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References from Balancing stability and cellular interaction in surface-engineered small extracellular vesicles for pulmonary delivery. Local targets link to admitted publications; unresolved targets remain external evidence.
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Challenges and strategies to enhance the systemic absorption of inhaled peptides and proteins
10.1007/s11095-022-03435-3 · 2023 · External reference
A review on Micro and nanoengineering in powder-based pulmonary drug delivery
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In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs
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Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions
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Physicochemical properties of mucus and their impact on transmucosal drug delivery
10.1016/j.ijpharm.2017.09.018 · 2017 · External reference
Quantitative analysis of drug delivery to the brain via nasal route
10.1016/j.jconrel.2014.06.053 · 2014 · External reference
Mucociliary respiratory epithelium integrity in molecular defense and susceptibility to pulmonary viral infections
10.3390/biology10020095 · 2021 · External reference
Influence of liquid-layer thickness on pulmonary surfactant spreading and collapse
10.1529/biophysj.107.127654 · 2008 · External reference
Nanostructure-Mediated transport of therapeutics through epithelial barriers
10.3390/ijms25137098 · 2024 · External reference
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier
2016 · External reference
Local mucociliary defence mechanisms
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Development of nanoparticle-based mucosal drug delivery systems for controlling pharmacokinetic behaviors
10.1248/bpb.b25-00071 · 2025 · External reference
Pulmonary delivery nanomedicines towards circumventing physiological barriers: strategies and characterization approaches
10.1016/j.addr.2022.114309 · 2022 · External reference
Unresolved reference
2025 · External reference
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
10.1016/j.addr.2008.11.002 · 2009 · External reference
Pulmonary drug delivery devices and nanosystems as potential treatment strategies for acute respiratory distress syndrome (ARDS)
10.1016/j.ijpharm.2024.124182 · 2024 · External reference
Mucus-producing 3D cell culture models
10.1016/j.addr.2021.113993 · 2021 · External reference
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
10.1016/j.cbi.2022.110048 · 2022 · External reference
Engineering nanoparticles to overcome the mucus barrier for drug delivery: design, evaluation and state-of-the-art
2021 · External reference
Advances in pulmonary protein delivery systems
10.1002/anbr.202300176 · 2024 · External reference
Exosome as drug delivery system: current advancements
10.1016/j.vesic.2023.100032 · 2024 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
Inhalable exosomes to target cardiac repair
10.20517/evcna.2024.81 · 2025 · External reference
Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design
10.20517/evcna.2024.19 · 2024 · External reference
Nebulization of extracellular vesicles: a promising small RNA delivery approach for lung diseases
10.1016/j.jconrel.2022.10.052 · 2022 · External reference
Inhalable dry powder mRNA vaccines based on extracellular vesicles
10.1016/j.matt.2022.06.012 · 2022 · External reference
Nebulised delivery of RNA formulations to the lungs: from aerosol to cytosol
10.1016/j.jconrel.2023.12.012 · 2024 · External reference
Therapeutic use of extracellular vesicles for acute and chronic lung disease
10.3390/ijms21072318 · 2020 · External reference
Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment
10.1038/s41392-025-02293-w · 2025 · External reference
Efficient extracellular vesicles freeze-dry method for direct formulations preparation and use
10.1016/j.colsurfb.2022.112745 · 2022 · External reference
Zeta potential of extracellular vesicles: toward understanding the attributes that determine colloidal stability
10.1021/acsomega.0c01582 · 2020 · External reference
Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA
10.1039/d0bm01497d · 2021 · External reference
Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery
10.1039/d3bm01089a · 2023 · External reference
Cellular and molecular mechanisms of goblet cell metaplasia in the respiratory airways
10.3109/01902148.2013.791733 · 2013 · External reference
Surface functionalization of exosomes using click chemistry
10.1021/bc500291r · 2014 · External reference
