Research graph
References from An integrated design strategy for structurally stable full-thickness human skin models with regulatory-qualified barrier assessment. Local targets link to admitted publications; unresolved targets remain external evidence.
Barrier function of the skin: “La Raison d'Être” of the Epidermis
10.1046/j.1523-1747.2003.12359.x · 2003 · External reference
The skin: an indispensable barrier
10.1111/j.1600-0625.2008.00786.x · 2008 · External reference
Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness
10.1126/science.7008197 · 1981 · External reference
Differentiation of normal and tumoral human keratinocytes cultured on dermis: reconstruction of either normal or tumoral architecture
10.1007/bf02623599 · 1988 · External reference
Skin culture model: a possible alternative to the use of excised human skin for assessing in vitro percutaneous absorption
10.1016/s0887-2333(98)00023-x · 1998 · External reference
The ECVAM international validation Study on in vitro tests for skin corrosivity. 2. Results and evaluation by the management team
10.1016/s0887-2333(98)00019-8 · 1998 · External reference
Skin constructs for replacement of skin tissues for in vitro testing
10.1016/s0169-409x(02)00112-6 · 2002 · External reference
3D model of harlequin ichthyosis reveals inflammatory therapeutic targets
10.1172/jci132987 · 2020 · External reference
Structural and functional validation of a full-thickness self-assembled skin equivalent for disease modeling
10.3390/pharmaceutics14061211 · 2022 · External reference
Skin integrated with perfusable vascular channels on a chip
10.1016/j.biomaterials.2016.11.031 · 2017 · External reference
Improvement of a three-layered in vitro skin model for topical application of irritating substances
10.3389/fbioe.2020.00388 · 2020 · External reference
Integration of mature adipocytes to Build-Up a functional three-layered full-skin equivalent
10.1089/ten.tec.2016.0141 · 2016 · External reference
Design of an integrated microvascularized human Skin-on-a-Chip tissue equivalent model
10.3389/fbioe.2022.915702 · 2022 · External reference
Control of tissue strain is essential for enhanced dermal innervation in the three-dimensional skin engineering
10.1021/acsbiomaterials.4c01097 · 2025 · External reference
Applications of human pluripotent stem cell-derived skin organoids in dermatology
10.1016/j.jid.2023.07.017 · 2023 · External reference
Targeting the complexity of In vitro skin models: a review of cutting-edge developments
10.1016/j.jid.2024.04.032 · 2024 · External reference
Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation
10.2340/00015555808993 · 2000 · External reference
The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C
10.1111/1523-1747.ep12336024 · 1997 · External reference
Characterization of the barrier function in a reconstituted human epidermis cultivated in chemically defined medium
10.1046/j.0412-5463.2001.00112.x · 2002 · External reference
A simple reconstructed human epidermis: preparation of the culture model and utilization in in vitro studies
10.1007/s00403-004-0507-y · 2004 · External reference
Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines
10.1016/j.tiv.2008.03.012 · 2008 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2025 · External reference
Progress on reconstructed human skin models for allergy research and identifying contact sensitizers
2021 · External reference
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
10.1007/s43188-023-00185-1 · 2023 · External reference
3D biofabrication of diseased human skin models in vitro
10.1186/s40824-023-00415-5 · 2023 · External reference
Cellular origin of the dermal-epidermal basement membrane
10.1002/aja.1001970404 · 1993 · External reference
Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism
10.1242/jcs.112.12.1843 · 1999 · External reference
Fibroblasts facilitate re-epithelialization in wounded human skin equivalents
10.1038/labinvest.3700014 · 2004 · External reference
Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and/or exogenously activated keratinocytes
10.1111/j.0022-202x.2004.23549.x · 2005 · External reference
Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition
10.1016/j.biomaterials.2004.09.054 · 2005 · External reference
Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents
10.1016/j.ejcb.2006.12.005 · 2007 · External reference
Assessment of the utility of the novel phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products
10.1016/j.tiv.2023.105726 · 2024 · External reference
The Phenion full-thickness skin model for percutaneous absorption testing
10.1159/000265681 · 2010 · External reference
Evaluation of EpiDerm full thickness-300 (EFT-300) as an in vitro model for skin irritation: studies on aliphatic hydrocarbons
10.1016/j.tiv.2009.08.019 · 2010 · External reference
Characterization of a new reconstructed full thickness skin model, T-Skin™, and its application for investigations of anti-aging compounds
10.3390/ijms20092240 · 2019 · External reference
