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References from DNASE1L3 maintains homeostatic levels of mitochondrial DNA on the mammalian cell surface. Local targets link to admitted publications; unresolved targets remain external evidence.
Integrated analysis of circulating cell free nucleic acids for cancer genotyping and immune phenotyping of tumor microenvironment
10.3389/fgene.2023.1138625 · 2023 · External reference
Human plasma and serum extracellular small RNA reference profiles and their clinical utility
10.1073/pnas.1714397115 · 2018 · External reference
Diverse human extracellular RNAs are widely detected in human plasma
2016 · External reference
exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids
10.1016/j.cell.2019.02.018 · 2019 · External reference
Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples
10.1038/s41587-025-02731-8 · 2025 · External reference
Quantitative and stoichiometric analysis of the microRNA content of exosomes
10.1073/pnas.1408301111 · 2014 · External reference
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
10.1073/pnas.1019055108 · 2011 · External reference
Small RNAs are modified with N-glycans and displayed on the surface of living cells
10.1016/j.cell.2021.04.023 · 2021 · External reference
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA
10.1016/j.cell.2024.07.044 · 2024 · External reference
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis
10.1038/s41586-025-09310-6 · 2025 · External reference
Spatial imaging of glycoRNA in single cells with ARPLA
10.1038/s41587-023-01801-z · 2023 · External reference
Cell surface RNAs control neutrophil recruitment
10.1016/j.cell.2023.12.033 · 2024 · External reference
FRET imaging of glycoRNA on small extracellular vesicles enabling sensitive cancer diagnostics
2025 · External reference
Extracellular exosomal RNAs are glyco-modified
10.1038/s41556-025-01682-1 · 2025 · External reference
An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release
10.1038/s42003-024-06129-1 · 2024 · External reference
Cell-free DNA topology depends on its subcellular and cellular origins in cancer
10.1172/jci.insight.159590 · 2022 · External reference
Comparison of the structures and topologies of plasma extracted circulating nuclear and mitochondrial cell-free DNA
10.3389/fgene.2023.1104732 · 2023 · External reference
Neutrophil extracellular traps kill bacteria
10.1126/science.1092385 · 2004 · External reference
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
10.1038/nm.4027 · 2016 · External reference
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus
10.1084/jem.20151876 · 2016 · External reference
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
10.1038/nature10992 · 2012 · External reference
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
10.1016/j.immuni.2012.01.009 · 2012 · External reference
A DNA-reacting factor in serum of a patient with lupus erythematosus diffusus
10.3181/00379727-96-23544 · 1957 · External reference
Complement fixation with cell nuclei and DNA in lupus erythematosus
10.3181/00379727-96-23545 · 1957 · External reference
Demonstration in the blood of patients with disseminated lupus erythematosus a substance determining a precipitation reaction with desoxyribonucleic acid
1957 · External reference
Anti-DNA antibodies--quintessential biomarkers of SLE
10.1038/nrrheum.2015.151 · 2016 · External reference
Immunological studies concerning the nephritis of systemic lupus erythematosus
10.1084/jem.126.4.607 · 1967 · External reference
Microparticles as a source of extracellular DNA
10.1007/s12026-010-8184-8 · 2011 · External reference
Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus
10.1016/j.jaut.2011.02.001 · 2011 · External reference
Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection
10.1006/mthe.2002.0625 · 2002 · External reference
Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity
10.1016/j.cell.2016.05.034 · 2016 · External reference
Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
10.1038/ng.975 · 2011 · External reference
Clinical spectrum of childhood-onset hypocomplementemic urticarial vasculitis in Oman: A retrospective multicenter study
10.1016/j.jaad.2020.12.031 · 2021 · External reference
An autosomal recessive DNASE1L3-related autoimmune disease with unusual clinical presentation mimicking systemic lupus erythematosus
10.1177/0961203316676382 · 2017 · External reference
Monogenic lupus caused by mutations in DNASE1L3: A rare cause of systemic lupus erythematosus in children
10.1111/sji.13162 · 2022 · External reference
Refractory and Fatal Presentation of Severe Autoimmune Hemolytic Anemia in a Child With the DNASE1L3 Mutation Complicated With an Additional DOCK8 Variant
10.1097/mph.0000000000001780 · 2021 · External reference
DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling
10.1007/s10875-022-01287-5 · 2022 · External reference
Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
10.1016/s2665-9913(19)30142-0 · 2020 · External reference
Monogenic lupus due to DNASE1L3 deficiency in a pediatric patient with urticarial rash, hypocomplementemia, pulmonary hemorrhage, and immune-complex glomerulonephritis
10.1016/j.ejmg.2021.104262 · 2021 · External reference
Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis
10.3899/jrheum.181232 · 2020 · External reference
Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus
10.3899/jrheum.171358 · 2018 · External reference
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
10.1084/jem.20201138 · 2021 · External reference
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
10.1038/nmeth.2688 · 2013 · External reference
ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing
10.1038/nmeth.4031 · 2016 · External reference
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
10.1016/j.cell.2025.01.040 · 2025 · External reference
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein
10.1038/s41587-025-02648-2 · 2025 · External reference
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling
10.1038/s41586-025-10052-8 · 2026 · External reference