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
10.1016/j.jconrel.2016.01.009 · 2016 · External reference
Immunogenicity of polyethylene glycol based nanomedicines: mechanisms, clinical implications and systematic approach
2020 · External reference
PEGylation technology: addressing concerns, moving forward
10.1080/10717544.2025.2494775 · 2025 · External reference
Zwitterionic 3D-Printed non-immunogenic stealth microrobots
2020 · External reference
Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers
2024 · External reference
Stealth mRNA nanovaccines to control lymph node trafficking
10.1016/j.jconrel.2024.08.018 · 2024 · External reference
Engineerable mesenchymal stem cell-derived extracellular vesicles as promising therapeutic strategies for pulmonary fibrosis
10.1186/s13287-025-04490-4 · 2025 · External reference
Engineering exosomes for targeted drug delivery
10.7150/thno.52570 · 2021 · External reference
Functionalized exosomes for targeted therapy in cancer and regenerative medicine: genetic, chemical, and physical modifications
10.1186/s12964-025-02268-y · 2025 · External reference
In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery
10.1016/j.addr.2006.07.012 · 2006 · External reference
Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics
10.1016/j.addr.2021.113901 · 2021 · External reference
Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease
10.1183/13993003.00876-2018 · 2018 · External reference
Medium throughput breathing human primary cell alveolus-on-chip model
10.1038/s41598-018-32523-x · 2018 · External reference
Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier
10.1016/j.actbio.2019.04.037 · 2019 · External reference
Efficient extracellular vesicles freeze-dry method for direct formulations preparation and use
10.1016/j.colsurfb.2022.112745 · 2022 · External reference
Functionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides
10.1007/s13346-022-01286-4 · 2023 · External reference
An open-source software for characterizing the transport of particles in biorelevant media
10.3390/nano12111899 · 2022 · External reference
Feature point tracking and trajectory analysis for video imaging in cell biology
10.1016/j.jsb.2005.06.002 · 2005 · External reference
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
10.1038/mt.2010.85 · 2010 · External reference
Influence of lipid chemistry on membrane fluidity: tail and headgroup interactions
10.1529/biophysj.106.084590 · 2006 · External reference
Liposomes, disks, and spherical micelles: aggregate structure in mixtures of gel phase phosphatidylcholines and Poly(Ethylene Glycol)-Phospholipids
10.1016/s0006-3495(03)74798-5 · 2003 · External reference
Shape and phase transitions in a PEGylated phospholipid System
10.1021/acs.langmuir.8b03829 · 2019 · External reference
Membrane composition modulates fusion by altering membrane properties and fusion peptide structure
10.1007/s00232-019-00064-7 · 2019 · External reference
Electrophoretic mobility and zeta potential of liposomes due to arginine and polyarginine adsorption
10.1016/j.colsurfa.2012.09.012 · 2014 · External reference
Nanoscopic profiling of small extracellular vesicles via High‐Speed atomic force microscopy (HS‐AFM) videography
10.1002/jev2.70050 · 2025 · External reference
Spatiotemporal tracking of small extracellular vesicle nanotopology in response to physicochemical stresses revealed by HS‐AFM
10.1002/jev2.12275 · 2022 · External reference
Ultrafiltration characteristics of pegylated proteins
10.1002/bit.21020 · 2006 · External reference
Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles
10.1016/j.biomaterials.2013.12.022 · 2014 · External reference
The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery
10.3389/fmolb.2023.1198044 · 2023 · External reference
Multiparametric single-vesicle flow cytometry resolves extracellular vesicle heterogeneity and reveals selective regulation of biogenesis and cargo distribution
10.1021/acsnano.3c11561 · 2024 · External reference
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
10.1038/s41565-020-0693-6 · 2020 · External reference
Effective visualization and easy tracking of extracellular vesicles in glioma cells
10.1186/s12575-019-0092-2 · 2019 · External reference
Single extracellular VEsicle nanoscopy
10.1002/jev2.12346 · 2023 · External reference
Formation of a protein corona on the surface of extracellular vesicles in blood plasma
10.1002/jev2.12140 · 2021 · External reference
Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery
10.1039/d3bm01089a · 2024 · External reference
Unresolved reference
External reference