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References from Role of plant alkaloids on human health: A review of biological activities. Local targets link to admitted publications; unresolved targets remain external evidence.
Histochemical investigation and kinds of alkaloids in leaves of different developmental stages in Thymus quinquecostatus
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2004 · External reference
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2007 · External reference
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1981 · External reference
Estimation of alkaloids and phenolics of five edible cucurbitaceous plants and their antibacterial activity
2015 · External reference
New perspectives on how to discover drugs from herbal medicines: CAM's outstanding contribution to modern therapeutics
2013 · External reference
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics
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2010 · External reference
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Cytisine: a natural product leads for the development of drugs acting at nicotinic acetylcholine receptors
10.1039/c2np00100d · 2012 · External reference
Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children
10.1191/0960327103ht404oa · 2003 · External reference
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2013 · External reference
Adverse reaction to atropine and the treatment of organophosphate intoxication
2002 · External reference
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2003 · External reference
Pharmacokinetics and pharmacodynamics in clinical use of scopolamine
10.1097/01.ftd.0000168293.48226.57 · 2005 · External reference
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1984 · External reference
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1986 · External reference
Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms
10.1007/s00213-005-0052-1 · 2005 · External reference
Tropane alkaloids from the bark of Erythroxylum vacciniifolium
10.1021/np020512m · 2003 · External reference
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Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
10.1186/1475-2875-10-144 · 2011 · External reference
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Quinidine in falciparum malaria
10.1016/s0140-6736(81)91275-7 · 1981 · External reference
Relationships between heart rate variability and antiarrhythmic effects of hydroquinidine
10.1023/a:1007709808576 · 1997 · External reference
Antimalarial activity and interactions between quinine, dihydroquinine and 3-hydroxyquinine against Plasmodium falciparum in vitro
10.1016/s0035-9203(96)90320-x · 1996 · External reference
Studies on synthetic antimalarial drugs: II.—general chemical considerations
10.1080/00034983.1945.11685229 · 1945 · External reference
Mechanism of relaxant response to papaverine on the smooth muscle of non-pregnant rat uterus
10.1540/jsmr.36.83 · 2000 · External reference
Crystal and molecular structure of the alkaloid papaverine hydrochloride
10.1007/bf01198178 · 1974 · External reference
Cyclic phosphodiesterase activity and the action of papaverine
10.1016/0006-291x(70)91046-6 · 1970 · External reference
A review on biological and chemical diversity in Berberis (Berberidaceae)
2015 · External reference
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
10.2337/db07-1552 · 2008 · External reference
Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells
2012 · External reference
Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor
2014 · External reference
Pharmacological actions of berberine on the central nervous system
10.1254/jjp.20.482 · 1970 · External reference
Berberine: alkaloid with wide spectrum of pharmacological activities
2010 · External reference
Opioid agonist-antagonist drugs in acute and chronic pain states
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Pharmacological effects of ephedrine alkaloids on human α1-and α2-adrenergic receptor subtypes
10.1124/jpet.107.120709 · 2007 · External reference
Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse
10.1111/j.2042-3306.1990.tb04312.x · 1990 · External reference
Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat
10.1111/j.2042-7158.1989.tb06492.x · 1989 · External reference
Pharmacological and biochemical affects of some reserpine derivatives
10.1111/j.2042-7158.1961.tb11868.x · 1961 · External reference
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St Anthony's fire and living ligatures: a short history of ergometrine
10.1016/s0140-6736(02)08658-0 · 2002 · External reference
Pharmacological Studies of ergometrine and methylergometrine
1957 · External reference
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α2-Adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine
10.1111/j.1476-5381.1993.tb13488.x · 1993 · External reference
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Vinca alkaloids
2013 · External reference
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Remission induction therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of vincristine, corticosteroids, L-asparaginase and anthracyclines
10.1053/ctrv.2001.0243 · 2001 · External reference
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Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches
10.1016/j.jep.2013.04.044 · 2013 · External reference
Theobroma cacao L., the Food of the Gods: a scientific approach beyond myths and claims
10.1016/j.phrs.2009.08.008 · 2010 · External reference
Caffeine: cognitive and physical performance enhancer or psychoactive drug?
