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References from Lineage-specific innovations expand mitochondrial proteomes in kinetoplastids. Local targets link to admitted publications; unresolved targets remain external evidence.
Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment
10.3390/ph18091415 · 2025 · External reference
Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
10.1016/j.ijpddr.2018.09.006 · 2018 · External reference
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
10.1016/s0140-6736(17)32758-7 · 2018 · External reference
Kinetoplastid mitochondria contain functional tRNAs which are encoded in nuclear DNA and also small minicircle and maxicircle transcripts of unknown function
10.1093/nar/17.14.5427 · 1989 · External reference
Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA
10.1016/0092-8674(86)90063-2 · 1986 · External reference
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes
10.1016/j.pt.2020.01.006 · 2020 · External reference
Pentatricopeptide Repeat Proteins Stimulate mRNA Adenylation/Uridylation to Activate Mitochondrial Translation in Trypanosomes
10.1016/j.molcel.2011.02.021 · 2011 · External reference
3′ adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria
10.1038/emboj.2008.87 · 2008 · External reference
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes
10.1126/science.aau7735 · 2018 · External reference
Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis
10.1073/pnas.2011301117 · 2020 · External reference
Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei
10.1038/s41564-022-01295-6 · 2023 · External reference
Mapping diversity in African trypanosomes using high resolution spatial proteomics
10.1038/s41467-023-40125-z · 2023 · External reference
Comprehensive sub-mitochondrial protein map of the parasitic protist Trypanosoma brucei defines critical features of organellar biology
10.1016/j.celrep.2023.113083 · 2023 · External reference
A comprehensive analysis of Trypanosoma brucei mitochondrial proteome
10.1002/pmic.200800477 · 2009 · External reference
Protein composition of Trypanosoma brucei mitochondrial membranes
10.1002/pmic.200900354 · 2009 · External reference
Mitochondrial adaptations throughout the Trypanosoma brucei life cycle
10.1111/jeu.12911 · 2022 · External reference
Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major
10.1016/j.molbiopara.2004.03.002 · 2004 · External reference
Trypanosoma brucei mitochondrial respiratome: composition and organization in procyclic form
10.1074/mcp.m110.006908 · 2011 · External reference
Trypanosoma brucei mitochondrial ribosomes: affinity purification and component identification by mass spectrometry
10.1074/mcp.m700490-mcp200 · 2008 · External reference
A draft map of the mouse pluripotent stem cell spatial proteome
10.1038/ncomms9992 · 2016 · External reference
Charting organellar importomes by quantitative mass spectrometry
10.1038/ncomms15272 · 2017 · External reference
Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum
10.3390/proteomes3040328 · 2015 · External reference
Mitochondrial proteome profiling of Leishmania tropica
10.1016/j.micpath.2019.103542 · 2019 · External reference
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology
10.1074/mcp.m112.023093 · 2013 · External reference
Biogenesis of a Mitochondrial Outer Membrane Protein in Trypanosoma brucei: TARGETING SIGNAL AND DEPENDENCE ON A UNIQUE BIOGENESIS FACTOR
10.1074/jbc.m116.755983 · 2017 · External reference
Development of the Twin-Strep-tag® and its application for purification of recombinant proteins from cell culture supernatants
10.1016/j.pep.2013.08.021 · 2013 · External reference
Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition
10.1038/s41587-023-02099-7 · 2024 · External reference
A mammalian organelle map by protein correlation profiling
10.1016/j.cell.2006.03.022 · 2006 · External reference
Developmental dynamics of mitochondrial mRNA abundance and editing reveal roles for temperature and the differentiation-repressive kinase RDK1 in cytochrome oxidase subunit II mRNA editing
10.1128/mbio.01854-23 · 2023 · External reference
The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function
10.1038/sj.emboj.7600862 · 2005 · External reference
A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex
10.1371/journal.ppat.1006679 · 2017 · External reference
