Research graph
References from Myocardial infarction treatment with a composite hydrogel containing metformin-induced vesicles of adipose-derived stem cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Heart disease and stroke Statistics-2023 update: a report from the American heart association
10.1161/cir.0000000000001123 · 2023 · External reference
The global burden of cardiovascular diseases and risk: a compass for future health
10.1016/j.jacc.2022.11.005 · 2022 · External reference
Acute myocardial infarction
10.1016/s0140-6736(16)30677-8 · 2017 · External reference
Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis
10.1096/fj.202302385r · 2024 · External reference
Efficacy and safety of stents in ST-Segment elevation myocardial infarction
10.1016/j.jacc.2019.09.038 · 2019 · External reference
10.1093/eurheartj/ehae654
10.1093/eurheartj/ehae654 · 2025 · External reference
Multicellular transcriptional analysis of Mammalian heart regeneration
10.1161/circulationaha.117.028252 · 2017 · External reference
Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair
2025 · External reference
Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice
10.1038/s41467-023-37832-y · 2023 · External reference
Mid- to long-term efficacy and safety of stem cell therapy for acute myocardial infarction: a systematic review and meta-analysis
10.1186/s13287-024-03891-1 · 2024 · External reference
Multiplexed targeting of miRNA-210 in stem cell-derived extracellular vesicles promotes selective regeneration in ischemic hearts
10.1038/s12276-021-00584-0 · 2021 · External reference
Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis
10.1038/s41419-020-2508-y · 2020 · External reference
Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and correlation to their cargoes
10.3390/ijms22083851 · 2021 · External reference
Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells
10.1038/s41551-018-0229-7 · 2018 · External reference
Hypoxia-induced extracellular vesicles derived from human umbilical cord Mesenchymal stem cells regulate macrophage polarization and enhance angiogenesis to promote diabetic wound healing
10.3390/biom15111504 · 2025 · External reference
Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway
10.1186/s12916-023-02778-x · 2023 · External reference
Head-to-head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: superiority of embryonic stem cells
10.1002/jev2.12445 · 2024 · External reference
Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration
10.1016/j.biomaterials.2021.120850 · 2021 · External reference
Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle
10.1126/sciadv.adl0372 · 2024 · External reference
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
10.7150/thno.72289 · 2022 · External reference
Injectable myocardial matrix hydrogel mitigates negative left ventricular remodeling in a chronic myocardial infarction model, JACC
2021 · External reference
Cardiac matrix-derived granular hydrogel enhances cell function in 3D culture
10.1021/acsami.4c12871 · 2024 · External reference
Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction
10.1016/j.jmst.2023.06.005 · 2023 · External reference
Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model
10.1016/j.biomaterials.2021.120653 · 2021 · External reference
E-jet 3D printed aligned nerve guidance conduits incorporated with decellularized extracellular matrix hydrogel encapsulating extracellular vesicles for peripheral nerve repair
10.1016/j.actbio.2025.01.025 · 2025 · External reference
Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering
10.1016/j.biomaterials.2009.06.045 · 2009 · External reference
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues
10.1038/s41551-022-00964-5 · 2023 · External reference
Perivascular extracellular matrix hydrogels mimic native matrix microarchitecture and promote angiogenesis via basic fibroblast growth factor
10.1016/j.biomaterials.2017.01.037 · 2017 · External reference
Effects of decellularization on glycosaminoglycans and collagen macromolecules in bovine bone extracellular matrix
10.1016/j.ijbiomac.2025.141007 · 2025 · External reference
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2
10.1016/j.apsb.2021.03.021 · 2021 · External reference
PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart
10.1161/circulationaha.121.054885 · 2021 · External reference
BRG1 protects the heart from acute myocardial infarction by reducing oxidative damage through the activation of the NRF2/HO1 signaling pathway
10.1016/j.freeradbiomed.2020.09.012 · 2020 · External reference
Extracellular Matrix/Glycopeptide hybrid hydrogel as an immunomodulatory niche for endogenous cardiac repair after myocardial infarction
10.1002/advs.202301244 · 2023 · External reference
Co-overexpression of VEGF and GDNF in adipose-derived stem cells optimizes therapeutic effect in neurogenic erectile dysfunction model
10.1111/cpr.12756 · 2020 · External reference
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
10.1007/s10456-025-09995-3 · 2025 · External reference
Stem cell microarrays for assessing growth factor signaling in engineered glycan microenvironments
10.1002/adhm.202101232 · 2022 · External reference
Human iPSC-derived cardiac-specific extracellular matrix scaffolds for cardiomyocyte maturation and post-myocardial infarction repair