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Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
10.1016/0165-0173(92)90012-b · 1992 · External reference
Clinical pharmacology of caffeine
10.1146/annurev.me.41.020190.001425 · 1990 · External reference
Pilocarpus spp.: a survey of its chemical constituents and biological activities
10.1590/s1516-93322004000200002 · 2004 · External reference
Chemical and pharmacological aspects of capsaicin
10.3390/molecules16021253 · 2011 · External reference
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Choline metabolism provides novel insights into non-alcoholic fatty liver disease and its progression
10.1097/mog.0b013e32834e7b4b · 2012 · External reference
10.1016/j.jchromb.2010.12.012
10.1016/j.jchromb.2010.12.012 · 2011 · External reference
Unresolved reference
1993 · External reference
Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits
10.2478/v10102-010-0003-5 · 2010 · External reference
Pharmacokinetics of cytisine, an α4β2 nicotinic receptor partial agonist, in healthy smokers following a single dose
10.1002/dta.1707 · 2015 · External reference
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Analysis of scopolamine and its eighteen metabolites in rat urine by liquid chromatography-tandem mass spectrometry
10.1016/j.talanta.2005.04.026 · 2005 · External reference
Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of in vivo and in vitro metabolites of scopolamine in rats
10.1093/chromsci/46.1.74 · 2008 · External reference
Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration
10.1093/jat/30.8.501 · 2006 · External reference
Metabolism and elimination of quinine in healthy volunteers
10.1007/s00228-003-0637-8 · 2003 · External reference
Pharmacokinetics of quinidine and three of its metabolites in man
10.1007/bf01063608 · 1984 · External reference
In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes
10.1016/s0022-3565(24)38103-0 · 1999 · External reference
Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence
10.1089/jwh.1998.7.547 · 1998 · External reference
Chromatographic tandam mass spectrometric detection of papaverine and its major metabolites in rat urine
10.1016/j.ijms.2007.07.013 · 2007 · External reference
Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry
10.1124/dmd.106.011361 · 2006 · External reference
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Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs
10.1097/00003643-199705001-00003 · 1997 · External reference
Metabolites of ephedrines in human urine after administration of a single therapeutic dose
10.1016/j.forsciint.2005.04.008 · 2006 · External reference
Mass spectrometry-based metabolomics application to identify quantitative resistance-related metabolites in barley against Fusarium head blight
10.1111/j.1364-3703.2010.00643.x · 2010 · External reference
Studies on the metabolism of reserpine
10.1016/s0022-3565(25)11786-2 · 1956 · External reference
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Growth and hepatic in vitro metabolism of ergotamine in mice divergently selected for response to endophyte toxicity
10.1080/00498250500153838 · 2005 · External reference
Determination of yohimbine and its two hydroxylated metabolites in humans by high-performance liquid chromatography and mass spectral analysis
10.1016/0378-4347(92)80041-n · 1992 · External reference
Biopharmaceutics and metabolism of yohimbine in humans
10.1016/s0928-0987(99)00046-9 · 1999 · External reference
Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography
10.1007/bf00686174 · 1993 · External reference
Selective metabolism of vincristine in vitro by CYP3A5
10.1124/dmd.106.009902 · 2006 · External reference
Unresolved reference
2007 · External reference
Recent advances in caffeine and theobromine toxicities: a review
10.1023/a:1007976831684 · 1997 · External reference
Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis
10.1124/dmd.111.038141 · 2011 · External reference
In vitro hepatic and skin metabolism of capsaicin
10.1124/dmd.107.019240 · 2008 · External reference
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1960 · External reference
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2003 · External reference
Pyrrole, pyrrolidine, pyridine, piperidine and tropane alkaloids
10.1039/a707613d · 2000 · External reference
Biological activities of Withania somnifera
2010 · External reference
Unresolved reference
2003 · External reference
The effect of stachydrine alkaloid on the blood coagulation system
1971 · External reference
In vitro anticancer activity of stachydrine isolated from Capparis decidua on prostate cancer cell lines
10.1080/14786419.2011.608673 · 2012 · External reference
Allelochemical activities of pyrrolizidine alkaloids: interactions with neuroreceptors and acetylcholine related enzymes
10.1023/b:joec.0000006367.51215.88 · 1997 · External reference
Nicotine-like actions of arecoline
1945 · External reference
Arecoline, nicotine, and related compounds. Tremorgenic activity and effect upon brain acetylcholine
10.1111/j.1749-6632.1967.tb13719.x · 1967 · External reference
Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models
10.1016/j.neuint.2007.07.006 · 2008 · External reference
Arecoline inhibits the 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells
10.1016/j.jhazmat.2006.12.035 · 2007 · External reference
A review of the systemic adverse effects of areca nut or betel nut
10.4103/0971-5851.133702 · 2014 · External reference
Unresolved reference
2004 · External reference
Medicinal significance, pharmacological activities, and analytical aspects of ricinine: a concise report
10.12980/jclm.4.2016j6-96 · 2016 · External reference
Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis
10.1016/s0091-3057(99)00007-6 · 1999 · External reference
Ricinus communis Linn: a phytopharmacological review
2012 · External reference
Restorative aspect of castor plant on mammalian physiology: a review
2011 · External reference
Evaluation of ricinine, a ricin biomarker, from a non-lethal castor bean ingestion
10.1093/jat/bks077 · 2012 · External reference
Ricinine-elicited seizures: a novel chemical model of convulsive seizures
10.1016/s0091-3057(99)00250-6 · 2000 · External reference
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1989 · External reference
Fetal muscle-type nicotinic acetylcholine receptor activation in TE-671 cells and inhibition of fetal movement in a day 40 pregnant goat model by optical isomers of the piperidine alkaloid coniine
10.1124/jpet.112.199588 · 2013 · External reference
Pharmacological actions of hemlock (Conium maculatum) alkaloids
10.1111/j.2042-7158.1963.tb12738.x · 1963 · External reference
Poison hemlock (Conium maculatum L.)
