Research graph
References from Adhiron binders as molecular tools for inhibiting activation dependent, IL-7 mediated long-term survival of CD4+ T-cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Activation of PI3K is indispensable for interleukin 7–mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
10.1084/jem.20040789 · 2004 · External reference
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
10.1038/s41467-018-06804-y · 2018 · External reference
IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
10.1016/j.smim.2012.04.010 · 2012 · External reference
Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene
10.1152/ajpcell.00506.2009 · 2010 · External reference
Prevention of graft-versus-host disease by anti–IL-7Rα antibody
10.1182/blood-2006-11-055673 · 2007 · External reference
Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double-blind, placebo-controlled study
10.1111/bcp.13748 · 2019 · External reference
10.1101/2025.05.13.653658
10.1101/2025.05.13.653658 · External reference
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
10.1038/s41467-024-46321-9 · 2024 · External reference
Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in systemic sclerosis
10.1016/j.bioorg.2025.109251 · 2025 · External reference
Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosiss
2025 · External reference
Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance
10.1016/j.clim.2014.02.007 · 2014 · External reference
Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors
2024 · External reference
Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
10.1002/art.27578 · 2010 · External reference
IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells
10.1002/(sici)1521-4141(199810)28:10<3057::aid-immu3057>3.0.co;2-z · 1998 · External reference
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
10.1038/s41467-021-24316-0 · 2021 · External reference
Immunomodulatory activity of humanized anti–IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes
10.1172/jci.insight.126054 · 2019 · External reference
Generating and validating renewable affimer protein binding reagents targeting SH2 domains
10.1038/s41598-024-79357-4 · 2024 · External reference
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones
10.1016/j.jim.2010.01.007 · 2010 · External reference
Fine-tuning CD4+ central memory T cell heterogeneity by strength of stimulation
10.1002/eji.200738044 · 2008 · External reference
Interleukin 7 regulates the survival and generation of memory CD4 cells
10.1084/jem.20030735 · 2003 · External reference
Analysis of γc-family cytokine target genes
10.1074/jbc.m209015200 · 2003 · External reference
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
10.1073/pnas.1222303110 · 2013 · External reference
IL-7 receptor blockade following T cell depletion promotes long-term allograft survival
10.1172/jci66287 · 2014 · External reference
Rational design of nanobody80 loop peptidomimetics: towards biased β2 adrenergic receptor ligands
10.1002/chem.201701321 · 2017 · External reference
Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
10.1016/j.celrep.2023.113184 · 2023 · External reference
Interleukin-7 receptor expression: intelligent design
10.1038/nri2023 · 2007 · External reference
Structural reorganization of the interleukin-7 signaling complex
10.1073/pnas.1116582109 · 2012 · External reference
Thymic stromal lymphopoietin, a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c+ myeloid dendritic cells to attract and stimulate T cells
10.1002/art.38338 · 2014 · External reference
Structure based antibody-like peptidomimetics
10.3390/ph5020209 · 2012 · External reference
Visualizing the site and dynamics of IgG salvage by the MHC Class I-related receptor, FcRn
10.4049/jimmunol.172.4.2021 · 2004 · External reference
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells
10.1073/pnas.1203692109 · 2012 · External reference
Development of a long-term, IL7 dependent cell death rescue assay in CD4+ T-cells
10.1016/j.jim.2021.113020 · 2021 · External reference
IL-7 in rheumatoid arthritis: pathogenesis, biomarker and rationale for anti-IL-7 therapy
2014 · External reference
Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) in peripheral blood from patients with multiple sclerosis (MS)
10.1016/j.jneuroim.2010.02.014 · 2010 · External reference
Affimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles
10.1016/j.isci.2024.110461 · 2024 · External reference
10.21203/rs.3.rs-7565154/v1
10.21203/rs.3.rs-7565154/v1 · External reference
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action
10.1073/pnas.1707856115 · 2018 · External reference
Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation
10.1016/j.jbc.2023.105325 · 2023 · External reference
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells
10.1084/jem.20052187 · 2006 · External reference
Structure−function studies of an engineered scaffold protein derived from Stefin A. II: development and applications of the SQT variant
10.1093/protein/gzr019 · 2011 · External reference
The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function
10.1038/cddis.2013.564 · 2014 · External reference
Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells
10.1074/jbc.m113.449918 · 2013 · External reference
Targeting Grb2 SH3 domains with affimer proteins provides novel insights into ras signalling modulation
10.3390/biom14081040 · 2024 · External reference
Affimer proteins are versatile and renewable affinity reagents
10.7554/elife.24903 · 2017 · External reference
Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications
10.1093/protein/gzu007 · 2014 · External reference
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
10.1038/ncomms14937 · 2017 · External reference
Model-based characterization of the pharmacokinetics, target engagement biomarkers, and immunomodulatory activity of PF-06342674, a humanized mAb against IL-7 receptor-α, in adults with type 1 diabetes
10.1208/s12248-019-0401-3 · 2020 · External reference
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
10.1182/blood-2007-06-096297 · 2008 · External reference
Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer
10.1182/bloodadvances.2024012689 · 2024 · External reference