Cell surface proteoglycan of mammary epithelial cells. Protease releases a heparan sulfate-rich ectodomain from a putative membrane-anchored domain
10.1016/s0021-9258(18)89237-7 · 1985 · External reference
Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction
10.1186/s13059-020-02145-6 · 2020 · External reference
Influence of trypsinization and alternative procedures for cell preparation before RNA extraction on RNA integrity
10.1016/j.ab.2014.06.017 · 2014 · External reference
The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers
10.1016/j.cmet.2010.11.012 · 2010 · External reference
The effect of ethidium bromide on mitochondrial DNA synthesis and mitochondrial DNA structure in HeLa cells
10.1083/jcb.51.1.116 · 1971 · External reference
SWAMNA: a comprehensive platform for analysis of nucleic acid modifications
10.1039/d3cc04402e · 2023 · External reference
Accumulation of 8-oxodG within the human mitochondrial genome positively associates with transcription
2023 · External reference
Cell-free nucleic acids as biomarkers in cancer patients
10.1038/nrc3066 · 2011 · External reference
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
10.1016/j.cell.2024.08.029 · 2024 · External reference
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy
10.1038/s41586-024-07340-0 · 2024 · External reference
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
10.1126/science.aao6047 · 2018 · External reference
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
10.1038/s41467-021-21984-w · 2021 · External reference
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology
10.1016/j.chembiol.2024.04.015 · 2024 · External reference
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
2025 · External reference
Scavenger receptors
10.1016/j.cub.2020.05.051 · 2020 · External reference
The role of human ribonuclease A family in health and diseases: A systematic review
10.1016/j.isci.2022.105284 · 2022 · External reference
Deoxyribonucleases and Their Applications in Biomedicine
10.3390/biom10071036 · 2020 · External reference
Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus
10.1136/annrheumdis-2020-218810 · 2021 · External reference
An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3
10.1186/s13075-014-0438-8 · 2014 · External reference
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
10.1038/ng.468 · 2009 · External reference
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
10.1038/ng.81 · 2008 · External reference
Molecular pixelation: spatial proteomics of single cells by sequencing
10.1038/s41592-024-02268-9 · 2024 · External reference
Cells as Single-Molecule Protein Proximity Networks
2025 · External reference
T-cell-antigen recognition and the immunological synapse
10.1038/nri1245 · 2003 · External reference
The immunological synapse
10.1158/2326-6066.cir-14-0161 · 2014 · External reference
Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease
10.1038/s41392-025-02332-6 · 2025 · External reference
B cells acquire antigen from target cells after synapse formation
10.1038/35078099 · 2001 · External reference
CpG motifs in bacterial DNA trigger direct B-cell activation
10.1038/374546a0 · 1995 · External reference
Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA
10.1073/pnas.1815031116 · 2019 · External reference
Unconventional mechanisms of eukaryotic protein secretion
10.1016/j.cub.2017.11.074 · 2018 · External reference
Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors
10.1016/j.molcel.2025.11.020 · 2025 · External reference
Structure of an activated DNA-PK and its implications for NHEJ
10.1016/j.molcel.2020.12.015 · 2021 · External reference
Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter
10.1074/jbc.m112.371013 · 2012 · External reference
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia
10.1126/scitranslmed.abj1008 · 2021 · External reference
Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury
10.1164/rccm.201706-1161oc · 2018 · External reference
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
10.1126/science.adp3971 · 2025 · External reference
Multiomic characterization of RNA microenvironments by oligonucleotide-mediated proximity-interactome mapping
10.1038/s41592-024-02457-6 · 2024 · External reference
HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution
2025 · External reference
DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci
2024 · External reference
Chemical fixation creates nanoscale clusters on the cell surface by aggregating membrane proteins
10.1038/s42003-022-03437-2 · 2022 · External reference
The 1982 revised criteria for the classification of systemic lupus erythematosus
10.1002/art.1780251101 · 1982 · External reference
Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE
10.1002/art.1780350606 · 1992 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Successful cord blood transplantation for del7q myelodysplastic syndrome in Pearson marrow pancreas syndrome
10.1002/ajh.27107 · 2023 · External reference
Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics
10.1021/acs.jproteome.9b00640 · 2020 · External reference
Electron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles
10.3389/fcell.2021.744248 · 2021 · External reference
Point by Point: An Introductory Guide to Sample Preparation for Single-Molecule, Super-Resolution Fluorescence Microscopy
10.1002/9780470559277.ch140241 · 2015 · External reference
Genome-Wide Mapping of Active Regulatory Elements Using ATAC-seq
10.1007/978-1-0716-2899-7_1 · 2023 · External reference
ATAC-See: A Tn5 Transposase-Mediated Assay for Detection of Chromatin Accessibility with Imaging
10.1007/978-1-0716-2899-7_15 · 2023 · External reference
Fast and accurate short read alignment with Burrows-Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
Model-based analysis of ChIP-Seq (MACS)
10.1186/gb-2008-9-9-r137 · 2008 · External reference
MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics
10.1038/nmeth.4256 · 2017 · External reference
Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
10.1093/bioinformatics/bti042 · 2005 · External reference
