Research graph
References from Hippo signaling and vestigial-like family member 3 at the stromal–immune interface in autoimmunity. Local targets link to admitted publications; unresolved targets remain external evidence.
Distinct fibroblast subsets drive inflammation and damage in arthritis
10.1038/s41586-019-1263-7 · 2019 · External reference
The role of stromal cells in the persistence of chronic inflammation
10.1111/j.1365-2249.2012.04634.x · 2013 · External reference
Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus
10.3389/fimmu.2022.1057932 · 2022 · External reference
Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
10.3389/fcell.2021.673599 · 2021 · External reference
Hippo pathway in cell–cell communication: emerging roles in development and regeneration
10.1186/s41232-024-00331-8 · 2024 · External reference
Hippo pathway in mammalian adaptive immune system
10.3390/cells8050398 · 2019 · External reference
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis
10.1038/s41467-023-44645-6 · 2024 · External reference
The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity
10.1172/jci.insight.127291 · 2019 · External reference
The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren’s syndrome
10.1038/labinvest.2013.114 · 2013 · External reference
Leonurine alleviates rheumatoid arthritis by regulating the Hippo signaling pathway
10.1016/j.phymed.2023.155243 · 2024 · External reference
Antiphospholipid antibodies induce proinflammatory and procoagulant pathways in endothelial cells
10.1016/j.jtauto.2023.100202 · 2023 · External reference
VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia
2025 · External reference
Hippo pathway in organ size control, tissue homeostasis, and cancer
10.1016/j.cell.2015.10.044 · 2015 · External reference
The Hippo signalling pathway and its implications in human health and diseases
10.1038/s41392-022-01191-9 · 2022 · External reference
Regulation of the Hippo pathway transcription factor TEAD
10.1016/j.tibs.2017.09.003 · 2017 · External reference
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
10.1038/cr.2014.10 · 2014 · External reference
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway
10.1074/jbc.ra120.012781 · 2020 · External reference
Targeting TEAD in cancer
10.3389/fonc.2025.1692512 · 2025 · External reference
A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases
10.1038/ni.3643 · 2017 · External reference
Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells
10.1016/j.gep.2022.119302 · 2023 · External reference
Cis-regulatory differences in isoform expression associate with life history strategy variation in Atlantic salmon
10.1371/journal.pgen.1009055 · 2020 · External reference
The role of Mst1 in lymphocyte homeostasis and function
10.3389/fimmu.2018.00149 · 2018 · External reference
Vestigial-like 3 plays an important role in osteoblast differentiation by regulating the expression of osteogenic transcription factors and BMP signaling
10.1007/s00223-022-00997-7 · 2022 · External reference
VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle
10.1242/jcs.225946 · 2019 · External reference
Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth
10.1101/gad.331546.119 · 2020 · External reference
YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
10.7554/elife.67312 · 2021 · External reference
The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells
10.1074/jbc.m113.529115 · 2014 · External reference
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
10.1038/ncb1748 · 2008 · External reference
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway
10.1016/j.devcel.2010.11.012 · 2010 · External reference
TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
10.1016/j.heliyon.2023.e21519 · 2023 · External reference
HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling
10.1016/j.isci.2024.108986 · 2024 · External reference
Dysregulated Hippo signaling pathway and YAP activation in atopic dermatitis: insights from clinical and animal studies
10.3390/ijms242417322 · 2023 · External reference
LATS1 is a central signal transmitter for achieving full type-I interferon activity
10.1126/sciadv.abj3887 · 2022 · External reference
The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway
10.1038/s41418-021-00849-1 · 2022 · External reference
Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction
10.1038/s41540-024-00414-9 · 2024 · External reference
