Research graph
References from Bioactive polythioctic acid-engineered ropivacaine alleviates bone cancer pain through prolonged analgesia and multi-functional neuroprotection. Local targets link to admitted publications; unresolved targets remain external evidence.
Piezoelectric analgesia blocks cancer-induced bone pain
10.1002/adma.202403979 · 2024 · External reference
Radiopharmaceuticals for palliation of bone pain in patients with castration-resistant prostate cancer metastatic to bone: a systematic review
10.1016/j.eururo.2015.09.005 · 2016 · External reference
Oxidation-activated nanotherapy boosts tumor immunity and disrupts tumor-nerve crosstalk to combat bone metastases and cancer pain
2026 · External reference
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
10.1172/jci133334 · 2020 · External reference
STING suppresses bone cancer pain via immune and neuronal modulation
10.1038/s41467-021-24867-2 · 2021 · External reference
Prescription drug monitoring program mandates and opioids dispensed following emergency department encounters for patients with sickle cell disease or cancer with bone metastasis
10.1001/jama.2021.10161 · 2021 · External reference
GPR37 activation alleviates bone cancer pain via the inhibition of osteoclastogenesis and neuronal hyperexcitability
2025 · External reference
Nerves in cancer
10.1038/s41568-019-0237-2 · 2020 · External reference
Pathological pain and the neuroimmune interface
10.1038/nri3621 · 2014 · External reference
Pain and nociception: mechanisms of cancer-induced bone pain
10.1200/jco.2013.51.7219 · 2014 · External reference
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief
10.7150/thno.43932 · 2020 · External reference
In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine
10.1016/j.biomaterials.2018.07.032 · 2019 · External reference
An injectable oil-based depot formulation of N-Acyloxymethyl prodrug of ropivacaine for long-acting local analgesia: formulation development and in Vitro/In vivo evaluation
2025 · External reference
The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain
10.1016/j.ejphar.2019.172475 · 2019 · External reference
Anandamide as a therapeutic target for alleviating neuropathic pain and inflammation in rat models
10.2174/0115672026391315250822063941 · 2025 · External reference
Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia
10.7150/thno.93322 · 2024 · External reference
Nanocrystals slow-releasing ropivacaine and doxorubicin to synergistically suppress tumor recurrence and relieve postoperative pain
10.1021/acsnano.3c05831 · 2023 · External reference
Local anesthetic cardiac toxicity is mediated by cardiomyocyte calcium dynamics
10.1097/aln.0000000000004389 · 2022 · External reference
The state of local anaesthetic systemic toxicity in 2025: the emergence of lidocaine as our next challenge
10.1016/j.bja.2025.07.042 · 2025 · External reference
Effect of stellate ganglion block treatment on posttraumatic stress disorder symptoms: a randomized clinical trial
10.1001/jamapsychiatry.2019.3474 · 2020 · External reference
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
10.1186/s12951-023-02230-5 · 2023 · External reference
Ropivacaine and celecoxib-loaded injectable composite hydrogel for improved chronic pain-exacerbated myocardial ischemia-reperfusion injury
10.1016/j.jconrel.2025.01.028 · 2025 · External reference
Injectable nanocomposite analgesic delivery system for musculoskeletal pain management
10.1016/j.actbio.2018.05.038 · 2018 · External reference
An engineered nanoplatform with tropism toward irradiated glioblastoma augments its radioimmunotherapy efficacy
2024 · External reference
Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer
10.1111/cpr.12393 · 2017 · External reference
Self-assembled dual fluorescence nanoparticles for CD44-targeted delivery of anti-miR-27a in liver cancer theranostics
10.7150/thno.25255 · 2018 · External reference
Cationic mesoporous silica nanoparticles alleviate osteoarthritis by targeting multiple inflammatory mediators
10.1016/j.biomaterials.2023.122366 · 2023 · External reference
Engineering 2D silicene-based mesoporous nanomedicine for in vivo near-infrared-triggered analgesia
2022 · External reference
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain
