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References from Uterine monocytes and macrophages: New insight into their pivotal homeostatic inflammatory role during reproductive life. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
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Tissue injury and repair in the female human reproductive tract
10.1530/rep.0.1250301 · 2003 · External reference
Unresolved reference
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10.1242/jcs.175943 · 2017 · External reference
The normal menstrual cycle in women
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Physiology of the menstrual cycle
10.1093/ajcn/28.4.333 · 1975 · External reference
Extent of endometrial shedding during normal menstruation
1965 · External reference
Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the global burden of disease study 2021
10.1016/s0140-6736(24)00550-6 · 2024 · External reference
Diagnosis and treatment of unexplained infertility
2008 · External reference
Unexplained infertility, the controversial matter in management of infertile couples
2015 · External reference
Immunologic insights in recurrent spontaneous abortion: molecular mechanisms and therapeutic interventions
10.1016/j.biopha.2024.117082 · 2024 · External reference
Decoding the endometrial niche of Asherman's syndrome at single-cell resolution
10.1038/s41467-023-41656-1 · 2023 · External reference
Immunomodulation for unexplained recurrent implantation failure: where are we now?
10.1530/rep-22-0150 · 2023 · External reference
The next frontier in ART: harnessing the uterine immune profile for improved performance
10.3390/ijms241411322 · 2023 · External reference
Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss
10.1016/s0140-6736(21)00682-6 · 2021 · External reference
Recurrent miscarriage: evidence to accelerate action
10.1016/s0140-6736(21)00681-4 · 2021 · External reference
Sporadic miscarriage: evidence to provide effective care
10.1016/s0140-6736(21)00683-8 · 2021 · External reference
Innate immunity in the human endometrium and ovary
10.1111/j.1600-0897.2011.01034.x · 2011 · External reference
Endometrial inflammation and effect on implantation improvement and pregnancy outcome
10.1530/rep-12-0217 · 2012 · External reference
The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend
10.1016/j.gde.2017.08.004 · 2017 · External reference
The immunological paradox of pregnancy: a reappraisal
10.1016/s0143-4004(03)00167-x · 2004 · External reference
Pregnancy-induced hyporesponsiveness to paternal alloantigens. II. Factors affecting altered expressions of immunity in parous rats
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Immunological tolerance
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Immunological tolerance
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Embryo implantation evolved from an ancestral inflammatory attachment reaction
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Implantation in eutherians: which came first, the inflammatory reaction or attachment?
2018 · External reference
Inflammation and implantation
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Reviewing the composition of vaginal microbiota: inclusion of nutrition and probiotic factors in the maintenance of Eubiosis
10.3390/nu12020419 · 2020 · External reference
Microbial diversity in the vaginal microbiota and its link to pregnancy outcomes
2023 · External reference
Towards a deeper understanding of the vaginal microbiota
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Inflammation and pregnancy: the role of the immune system at the implantation site
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The extracellular matrix and the immune system: a mutually dependent relationship
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1985 · External reference
Endometrial development and fertility
1963 · External reference
Biopsy studies of human endometrium: criteria of dating and information about amenorrhea, menorrhagia, and time of ovulation
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Uterine glands: development, function and experimental model systems
10.1093/molehr/gat031 · 2013 · External reference
What exactly is endometrial receptivity?
10.1016/j.fertnstert.2019.02.009 · 2019 · External reference
Immunohistochemical characterization of stromal leucocytes in nonpregnant human endometrium
10.1111/j.1600-0897.1988.tb00208.x · 1988 · External reference
Immunoregulatory cells in human decidua: morphology, immunohistochemistry and function
10.1051/rnd:19881006 · 1980 · External reference
The blood supply of the uterus. 2. Venous pattern
10.1111/j.1471-0528.1970.tb03593.x · 1970 · External reference
The immunocytochemical distribution of leukocytic subpopulations in human endometrium
1987 · External reference
Human uterine natural killer cells
1996 · External reference
Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle
10.1016/0198-8859(89)90060-8 · 1989 · External reference
Dating the endometrial biopsy
10.1016/s0002-9378(16)33500-1 · 1975 · External reference
Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells
10.1111/j.1600-0897.1999.tb00097.x · 1999 · External reference
Decidua in human implantation
10.1093/humrep/10.suppl_2.14 · 1995 · External reference
Leukocyte networks and human endometrial remodelling
10.1016/s0165-0378(02)00011-6 · 2002 · External reference
Variation during the menstrual cycle of immune cell populations in human endometrium
10.1016/0028-2243(91)90058-s · 1991 · External reference
Macrophage- and lymphocyte-subtypes in the endometrium during different phases of the ovarian cycle
10.1016/0020-7292(92)90974-n · 1992 · External reference
Structural changes in endometrial basal glands during menstruation
10.1111/j.1471-0528.2010.02630.x · 2010 · External reference
The importance of the macrophage within the human endometrium
10.1189/jlb.0712327 · 2013 · External reference
Unresolved reference
2026 · External reference
Decidualization of the human endometrium
10.1002/rmb2.12088 · 2018 · External reference
Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization
10.1387/ijdb.130344ts · 2014 · External reference
Uterine glands: developmental biology and functional roles in pregnancy
10.1210/er.2018-00281 · 2019 · External reference
The hormonal control of endometrial receptivity: estrogen (E2) and progesterone
10.1016/s0165-0378(98)00019-9 · 1998 · External reference
The implantation window
10.1016/s0950-3552(05)80092-6 · 1992 · External reference
How do pre-pregnancy endometrial macrophages contribute to pregnancy?
