Research graph
References from A genome-scale adaptation map identifies the FANCM-RMI1/2 complex as an opposing modulator of cell fitness upon BRCA1 or BRCA2 loss. Local targets link to admitted publications; unresolved targets remain external evidence.
The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse
10.1016/s0092-8674(00)81302-1 · 1996 · External reference
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
10.1038/386804a0 · 1997 · External reference
Accurate classification of BRCA1 variants with saturation genome editing
10.1038/s41586-018-0461-z · 2018 · External reference
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality
2025 · External reference
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer
10.1146/annurev-cancerbio-030617-050502 · 2018 · External reference
Hereditary breast cancer: syndromes, tumour pathology and molecular testing
10.1111/his.14808 · 2023 · External reference
Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations
10.1093/jnci/90.15.1138 · 1998 · External reference
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
10.1038/nature17676 · 2016 · External reference
The tandem duplicator phenotype as a distinct genomic configuration in cancer
10.1073/pnas.1520010113 · 2016 · External reference
The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice
10.1038/s41467-020-19532-z · 2020 · External reference
The Causes and Consequences of Genetic Interactions (Epistasis)
10.1146/annurev-genom-083118-014857 · 2019 · External reference
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA
10.15252/embj.2019103654 · 2021 · External reference
MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner
10.1038/s41467-022-32861-5 · 2022 · External reference
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells
10.1016/j.celrep.2018.04.046 · 2018 · External reference
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in
10.1038/s41586-018-0324-7 · 2018 · External reference
USP1 in regulation of DNA repair pathways
10.1016/j.dnarep.2025.103807 · 2025 · External reference
Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair
10.1073/pnas.0908258106 · 2009 · External reference
Restriction of replication fork regression activities by a conserved SMC complex
10.1016/j.molcel.2014.09.013 · 2014 · External reference
Defining the budding yeast chromatin-associated interactome
10.1038/msb.2010.104 · 2010 · External reference
ETAA1 acts at stalled replication forks to maintain genome integrity
10.1038/ncb3415 · 2016 · External reference
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
10.1038/ng1626 · 2005 · External reference
MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
2017 · External reference
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
10.1038/s41467-017-00634-0 · 2017 · External reference
The DNA translocase activity of FANCM protects stalled replication forks
10.1093/hmg/dds013 · 2012 · External reference
Profound synthetic lethality between SMARCAL1 and FANCM
10.1016/j.molcel.2024.10.016 · 2024 · External reference
Comprehensive interrogation of synthetic lethality in the DNA damage response
10.1038/s41586-025-08815-4 · 2025 · External reference
Protein neddylation and its role in health and diseases
2024 · External reference
A tumor suppressive DNA translocase named FANCM
10.1080/10409238.2019.1568963 · 2019 · External reference
FANCM regulates repair pathway choice at stalled replication forks
10.1016/j.molcel.2021.03.044 · 2021 · External reference
FANCM Connects the Genome Instability Disorders Bloom’s Syndrome and Fanconi Anemia
10.1016/j.molcel.2009.12.006 · 2009 · External reference
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase–double Holliday junction dissolvasome
10.1101/gad.1725108 · 2008 · External reference
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
10.1101/gad.13.20.2633 · 1999 · External reference
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
10.1038/nature03404 · 2005 · External reference
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
10.1016/j.cell.2011.03.041 · 2011 · External reference
BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
10.1016/j.molcel.2023.12.025 · 2024 · External reference
Replication fork stability confers chemoresistance in BRCA-deficient cells
10.1038/nature18325 · 2016 · External reference
The expanding roles of homologous recombination proteins in genome stability
10.1038/s44318-025-00673-0 · 2026 · External reference
Replication fork reversal triggers fork degradation in BRCA2-defective cells
10.1038/s41467-017-01164-5 · 2017 · External reference
Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments
10.1016/j.molcel.2017.07.001 · 2017 · External reference
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
10.1016/j.molcel.2021.06.011 · 2021 · External reference
Replication gap suppression depends on the double-strand DNA binding activity of BRCA2
10.1038/s41467-023-36149-0 · 2023 · External reference
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
10.1016/j.molcel.2021.09.013 · 2021 · External reference
MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
10.1038/s41467-017-01180-5 · 2017 · External reference
SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks
10.1083/jcb.201709121 · 2018 · External reference
Replication Gaps Underlie BRCA Deficiency and Therapy Response
10.1158/0008-5472.can-20-1602 · 2021 · External reference
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
10.1038/nsmb.1927 · 2010 · External reference
DNA Fiber Analysis: Mind the Gap!