10.1016/j.phrs.2019.104339 · 2019 · External reference
Sustained release of levobupivacaine from temperature-sensitive injectable hydrogel for long-term local anesthesia in postoperative pain management
10.1016/j.biomaterials.2023.122129 · 2023 · External reference
Ropivacaine microsphere-loaded electroconductive nerve dressings for long-acting analgesia and functional recovery following diabetic peripheral nerve injury
2023 · External reference
A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer
10.1038/s41467-023-43571-x · 2023 · External reference
Co-crystals of highly and poorly soluble local anesthetics bidirectionally regulate their release for long-acting analgesia
10.1016/j.jconrel.2025.114476 · 2026 · External reference
A carrier-free long-acting ropivacaine formulation using methylprednisolone sodium succinate as a dual-functional adjuvant
10.7150/thno.107397 · 2025 · External reference
A poly(lipoic acid)-based elastomer adhesive with synergistic activity of microenvironment regulation and peripheral neuropathy repair facilitates infectious diabetic wound healing
10.1016/j.biomaterials.2025.123489 · 2026 · External reference
Natural antioxidant lipoic acid constructed nanodrug for oral therapy of inflammatory bowel disease
10.1021/acsnano.5c15530 · 2026 · External reference
Blocking cancer-nerve crosstalk for treatment of metastatic bone cancer pain
10.1002/adma.202108653 · 2022 · External reference
Hydrogen-releasing electroactive nerve guidance conduits promote peripheral nerve regeneration by remodeling the microenvironment
10.1016/j.biomaterials.2025.123752 · 2026 · External reference
Salidroside alleviates bone cancer pain by inhibiting Th17/Treg imbalance through the AMPK/SIRT1 pathway
10.1016/j.phymed.2025.157000 · 2025 · External reference
Bone-targeted nanoplatform combining zoledronate and photothermal therapy to treat breast cancer bone metastasis
10.1021/acsnano.9b00097 · 2019 · External reference
Transcriptome sequencing explores the mechanism of baicalin on bone cancer pain
10.2147/jir.s336028 · 2021 · External reference
NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use
10.1158/0008-5472.can-14-1220 · 2014 · External reference
Macrophage membrane-modified reactive oxygen species-responsive prodrug self-assembled nanoparticles for the targeted treatment of traumatic spinal cord injury
10.1016/j.cej.2024.150453 · 2024 · External reference
Unraveling oral fate of Poly(Lipoic acid)s: mechanistic insights and delivery Horizons
2026 · External reference
Mechanically regulated nanozymes for remote metabolic reprogramming and precise cancer therapy
2026 · External reference
Scintillon-mimicking mechanoluminescence for theranostic applications
10.1021/jacs.5c21878 · 2026 · External reference
Prescription drug monitoring program mandates and opioids dispensed following emergency department encounters for patients with sickle cell disease or cancer with bone metastasis
10.1001/jama.2021.10161 · ExternalCitation · doi-reference
Effect of stellate ganglion block treatment on posttraumatic stress disorder symptoms: a randomized clinical trial
10.1001/jamapsychiatry.2019.3474 · ExternalCitation · doi-reference
Blocking cancer-nerve crosstalk for treatment of metastatic bone cancer pain
10.1002/adma.202108653 · ExternalCitation · doi-reference
Piezoelectric analgesia blocks cancer-induced bone pain
10.1002/adma.202403979 · ExternalCitation · doi-reference
Injectable nanocomposite analgesic delivery system for musculoskeletal pain management
10.1016/j.actbio.2018.05.038 · ExternalCitation · doi-reference
In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine
10.1016/j.biomaterials.2018.07.032 · ExternalCitation · doi-reference
Sustained release of levobupivacaine from temperature-sensitive injectable hydrogel for long-term local anesthesia in postoperative pain management
10.1016/j.biomaterials.2023.122129 · ExternalCitation · doi-reference
Cationic mesoporous silica nanoparticles alleviate osteoarthritis by targeting multiple inflammatory mediators
10.1016/j.biomaterials.2023.122366 · ExternalCitation · doi-reference
A poly(lipoic acid)-based elastomer adhesive with synergistic activity of microenvironment regulation and peripheral neuropathy repair facilitates infectious diabetic wound healing
