038/nm1365 · 2006 · External reference
"A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling
10.1186/s13024-021-00508-6 · 2022 · External reference
"Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129
10.1186/s13024-017-0179-7 · 2017 · External reference
"Retinal transduction profiling of diverse AAV serotypes via intravitreal injection
10.1128/jvi.00637-25 · 2025 · External reference
"Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement
10.1038/s41467-025-57445-x · 2025 · External reference
"Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression
10.1016/j.virol.2008.08.027 · 2008 · External reference
"Tunable dual-AAV sparse labeling of PV(+) retinal ganglion cells enables single-neuron projection by fMOST."
2025 · External reference
"AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors
10.1016/j.neuron.2016.11.045 · 2017 · External reference