Trypanosome alternative oxidase is regulated post-transcriptionally at the level of RNA stability
10.1111/j.1550-7408.2002.tb00367.x · 2002 · External reference
Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite
10.1371/journal.pntd.0005552 · 2017 · External reference
Sur la frequence de la leishmaniose du gecko dans le Sud oranais
1939 · External reference
Guide RNA-Binding Complex from Mitochondria of Trypanosomatids
10.1016/j.molcel.2008.08.023 · 2008 · External reference
The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function
10.1016/j.str.2024.03.010 · 2024 · External reference
Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis
10.1111/febs.15177 · 2020 · External reference
CTS tag-based methods for investigating mitochondrial RNA modification factors in Trypanosoma brucei
10.1016/bs.mie.2021.06.004 · 2021 · External reference
Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing
10.1126/science.adg4725 · 2023 · External reference
RET1-catalyzed Uridylylation Shapes the Mitochondrial Transcriptome in Trypanosoma brucei
10.1128/mcb.01281-09 · 2010 · External reference
Detecting sequence signals in targeting peptides using deep learning
10.26508/lsa.201900429 · 2019 · External reference
DeepLoc 2.1: multi-label membrane protein type prediction using protein language models
10.1093/nar/gkae237 · 2024 · External reference
Organization of minicircle cassettes and guide RNA genes in Trypanosoma brucei
10.1261/rna.079022.121 · 2022 · External reference
Assembly and annotation of the mitochondrial minicircle genome of a differentiation-competent strain of Trypanosoma brucei
10.1093/nar/gkz928 · 2019 · External reference
Comparative mitochondrial genome and transcriptome analyses reveal strain-specific features of RNA editing in Trypanosoma brucei
10.1093/nar/gkaf661 · 2025 · External reference
Disruption of RNA editing in Leishmania tarentolae by the loss of minicircle-encoded guide RNA genes
10.1002/j.1460-2075.1994.tb06907.x · 1994 · External reference
Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae
10.1371/journal.pntd.0003841 · 2015 · External reference
Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei
10.1016/j.molbiopara.2010.11.003 · 2011 · External reference
Translation of the edited mRNA for cytochrome b in trypanosome mitochondria
10.1126/science.287.5458.1639 · 2000 · External reference
Detection of the mitochondrially encoded cytochrome c oxidase subunit I in the trypanosomatid protozoan Leishmania tarentolae. Evidence for translation of unedited mRNA in the kinetoplast
10.1074/jbc.m907246199 · 2000 · External reference
Identification of the mitochondrially encoded subunit 6 of F1FO ATPase in Trypanosoma brucei
10.1016/j.molbiopara.2015.08.002 · 2015 · External reference
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
10.1038/s41467-022-33588-z · 2022 · External reference
The nucleotide sequence of a segment of Trypanosoma brucei mitochondrial maxi-circle DNA that contains the gene for apocytochrome b and some unusual unassigned reading frames
10.1093/nar/11.20.6925 · 1983 · External reference
Differences in mitochondrial NADH dehydrogenase activities in trypanosomatids
10.1017/s0031182020002425 · 2021 · External reference
A simple method for displaying the hydropathic character of a protein
10.1016/0022-2836(82)90515-0 · 1982 · External reference
Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I
10.1073/pnas.2103803118 · 2021 · External reference
Kinetoplast DNA structure, RNA editing patterns and small respiratory Complex I in Trypanosoma musculi
2025 · External reference
Structural basis of the RNA-editing cascade in trypanosome mitochondria
10.1038/s41586-026-10831-x · 2026 · External reference
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Comparative analysis of respiratory chain and oxidative phosphorylation in Leishmania tarentolae, Crithidia fasciculata, Phytomonas serpens and procyclic stage of Trypanosoma brucei
10.1016/j.molbiopara.2014.02.003 · 2014 · External reference
Trypanosome RNA editing: the complexity of getting U in and taking U out
10.1002/wrna.1313 · 2016 · External reference
Estimating the timing of early eukaryotic diversification with multigene molecular clocks
10.1073/pnas.1110633108 · 2011 · External reference
An excavate root for the eukaryote tree of life