Concentrated collagen hydrogels as dermal substitutes
10.1016/j.biomaterials.2009.09.073 · 2010 · External reference
Cross-linked collagen hydrogel matrix resisting contraction to facilitate full-thickness skin equivalents
10.1021/acsami.7b04017 · 2017 · External reference
Tissue-scale tensional homeostasis in skin regulates structure and physiological function
10.1038/s42003-020-01365-7 · 2020 · External reference
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro
10.1073/pnas.76.3.1274 · 1979 · External reference
Reconstruction of 'simplified' skin: control of fabrication
10.1111/j.1365-2133.1984.tb15608.x · 1984 · External reference
Establishment of 3D organotypic cultures using human neonatal epidermal cells
10.1038/nprot.2006.448 · 2007 · External reference
Design and fabrication of human skin by three-dimensional bioprinting
10.1089/ten.tec.2013.0335 · 2014 · External reference
Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes
10.1089/ten.tec.2011.0561 · 2012 · External reference
Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces
10.1073/pnas.1217279110 · 2013 · External reference
An intact keratin network is crucial for mechanical integrity and barrier function in keratinocyte cell sheets
10.1007/s00018-019-03424-7 · 2020 · External reference
Keratins and the keratinocyte activation cycle
10.1046/j.1523-1747.2001.01327.x · 2001 · External reference
Numerous keratinocyte subtypes involved in wound re-epithelialization
10.1038/sj.jid.5700101 · 2006 · External reference
Characterization of the human gene encoding cytokeratin 17 and its expression pattern
1992 · External reference
Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16
10.1083/jcb.132.3.381 · 1996 · External reference
Differential keratin expression during epiboly in a wound model of bioengineered skin and in human chronic wounds
10.1177/1534734611418157 · 2011 · External reference
Constructive remodeling of a synthetic endothelial extracellular matrix
10.1038/srep18290 · 2015 · External reference
Epidermal basement membrane zone components: ultrastructural distribution and molecular interactions
10.1016/s0923-1811(03)00045-8 · 2003 · External reference
Engineering a multilayered skin equivalent: the importance of endogenous extracellular matrix maturation to provide robustness and reproducibility
2019 · External reference
Production of basement membrane components by a reconstructed epidermis cultured in the absence of serum and dermal factors
10.1111/j.1365-2133.1993.tb11839.x · 1993 · External reference
Effect of fibroblasts on epidermal regeneration
10.1046/j.1365-2133.2002.04871.x · 2002 · External reference
Authentic fibroblast matrix in dermal equivalents normalises epidermal histogenesis and dermo-epidermal junction in organotypic co-culture
10.1078/0171-9335-00435 · 2004 · External reference
Mussel-Inspired surface chemistry for multifunctional coatings
10.1126/science.1147241 · 2007 · External reference
Epidermal morphogenesis during progressive in vitro 3D reconstruction at the air-liquid interface
10.1111/exd.12020 · 2012 · External reference
Single-molecule mechanics of mussel adhesion
10.1073/pnas.0605552103 · 2006 · External reference
From static to dynamic: the influence of mechanotransduction on skin equivalents analyzed by bioimaging and RNAseq
2024 · External reference
Novel chip for applying mechanical forces on human skin models under dynamic culture conditions
10.1089/ten.tec.2023.0195 · 2024 · External reference
Laminin 10/11: an alternative adhesive ligand for epidermal keratinocytes with a functional role in promoting proliferation and migration
10.1034/j.1600-0625.2002.110501.x · 2002 · External reference
Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices
10.1371/journal.pone.0174478 · 2017 · External reference
Proteoglycans and sulfated glycosaminoglycans
2009 · External reference
Nanoscale topography and poroelastic properties of model tissue breast gland basement membranes
10.1016/j.bpj.2018.09.020 · 2018 · External reference
Bioengineering of a full-thickness skin equivalent in a 96-Well insert format for substance permeation studies and Organ-On-A-Chip applications
2018 · External reference
Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells
10.1016/s0945-053x(03)00017-9 · 2003 · External reference
Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate
10.1016/s0168-8278(02)00103-4 · 2002 · External reference
The effect of matrix characteristics on fibroblast proliferation in 3D gels
10.1016/j.biomaterials.2010.07.046 · 2010 · External reference
Fabrication of human skin equivalents using decellularized extracellular matrix
10.1002/cpz1.393 · 2022 · External reference
Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model
10.1038/jid.2010.115 · 2010 · External reference
Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models
10.1038/s41598-017-12041-y · 2017 · External reference
Fully three-dimensional bioprinted skin equivalent constructs with validated morphology and barrier function
10.1089/ten.tec.2018.0318 · 2019 · External reference