10.1016/bs.mie.2017.03.019 · 2017 · External reference
Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
10.1016/j.molcel.2024.04.004 · 2024 · External reference
RAD51 protects abasic sites to prevent replication fork breakage
10.1016/j.molcel.2024.07.004 · 2024 · External reference
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
10.15252/embj.2022113190 · 2023 · External reference
Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors
10.1016/j.molcel.2025.01.031 · 2025 · External reference
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors
10.1126/science.abb4542 · 2021 · External reference
Participation of DNA repair in the response to 5-fluorouracil
10.1007/s00018-008-8557-5 · 2009 · External reference
FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres
10.1073/pnas.1708065114 · 2017 · External reference
BRCA1 Mutational Complementation Induces Synthetic Viability
10.1016/j.molcel.2020.04.006 · 2020 · External reference
A BRCA1 coiled-coil domain variant disrupting PALB2 interaction promotes the development of mammary tumors and confers a targetable defect in homologous recombination repair
10.1158/0008-5472.can-21-1415 · 2021 · External reference
A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2
10.1016/j.ccr.2012.05.015 · 2012 · External reference
Defining a Cancer Dependency Map
10.1016/j.cell.2017.06.010 · 2017 · External reference
The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer
10.1038/s43018-021-00266-w · 2021 · External reference
The transcriptomic architecture of common cancers reflects synthetic lethal interactions
10.1038/s41588-025-02108-2 · 2025 · External reference
Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer
10.1016/j.annonc.2024.01.003 · 2024 · External reference
Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome
10.1073/pnas.1117279109 · 2012 · External reference
PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ
10.1016/j.isci.2019.02.026 · 2019 · External reference
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities
10.1038/s41467-023-43446-1 · 2023 · External reference
EXO1 protects BRCA1-deficient cells against toxic DNA lesions
10.1016/j.molcel.2023.12.039 · 2024 · External reference
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
10.1016/j.molcel.2023.12.040 · 2024 · External reference
The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination–Deficient Tumors
10.1158/0008-5472.can-24-0293 · 2024 · External reference
Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency
10.1158/1535-7163.mct-24-0515 · 2025 · External reference
10.1038/s44318-026-00913-x · 2026 · Admitted local publication
Regulation of Recombination and Genomic Maintenance
10.1101/cshperspect.a016501 · 2015 · External reference
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers
10.1016/j.molcel.2017.09.036 · 2017 · External reference
The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks
10.1016/j.molcel.2007.11.032 · 2008 · External reference
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2
10.1038/nsmb1245 · 2007 · External reference
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
10.1038/nsmb1251 · 2007 · External reference
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability
10.1016/j.molcel.2025.05.010 · 2025 · External reference
A fork in the road: Where homologous recombination and stalled replication fork protection part ways
10.1016/j.semcdb.2020.07.004 · 2021 · External reference
Isomerization of BRCA1-BARD1 promotes replication fork protection
10.1038/s41586-019-1363-4 · 2019 · External reference
Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4
10.1101/gad.256214.114 · 2015 · External reference
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
10.1038/ncb3626 · 2017 · External reference
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
10.1016/j.molcel.2018.09.014 · 2018 · External reference
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
10.1038/nature03443 · 2005 · External reference
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
10.1038/nature03445 · 2005 · External reference
Welcome to the Tidyverse
10.21105/joss.01686 · 2019 · External reference
bioinfo-pf-curie/nf-CRISPR, v1.0.0
2023 · External reference
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
10.1186/s13059-014-0554-4 · 2014 · External reference
DNA combing versus DNA spreading and the separation of sister chromatids
10.1083/jcb.202305082 · 2024 · External reference
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
10.7554/elife.19760 · 2016 · External reference
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
10.1158/0008-5472.can-21-4339 · 2022 · External reference
Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer
10.1126/scitranslmed.aab0021 · 2015 · External reference
