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References from Boosting oral bioavailability of taraxasterol via a nanocrystal-mucoadhesive micropatch platform for potent multi-mechanistic protection against drug-induced liver injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Drug-induced liver injury
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Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice
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Taraxasterol attenuates zearalenone-induced kidney damage in mice by modulating oxidative stress and endoplasmic reticulum stress
10.1016/j.ecoenv.2024.117093 · 2024 · External reference
Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments
10.1016/j.phymed.2023.154872 · 2023 · External reference
Mechanisms of drug induced liver injury
10.1007/s00018-025-05744-3 · 2025 · External reference
Quantification of taraxasterol in rat plasma by LC/MS/MS: application to a pharmacokinetic study
10.1002/bmc.3473 · 2015 · External reference
Nanocrystals for improving oral bioavailability of drugs: intestinal transport mechanisms and influencing factors
10.1208/s12249-021-02041-7 · 2021 · External reference
Vitamin E TPGS-based nanomedicine, nanotheranostics, and targeted drug delivery: past, present, and future
10.3390/pharmaceutics15030722 · 2023 · External reference
Recent advances in vitamin E TPGS-based organic nanocarriers for enhancing the oral bioavailability of active compounds: a systematic review
10.3390/pharmaceutics17040485 · 2025 · External reference
Unraveling the impact of stabilizers on nanocrystal preparation and oral absorption: a case study of poorly soluble andrographolide
10.1021/acs.nanolett.4c05230 · 2025 · External reference
Mucoadhesive ionic liquid gel patches for oral delivery
10.1021/acsbiomaterials.0c01024 · 2023 · External reference
Ionic liquids and deep eutectic solvents for enhanced delivery of antibodies in the gastrointestinal tract
2020 · External reference
Intestinal patch systems for oral drug delivery
10.1016/j.coph.2017.08.005 · 2017 · External reference
Superior adhesion of a multifunctional protein-based micropatch to intestinal tissue by harnessing the hydrophobic effect
10.1002/smtd.202200153 · 2022 · External reference
Preparation and characterization of arginine-modified chitosan/hydroxypropyl methylcellose antibacterial film
10.1016/j.ijbiomac.2019.12.141 · 2020 · External reference
Development of a hydroxypropyl methyl cellulose/polyacrylic acid interpolymer complex formulated buccal mucosa adhesive film to facilitate the delivery of insulin for diabetes treatment
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Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan-carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating
2018 · External reference
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10.1016/j.jconrel.2013.08.006 · 2013 · External reference
Nanosuspension for enhancement of oral bioavailability of felodipine
10.1007/s13204-012-0188-3 · 2013 · External reference
Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants: I. Acute toxicity and pharmacokinetics studies
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Properties and biocompatibility of chitosan films modified by blending with PVA and chemically crosslinked
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10.30574/gscbps.2020.12.2.0262 · 2020 · External reference
Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin
10.1016/j.ijbiomac.2022.08.190 · 2022 · External reference
Polyelectrolyte complexes based on alginate/tanfloc: optimization, characterization and medical application
10.1016/j.ijbiomac.2017.05.033 · 2017 · External reference
Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson's disease: physical characterization and ex vivo drug permeation through buccal mucosa
10.1080/03639045.2017.1349785 · 2017 · External reference
A focus on mucoadhesive polymers and their application in buccal dosage forms
10.1016/j.jddst.2015.06.016 · 2016 · External reference
Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films
10.1016/j.ejps.2017.08.019 · 2017 · External reference
Chitosan nanoparticle antigen uptake in epithelial monolayers can predict mucosal but not systemic in vivo immune response by oral delivery
10.1016/j.carbpol.2018.02.084 · 2018 · External reference
Advances and applications of chitosan-based nanomaterials as oral delivery carriers: a review
10.1016/j.ijbiomac.2020.03.148 · 2020 · External reference
Chitosan functionalized nanocochleates for enhanced oral absorption of cyclosporine A
2017 · External reference
Oxidative stress–induced liver damage and remodeling of the liver vasculature
10.1016/j.ajpath.2023.06.002 · 2023 · External reference
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-kappaB and Nrf2/HO-1 signaling pathways
10.1016/j.lfs.2020.118546 · 2020 · External reference
Protective effects of taraxasterol against ethanol-induced liver injury by regulating CYP2E1/Nrf2/HO-1 and NF-kappaB signaling pathways in mice
10.1155/2018/8284107 · 2018 · External reference
Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice
10.1016/j.jhep.2022.10.028 · 2023 · External reference
Interleukin 2 promotes hepatic regulatory T cell responses and protects from biliary fibrosis in murine sclerosing cholangitis
10.1002/hep.30061 · 2018 · External reference
Mechanisms of bile acid mediated inflammation in the liver
10.1016/j.mam.2017.06.001 · 2017 · External reference
Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity
10.1016/j.jep.2024.119308 · 2025 · External reference
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides
10.1016/j.jep.2024.118108 · 2024 · External reference
Taraxasterol protects against acetaminophen-induced hepatotoxicity by reducing liver inflammatory response and ameliorating oxidative stress in mice
10.1016/j.intimp.2024.112580 · 2024 · External reference
The solubility-permeability interplay and its implications in formulation design and development for poorly soluble drugs
10.1208/s12248-012-9337-6 · 2012 · External reference
Nanocrystal drug delivery systems significantly enhance the therapeutic efficacy of anticancer agents
10.1007/s44174-025-00432-z · 2025 · External reference
TPGS conjugated pro-liposomal nano-drug delivery system potentiate the antioxidant and hepatoprotective activity of Myricetin
2021 · External reference
The basics and underlying mechanisms of mucoadhesion
10.1016/j.addr.2005.07.001 · 2005 · External reference
Tight junction modulation at the blood-brain barrier: current and future perspectives
10.1016/j.bbamem.2020.183298 · 2020 · External reference