Radial matrix constraint influences tissue contraction and promotes maturation of bi-layered skin equivalents
10.1016/j.bioadv.2023.213702 · 2024 · External reference
A sustainable strategy for generating highly stable human skin equivalents based on fish collagen
10.1016/j.bioadv.2024.213780 · 2024 · External reference
Cellular origin of the dermal-epidermal basement membrane
10.1002/aja.1001970404 · ExternalCitation · doi-reference
Fabrication of human skin equivalents using decellularized extracellular matrix
10.1002/cpz1.393 · ExternalCitation · doi-reference
Differentiation of normal and tumoral human keratinocytes cultured on dermis: reconstruction of either normal or tumoral architecture
10.1007/bf02623599 · ExternalCitation · doi-reference
An intact keratin network is crucial for mechanical integrity and barrier function in keratinocyte cell sheets
10.1007/s00018-019-03424-7 · ExternalCitation · doi-reference
A simple reconstructed human epidermis: preparation of the culture model and utilization in in vitro studies
10.1007/s00403-004-0507-y · ExternalCitation · doi-reference
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
10.1007/s43188-023-00185-1 · ExternalCitation · doi-reference
Radial matrix constraint influences tissue contraction and promotes maturation of bi-layered skin equivalents
10.1016/j.bioadv.2023.213702 · ExternalCitation · doi-reference
A sustainable strategy for generating highly stable human skin equivalents based on fish collagen
10.1016/j.bioadv.2024.213780 · ExternalCitation · doi-reference
Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition
10.1016/j.biomaterials.2004.09.054 · ExternalCitation · doi-reference
Concentrated collagen hydrogels as dermal substitutes
10.1016/j.biomaterials.2009.09.073 · ExternalCitation · doi-reference
The effect of matrix characteristics on fibroblast proliferation in 3D gels
10.1016/j.biomaterials.2010.07.046 · ExternalCitation · doi-reference
Skin integrated with perfusable vascular channels on a chip
10.1016/j.biomaterials.2016.11.031 · ExternalCitation · doi-reference
Nanoscale topography and poroelastic properties of model tissue breast gland basement membranes
10.1016/j.bpj.2018.09.020 · ExternalCitation · doi-reference
Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents
10.1016/j.ejcb.2006.12.005 · ExternalCitation · doi-reference
Applications of human pluripotent stem cell-derived skin organoids in dermatology
10.1016/j.jid.2023.07.017 · ExternalCitation · doi-reference
Targeting the complexity of In vitro skin models: a review of cutting-edge developments
10.1016/j.jid.2024.04.032 · ExternalCitation · doi-reference
Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines
10.1016/j.tiv.2008.03.012 · ExternalCitation · doi-reference
Evaluation of EpiDerm full thickness-300 (EFT-300) as an in vitro model for skin irritation: studies on aliphatic hydrocarbons
10.1016/j.tiv.2009.08.019 · ExternalCitation · doi-reference
Assessment of the utility of the novel phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products
10.1016/j.tiv.2023.105726 · ExternalCitation · doi-reference
Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate
10.1016/s0168-8278(02)00103-4 · ExternalCitation · doi-reference
Skin constructs for replacement of skin tissues for in vitro testing
10.1016/s0169-409x(02)00112-6 · ExternalCitation · doi-reference
The ECVAM international validation Study on in vitro tests for skin corrosivity. 2. Results and evaluation by the management team
10.1016/s0887-2333(98)00019-8 · ExternalCitation · doi-reference
Skin culture model: a possible alternative to the use of excised human skin for assessing in vitro percutaneous absorption
10.1016/s0887-2333(98)00023-x · ExternalCitation · doi-reference
Epidermal basement membrane zone components: ultrastructural distribution and molecular interactions
10.1016/s0923-1811(03)00045-8 · ExternalCitation · doi-reference
Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells
10.1016/s0945-053x(03)00017-9 · ExternalCitation · doi-reference
Cross-linked collagen hydrogel matrix resisting contraction to facilitate full-thickness skin equivalents
10.1021/acsami.7b04017 · ExternalCitation · doi-reference
Control of tissue strain is essential for enhanced dermal innervation in the three-dimensional skin engineering
10.1021/acsbiomaterials.4c01097 · ExternalCitation · doi-reference
Laminin 10/11: an alternative adhesive ligand for epidermal keratinocytes with a functional role in promoting proliferation and migration
10.1034/j.1600-0625.2002.110501.x · ExternalCitation · doi-reference
Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model
10.1038/jid.2010.115 · ExternalCitation · doi-reference
Fibroblasts facilitate re-epithelialization in wounded human skin equivalents
10.1038/labinvest.3700014 · ExternalCitation · doi-reference
Establishment of 3D organotypic cultures using human neonatal epidermal cells
10.1038/nprot.2006.448 · ExternalCitation · doi-reference
Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models