Soluble Monomeric IgG1 Fc
10.1074/jbc.m112.368647 · 2012 · External reference
IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells
10.1002/(sici)1521-4141(199810)28:10<3057::aid-immu3057>3.0.co;2-z · ExternalCitation · doi-reference
Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
10.1002/art.27578 · ExternalCitation · doi-reference
Thymic stromal lymphopoietin, a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c+ myeloid dendritic cells to attract and stimulate T cells
10.1002/art.38338 · ExternalCitation · doi-reference
Rational design of nanobody80 loop peptidomimetics: towards biased β2 adrenergic receptor ligands
10.1002/chem.201701321 · ExternalCitation · doi-reference
Fine-tuning CD4+ central memory T cell heterogeneity by strength of stimulation
10.1002/eji.200738044 · ExternalCitation · doi-reference
Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in systemic sclerosis
10.1016/j.bioorg.2025.109251 · ExternalCitation · doi-reference
Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
10.1016/j.celrep.2023.113184 · ExternalCitation · doi-reference
Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance
10.1016/j.clim.2014.02.007 · ExternalCitation · doi-reference
Affimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles
10.1016/j.isci.2024.110461 · ExternalCitation · doi-reference
Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation
10.1016/j.jbc.2023.105325 · ExternalCitation · doi-reference
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones
10.1016/j.jim.2010.01.007 · ExternalCitation · doi-reference
Development of a long-term, IL7 dependent cell death rescue assay in CD4+ T-cells
10.1016/j.jim.2021.113020 · ExternalCitation · doi-reference
Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) in peripheral blood from patients with multiple sclerosis (MS)
10.1016/j.jneuroim.2010.02.014 · ExternalCitation · doi-reference
IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
10.1016/j.smim.2012.04.010 · ExternalCitation · doi-reference
The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function
10.1038/cddis.2013.564 · ExternalCitation · doi-reference
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
10.1038/ncomms14937 · ExternalCitation · doi-reference
Interleukin-7 receptor expression: intelligent design
10.1038/nri2023 · ExternalCitation · doi-reference
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
10.1038/s41467-018-06804-y · ExternalCitation · doi-reference
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
10.1038/s41467-021-24316-0 · ExternalCitation · doi-reference
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
10.1038/s41467-024-46321-9 · ExternalCitation · doi-reference
Generating and validating renewable affimer protein binding reagents targeting SH2 domains
10.1038/s41598-024-79357-4 · ExternalCitation · doi-reference
Structural reorganization of the interleukin-7 signaling complex
10.1073/pnas.1116582109 · ExternalCitation · doi-reference
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells
10.1073/pnas.1203692109 · ExternalCitation · doi-reference
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
10.1073/pnas.1222303110 · ExternalCitation · doi-reference
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action
10.1073/pnas.1707856115 · ExternalCitation · doi-reference
Soluble Monomeric IgG1 Fc
10.1074/jbc.m112.368647 · ExternalCitation · doi-reference
Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells
10.1074/jbc.m113.449918 · ExternalCitation · doi-reference
Analysis of γc-family cytokine target genes
10.1074/jbc.m209015200 · ExternalCitation · doi-reference
Interleukin 7 regulates the survival and generation of memory CD4 cells
10.1084/jem.20030735 · ExternalCitation · doi-reference
Activation of PI3K is indispensable for interleukin 7–mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
10.1084/jem.20040789 · ExternalCitation · doi-reference
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells
10.1084/jem.20052187 · ExternalCitation · doi-reference
Structure−function studies of an engineered scaffold protein derived from Stefin A. II: development and applications of the SQT variant
10.1093/protein/gzr019 · ExternalCitation · doi-reference
Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications
10.1093/protein/gzu007 · ExternalCitation · doi-reference
10.1101/2025.05.13.653658
10.1101/2025.05.13.653658 · ExternalCitation · doi-reference
Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double-blind, placebo-controlled study
10.1111/bcp.13748 · ExternalCitation · doi-reference
Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene
10.1152/ajpcell.00506.2009 · ExternalCitation · doi-reference
Immunomodulatory activity of humanized anti–IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes
10.1172/jci.insight.126054 · ExternalCitation · doi-reference
IL-7 receptor blockade following T cell depletion promotes long-term allograft survival
10.1172/jci66287 · ExternalCitation · doi-reference
Prevention of graft-versus-host disease by anti–IL-7Rα antibody
10.1182/blood-2006-11-055673 · ExternalCitation · doi-reference
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
10.1182/blood-2007-06-096297 · ExternalCitation · doi-reference
Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer
10.1182/bloodadvances.2024012689 · ExternalCitation · doi-reference
Model-based characterization of the pharmacokinetics, target engagement biomarkers, and immunomodulatory activity of PF-06342674, a humanized mAb against IL-7 receptor-α, in adults with type 1 diabetes
10.1208/s12248-019-0401-3 · ExternalCitation · doi-reference
10.21203/rs.3.rs-7565154/v1
10.21203/rs.3.rs-7565154/v1 · ExternalCitation · doi-reference
Targeting Grb2 SH3 domains with affimer proteins provides novel insights into ras signalling modulation
10.3390/biom14081040 · ExternalCitation · doi-reference
Structure based antibody-like peptidomimetics
10.3390/ph5020209 · ExternalCitation · doi-reference
Visualizing the site and dynamics of IgG salvage by the MHC Class I-related receptor, FcRn
10.4049/jimmunol.172.4.2021 · ExternalCitation · doi-reference
Affimer proteins are versatile and renewable affinity reagents
10.7554/elife.24903 · ExternalCitation · doi-reference
