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References from Mitochondrial reprogramming of alveolar macrophages by umbilical cord mesenchymal stem cells restores immune homeostasis in Porphyromonas gingivalis lipopolysaccharide–induced aspiration pneumonia. Local targets link to admitted publications; unresolved targets remain external evidence.
Aspiration pneumonia
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Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells
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Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts
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Exposure to Porphyromonas gingivalis induces production of proinflammatory cytokine via TLR2 from human respiratory epithelial cells
10.3390/jcm9113433 · 2020 · External reference
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10.1128/spectrum.02049-21 · 2022 · External reference
Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1beta in Klebsiella-mediated acute respiratory distress syndrome
10.1136/thoraxjnl-2021-217928 · 2023 · External reference
Mitochondrial control of immunity: beyond ATP
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Mitochondrial dynamics and cristae shape changes during metabolic reprogramming
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10.1002/sctm.20-0186 · 2020 · External reference
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10.1002/sctm.21-0021 · 2021 · External reference
Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products
10.1186/s13287-021-02222-y · 2021 · External reference
Clinical implications of differential functional capacity between tissue-specific human mesenchymal stromal/stem cells
10.1111/febs.16438 · 2023 · External reference
MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization
10.1186/s13287-022-02855-7 · 2022 · External reference
Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis
10.1186/s13287-024-04091-7 · 2024 · External reference
Dipyridamole attenuates experimental periodontitis by regulating M1 macrophage polarization via PKA/PKG pathways
10.1111/jre.13378 · 2025 · External reference
Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
10.4049/jimmunol.179.3.1855 · 2007 · External reference
Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
10.1073/pnas.0907996106 · 2009 · External reference
Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer
10.1164/rccm.201701-0170oc · 2017 · External reference
Mesenchymal stem cell-derived extracellular vesicles alleviate acute lung injury via transfer of miR-27a-3p
10.1097/ccm.0000000000004315 · 2020 · External reference
Mesenchymal stem cell-mediated immunomodulation of recruited mononuclear phagocytes during acute lung injury: a high-dimensional analysis study
10.7150/thno.52514 · 2021 · External reference
Multilineage potential of adult human mesenchymal stem cells
10.1126/science.284.5411.143 · 1999 · External reference
Human placental MSC-secreted IL-1beta enhances neutrophil bactericidal functions during hypervirulent klebsiella infection
10.1016/j.celrep.2020.108188 · 2020 · External reference
Bioinformatics analysis of macrophages exposed to porphyromonas gingivalis: implications in acute vs. chronic infections
10.1371/journal.pone.0015613 · 2010 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
SRplot: a free online platform for data visualization and graphing
10.1371/journal.pone.0294236 · 2023 · External reference
Lack of IFN-gamma response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: implications for anti-TNFalpha-refractory patients
10.1016/j.phrs.2025.107716 · 2025 · External reference
Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation
10.1152/ajplung.00223.2022 · 2023 · External reference
Single-cell analysis of peri-implant gingival tissue to assess implant biocompatibility and immune response
10.2186/jpr.jpr_d_23_00309 · 2025 · External reference
Zirconia minimizes myeloid innate immunity as dental implants: an in silico and in vivo study
10.1111/clr.70037 · 2025 · External reference
Titanium implants trigger extra-periodontal T cell-mediated immunity
10.1039/d4bm00246f · 2025 · External reference
Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate
10.1038/s42003-024-05964-6 · 2024 · External reference
Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1alpha activation
10.1002/stem.3375 · 2021 · External reference
Therapeutic mitochondrial transfer via mesenchymal stem cell-derived microvesicles for macrophage modulation in myocardial infarction complicated by diabetes
10.1016/j.biomaterials.2025.123563 · 2026 · External reference
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4
10.1128/iai.72.9.5041-5051.2004 · 2004 · External reference
Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection
10.1126/sciimmunol.abj5761 · 2022 · External reference
Reprogramming mitochondrial metabolism to enhance macrophages polarization by ROS-responsive nanoparticles for osteoarthritis
10.1016/j.biomaterials.2025.123395 · 2025 · External reference
Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis
10.1186/s12931-024-02739-9 · 2024 · External reference
Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the In vitro and In vivo models of ARDS
10.1002/stem.2372 · 2016 · External reference
Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury
10.3389/fimmu.2024.1422355 · 2024 · External reference
Mesenchymal stromal cells induce peculiar alternatively activated macrophages capable of dampening both innate and adaptive immune responses
10.1002/stem.2369 · 2016 · External reference
MSC-secreted TGF-beta regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway
10.1186/s13287-019-1447-y · 2019 · External reference
Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages
10.1186/s12951-021-01236-1 · 2022 · External reference
Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
10.1186/s13287-019-1224-y · 2019 · External reference
Human umbilical cord mesenchymal stem cells promote macrophage PD-L1 expression and attenuate acute lung injury in mice
10.2174/1574888x17666220127110332 · 2022 · External reference
Author correction: heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts
10.1038/s41598-021-81798-0 · 2021 · External reference