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
10.1152/ajplung.00300.2014 · 2015 · External reference
Extracellular matrix stiffness regulates osteogenic differentiation through MAPK activation
10.1371/journal.pone.0135519 · 2015 · External reference
VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid–liquid phase separation
10.1038/s41467-023-36189-6 · 2023 · External reference
Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells
10.1111/jcmm.17279 · 2022 · External reference
YAP regulates cell mechanics by controlling focal adhesion assembly
10.1038/ncomms15321 · 2017 · External reference
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling
10.1073/pnas.1919702117 · 2020 · External reference
Emerging roles of the Hippo signaling pathway in modulating immune response and inflammation-driven tissue repair and remodeling
10.1111/febs.16449 · 2022 · External reference
Mechanosensation to inflammation: roles for YAP/TAZ in innate immune cells
10.1126/scisignal.adc9656 · 2023 · External reference
YAP-mediated mechanotransduction tunes the macrophage inflammatory response
10.1126/sciadv.abb8471 · 2020 · External reference
YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction
10.1371/journal.pbio.3000941 · 2020 · External reference
Targeting Hippo pathway diminishes disease signaling in scleroderma skin
10.4049/jimmunol.212.supp.0964.5177 · 2024 · External reference
Highly expressed VGLL3 in keloid fibroblasts promotes glycolysis and collagen production via the activation of Wnt/β-catenin signaling
10.1016/j.cellsig.2025.111604 · 2025 · External reference
Role of YAP/TAZ in mechanotransduction
10.1038/nature10137 · 2011 · External reference
The Hippo pathway effector YAP inhibits NF-κB signaling and ccRCC growth by opposing ZHX2
2025 · External reference
The crosstalk between Hippo-YAP pathway and innate immunity
10.3389/fimmu.2020.00323 · 2020 · External reference
Hippo/YAP signaling’s multifaceted crosstalk in cancer
2025 · External reference
VGLL3 activates inflammatory responses by inducing interleukin-1α secretion
10.1096/fj.202100679rr · 2021 · External reference
The Hippo pathway kinases LATS1/2 suppress cancer immunity
10.1016/j.cell.2016.11.005 · 2016 · External reference
Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade
10.1038/ncb3496 · 2017 · External reference
Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway
10.1186/s13075-022-02880-0 · 2022 · External reference
TLR3 activation evokes IL-6 secretion, autocrine regulation of Stat3 signaling and TLR2 expression in human bronchial epithelial cells
10.1007/s12079-012-0185-z · 2013 · External reference
Influenza A virus NS1 protein hijacks YAP/TAZ to suppress TLR3-mediated innate immune response
10.1371/journal.ppat.1010505 · 2022 · External reference
The role of non-canonical Hippo pathway in regulating immune homeostasis
10.1186/s40001-023-01484-x · 2023 · External reference
Hippo pathway counter-regulates innate immunity in hepatitis B virus infection
10.3389/fimmu.2021.684424 · 2021 · External reference
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival
10.1182/blood-2011-09-378364 · 2012 · External reference
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells
10.1073/pnas.0810773105 · 2008 · External reference
Hippo pathway kinase Mst1 is required for long-lived humoral immunity
10.4049/jimmunol.1701407 · 2019 · External reference
Mst1 positively regulates B-cell receptor signaling via CD19 transcriptional levels
10.1182/bloodadvances.2016000588 · 2016 · External reference
Novel role of Hippo effector YAP1 as a rheostat controlling inflammation in dendritic cells
10.1093/jleuko/qiag024 · 2026 · External reference
Regulatory mechanism of macrophage polarization based on Hippo pathway
10.3389/fimmu.2023.1279591 · 2023 · External reference
YAP aggravates inflammatory bowel disease by regulating M1/M2 macrophage polarization and gut microbial homeostasis
10.1016/j.celrep.2019.03.028 · 2019 · External reference
Why women have more autoimmune diseases than men: an evolutionary perspective
10.1111/eva.13167 · 2021 · External reference
Sex differences in autoimmune disease from a pathological perspective
10.2353/ajpath.2008.071008 · 2008 · External reference
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis
10.1038/s41598-018-20308-1 · 2018 · External reference
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon
10.1038/nature16062 · 2015 · External reference
