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References from Hypoxia-programmed apoptotic-mimetic M2 macrophage-derived small extracellular vesicles for hydrogel-mediated immunoregenerative bone repair. Local targets link to admitted publications; unresolved targets remain external evidence.
Bone tissue engineering: recent advances and challenges
10.1615/critrevbiomedeng.v40.i5.10 · 2012 · External reference
A materials perspective on the design of damage-resilient bone implants through additive/advanced manufacturing
10.1007/s11837-019-03999-3 · 2020 · External reference
A long-lasting guided bone regeneration membrane from sequentially functionalised photoactive atelocollagen
10.1016/j.actbio.2021.12.004 · 2022 · External reference
A bioactive glass functional hydrogel enhances bone augmentation via synergistic angiogenesis, self-swelling and osteogenesis
2023 · External reference
Osteoimmunity-regulating biomaterials promote bone regeneration
2023 · External reference
Osteoimmunomodulatory biomaterials: engineering strategies, current progress, and future perspectives for bone regeneration
2025 · External reference
Multiscale architecture design of 3d printed biodegradable zn-based porous scaffolds for immunomodulatory osteogenesis
10.1038/s41467-024-47189-5 · 2024 · External reference
Immunomodulatory multifunctional janus collagen-based membrane for advanced bone regeneration
10.1038/s41467-025-59651-z · 2025 · External reference
Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: molecular insights and therapeutic prospects
10.1016/j.cej.2024.150631 · 2024 · External reference
Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review
10.3389/fbioe.2025.1640560 · 2025 · External reference
Osteoimmunomodulation by bone implant materials: harnessing physicochemical properties and chemical composition
10.1039/d5bm00357a · 2025 · External reference
Ligand-selective targeting of macrophage hydrogel elicits bone immune-stem cell endogenous self-healing program to promote bone regeneration
2024 · External reference
Matrix metalloproteinase-responsive hydrogel with on-demand release of phosphatidylserine promotes bone regeneration through immunomodulation
10.1002/advs.202306924 · 2024 · External reference
Early-responsive immunoregulation therapy improved microenvironment for bone regeneration via engineered extracellular vesicles
10.1002/adhm.202303681 · 2024 · External reference
A genetically engineered "reinforced concrete" scaffold regulates the n2 neutrophil innate immune Cascade to repair bone defects
10.1002/adhm.202304585 · 2024 · External reference
Temporal immunomodulatory hydrogel regulating the immune-osteogenic Cascade for infected bone defects regeneration
10.1002/adma.202514419 · 2026 · External reference
Znce-ldo nanozyme-based multifunctional hydrogel promotes bone regeneration by inflammatory macrophage reprogramming and piezo1 activation
10.1021/acsnano.5c10123 · 2025 · External reference
Peptide-based inflammation-responsive implant coating sequentially regulates bone regeneration to enhance interfacial osseointegration
10.1038/s41467-025-58444-8 · 2025 · External reference
Extracellular vesicles as mediators of intercellular communication: implications for drug discovery and targeted therapies
10.3390/futurepharmacol5030048 · 2025 · External reference
Bioengineering extracellular vesicles: smart nanomaterials for bone regeneration
10.1186/s12951-023-01895-2 · 2023 · External reference
Extracellular vesicle-loaded hydrogels for tissue repair and regeneration
2023 · External reference
Extracellular vesicles-in-hydrogel (Evih) targeting pathophysiology for tissue repair
2025 · External reference
Advances in the study of extracellular vesicles for bone regeneration
10.3390/ijms25063480 · 2024 · External reference
Osteoinductive dental pulp stem cell-derived extracellular vesicle-loaded multifunctional hydrogel for bone regeneration
10.1021/acsnano.3c11542 · 2024 · External reference
Engineering preparation and sustained delivery of bone functional exosomes-laden biodegradable hydrogel for in situ bone regeneration
10.1016/j.compositesb.2023.110803 · 2023 · External reference
Bioactive glass-elicited stem cell-derived extracellular vesicles regulate m2 macrophage polarization and angiogenesis to improve tendon regeneration and functional recovery
10.1016/j.biomaterials.2023.121998 · 2023 · External reference
M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator
2023 · External reference
M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis, Bioact
2024 · External reference
Osteo-immunomodulatory effects of macrophage-derived extracellular vesicles treated with biphasic calcium phosphate ceramics on bone regeneration
10.1088/1748-605x/ad5242 · 2024 · External reference
Extracellular vesicles and hydrogels: an innovative approach to tissue regeneration
10.1021/acsomega.3c08280 · 2024 · External reference
Exosome-integrated hydrogels for bone tissue engineering
10.3390/gels10120762 · 2024 · External reference
Extracellular vesicle-integrated biomaterials in bone tissue engineering applications: current progress and future perspectives
10.2147/ijn.s522198 · 2025 · External reference
Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity
10.1186/s12951-024-02333-7 · 2024 · External reference
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake
10.1038/s41368-024-00293-0 · 2024 · External reference
Targeting efferocytosis in inflammaging
10.1146/annurev-pharmtox-032723-110507 · 2024 · External reference
Drugging the efferocytosis process: concepts and opportunities
10.1038/s41573-022-00470-y · 2022 · External reference
Smart materials and devices for enhanced delivery of extracellular vesicles
10.1002/adma.202501081 · 2025 · External reference
Injectable extracellular vesicle hydrogels with tunable viscoelasticity for depot vaccine
10.1038/s41467-025-59278-0 · 2025 · External reference
Gelatin methacryloyl hydrogel, from standardization, performance, to biomedical application
10.1002/adhm.202300395 · 2023 · External reference
Strategies of functionalized gelma-based bioinks for bone regeneration: recent advances and future perspectives
2024 · External reference
Versatile hypoxic extracellular vesicles laden in an injectable and bioactive hydrogel for accelerated bone regeneration
2023 · External reference
Hydrogel-exosome system in tissue engineering: a promising therapeutic strategy
2024 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research
2020 · External reference
Hypoxia promotes ev secretion by impairing lysosomal homeostasis in hnscc through negative regulation of atp6v1a by hif-1α
10.1002/jev2.12310 · 2023 · External reference
Hypoxia-induced hif1α activation regulates small extracellular vesicle release in human embryonic kidney cells
10.1038/s41598-022-05161-7 · 2022 · External reference
Immunomodulatory cytoskeleton of bionic periosteum affects mitochondrial dynamics to promote osteogenesis
2026 · External reference
An immunomodulating regenerating hydrogel that rescues the oxidative microenvironment and reverses cell senescence for osteoporotic bone defects
10.1021/acsnano.5c06549 · 2025 · External reference
Topological cues of microparticles train stem cells for tissue repair via mechanotransduction
2025 · External reference
Signal converter-based therapy platform promoting aging bone healing by improving permeability of the mitochondrial membrane
10.1002/adma.202500156 · 2025 · External reference
Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis
10.7150/thno.97335 · 2024 · External reference
Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ
10.7150/thno.102779 · 2024 · External reference
Polyphenol-derived nanoarmor-functionalized photothermal hydrogel platform for programmed modulation of the regenerative microenvironment and bone defect healing
10.1002/smll.202510733 · 2026 · External reference
Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
10.1038/s41467-022-29191-x · 2022 · External reference