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References from Conserved and divergent mitochondrial assemblies in kinetoplastid parasites. Local targets link to admitted publications; unresolved targets remain external evidence.
Integrated genomic and fossil evidence illuminates life’s early evolution and eukaryote origin
10.1038/s41559-018-0644-x · 2018 · External reference
Revisions to the Classification, Nomenclature, and Diversity of Eukaryotes
10.1111/jeu.12691 · 2019 · External reference
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes
10.1126/science.aau7735 · 2018 · External reference
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes
10.1016/j.pt.2020.01.006 · 2020 · External reference
10.1016/j.molcel.2026.08.032 · 2026 · Admitted local publication
Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis
10.1073/pnas.2011301117 · 2020 · External reference
Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing
10.1126/science.adg4725 · 2023 · External reference
Structural basis of the RNA-editing cascade in trypanosome mitochondria
10.1038/s41586-026-10831-x · 2026 · External reference
The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function
10.1016/j.str.2024.03.010 · 2024 · External reference
Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase
10.1016/j.str.2022.11.015 · 2022 · External reference
CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics
2023 · External reference
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
10.1038/s41467-022-33588-z · 2022 · External reference
Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei
10.1093/nar/gkaa575 · 2020 · External reference
Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
10.1038/s41467-018-08137-2 · 2019 · External reference
Transcription initiation defines kinetoplast RNA boundaries
10.1073/pnas.1808981115 · 2018 · External reference
PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes
10.15252/embj.201796808 · 2017 · External reference
Pentatricopeptide Repeat Proteins Stimulate mRNA Adenylation/Uridylation to Activate Mitochondrial Translation in Trypanosomes
10.1016/j.molcel.2011.02.021 · 2011 · External reference
A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components
10.1261/rna.2134303 · 2003 · External reference
Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism
10.1016/j.cell.2006.06.047 · 2006 · External reference
Apocytochrome b and other mitochondrial DNA sequences are differentially expressed during the life cycle of Trypanosoma brucei
10.1093/nar/13.12.4577 · 1985 · External reference
Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei
10.1371/journal.pbio.3000741 · 2020 · External reference
Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery
10.1126/science.aaw5570 · 2019 · External reference
Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids
10.1016/j.pt.2022.08.010 · 2022 · External reference
Structural basis for guide RNA selection by the RESC1-RESC2 complex
10.1093/nar/gkad217 · 2023 · External reference
Mitoribosomal small subunit maturation involves formation of initiation-like complexes
10.1073/pnas.2114710118 · 2022 · External reference
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis
10.1016/j.molcel.2020.06.030 · 2020 · External reference
Guide RNA-Binding Complex from Mitochondria of Trypanosomatids
10.1016/j.molcel.2008.08.023 · 2008 · External reference
RNA binding and core complexes constitute the U-insertion/deletion editosome
10.1128/mcb.01075-14 · 2014 · External reference
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney
10.1038/s41421-022-00487-y · 2022 · External reference
Complex I of Trypanosomatidae: does it exist?
10.1016/j.pt.2008.03.013 · 2008 · External reference
Enigmatic presence of mitochondrial complex I in Trypanosoma brucei bloodstream forms
10.1128/ec.05282-11 · 2012 · External reference
Comparative analysis of respiratory chain and oxidative phosphorylation in Leishmania tarentolae, Crithidia fasciculata, Phytomonas serpens and procyclic stage of Trypanosoma brucei
10.1016/j.molbiopara.2014.02.003 · 2014 · External reference
Gene co-expression network analysis of Trypanosoma brucei in tsetse fly vector
10.1186/s13071-021-04597-6 · 2021 · External reference
The Mba1 homologue of Trypanosoma brucei is involved in the biogenesis of oxidative phosphorylation complexes
10.1111/mmi.15048 · 2023 · External reference
Automated model building and protein identification in cryo-EM maps
10.1038/s41586-024-07215-4 · 2024 · External reference
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences
10.1016/s0969-2126(01)00621-9 · 2001 · External reference
Cryo-EM structure of the yeast respiratory supercomplex
10.1038/s41594-018-0169-7 · 2019 · External reference
Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex
10.1038/s41594-025-01531-7 · 2025 · External reference
Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2
10.1016/j.cell.2017.07.050 · 2017 · External reference
Cryo-EM structure of the respiratory I + III2 supercomplex from Arabidopsis thaliana at 2 Å resolution
10.1038/s41477-022-01308-6 · 2023 · External reference
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
