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References from ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers. Local targets link to admitted publications; unresolved targets remain external evidence.
Inborn errors of immunity: an expanding universe of disease and genetic architecture
10.1038/s41576-023-00656-z · 2024 · External reference
Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee
10.1007/s10875-022-01289-3 · 2022 · External reference
Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease
10.1073/pnas.2102804118 · 2021 · External reference
Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency
10.1016/j.jaci.2021.03.045 · 2021 · External reference
Biallelic ZNFX1 variants are associated with a spectrum of immuno-hematological abnormalities
10.1111/cge.14081 · 2022 · External reference
Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium
2024 · External reference
Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteins
10.1093/bib/bbab118 · 2021 · External reference
Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes
10.1073/pnas.2401968121 · 2024 · External reference
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS
10.1038/s41556-019-0416-0 · 2019 · External reference
ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA
10.1172/jci.insight.171850 · 2024 · External reference
Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection
10.1038/s41586-021-03566-4 · 2021 · External reference
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
10.1016/j.cell.2025.08.006 · 2025 · External reference
Helicases: amino acid sequence comparisons and structure-function relationships
10.1016/s0959-440x(05)80116-2 · 1993 · External reference
Regulation and mechanisms of action of RNA helicases
10.1080/15476286.2024.2415801 · 2024 · External reference
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
10.1107/s0907444904026460 · 2004 · External reference
Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2
10.1016/j.molcel.2011.02.010 · 2011 · External reference
Two RNAi Complexes, RITS and RDRC, Physically Interact and Localize to Noncoding Centromeric RNAs
10.1016/j.cell.2004.11.034 · 2004 · External reference
ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals
10.1016/j.molcel.2018.04.009 · 2018 · External reference
SF1 and SF2 helicases: family matters
10.1016/j.sbi.2010.03.011 · 2010 · External reference
DNA binding to RecD: role of the 1B domain in SF1B helicase activity
10.1038/emboj.2008.144 · 2008 · External reference
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA
10.1016/j.molcel.2026.02.015 · 2026 · External reference
Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213
10.1038/s44319-024-00280-w · 2024 · External reference
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
10.7554/elife.56185 · 2020 · External reference
The Yeast E4 Ubiquitin Ligase Ufd2 Interacts with the Ubiquitin-like Domains of Rad23 and Dsk2 via a Novel and Distinct Ubiquitin-like Binding Domain
10.1074/jbc.m110.112532 · 2010 · External reference
The U box is a modified RING finger—a common domain in ubiquitination
10.1016/s0960-9822(00)00398-5 · 2000 · External reference
Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases
10.1016/j.molcel.2012.07.001 · 2012 · External reference
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
10.1038/s41594-023-01111-7 · 2023 · External reference
Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture
10.1002/prot.22568 · 2009 · External reference
Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymes
10.1038/s44318-024-00301-3 · 2024 · External reference
Ubiquitination in the regulation of inflammatory cell death and cancer
10.1038/s41418-020-00708-5 · 2021 · External reference
HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation
10.15252/embj.2021109700 · 2022 · External reference
The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates
10.1038/s41556-022-00940-w · 2022 · External reference
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis
10.1016/j.molcel.2018.10.012 · 2018 · External reference
MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
10.1016/j.cell.2011.06.041 · 2011 · External reference
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
10.1038/nature23890 · 2017 · External reference
Stress granules plug and stabilize damaged endolysosomal membranes
10.1038/s41586-023-06726-w · 2023 · External reference
New tools for automated cryo-EM single-particle analysis in RELION-4.0
10.1042/bcj20210708 · 2021 · External reference
Measuring the effects of particle orientation to improve the efficiency of electron cryomicroscopy
10.1038/s41467-017-00782-3 · 2017 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
10.1107/s2059798318002425 · 2018 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
Real-space refinement in PHENIX for cryo-EM and crystallography
10.1107/s2059798318006551 · 2018 · External reference
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
10.1038/msb.2011.75 · 2011 · External reference
MUSCLE: multiple sequence alignment with high accuracy and high throughput
10.1093/nar/gkh340 · 2004 · External reference
The Ensembl REST API: Ensembl Data for Any Language
10.1093/bioinformatics/btu613 · 2015 · External reference
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules
10.1093/nar/gkw408 · 2016 · External reference
Mechanism of client selection by the protein quality-control factor UBE2O
10.1038/s41594-022-00807-6 · 2022 · External reference
Electron microscopy: Ultrastable gold substrates for electron cryomicroscopy
10.1126/science.1259530 · 2014 · External reference
A precision cryostat design for manual and semi-automated cryo-plunge instruments
10.1063/1.4967864 · 2016 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Data-driven regularization lowers the size barrier of cryo-EM structure determination
10.1038/s41592-024-02304-8 · 2024 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Ensembl 2024
10.1093/nar/gkad1049 · 2024 · External reference
