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References from Reprogramming PD-L1 endosomal recycling and lysosomal degradation via engineered exosome-based nanocomposites overcomes immune resistance in lung cancer brain metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics
10.3322/caac.21871 · 2025 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Survival and quality of life after first-time diagnosis of brain metastases: a multicenter, prospective, observational study
2025 · External reference
Therapeutic strategies for EGFR-Mutated non-small cell lung cancer patients with osimertinib resistance
10.1186/s13045-022-01391-4 · 2022 · External reference
The effect of advances in lung-cancer treatment on population mortality
10.1056/nejmoa1916623 · 2020 · External reference
Genomic profiling of driver gene alterations in patients with non-small cell lung cancer, patterns of treatment and impact on survival outcomes: a single center experience of more than 1200 patients
10.1016/j.cllc.2025.02.001 · 2025 · External reference
Nationwide data from comprehensive genomic profiling assays for detecting driver oncogenes in non-small cell lung cancer
10.1111/cas.16130 · 2024 · External reference
Opportunities and challenges for non-small cell lung cancer brain metastases in the immunotherapy era
10.1016/j.ctrv.2025.103014 · 2025 · External reference
Brain metastases and immune checkpoint inhibitors in non-small cell lung cancer: a systematic review and meta-analysis
10.1007/s00262-022-03224-2 · 2022 · External reference
Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease
10.1016/s1474-4422(24)00476-9 · 2025 · External reference
The blood-brain barrier: structure, regulation, and drug delivery
10.1038/s41392-023-01481-w · 2023 · External reference
The immune landscape in brain metastasis
10.1093/neuonc/noae219 · 2025 · External reference
Tumor immune microenvironment of brain metastases: toward unlocking antitumor immunity
10.1158/2159-8290.cd-21-0976 · 2022 · External reference
The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers
10.3389/fimmu.2022.964442 · 2022 · External reference
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation
10.1038/s41467-024-48597-3 · 2024 · External reference
Dual-responsive nanoparticle system for enhanced blood-brain barrier crossing and glioblastoma penetration
10.1016/j.biomaterials.2025.123730 · 2026 · External reference
Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment
10.1038/s41467-023-40579-1 · 2023 · External reference
The penetration of therapeutics across the blood-brain barrier: classic case studies and clinical implications
2024 · External reference
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
10.1038/nature23643 · 2017 · External reference
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
10.1038/nature23669 · 2017 · External reference
The hippo pathway component TAZ promotes immune evasion in human cancer through PD-L1
10.1158/0008-5472.can-17-3139 · 2018 · External reference
YAP-induced PD-L1 expression drives immune evasion in BRAFi-Resistant melanoma
10.1158/2326-6066.cir-17-0320 · 2018 · External reference
Verteporfin inhibits PD-L1 through autophagy and the STAT1-IRF1-TRIM28 signaling axis, exerting antitumor efficacy
10.1158/2326-6066.cir-19-0159 · 2020 · External reference
Oxygen-generating transdermal nanoplatform codelivering BRD4 proteolysis-targeting Chimera/Verteporfin/CaO(2) synergistically remodels immunosuppressive melanoma microenvironment to potentiate combination immunotherapy
10.1021/acsnano.5c04580 · 2025 · External reference
Verteporfin-mediated in situ nanovaccine based on local conventional-dose hypofractionated radiotherapy enhances antitumor and immunomodulatory effect
10.1002/advs.202413387 · 2025 · External reference
PD-L1-targeted photodynamic therapy orchestrates checkpoint blockade and immunogenic cell death for synergistic cancer immunotherapy
10.1016/j.redox.2026.104075 · 2026 · External reference
Anti-cancer activity of verteporfin in cholangiocarcinoma
10.3390/cancers15092454 · 2023 · External reference
Engineering exosomes for targeted neurodegenerative therapy: innovations in biogenesis, drug loading, and clinical translation
10.7150/thno.117143 · 2026 · External reference
Camouflaging nanoreactor traverse the blood-brain barrier to catalyze redox Cascade for synergistic therapy of glioblastoma
10.1016/j.biomaterials.2024.122702 · 2024 · External reference
Tumor cell-derived exosomes home to their cells of origin and can be used as trojan horses to deliver cancer drugs
10.7150/thno.39434 · 2020 · External reference
Exosomes-Nature's lipid nanoparticles, a rising star in drug delivery and diagnostics
10.1021/acsnano.2c08774 · 2022 · External reference
αvβ3 integrin targeting RGD peptide-based nanoparticles as an effective strategy for selective drug delivery to tumor microenvironment
2024 · External reference
Nano diaminopropane tetrac and integrin alphavbeta3 expression in different cancer types: anti-Cancer efficacy and safety
2021 · External reference
Emerging therapeutic opportunities for integrin inhibitors
10.1038/s41573-021-00284-4 · 2022 · External reference
Tumour acidosis: from the passenger to the driver's seat
10.1038/nrc.2017.77 · 2017 · External reference
Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells
10.1016/j.freeradbiomed.2024.01.003 · 2024 · External reference
ROS-Induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
10.1007/s00204-023-03476-6 · 2023 · External reference
Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018
10.1038/s41418-017-0012-4 · 2018 · External reference
YAP1 contributes to NSCLC invasion and migration by promoting slug transcription via the transcription co-factor TEAD
10.1038/s41419-018-0515-z · 2018 · External reference
Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma
10.1002/1878-0261.13061 · 2021 · External reference
Epithelial to mesenchymal transition regulates surface PD-L1 via CMTM6 and CMTM7 induction in breast cancer
10.3390/cancers13051165 · 2021 · External reference
Autophagy in tumor immune escape and immunotherapy
10.1186/s12943-025-02277-y · 2025 · External reference
Peptide mediated in vivo tumor targeting of nanoparticles through optimization in single and multilayer in vitro cell models
10.3390/cancers10030084 · 2018 · External reference
Splenic stromal niches in homeostasis and immunity
10.1038/s41577-023-00857-x · 2023 · External reference
Cancer nanomedicine: progress, challenges and opportunities
10.1038/nrc.2016.108 · 2017 · External reference