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References from Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammatory molecules associated with ultraviolet radiation-mediated skin aging
10.3390/ijms22083974 · 2021 · External reference
The skin aging exposome
10.1016/j.jdermsci.2016.09.015 · 2017 · External reference
Skin senescence: mechanisms and impact on whole-body aging
10.1016/j.molmed.2021.12.003 · 2022 · External reference
Connective tissue and fibroblast senescence in skin aging
10.1016/j.jid.2020.11.010 · 2021 · External reference
Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals
10.1093/gerona/gls154 · 2013 · External reference
Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/42MAPK signaling
10.1158/0008-5472.can-20-0108 · 2020 · External reference
Mortality is written on the face
10.1093/gerona/glv090 · 2016 · External reference
Skin ageing and topical rejuvenation strategies
10.1093/bjd/ljad282 · 2023 · External reference
D-mannose induces regulatory T cells and suppresses immunopathology
10.1038/nm.4375 · 2017 · External reference
Plasma mannose levels are associated with incident type 2 diabetes and cardiovascular disease
10.1016/j.cmet.2017.07.006 · 2017 · External reference
Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy
10.1172/jci2350 · 1998 · External reference
Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice
10.1038/nm.2548 · 2011 · External reference
D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial
10.1007/s00345-013-1091-6 · 2014 · External reference
Mannose impairs tumour growth and enhances chemotherapy
10.1038/s41586-018-0729-3 · 2018 · External reference
Mannose alters gut microbiome, prevents diet-induced obesity, and improves host metabolism
10.1016/j.celrep.2018.08.064 · 2018 · External reference
D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-alpha-induced inflammation in human keratinocytes via mTOR/NF-kappaB pathway
10.1016/j.intimp.2022.109378 · 2022 · External reference
Mesoporous silica-based nanoplatforms are Theranostic agents for the treatment of inflammatory disorders
10.3390/pharmaceutics15020439 · 2023 · External reference
Mesoporous silica nanoparticles-based nanoplatforms: basic construction, current state, and emerging applications in anticancer therapeutics
10.1002/adhm.202201884 · 2023 · External reference
Polysaccharide/mesoporous silica nanoparticle-based drug delivery systems: a review
10.1016/j.ijbiomac.2021.10.142 · 2021 · External reference
Mesoporous silica nanoparticles as a potential nanoplatform: therapeutic applications and considerations
10.3390/ijms24076349 · 2023 · External reference
Biocompatible phenylboronic-acid-capped ZnS nanocrystals designed as caps in mesoporous silica hybrid materials for on-Demand pH-Triggered release in cancer cells
10.1021/acsami.8b13698 · 2018 · External reference
Sirtuin signaling in cellular senescence and aging
10.5483/bmbrep.2019.52.1.290 · 2019 · External reference
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
10.1016/j.bcp.2012.06.031 · 2012 · External reference
Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases
10.1016/j.mad.2015.03.008 · 2015 · External reference
SIRT1: regulation of longevity via autophagy
10.1016/j.cellsig.2009.02.014 · 2009 · External reference
SIRT1 and aging related signaling pathways
10.1016/j.mad.2020.111215 · 2020 · External reference
Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-kappaB pathway in gut of the annual fish Nothobranchius guentheri
10.1016/j.fsi.2018.06.027 · 2018 · External reference
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
10.1016/j.celrep.2014.01.031 · 2014 · External reference
Autophagy plays an essential role in ultraviolet radiation-driven skin photoaging
2022 · External reference
Biomarkers, oxidative stress and autophagy in skin aging
10.1016/j.arr.2020.101036 · 2020 · External reference
Autophagy induction regulates aquaporin 3-mediated skin fibroblast ageing
10.1111/bjd.20662 · 2022 · External reference
UVA-Induced photoaging inhibits autophagic degradation by impairing lysosomal function in dermal fibroblasts
10.1016/j.bbrc.2019.08.103 · 2019 · External reference
Impairment of the autophagy system in repetitively UVA-irradiated fibroblasts
10.1111/phpp.12516 · 2020 · External reference
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
10.1038/s42003-020-0922-4 · 2020 · External reference
Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy
10.7150/thno.28778 · 2018 · External reference
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma
10.1016/j.biopha.2022.113602 · 2022 · External reference
FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis
10.1186/s10020-023-00639-0 · 2023 · External reference
CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting
10.1093/nar/gkac394 · 2022 · External reference
System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity
10.1111/acel.13595 · 2022 · External reference
Mannose ameliorates experimental colitis by protecting intestinal barrier integrity
10.1038/s41467-022-32505-8 · 2022 · External reference
Aging cell culture - genetic and metabolic effects of passage number on zebrafish Z3 cells
10.33594/000000494 · 2022 · External reference
Galangin reverses H(2)O(2)-Induced dermal fibroblast senescence via SIRT1-PGC-1alpha/Nrf2 signaling
2022 · External reference
Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription
10.1111/acel.13680 · 2022 · External reference
SIRT1 - a new Mammalian substrate of nuclear autophagy
10.1080/15548627.2020.1860541 · 2021 · External reference
SIRT1 is downregulated by autophagy in senescence and ageing
10.1038/s41556-020-00579-5 · 2020 · External reference
D-Mannose regulates hepatocyte lipid metabolism via PI3K/Akt/mTOR signaling pathway and ameliorates hepatic steatosis in alcoholic liver disease
2022 · External reference
Significance of skin barrier dysfunction in atopic dermatitis
10.4168/aair.2018.10.3.207 · 2018 · External reference
UV irradiation to mouse skin decreases hippocampal neurogenesis and synaptic protein expression via HPA axis activation
10.1038/s41598-017-15773-z · 2017 · External reference
Autophagy in healthy aging and disease
10.1038/s43587-021-00098-4 · 2021 · External reference
Regulation of the aging process by autophagy
10.1016/j.molmed.2009.03.004 · 2009 · External reference
SIRT1 is a regulator of autophagy: implications for the progression and treatment of myocardial ischemia-reperfusion
10.1016/j.phrs.2023.106957 · 2024 · External reference