10.1016/j.biomaterials.2025.123489 · ExternalCitation · doi-reference
Hydrogen-releasing electroactive nerve guidance conduits promote peripheral nerve regeneration by remodeling the microenvironment
10.1016/j.biomaterials.2025.123752 · ExternalCitation · doi-reference
The state of local anaesthetic systemic toxicity in 2025: the emergence of lidocaine as our next challenge
10.1016/j.bja.2025.07.042 · ExternalCitation · doi-reference
Macrophage membrane-modified reactive oxygen species-responsive prodrug self-assembled nanoparticles for the targeted treatment of traumatic spinal cord injury
10.1016/j.cej.2024.150453 · ExternalCitation · doi-reference
The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain
10.1016/j.ejphar.2019.172475 · ExternalCitation · doi-reference
Radiopharmaceuticals for palliation of bone pain in patients with castration-resistant prostate cancer metastatic to bone: a systematic review
10.1016/j.eururo.2015.09.005 · ExternalCitation · doi-reference
Ropivacaine and celecoxib-loaded injectable composite hydrogel for improved chronic pain-exacerbated myocardial ischemia-reperfusion injury
10.1016/j.jconrel.2025.01.028 · ExternalCitation · doi-reference
Co-crystals of highly and poorly soluble local anesthetics bidirectionally regulate their release for long-acting analgesia
10.1016/j.jconrel.2025.114476 · ExternalCitation · doi-reference
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain
10.1016/j.phrs.2019.104339 · ExternalCitation · doi-reference
Salidroside alleviates bone cancer pain by inhibiting Th17/Treg imbalance through the AMPK/SIRT1 pathway
10.1016/j.phymed.2025.157000 · ExternalCitation · doi-reference
Nanocrystals slow-releasing ropivacaine and doxorubicin to synergistically suppress tumor recurrence and relieve postoperative pain
10.1021/acsnano.3c05831 · ExternalCitation · doi-reference
Natural antioxidant lipoic acid constructed nanodrug for oral therapy of inflammatory bowel disease
10.1021/acsnano.5c15530 · ExternalCitation · doi-reference
Bone-targeted nanoplatform combining zoledronate and photothermal therapy to treat breast cancer bone metastasis
10.1021/acsnano.9b00097 · ExternalCitation · doi-reference
Scintillon-mimicking mechanoluminescence for theranostic applications
10.1021/jacs.5c21878 · ExternalCitation · doi-reference
Pathological pain and the neuroimmune interface
10.1038/nri3621 · ExternalCitation · doi-reference
STING suppresses bone cancer pain via immune and neuronal modulation
10.1038/s41467-021-24867-2 · ExternalCitation · doi-reference
A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer
10.1038/s41467-023-43571-x · ExternalCitation · doi-reference
Nerves in cancer
10.1038/s41568-019-0237-2 · ExternalCitation · doi-reference
Local anesthetic cardiac toxicity is mediated by cardiomyocyte calcium dynamics
10.1097/aln.0000000000004389 · ExternalCitation · doi-reference
Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer
10.1111/cpr.12393 · ExternalCitation · doi-reference
NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use
10.1158/0008-5472.can-14-1220 · ExternalCitation · doi-reference
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
10.1172/jci133334 · ExternalCitation · doi-reference
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
10.1186/s12951-023-02230-5 · ExternalCitation · doi-reference
Pain and nociception: mechanisms of cancer-induced bone pain
10.1200/jco.2013.51.7219 · ExternalCitation · doi-reference
Transcriptome sequencing explores the mechanism of baicalin on bone cancer pain
10.2147/jir.s336028 · ExternalCitation · doi-reference
Anandamide as a therapeutic target for alleviating neuropathic pain and inflammation in rat models
10.2174/0115672026391315250822063941 · ExternalCitation · doi-reference
A carrier-free long-acting ropivacaine formulation using methylprednisolone sodium succinate as a dual-functional adjuvant
10.7150/thno.107397 · ExternalCitation · doi-reference
Self-assembled dual fluorescence nanoparticles for CD44-targeted delivery of anti-miR-27a in liver cancer theranostics
10.7150/thno.25255 · ExternalCitation · doi-reference
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief
10.7150/thno.43932 · ExternalCitation · doi-reference
Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia
10.7150/thno.93322 · ExternalCitation · doi-reference