2026 · External reference
Collagen as the extracellular matrix biomaterials in the arena of medical sciences
10.1016/j.tice.2024.102497 · 2024 · External reference
New insights into the reparative angiogenesis after myocardial infarction
10.3390/ijms241512298 · 2023 · External reference
Pericardial delivery of sodium alginate-infusible extracellular matrix composite hydrogel promotes angiogenesis and intercellular electrical conduction after myocardial infarction
10.1021/acsami.4c12593 · 2024 · External reference
Cellular alignment and matrix stiffening induced changes in human induced pluripotent stem cell derived cardiomyocytes
2025 · External reference
Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway
10.1016/j.intimp.2025.114262 · 2025 · External reference
C1qTNF-related protein 1 attenuates doxorubicin-induced cardiac injury via activation of AKT
10.1016/j.lfs.2018.06.029 · 2018 · External reference
CTRP1 Attenuates cerebral Ischemia/Reperfusion injury via the PERK signaling pathway
10.3389/fcell.2021.700854 · 2021 · External reference
Cardiomyocyte S1PR1 promotes cardiac regeneration via AKT/mTORC1 signaling pathway
10.7150/thno.103797 · 2025 · External reference
Basic and translational research in cardiac repair and regeneration: JACC state-of-the-art review
10.1016/j.jacc.2021.09.019 · 2021 · External reference
Targeting inflammation after acute myocardial infarction
10.1016/j.jacc.2025.07.064 · 2025 · External reference
Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction, matrix biology
10.1016/j.matbio.2024.08.001 · 2024 · External reference
Combining decellularized adipose tissue with decellularized adventitia extravascular matrix or small intestinal submucosa matrix for the construction of vascularized tissue-engineered adipose
10.1016/j.actbio.2023.08.060 · 2023 · External reference
Adventitia-derived extracellular matrix hydrogel enhances contractility of human vasa vasorum-derived pericytes via α2β1 integrin and TGFβ receptor
10.1002/jbm.a.37422 · 2022 · External reference
Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction
10.7150/thno.32637 · 2019 · External reference
A novel conductive polypyrrole-chitosan hydrogel containing human endometrial mesenchymal stem cell-derived exosomes facilitated sustained release for cardiac repair
2024 · External reference
Injection-Free delivery of MSC-derived extracellular vesicles for myocardial infarction therapeutics
10.1002/adhm.202100312 · 2022 · External reference
Regional and cell specific bioactivity of injectable extracellular matrix biomaterials in myocardial infarction
10.1038/s41467-025-65351-5 · 2025 · External reference
Injectable BMSC-based extracellular matrix-mimicking microtissue for myocardial infarction repair
2025 · External reference
Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities
10.7150/thno.40122 · 2020 · External reference
Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy
2025 · External reference
Exosomes from LPS-preconditioned bone marrow MSCs accelerated peripheral nerve regeneration via M2 macrophage polarization: involvement of TSG-6/NF-κB/NLRP3 signaling pathway
10.1016/j.expneurol.2022.114139 · 2022 · External reference
Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway
10.4252/wjsc.v14.i2.183 · 2022 · External reference
Regulated cell death in acute myocardial infarction: molecular mechanisms and therapeutic implications
10.1016/j.arr.2024.102629 · 2025 · External reference
Columbianadin ameliorates myocardial injury by inhibiting autophagy through the PI3K/Akt/mTOR signaling pathway in AMI mice and hypoxic H9c2 cells
10.1002/ptr.8387 · 2025 · External reference
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis
10.1016/j.phymed.2024.155791 · 2024 · External reference
Avenanthramide C from oats protects pyroptosis through dependent ROS-induced mitochondrial damage by PI3K ubiquitination and phosphorylation in pediatric pneumonia
10.1021/acs.jafc.1c06223 · 2022 · External reference
Puerarin alleviates cerebral ischemia/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K/Akt activation
10.1016/j.phymed.2025.157094 · 2025 · External reference
Muscone suppresses myocardial ischemia damage by regulating PI3K/Akt signaling pathway
10.1016/j.bbadis.2022.166539 · 2022 · External reference
Signaling pathways and targeted therapy for myocardial infarction
10.1038/s41392-022-00925-z · 2022 · External reference
CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice
10.1186/s12967-022-03672-5 · 2022 · External reference
C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway
10.1016/j.freeradbiomed.2018.05.004 · 2018 · External reference
C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart
10.1161/circulationaha.112.099937 · 2012 · External reference
C1q/TNF-related protein 1 links macrophage lipid metabolism to inflammation and atherosclerosis
10.1016/j.atherosclerosis.2016.04.024 · 2016 · External reference
The novel adipokine CTRP1 is significantly associated with the incidence of major adverse cardiovascular events
10.1016/j.atherosclerosis.2019.04.222 · 2019 · External reference
Somewhere over the sex differences rainbow of myocardial infarction remodeling: hormones, chromosomes, inflammasome, oh my
10.1080/14789450.2019.1664293 · 2019 · External reference
