Research graph
References from Hypoxia? NNoT a PROblem!. Local targets link to admitted publications; unresolved targets remain external evidence.
Nicotinamide nucleotide transhydrogenase directly couples redox homeostasis to proline biosynthesis in human glioma
2026 · External reference
The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria
10.1074/jbc.m116.730473 · 2016 · External reference
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
10.1038/s41392-020-00326-0 · 2020 · External reference
Oxidative Stress in Cancer
10.1016/j.ccell.2020.06.001 · 2020 · External reference
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function
10.1084/jem.20191689 · 2020 · External reference
Mitochondrial Nicotinamide Nucleotide Transhydrogenase: Role in Energy Metabolism, Redox Homeostasis, and Cancer
10.1089/ars.2024.0694 · 2024 · External reference
The hallmarks of cancer metabolism: Still emerging
10.1016/j.cmet.2022.01.007 · 2022 · External reference
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
10.1016/j.celrep.2022.110320 · 2022 · External reference
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
10.1038/ncomms15267 · 2017 · External reference
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
10.1073/pnas.1117773108 · 2011 · External reference