10.1016/j.fct.2004.04.009 · 2004 · External reference
Action of lobeline and capsaicine on afferent endings in the pulmonary artery of the cat
10.1161/01.res.10.5.792 · 1962 · External reference
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2006 · External reference
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2010 · External reference
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2002 · External reference
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Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense
10.1016/0378-8741(84)90015-1 · 1984 · External reference
Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris
10.1002/jps.2600770522 · 1988 · External reference
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1998 · External reference
The biological activity of swainsonine: an indolizidine alkaloid isolated from Swainsona canescens
10.1016/0041-0101(83)90163-0 · 1983 · External reference
Analysis of swainsonine and its early metabolic precursors in cultures of Metarhizium anisopliae
10.1023/a:1018505130422 · 1997 · External reference
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Effect of strychnine on activity of motor and internuncial neurons of the spinal cord during stimulation of the anterior lobe of the cerebellum
10.1007/bf00784027 · 1963 · External reference
Action and mechanism of action of veratrine on renin secretion from rat kidney slices
10.1016/s0022-3565(25)21861-4 · 1984 · External reference
Veratrine-induced decrease of (Na++ K+)-adenosine triphosphatase activity in rat brain slices
10.1016/s0022-3565(25)23762-4 · 1989 · External reference
Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica
10.1016/s0378-8741(03)00224-1 · 2003 · External reference
Anti-inflammatory activity of alkaloids: an update from 2000 to 2010
10.3390/molecules16108515 · 2011 · External reference
Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents
10.3390/molecules19044395 · 2014 · External reference
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism
10.1016/j.jep.2005.12.021 · 2006 · External reference
Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis
10.5507/bp.2006.001 · 2006 · External reference
Biological activities of emetine
10.2174/1874848101104010008 · 2011 · External reference
Summary of NHG practice guideline 'Acute cough'
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Studies on plant resources, pharmacology and clinical treatment with berbamine
10.1002/ptr.2650050508 · 1991 · External reference
Berbamine derivatives: a novel class of compounds for anti-leukemia activity
10.1016/j.ejmech.2009.02.018 · 2009 · External reference
Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells
10.1038/aps.2009.167 · 2009 · External reference
Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts
10.1158/1535-7163.mct-10-0735 · 2011 · External reference
Amaryllidaceae isocarbostyril alkaloids and their derivatives as promising antitumor agents
10.1593/tlo.08100 · 2008 · External reference
Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis
10.1007/s10495-005-1896-x · 2005 · External reference
Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium
1996 · External reference
Stereoselective μ-and δ-opioid receptor-related antinociception and binding with (+)-thebaine
10.1016/s0014-2999(98)00862-0 · 1999 · External reference
Novel, unifying mechanism for mescaline in the central nervous system: electrochemistry, catechol redox metabolite, receptor, cell signaling and structure activity relationships
10.4161/oxim.2.4.9380 · 2009 · External reference
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The pharmacology of psilocybin
10.1080/1355621021000005937 · 2002 · External reference
The pharmacology of lysergic acid diethylamide: a review
10.1111/j.1755-5949.2008.00059.x · 2008 · External reference
Antinociceptive action of isolated mitragynine from Mitragyna speciosa through activation of opioid receptor system
10.3390/ijms130911427 · 2012 · External reference
Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities
10.4103/0974-8490.118806 · 2013 · External reference
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands
2002 · External reference
Antinociceptive effect of 7-hydroxymitragynine in mice: discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa
10.1016/j.lfs.2003.09.054 · 2004 · External reference
Chemical constituents antioxidant and anticholinesterasic activity of Tabernaemontana catharinensis
10.1155/2013/519858 · 2013 · External reference
Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A. DC in a human laryngeal epithelial carcinoma cell line (Hep-2)
10.1590/s1415-47572013005000010 · 2013 · External reference
Ibogaine: a review. The alkaloids:
2001 · External reference
A dose-response study of ibogaine-induced neuropathology in the rat cerebellum
10.1093/toxsci/57.1.95 · 2000 · External reference
The anti-addiction drug ibogaine and the heart: a delicate relation
10.3390/molecules20022208 · 2015 · External reference
Pharmacognosy and health benefits of cocoa seeds (chocolate)
2013 · External reference
Theobromine inhibits sensory nerve activation and cough
