Research graph
References from DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3′ UTRs. Local targets link to admitted publications; unresolved targets remain external evidence.
How germ granules promote germ cell fate
10.1038/s41576-024-00744-8 · 2024 · External reference
Pathway to totipotency: lessons from germ cells
10.1016/j.cell.2006.11.016 · 2006 · External reference
Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm
10.1007/s00018-021-04012-4 · 2021 · External reference
Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling
10.1095/biolreprod.106.053686 · 2006 · External reference
Germ cell specification in mice: signaling, transcription regulation, and epigenetic consequences
10.1530/rep-10-0043 · 2010 · External reference
Germline stem cells
10.1101/cshperspect.a002642 · 2011 · External reference
Mechanisms guiding primordial germ cell migration: strategies from different organisms
10.1038/nrm2815 · 2010 · External reference
Primordial germ cells in mice
10.1101/cshperspect.a008375 · 2012 · External reference
A molecular programme for the specification of germ cell fate in mice
10.1038/nature00927 · 2002 · External reference
Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice
10.1016/j.ydbio.2004.11.025 · 2005 · External reference
Male germ cell specification and differentiation
10.1016/s1534-5807(02)00173-9 · 2002 · External reference
Single-cell roadmap of human gonadal development
10.1038/s41586-022-04918-4 · 2022 · External reference
Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
10.1242/dev.005611 · 2007 · External reference
dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival
10.1016/s0960-9822(03)00537-2 · 2003 · External reference
Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes
10.1038/s41598-023-33706-x · 2023 · External reference
The ter mutation first causes primordial germ cell deficiency in ter/ter mouse embryos at 8 days of gestation
10.1046/j.1440-169x.1995.t01-2-00007.x · 1995 · External reference
A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas
10.1093/jnci/50.1.235 · 1973 · External reference
The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
10.1038/nature03595 · 2005 · External reference
Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence
10.1371/journal.pone.0232047 · 2020 · External reference
Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos
10.1093/humrep/dead031 · 2023 · External reference
A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice
1985 · External reference
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs
10.1038/nature21690 · 2017 · External reference
RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage
2025 · External reference
Nanos genes and their role in development and beyond
10.1007/s00018-018-2766-3 · 2018 · External reference
The Drosophila posterior-group gene nanos functions by repressing hunchback activity
10.1038/338646a0 · 1989 · External reference
A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1
10.1016/j.celrep.2022.110894 · 2022 · External reference
Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development
10.15252/embr.201540828 · 2016 · External reference
Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development
10.1242/dev.02697 · 2007 · External reference
nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development
10.1016/s0925-4773(03)00043-1 · 2003 · External reference
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression
10.1101/gad.237289.113 · 2014 · External reference
Conserved role of nanos proteins in germ cell development
10.1126/science.1085222 · 2003 · External reference
Nanos2 suppresses meiosis and promotes male germ cell differentiation
10.1101/gad.1612708 · 2008 · External reference
A non-radioactive, improved PAR-CLIP and small RNA cDNA library preparation protocol
10.1093/nar/gkab011 · 2021 · External reference
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
10.1016/j.cell.2010.03.009 · 2010 · External reference
Large-scale tethered function assays identify factors that regulate mRNA stability and translation
10.1038/s41594-020-0477-6 · 2020 · External reference
The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming
10.1242/dev.175950 · 2019 · External reference
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
10.1038/s41580-021-00417-y · 2022 · External reference
The nexus between RNA-binding proteins and their effectors
10.1038/s41576-022-00550-0 · 2023 · External reference
TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding
10.1038/nmeth.4582 · 2018 · External reference
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells
10.1016/j.cell.2011.06.052 · 2011 · External reference
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation
10.1038/s41467-022-33552-x · 2022 · External reference
Stacking interactions in PUF-RNA complexes
10.1261/rna.2540311 · 2011 · External reference
Alternate modes of cognate RNA recognition by human PUMILIO proteins
10.1016/j.str.2010.12.019 · 2011 · External reference
Modular recognition of RNA by a human pumilio-homology domain
10.1016/s0092-8674(02)00873-5 · 2002 · External reference
Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets
10.1128/mcb.00155-08 · 2008 · External reference
NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells
10.1016/j.isci.2021.102762 · 2021 · External reference
Two-factor authentication underpins the precision of the piRNA pathway
10.1038/s41586-024-07963-3 · 2024 · External reference
Sequence, Structure, and Context Preferences of Human RNA Binding Proteins
10.1016/j.molcel.2018.05.001 · 2018 · External reference
Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences
10.1101/gr.258848.119 · 2020 · External reference
A large-scale binding and functional map of human RNA-binding proteins
10.1038/s41586-020-2077-3 · 2020 · External reference
A compendium of RNA-binding motifs for decoding gene regulation
10.1038/nature12311 · 2013 · External reference
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA
10.1038/s41586-025-08787-5 · 2025 · External reference
Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells
2022 · External reference
Simultaneous profiling of the RNA targets of two RNA-binding proteins using TRIBE-STAMP
10.1016/bs.mie.2024.07.008 · 2024 · External reference
A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity
10.7554/elife.48968 · 2019 · External reference
Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio
10.7554/elife.17096 · 2016 · External reference
Cooperativity in RNA-protein interactions: global analysis of RNA binding specificity
10.1016/j.celrep.2012.04.003 · 2012 · External reference
The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins
1997 · External reference
hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo
10.1016/0012-1606(87)90045-5 · 1987 · External reference
The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo
10.1242/dev.112.3.679 · 1991 · External reference
Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos
10.1016/0092-8674(95)90353-4 · 1995 · External reference
Recruitment of Nanos to hunchback mRNA by Pumilio
10.1101/gad.13.20.2704 · 1999 · External reference
Nanos is the localized posterior determinant in Drosophila
10.1016/0092-8674(91)90110-k · 1991 · External reference
Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos
10.1038/15666 · 1999 · External reference
A CCHC metal-binding domain in Nanos is essential for translational regulation
10.1093/emboj/16.4.834 · 1997 · External reference
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
10.1107/s2059798319011471 · 2019 · External reference
Coot: model-building tools for molecular graphics
10.1107/s0907444904019158 · 2004 · External reference
Data processing and analysis with the autoPROC toolbox
10.1107/s0907444911007773 · 2011 · External reference
PCLIPtools: A Robust Framework for Identifying RNA-Protein Interaction Sites from PAR-CLIP experiments
2025 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
BEDTools: a flexible suite of utilities for comparing genomic features
10.1093/bioinformatics/btq033 · 2010 · External reference
STREME: accurate and versatile sequence motif discovery
10.1093/bioinformatics/btab203 · 2021 · External reference
The UCSC Table Browser data retrieval tool
10.1093/nar/gkh103 · 2004 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity
10.1021/acssynbio.6b00343 · 2017 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Expanding and improving analyses of nucleotide recoding RNA-seq experiments with the EZbakR suite
2024 · External reference
Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway® recombination cloning technology and Flp-In T-REx® lines
10.1016/b978-0-12-418687-3.00008-2 · 2013 · External reference
PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells
10.1016/j.stem.2012.12.012 · 2013 · External reference
Ensembl 2025
10.1093/nar/gkae1071 · 2025 · External reference
A fast, lock-free approach for efficient parallel counting of occurrences of k-mers
10.1093/bioinformatics/btr011 · 2011 · External reference
Unresolved reference
2013 · External reference
AmiGO: online access to ontology and annotation data
10.1093/bioinformatics/btn615 · 2009 · External reference
The Gene Ontology knowledgebase in 2023
2023 · External reference
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
10.1038/75556 · 2000 · External reference
Improving the study of RNA dynamics through advances in RNA-seq with metabolic labeling and nucleotide-recoding chemistry
2023 · External reference
Enzymatic assembly of DNA molecules up to several hundred kilobases
10.1038/nmeth.1318 · 2009 · External reference
Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression
10.1371/journal.pone.0187236 · 2017 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Phaser crystallographic software
10.1107/s0021889807021206 · 2007 · External reference
Generation of Conditional Knockout Mice by Sequential Insertion of Two loxP Sites In Cis Using CRISPR/Cas9 and Single-Stranded DNA Oligonucleotides
10.1007/978-1-4939-8831-0_11 · 2019 · External reference
Genome Editing in Mouse and Rat by Electroporation
10.1007/978-1-0716-3016-7_10 · 2023 · External reference
Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies
2018 · External reference
