Research graph
References from Engineered microvesicle-mediated multimodal therapy resolves ulcerative colitis via synergistic immunoregulation, barrier restoration, and microbiota remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Ulcerative colitis
10.1038/s41572-020-0205-x · 2020 · External reference
Targeting immune cell circuits and trafficking in inflammatory bowel disease
10.1038/s41590-019-0415-0 · 2019 · External reference
Ulcerative colitis in adults: a review
10.1001/jama.2023.15389 · 2023 · External reference
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
10.1038/s41575-019-0172-4 · 2019 · External reference
Immunopathogenesis of IBD: current state of the art
10.1038/nrgastro.2015.186 · 2016 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
Macrophage immunotherapy: overcoming impediments to realize promise
10.1016/j.it.2022.10.002 · 2022 · External reference
Macrophage activation and polarization: nomenclature and experimental guidelines
10.1016/j.immuni.2014.06.008 · 2014 · External reference
New insights into the multidimensional concept of macrophage ontogeny, activation and function
10.1038/ni.3324 · 2016 · External reference
Macrophage plasticity and polarization: in vivo veritas
10.1172/jci59643 · 2012 · External reference
The roles of extracellular vesicles in the immune system
10.1038/s41577-022-00763-8 · 2023 · External reference
The physico-chemical landscape of extracellular vesicles
10.1038/s44222-024-00255-5 · 2025 · External reference
The role of extracellular vesicles in cancer
10.1016/j.cell.2023.03.010 · 2023 · External reference
Shedding light on the cell biology of extracellular vesicles
10.1038/nrm.2017.125 · 2018 · External reference
M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator
2023 · External reference
Isolation of mitochondria-derived mitovesicles and subpopulations of microvesicles and exosomes from brain tissues
10.1038/s41596-022-00719-1 · 2022 · External reference
Inhibition and rescue of hyperglycemia-induced cellular senescence by mitochondrial transfer from enucleated mesenchymal stem cell-derived microvesicles for chronic wound healing
10.1002/advs.202501612 · 2025 · External reference
Manganese oxide nanozyme-loaded CO-releasing halloysite nanotubes for remodeling colonic immune, microbiota, and intestinal barrier homeostasis with concurrent pain relief in ulcerative colitis
2026 · External reference
Targeted intestinal barrier repair via probiotic-derived engineered outer membrane vesicles: a 3A1M strategy with antioxidant, anti-inflammatory, anti-ferroptotic, and microbiome modulation effects
10.1016/j.apsb.2026.01.031 · 2026 · External reference
Toll-like receptors and inflammatory bowel disease
10.3389/fimmu.2018.00072 · 2018 · External reference
The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
10.1038/ni.1863 · 2010 · External reference
Intestinal mucosal barrier function in health and disease
10.1038/nri2653 · 2009 · External reference
The microbiome and gut homeostasis
10.1126/science.abp9960 · 2022 · External reference
Modulation of macrophage phenotype by cell shape
10.1073/pnas.1308887110 · 2013 · External reference
Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages
10.3389/fimmu.2014.00532 · 2014 · External reference
Macrophage polarization in intestinal inflammation and gut homeostasis
10.1007/s00011-020-01398-y · 2020 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
Ectosomes and exosomes: shedding the confusion between extracellular vesicles
10.1016/j.tcb.2015.01.004 · 2015 · External reference
Extracellular-vesicle miRNAs promote the intestinal microenvironment by interacting with microbes in colitis
10.1080/19490976.2022.2128604 · 2022 · External reference
M2 macrophage-derived exosomal miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1/YAP/β-catenin signalling axis
10.1093/ecco-jcc/jjaa214 · 2021 · External reference
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines
10.1172/jci133371 · 2021 · External reference
Toll-like receptors in inflammatory bowel diseases: a decade later
10.1002/ibd.21282 · 2010 · External reference
Chemokines and chemokine receptors: positioning cells for host defense and immunity
10.1146/annurev-immunol-032713-120145 · 2014 · External reference
Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis
10.1038/s41564-022-01094-z · 2022 · External reference
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
10.1038/s41579-025-01163-0 · 2025 · External reference
An oral dual-targeting inulin-based nanomicelle for ulcerative colitis therapy via combined H2S-mediated immunomodulation with prebiotic microbiota regulation
10.1016/j.nantod.2026.103055 · 2026 · External reference