10.1096/fj.04-1990fje · 2005 · External reference
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DFT study and biological activity of some methylxanthines
2014 · External reference
Mode of antinociceptive and toxic action of alkaloids of Aconitum spec
10.1007/pl00005136 · 1997 · External reference
Biological and pharmacological properties of Aconitum chasmanthum
2003 · External reference
Unresolved reference
1999 · External reference
Kurchi alkaloids: their isolation, constitution & biological activity
1958 · External reference
Antibacterial activity of Holarrhena antidysenterica [Kurchi] against the enteric pathogens
2000 · External reference
Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL
2004 · External reference
A new family of H 3 receptor antagonists based on the natural product Conessine
10.1016/j.bmcl.2007.12.059 · 2008 · External reference
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1996 · External reference
Biological characterization of Cynara cardunculus L. methanolic extracts: antioxidant, anti-proliferative, anti-migratory and anti-angiogenic activities
10.3390/agriculture2040472 · 2012 · External reference
Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms
10.1016/j.taap.2015.03.004 · 2015 · External reference
Boldo and boldine: an emerging case of natural drug development
10.1016/1043-6618(94)80093-6 · 1994 · External reference
Advances in development of dopaminergic aporphinoids
10.1021/jm060959i · 2007 · External reference
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2008 · External reference
The stachydrine catabolism region in Sinorhizobium meliloti encodes a multi-enzyme complex similar to the xenobiotic degrading systems in other bacteria
10.1016/s0378-1119(99)00554-5 · 2000 · External reference
Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update
10.2174/138920007781368863 · 2007 · External reference
Metabolic profiling of pyrrolizidine alkaloids in foliage of two Echium spp. Invaders in Australia—a case of novel weapons?
10.3390/ijms161125979 · 2015 · External reference
A metabonomic analysis of serum from rats treated with ricinine using ultra performance liquid chromatography coupled with mass spectrometry
2014 · External reference
Oleander toxicity: an examination of human and animal toxic exposures
10.1016/0300-483x(95)03296-r · 1996 · External reference
Identification of metabolites of lobeline in the rat urine by liquid chromatography–tandem mass spectrometry
10.1016/j.ijms.2007.09.015 · 2008 · External reference
Simultaneous determination of sparteine and its 2-dehydro and 5-dehydro metabolites in urine by high-performance liquid chromatography with electrochemical detection
10.1016/s0378-4347(00)83822-0 · 1990 · External reference
Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans
10.1016/s0026-895x(25)10578-6 · 1995 · External reference
Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry
10.1002/rcm.4329 · 2009 · External reference
Swainsonine affects the processing of glycoproteins in vivo
10.1016/0014-5793(83)81174-0 · 1983 · External reference
Metabolism of strychnine in vitro
10.1016/s0090-9556(25)09218-9 · 1985 · External reference
Simultaneous analysis of strychnine and brucine and their major metabolites by liquid chromatography–electrospray ion trap mass spectrometry
10.1093/jat/bks004 · 2012 · External reference
Metabolism of brucine: the important metabolic pathways of dihydroindole-type alkaloid for excretion in rats
10.4155/bio.13.290 · 2014 · External reference
Metabolism of sanguinarine: the facts and the myths
10.2174/138920007779815959 · 2007 · External reference
Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities
10.1248/bpb.24.678 · 2001 · External reference
Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats
10.1007/bf03190402 · 2002 · External reference
Metabolic fate of noscapine. II. Isolation and identification of novel metabolites produced by C-C bond cleavage
10.3109/00498257909038719 · 1979 · External reference
Pharmacokinetics and metabolism of [3H] thebaine
10.3109/00498257409052087 · 1974 · External reference
Opioid metabolism
10.1016/s0025-6196(11)60750-7 · 2009 · External reference
Metabolic fate of mescaline in man
10.1007/bf00427703 · 1966 · External reference
Distribution, metabolism and excretion of bufotenine in the rat with preliminary studies of its O-methyl derivative
10.1016/s0022-3565(25)27800-4 · 1967 · External reference
Studies on the metabolism of mitragynine, the main alkaloid of the herbal drug Kratom, in rat and human urine using liquid chromatography-linear ion trap mass spectrometry
10.1002/jms.1607 · 2009 · External reference
Separation and identification of Aconitum alkaloids and their metabolites in human urine
10.1016/j.toxicon.2005.06.014 · 2005 · External reference
Identification and characterization of in vitro and in vivo metabolites of steroidal alkaloid veratramine
10.1002/bdd.1942 · 2015 · External reference
Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC–MS/MS
10.1016/j.jchromb.2013.07.009 · 2013 · External reference
Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes
2001 · External reference