10.1038/s41598-017-12041-y · ExternalCitation · doi-reference
Tissue-scale tensional homeostasis in skin regulates structure and physiological function
10.1038/s42003-020-01365-7 · ExternalCitation · doi-reference
Numerous keratinocyte subtypes involved in wound re-epithelialization
10.1038/sj.jid.5700101 · ExternalCitation · doi-reference
Constructive remodeling of a synthetic endothelial extracellular matrix
10.1038/srep18290 · ExternalCitation · doi-reference
Characterization of the barrier function in a reconstituted human epidermis cultivated in chemically defined medium
10.1046/j.0412-5463.2001.00112.x · ExternalCitation · doi-reference
Effect of fibroblasts on epidermal regeneration
10.1046/j.1365-2133.2002.04871.x · ExternalCitation · doi-reference
Keratins and the keratinocyte activation cycle
10.1046/j.1523-1747.2001.01327.x · ExternalCitation · doi-reference
Barrier function of the skin: “La Raison d'Être” of the Epidermis
10.1046/j.1523-1747.2003.12359.x · ExternalCitation · doi-reference
Single-molecule mechanics of mussel adhesion
10.1073/pnas.0605552103 · ExternalCitation · doi-reference
Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces
10.1073/pnas.1217279110 · ExternalCitation · doi-reference
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro
10.1073/pnas.76.3.1274 · ExternalCitation · doi-reference
Authentic fibroblast matrix in dermal equivalents normalises epidermal histogenesis and dermo-epidermal junction in organotypic co-culture
10.1078/0171-9335-00435 · ExternalCitation · doi-reference
Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16
10.1083/jcb.132.3.381 · ExternalCitation · doi-reference
Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes
10.1089/ten.tec.2011.0561 · ExternalCitation · doi-reference
Design and fabrication of human skin by three-dimensional bioprinting
10.1089/ten.tec.2013.0335 · ExternalCitation · doi-reference
Integration of mature adipocytes to Build-Up a functional three-layered full-skin equivalent
10.1089/ten.tec.2016.0141 · ExternalCitation · doi-reference
Fully three-dimensional bioprinted skin equivalent constructs with validated morphology and barrier function
10.1089/ten.tec.2018.0318 · ExternalCitation · doi-reference
Novel chip for applying mechanical forces on human skin models under dynamic culture conditions
10.1089/ten.tec.2023.0195 · ExternalCitation · doi-reference
The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C
10.1111/1523-1747.ep12336024 · ExternalCitation · doi-reference
Epidermal morphogenesis during progressive in vitro 3D reconstruction at the air-liquid interface
10.1111/exd.12020 · ExternalCitation · doi-reference
Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and/or exogenously activated keratinocytes
10.1111/j.0022-202x.2004.23549.x · ExternalCitation · doi-reference
Reconstruction of 'simplified' skin: control of fabrication
10.1111/j.1365-2133.1984.tb15608.x · ExternalCitation · doi-reference
Production of basement membrane components by a reconstructed epidermis cultured in the absence of serum and dermal factors
10.1111/j.1365-2133.1993.tb11839.x · ExternalCitation · doi-reference
The skin: an indispensable barrier
10.1111/j.1600-0625.2008.00786.x · ExternalCitation · doi-reference
Mussel-Inspired surface chemistry for multifunctional coatings
10.1126/science.1147241 · ExternalCitation · doi-reference
Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness
10.1126/science.7008197 · ExternalCitation · doi-reference
The Phenion full-thickness skin model for percutaneous absorption testing
10.1159/000265681 · ExternalCitation · doi-reference
3D model of harlequin ichthyosis reveals inflammatory therapeutic targets
10.1172/jci132987 · ExternalCitation · doi-reference
Differential keratin expression during epiboly in a wound model of bioengineered skin and in human chronic wounds
10.1177/1534734611418157 · ExternalCitation · doi-reference
3D biofabrication of diseased human skin models in vitro
10.1186/s40824-023-00415-5 · ExternalCitation · doi-reference
Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism
10.1242/jcs.112.12.1843 · ExternalCitation · doi-reference
Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices
10.1371/journal.pone.0174478 · ExternalCitation · doi-reference
Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation
10.2340/00015555808993 · ExternalCitation · doi-reference
Improvement of a three-layered in vitro skin model for topical application of irritating substances
10.3389/fbioe.2020.00388 · ExternalCitation · doi-reference
Design of an integrated microvascularized human Skin-on-a-Chip tissue equivalent model
10.3389/fbioe.2022.915702 · ExternalCitation · doi-reference
Characterization of a new reconstructed full thickness skin model, T-Skin™, and its application for investigations of anti-aging compounds
10.3390/ijms20092240 · ExternalCitation · doi-reference
Structural and functional validation of a full-thickness self-assembled skin equivalent for disease modeling
10.3390/pharmaceutics14061211 · ExternalCitation · doi-reference