10.1126/sciadv.ade4973 · 2023 · External reference
Genomic Signatures of Mitonuclear Coevolution in Mammals
10.1093/molbev/msac233 · 2022 · External reference
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations
10.1093/nar/gkaa1011 · 2021 · External reference
Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale
10.1016/j.celrep.2017.06.014 · 2017 · External reference
10.1016/j.cell.2026.08.027 · 2026 · Admitted local publication
TriTrypDB: An integrated functional genomics resource for kinetoplastida
10.1371/journal.pntd.0011058 · 2023 · External reference
10.1016/j.cell.2026.08.029 · 2026 · Admitted local publication
Metabolism of Leishmania: proven and predicted
10.1016/j.pt.2007.02.004 · 2007 · External reference
An essential, kinetoplastid-specific GDP-Fuc: beta-D-Gal alpha-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei
10.7554/elife.70272 · 2021 · External reference
A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania
10.1073/pnas.2108963118 · 2021 · External reference
Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania
10.1074/jbc.m117.778480 · 2017 · External reference
Failure is not an option - mitochondrial genome segregation in trypanosomes
10.1242/jcs.221820 · 2018 · External reference
Primary sequence and partial secondary structure of the 12S kinetoplast (mitochondrial) ribosomal RNA from Leishmania tarentolae: Conservation of peptidyl-transferase structural elements
10.1093/nar/13.7.2337 · 1985 · External reference
A minimal ribosomal RNA: Sequence and secondary structure of the 9S kinetoplast ribosomal RNA from Leishmania tarentolae
10.1073/pnas.82.5.1401 · 1985 · External reference
Cell biology. Irremediable complexity?
10.1126/science.1198594 · 2010 · External reference
10.1016/j.molcel.2026.08.031 · 2026 · Admitted local publication
Isolation of kinetoplast-mitochondrial complexes from Leishmania tarentolae
10.1111/j.1550-7408.1974.tb03752.x · 1974 · External reference
10.1016/j.cell.2026.08.056 · 2026 · Admitted local publication
Absolute yeast mitochondrial proteome quantification reveals trade-off between biosynthesis and energy generation during diauxic shift
10.1073/pnas.1918216117 · 2020 · External reference
Trypanosomatid mitochondrial RNA editing: dramatically complex transcript repertoires revealed with a dedicated mapping tool
10.1093/nar/gkx1202 · 2018 · External reference
A mitochondrial protein compendium elucidates complex I disease biology
10.1016/j.cell.2008.06.016 · 2008 · External reference
HMMER web server: 2018 update
10.1093/nar/gky448 · 2018 · External reference
OrthoFinder: phylogenetic orthology inference for comparative genomics
10.1186/s13059-019-1832-y · 2019 · External reference
BLAST+: architecture and applications
10.1186/1471-2105-10-421 · 2009 · External reference
U-insertion/deletion Edited Sequence Database
10.1093/nar/26.1.170 · 1998 · External reference
Preservation of living metacyclic forms of the Trypanosoma brucei subgroup
10.1038/1941186a0 · 1962 · External reference
KISS: the kinetoplastid RNA editing sequence search tool
10.1261/rna.232907 · 2007 · External reference
Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei
10.1016/j.molbiopara.2007.12.008 · 2008 · External reference
Trypanosoma brucei Tb927.2.6100 is an essential protein associated with kinetoplast DNA
10.1128/ec.00352-12 · 2013 · External reference
The Trypanosoma brucei MitoCarta and its regulation and splicing pattern during development
10.1093/nar/gkq618 · 2010 · External reference
Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome
10.1096/fj.201901184rr · 2019 · External reference
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
10.1093/nar/gkv1003 · 2016 · External reference
TrypTag.org: from images to discoveries using genome-wide protein localisation in Trypanosoma brucei
10.1016/j.pt.2023.02.008 · 2023 · External reference
Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes
10.1073/pnas.87.24.9736 · 1990 · External reference
Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3′ Processome to Generate Guide RNAs
10.1016/j.molcel.2016.01.004 · 2016 · External reference
Saccharomyces Genome Database: the genomics resource of budding yeast
10.1093/nar/gkr1029 · 2012 · External reference
Using the Arabidopsis Information Resource (TAIR) to Find Information About Arabidopsis Genes
10.1002/cpz1.574 · 2022 · External reference