Food quality and life-history genotype influence maturation and reproductive traits in female Atlantic salmon
10.1111/mec.17735 · 2025 · External reference
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics
10.1186/s13293-025-00705-8 · 2025 · External reference
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
10.1038/ng.714 · 2010 · External reference
Crosstalk between YAP/TAZ and ERα in mechanical and hormonal signaling in the skeletal system
10.3724/abbs.2025186 · 2025 · External reference
A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer
10.1016/j.molcel.2019.06.010 · 2019 · External reference
Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer
10.1038/s41467-022-28691-0 · 2022 · External reference
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
10.1038/nature13545 · 2014 · External reference
Interplay between YAP/TAZ and metabolism
10.1016/j.cmet.2018.07.010 · 2018 · External reference
The interplay between hippo signaling and mitochondrial metabolism: implications for cellular homeostasis and disease
10.1016/j.mito.2024.101885 · 2024 · External reference
The Hippo signaling network and its biological functions
10.1146/annurev-genet-120417-031621 · 2018 · External reference
Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy
10.1016/j.humimm.2021.01.004 · 2021 · External reference
Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta
10.1073/pnas.2002630117 · 2020 · External reference
Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiation
10.1073/pnas.2204069119 · 2022 · External reference
The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice
10.1038/s41419-021-03409-0 · 2021 · External reference
The TEA domain transcription factors TEAD1 and TEAD3 and WNT signaling determine HLA-G expression in human extravillous trophoblasts
10.1073/pnas.2425339122 · 2025 · External reference
Hippo-YAP1 signaling pathway and severe preeclampsia (sPE) in the Chinese population
10.1016/j.preghy.2019.11.002 · 2020 · External reference
miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia
10.1016/j.omtn.2022.09.006 · 2022 · External reference
Type I interferons in autoimmunity: implications in clinical phenotypes and treatment response
10.3899/jrheum.2022-0827 · 2023 · External reference
Identification of novel fibroblast subsets in diffuse cutaneous systemic sclerosis
10.1016/j.ard.2025.11.027 · 2026 · External reference
YAP/TAZ: key players for rheumatoid arthritis severity by driving fibroblast like synoviocytes phenotype and fibro-inflammatory response
10.3389/fimmu.2021.791907 · 2021 · External reference
Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis
10.1002/art.34477 · 2012 · External reference
YAP1 overexpression is associated with kidney dysfunction in lupus nephritis
10.1159/000517575 · 2021 · External reference
Regulation of photosensitivity by the Hippo pathway in lupus skin
10.1002/art.42460 · 2023 · External reference
Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
10.1136/annrheumdis-2021-220875 · 2022 · External reference
Role of the Hippo pathway in autoimmune diseases
10.1016/j.exger.2023.112336 · 2024 · External reference
Microvascular endothelial cells license APS vasculopathy through YAP1- and CCN2-mediated signaling
10.1161/circulationaha.125.073552 · 2025 · External reference
YAP activates STAT3 signalling to promote colonic epithelial cell proliferation in DSS-induced colitis and colitis associated cancer
10.2147/jir.s377077 · 2022 · External reference
YAP represses intestinal inflammation through epigenetic silencing of JMJD3
10.1186/s13148-024-01626-w · 2024 · External reference
Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present)
10.1080/13543776.2022.2096436 · 2022 · External reference
Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration
2025 · External reference
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
10.1101/gad.192856.112 · 2012 · External reference
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
10.1016/j.stem.2024.03.003 · 2024 · External reference
Targeting YAP/TAZ–TEAD and their protein-protein interaction for precision cancer therapy
10.1016/j.ejmech.2025.118330 · 2026 · External reference
Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma
10.1016/j.ejmech.2025.117328 · 2025 · External reference
Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
10.1038/ncomms3976 · 2013 · External reference
YAP/TAZ: molecular pathway and disease therapy
2023 · External reference