10.1016/j.jri.2022.103736 · 2022 · External reference
Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice
10.1095/biolreprod60.2.251 · 1999 · External reference
Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions
10.1093/molehr/gau034 · 2014 · External reference
Cyclical endometrial repair and regeneration
10.1242/dev.199577 · 2021 · External reference
Menstrual physiology: implications for endometrial pathology and beyond
10.1093/humupd/dmv038 · 2015 · External reference
Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model
10.1038/s41598-017-17565-x · 2017 · External reference
Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/beta-catenin signaling pathway
2024 · External reference
Site and menstrual cycle-dependent expression of proteins of the tumour necrosis factor (TNF) receptor family, and BCL-2 oncoprotein and phase-specific production of TNF alpha in human endometrium
10.1093/oxfordjournals.humrep.a135928 · 1995 · External reference
Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis
10.1111/j.1749-6632.2002.tb02766.x · 2002 · External reference
The dual roles of uterine monocytes in regulation of tissue homeostasis throughout reproductive cycles in health and disease
10.1038/s41590-026-02651-y · 2026 · External reference
Atrophy and apoptosis in the cyclical human endometrium
10.1002/path.1711190305 · 1976 · External reference
Fate mapping via Ms4a3-expression history traces monocyte-derived cells
10.1016/j.cell.2019.08.009 · 2019 · External reference
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
10.1016/j.immuni.2012.12.001 · 2013 · External reference
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
10.1038/ni.2967 · 2014 · External reference
Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors
10.1038/mi.2012.89 · 2013 · External reference
TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection
10.15252/embr.201540473 · 2015 · External reference
Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues
10.1038/s41556-022-00961-5 · 2022 · External reference
Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis
2021 · External reference
Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties
10.3389/fimmu.2024.1364036 · 2024 · External reference
An integrated single-cell reference atlas of the human endometrium
10.1038/s41588-024-01873-w · 2024 · External reference
CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo
10.1189/jlb.3hi1114-531r · 2015 · External reference
Macrophages inhibit and enhance endometriosis depending on their origin
10.1073/pnas.2013776118 · 2021 · External reference
Immunolocalization of the matrix metalloproteinases gelatinase B and stromelysin 1 in human endometrium throughout the menstrual cycle
10.1530/jrf.0.1070043 · 1996 · External reference
Endometrial leukocytes and menstruation
10.1093/humupd/6.1.16 · 2000 · External reference
Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in hepatocellular carcinoma
10.1016/j.cell.2020.08.040 · 2020 · External reference
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
10.1126/science.aau0964 · 2019 · External reference
Folate receptor beta (FRbeta) expression in tissue-resident and tumor-associated macrophages associates with and depends on the expression of PU.1
10.3390/cells9061445 · 2020 · External reference
The presence and regulation of connective tissue growth factor in the human endometrium
10.1093/humrep/der476 · 2012 · External reference
Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal/mild endometriosis
10.1093/cei/uxad029 · 2023 · External reference
Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by integrin-dependent cell adhesion
10.1095/biolreprod61.2.548 · 1999 · External reference
Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway
10.1016/j.fertnstert.2011.12.049 · 2012 · External reference
Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation
10.1210/jc.2004-0507 · 2004 · External reference
Cytokine control in human endometrium
10.1530/rep.0.1210003 · 2001 · External reference
Responsiveness of human endometrial stromal cells to cytokines
10.1111/j.1749-6632.1991.tb37854.x · 1991 · External reference
The CCL17-CCR4 axis between endometrial stromal cells and macrophages contributes to the high levels of IL-6 in ectopic milieu
10.1111/aji.12644 · 2017 · External reference
Regulation of monocyte chemotactic protein-1 expression in human endometrial endothelial cells by sex steroids: a potential mechanism for leukocyte recruitment in endometriosis
10.1177/1933719109352380 · 2010 · External reference
More than just attractive: how CCL2 influences myeloid cell behavior beyond chemotaxis
10.3389/fimmu.2019.02759 · 2019 · External reference
Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2
10.1093/humrep/dev067 · 2015 · External reference
Self-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge
10.1038/srep44270 · 2017 · External reference
The expression, activity and regulation of granulocyte macrophage-colony stimulating factor in human endometrial epithelial and stromal cells