10.1021/acsinfecdis.9b00426 · 2020 · External reference
DNDI-6174, a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 complex
10.1126/scitranslmed.adh9902 · 2023 · External reference
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants
10.7554/elife.62047 · 2021 · External reference
Structure of the intact 14-subunit human cytochrome c oxidase
10.1038/s41422-018-0071-1 · 2018 · External reference
Crystallographic cyanide-probing for cytochrome c oxidase reveals structural bases suggesting that a putative proton transfer H-pathway pumps protons
10.1016/j.jbc.2023.105277 · 2023 · External reference
Reversible dimerization of cytochrome c oxidase regulates mitochondrial respiration
10.1016/j.mito.2019.08.002 · 2019 · External reference
The allosteric ATP-inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP-dependent phosphorylation
10.1016/s0014-5793(99)01773-1 · 2000 · External reference
The subunit composition and function of mammalian cytochrome c oxidase
10.1016/j.mito.2015.07.002 · 2015 · External reference
Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation
10.1016/j.cmet.2011.03.024 · 2011 · External reference
Multiple phosphorylations of cytochrome c oxidase and their functions
10.1002/pmic.201100618 · 2012 · External reference
Complex IV - The regulatory center of mitochondrial oxidative phosphorylation
10.1016/j.mito.2020.10.004 · 2021 · External reference
cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity
10.1074/jbc.m411335200 · 2005 · External reference
Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation
10.1016/j.bbabio.2011.07.001 · 2012 · External reference
Atomic model for the dimeric FO region of mitochondrial ATP synthase
10.1126/science.aao4815 · 2017 · External reference
10.1016/j.cell.2026.08.057 · 2026 · Admitted local publication
The ATP synthase is involved in generating mitochondrial cristae morphology
10.1093/emboj/21.3.221 · 2002 · External reference
Structure of the dimeric ATP synthase from bovine mitochondria
10.1073/pnas.2013998117 · 2020 · External reference
Cryo-EM structure of the entire mammalian F-type ATP synthase
10.1038/s41594-020-0503-8 · 2020 · External reference
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1
10.1126/science.aaw4852 · 2019 · External reference
In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits
10.1073/pnas.1612386114 · 2017 · External reference
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit
10.15252/embj.2020106292 · 2021 · External reference
Emerging roles of PPR proteins in trypanosomes: Switches, blocks, and triggers
10.4161/rna.26215 · 2013 · External reference
The PPR motif - a TPR-related motif prevalent in plant organellar proteins
10.1016/s0968-0004(99)01520-0 · 2000 · External reference
10.1016/j.cell.2026.08.027 · 2026 · Admitted local publication
Compositionally and functionally distinct editosomes in Trypanosoma brucei
10.1261/rna.45506 · 2006 · External reference
Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1
10.1038/s41594-018-0172-z · 2019 · External reference
Supercomplexes in the respiratory chains of yeast and mammalian mitochondria
10.1093/emboj/19.8.1777 · 2000 · External reference
Draft Genome Sequence of Leishmania tarentolae Parrot Tar II, Obtained by Single-Molecule Real-Time Sequencing
10.1128/mra.00050-20 · 2020 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
Coot: model-building tools for molecular graphics
10.1107/s0907444904019158 · 2004 · External reference
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
10.1107/s2059798319011471 · 2019 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility
10.1002/prot.21086 · 2006 · External reference
RosettaLigand docking with full ligand and receptor flexibility
10.1016/j.jmb.2008.11.010 · 2009 · External reference
AmberTools
10.1021/acs.jcim.3c01153 · 2023 · External reference
PatchDock and SymmDock: servers for rigid and symmetric docking
10.1093/nar/gki481 · 2005 · External reference
LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
10.1093/protein/8.2.127 · 1995 · External reference
RING 4.0: faster residue interaction networks with novel interaction types across over 35,000 different chemical structures
10.1093/nar/gkae337 · 2024 · External reference
ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
10.1107/s2059798318002425 · 2018 · External reference
Revisiting the functional annotation of TriTryp using sequence similarity tools
10.1016/j.heliyon.2024.e39243 · 2024 · External reference
Unresolved reference
2024 · External reference
BLAST+: architecture and applications
10.1186/1471-2105-10-421 · 2009 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
AlphaFold Protein Structure Database and 3D-Beacons: New Data and Capabilities
10.1016/j.jmb.2025.168967 · 2025 · External reference
Fast and accurate protein structure search with Foldseek
10.1038/s41587-023-01773-0 · 2024 · External reference
TPRpred: a tool for prediction of TPR-, PPR- and SEL1-like repeats from protein sequences
10.1186/1471-2105-8-2 · 2007 · External reference
MolProbity: all-atom structure validation for macromolecular crystallography
10.1107/s0907444909042073 · 2010 · External reference
