Research graph
References from A core-shell microneedle patch coordinates early anti-inflammatory modulation and sustained pro-angiogenic stimulation for cardiac repair after myocardial infarction. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study
10.1016/j.jacc.2020.11.010 · 2020 · External reference
Mortality from ischemic heart disease: analysis of data from the World Health Organization and coronary artery disease risk factors from NCD Risk Factor Collaboration
2019 · External reference
Advanced cardiac patches for the treatment of myocardial infarction
10.1161/circulationaha.123.067097 · 2024 · External reference
Myocardial ischaemia–reperfusion injury and cardioprotection in perspective
10.1038/s41569-020-0403-y · 2020 · External reference
The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis
10.1161/circresaha.116.303577 · 2016 · External reference
The inflammatory response in myocardial injury, repair, and remodelling
10.1038/nrcardio.2014.28 · 2014 · External reference
Spatial multi-omic map of human myocardial infarction
10.1038/s41586-022-05060-x · 2022 · External reference
Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury
10.1152/ajpheart.00158.2018 · 2018 · External reference
Signaling pathways and targeted therapy for myocardial infarction
10.1038/s41392-022-00925-z · 2022 · External reference
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
10.1038/s41569-023-00946-3 · 2024 · External reference
The NLRP3 inflammasome in acute myocardial infarction
10.1038/nrcardio.2017.161 · 2018 · External reference
Targeting the NLRP3 inflammasome in inflammatory diseases
10.1038/nrd.2018.97 · 2018 · External reference
Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities
10.1016/j.pharmthera.2018.01.001 · 2018 · External reference
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
10.1038/nm.3806 · 2015 · External reference
The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction
2017 · External reference
MCC950 closes the active conformation of NLRP3 to an inactive state
10.1038/s41589-019-0278-6 · 2019 · External reference
Activation of the macrophage-associated inflammasome exacerbates myocardial fibrosis through the 15-HETE-mediated pathway in acute myocardial infarction
10.1016/j.eng.2024.05.015 · 2024 · External reference
Spatiotemporal signaling underlies progressive vascular rarefaction in myocardial infarction
10.1038/s41467-023-44227-6 · 2023 · External reference
Protein therapeutics for cardiac regeneration after myocardial infarction
10.1007/s12265-010-9207-5 · 2010 · External reference
MMP 9-instructed assembly of bFGF nanofibers in ischemic myocardium to promote heart repair
10.7150/thno.77345 · 2022 · External reference
Injection of ROS‐responsive hydrogel loaded with basic fibroblast growth factor into the pericardial cavity for heart repair
2021 · External reference
Hydrogel‐based growth factor delivery platforms: strategies and recent advances
10.1002/adma.202210707 · 2024 · External reference
An injectable carrier for spatiotemporal and sequential release of therapeutic substances to treat myocardial infarction
10.1016/j.jconrel.2023.10.056 · 2024 · External reference
Injectable hydrogels with tailored recombinant humanized collagen type I for the repair of damaged hearts by remodeling the myocardial microenvironment
10.1186/s42825-025-00212-x · 2025 · External reference
The application of nanomedicines in repairing damage in myocardial infarction
10.1016/j.jconrel.2025.114388 · 2025 · External reference
Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease
10.1126/sciadv.aaz3621 · 2020 · External reference
Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model
10.1161/circulationaha.106.662577 · 2007 · External reference
Bifunctional peptide amphiphile hydrogel orchestrates concerted antioxidant and anti‐inflammatory actions to counter myocardial Ischemia/Reperfusion Injury
2026 · External reference
One endothelium-targeted combined nucleic acid delivery system for myocardial infarction therapy
10.1021/acsnano.3c11661 · 2024 · External reference
Flexible polymeric patch based nanotherapeutics against non-cancer therapy
2022 · External reference
Microneedle patch loaded with exosomes containing microRNA‐29b prevents cardiac fibrosis after myocardial infarction
2023 · External reference
Microneedle stent for intravascular anchoring effect
2026 · External reference
Microneedles at the forefront of next generation theranostics
10.1002/advs.202412140 · 2025 · External reference
Differential dual‐release bilayer microneedles loaded with aluminum adjuvants as a safe and effective vaccine platform
10.1002/adfm.202201952 · 2022 · External reference
Double-layered core-shell microneedle patch integrated with microparticles for long-acting treatment of osteoporosis
10.1016/j.jconrel.2025.113898 · 2025 · External reference
Highly efficient intrastromal dual-drug delivery by a dissolving bilayer microneedle for synergistic therapy against corneal neovascularization
10.1021/acsnano.5c10610 · 2025 · External reference
Spatiotemporal immunomodulation of macrophages via NLRP3/IL‐1β pathway by Core‐Shell microneedles to promote healing of biofilm‐infected diabetic ulcers
10.1002/smll.202505179 · 2025 · External reference
Minimally invasive snakebite inspired microneedle delivery system for internal organs
2025 · External reference
Chiral D-peptide composite hydrogels enable sustained RepSox delivery and antifibrotic remodeling after myocardial infarction
10.1016/j.biomaterials.2026.124343 · 2026 · External reference
Hydrogel crosslinked by chiral bioactive peptides for synergistic oxidative stress scavenging and targeted anti‐fibrotic therapy after myocardial infarction
10.1002/adfm.76154 · 2026 · External reference
Extracellular matrix/glycopeptide hybrid hydrogel as an immunomodulatory niche for endogenous cardiac repair after myocardial infarction
10.1002/advs.202301244 · 2023 · External reference
An injectable hydrogel with oxygen-generating and antioxidant properties for cardiac repair
2025 · External reference
Macrophage hitchhiking nanoparticles for the treatment of myocardial infarction: an in vitro and in vivo study
2023 · External reference
Inflammation in acute myocardial infarction: the good, the bad and the ugly
10.1093/eurheartj/ehad486 · 2024 · External reference
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury
10.1093/cvr/cvt091 · 2013 · External reference
Light-activated gold–selenium core–shell nanocomposites with NIR-II photoacoustic imaging performances for heart-targeted repair
10.1021/acsnano.2c07311 · 2022 · External reference
Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury
10.7150/thno.48436 · 2021 · External reference
Reinforcing stromal cell spheroid through red‐light preconditioning for advanced vascularization
2025 · External reference
Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction
10.1016/j.jacc.2016.01.073 · 2016 · External reference
Nanoparticle–patch system for localized, effective, and sustained miRNA administration into infarcted myocardium to alleviate myocardial ischemia–reperfusion injury
2024 · External reference
Microneedles-based theranostic platform: from the past to the future
10.1021/acsnano.4c04277 · 2024 · External reference
Going below and beyond the surface: microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
2023 · External reference
Nanoparticle-Patch System for localized, effective, and sustained miRNA administration into infarcted myocardium to alleviate myocardial ischemia-reperfusion injury
2024 · External reference
Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds
10.1016/j.jare.2024.01.002 · 2024 · External reference
Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation
2025 · External reference
Self‐oxygenating PROTAC microneedle for spatiotemporally‐confined protein degradation and enhanced glioblastoma therapy
10.1002/adma.202411869 · 2025 · External reference