10.1093/molehr/5.5.459 · 1999 · External reference
Epithelial cells are the major source of biologically active granulocyte macrophage colony-stimulating factor in human endometrium
10.1093/oxfordjournals.humrep.a135899 · 1995 · External reference
Uterine epithelial cells synthesize granulocyte-macrophage colony-stimulating factor and interleukin-6 in pregnant and nonpregnant mice
10.1095/biolreprod46.6.1069 · 1992 · External reference
Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor
10.1182/blood.v71.4.997.997 · 1988 · External reference
Endometrial leucocytes: expression of steroid hormone receptors
10.1136/jcp.51.2.121 · 1998 · External reference
Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors
10.1111/j.1365-2567.2008.02820.x · 2008 · External reference
Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERalpha36 and GPR30/GPER1
10.1189/jlb.3a0914-430rr · 2016 · External reference
Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages
10.1371/journal.pone.0005539 · 2009 · External reference
Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle
10.1093/humrep/den298 · 2008 · External reference
Endometriosis-associated macrophages: origin, phenotype, and function
10.3389/fendo.2020.00007 · 2020 · External reference
Estrogen and progesterone receptor expression in macrophages and regulation of hepatocyte growth factor by ovarian steroids in women with endometriosis
10.1093/humrep/deh897 · 2005 · External reference
Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells
10.1210/endo.140.10.7070 · 1999 · External reference
Androgens, oestrogens and endometrium: a fine balance between perfection and pathology
10.1530/joe-20-0106 · 2020 · External reference
Uterine epithelial estrogen receptor-alpha controls Decidualization via a paracrine mechanism
10.1210/me.2015-1142 · 2015 · External reference
TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-kappaB signal pathways
2014 · External reference
Decidualized human endometrial stromal cells are sensors of hormone withdrawal in the menstrual inflammatory cascade
10.1095/biolreprod.113.108175 · 2014 · External reference
The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-beta
10.1530/rep-17-0342 · 2017 · External reference
Single-cell sequencing uncovers disrupted stromal-macrophage communication as a driver of intrauterine adhesion progression
10.1038/s42003-025-08634-3 · 2025 · External reference
Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells induces macrophage tolerance through interleukin-33 in the progression of endometriosis
2014 · External reference
Reciprocal communication between endometrial stromal cells and macrophages
10.1177/1933719110371854 · 2010 · External reference
Inflammation influences steroid hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis
10.1016/j.jri.2016.06.004 · 2016 · External reference
Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs
10.1111/j.1600-0897.2008.00661.x · 2009 · External reference
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
10.1182/blood-2006-10-052977 · 2007 · External reference
NK cells control HIV-1 infection of macrophages through soluble factors and cellular contacts in the human decidua
10.1186/s12977-016-0271-z · 2016 · External reference
Decidual NK cells transfer Granulysin to selectively kill Bacteria in trophoblasts
10.1016/j.cell.2020.07.019 · 2020 · External reference
CD4(+)T and CD8(+)T cells in uterus exhibit both selective dysfunction and residency signatures
10.1155/2024/5582151 · 2024 · External reference
Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology
10.1126/science.aaa6566 · 2015 · External reference
Innate lymphoid cells: 10 years on
10.1016/j.cell.2018.07.017 · 2018 · External reference
Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity
10.1016/j.immuni.2017.01.008 · 2017 · External reference
GM-CSF calibrates macrophage defense and wound healing programs during intestinal infection and inflammation
10.1016/j.celrep.2020.107857 · 2020 · External reference
Composition, development, and function of uterine innate lymphoid cells
10.4049/jimmunol.1500689 · 2015 · External reference
Dynamic roles of ILC3 in endometrial repair and regeneration
10.1093/discim/kyaf004 · 2025 · External reference
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
10.1016/j.immuni.2008.02.017 · 2008 · External reference
Integrin alphavbeta8-mediated TGF-beta activation by effector regulatory T cells is essential for suppression of T-cell-mediated inflammation
10.1016/j.immuni.2015.04.012 · 2015 · External reference
Alternative activation of macrophages
10.1038/nri978 · 2003 · External reference
Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
10.1038/s42003-021-02018-z · 2021 · External reference
IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage
10.1073/pnas.1621253114 · 2017 · External reference
Differential expression of interleukins (IL) IL-13 and IL-15 throughout the menstrual cycle in endometrium of normal fertile women and women with recurrent spontaneous abortion
10.1016/s0165-0378(02)00043-8 · 2002 · External reference
Differential expression of interleukins (IL)-13 and IL-15 in ectopic and eutopic endometrium of women with endometriosis and normal fertile women
10.1034/j.1600-0897.2003.00028.x · 2003 · External reference
ILC2s govern imprinting of alveolar macrophage-mediated immune responses upon secondary helminth infection in the lung
10.1016/j.mucimm.2026.100367 · 2026 · External reference
Innate immune crosstalk in asthmatic airways: innate lymphoid cells coordinate polarization of lung macrophages
10.1016/j.jaci.2018.10.040 · 2019 · External reference
PD-1 affects the immunosuppressive function of group 2 innate lymphoid cells in human non-small cell lung Cancer
10.3389/fimmu.2021.680055 · 2021 · External reference
Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis
10.1093/humrep/16.9.1802 · 2001 · External reference
Monocyte-mediated enhancement of endometrial cell proliferation in women with endometriosis
10.1016/s0015-0282(16)56456-5 · 1994 · External reference
Macrophages: master regulators of inflammation and fibrosis
10.1055/s-0030-1255354 · 2010 · External reference
A comprehensive review of Asherman's syndrome: causes, symptoms and treatment options
10.1097/gco.0000000000000378 · 2017 · External reference
Asherman syndrome--one century later
10.1016/j.fertnstert.2008.02.096 · 2008 · External reference
Review of intrauterine adhesions
10.1016/j.jmig.2010.04.016 · 2010 · External reference
IL-4-induced M2 macrophages inhibit fibrosis of endometrial stromal cells
10.1016/j.repbio.2023.100852 · 2024 · External reference
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10.3109/00016347709162009 · 1977 · External reference
The role of macrophages in reproductive-related diseases
10.1016/j.heliyon.2022.e11686 · 2022 · External reference
M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions
10.1016/j.jfma.2017.03.011 · 2018 · External reference
The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy
10.1093/humrep/dey347 · 2019 · External reference
Decidual IDO(+) macrophage promotes the proliferation and restricts the apoptosis of trophoblasts
10.1016/j.jri.2021.103364 · 2021 · External reference
Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage
10.1093/molehr/gau008 · 2014 · External reference
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage
10.1093/molehr/gaaa035 · 2020 · External reference
PPARgamma expression is diminished in macrophages of recurrent miscarriage placentas
10.3390/ijms19071872 · 2018 · External reference
Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss
10.1016/j.jri.2021.103324 · 2021 · External reference
Reply of the authors: recurrent implantation failure: reality or a statistical mirage?
10.1016/j.fertnstert.2023.04.012 · 2023 · External reference
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis
10.1093/humupd/dmad010 · 2023 · External reference
Chemokine (C-C motif) ligand-2 (CCL2) and oxidative stress markers in recurrent pregnancy loss and repeated implantation failure
10.1007/s10815-017-0992-5 · 2017 · External reference
The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure I: techniques
10.1016/j.jri.2011.03.013 · 2011 · External reference
Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients
10.1093/humrep/deac118 · 2022 · External reference
Impact of endometrial scratching on reproductive outcome in patients: a systematic review and meta-analysis
10.1097/md.0000000000030150 · 2022 · External reference
Intrauterine administration of autologous peripheral blood mononuclear cells promotes implantation rates in patients with repeated failure of IVF-embryo transfer
10.1093/humrep/del312 · 2006 · External reference
Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure
10.1016/j.jri.2016.11.006 · 2017 · External reference
Intrauterine administration of autologous hCG- activated peripheral blood mononuclear cells improves pregnancy outcomes in patients with recurrent implantation failure; a double-blind, randomized control trial study
10.1016/j.jri.2020.103182 · 2020 · External reference
Intrauterine administration of autologous peripheral blood mononuclear cells increases clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure
10.1016/j.jri.2011.07.001 · 2011 · External reference
Intrauterine CRH-treated PBMC in repeated implantation failure
10.1111/eci.13084 · 2019 · External reference
Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures
10.1017/s0967199414000719 · 2016 · External reference
Repeated implantation failure: a new potential treatment option
10.1111/eci.12417 · 2015 · External reference
Endometrium immunomodulation by intrauterine insemination administration of treated peripheral blood mononuclear cell prior frozen/thawed embryos in patients with repeated implantation failure
10.1017/s0967199419000145 · 2019 · External reference
Human peripheral blood mononuclear cells (PBMC) in early pregnancy promote embryo invasion in vitro: HCG enhances the effects of PBMC
10.1093/humrep/17.1.207 · 2002 · External reference