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References from Kinetics of local C3 production orchestrates neutrophil recruitment in lung injury. Local targets link to admitted publications; unresolved targets remain external evidence.
The stromal intervention: regulation of immunity and inflammation at the epithelial-mesenchymal barrier
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Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report
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The integrated pulmonary immune response to pneumonia
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Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense
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Regulation of immune responses by the airway epithelial cell landscape
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Recognition of microorganisms and activation of the immune response
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Diapedesis-induced integrin signaling via LFA-1 facilitates tissue immunity by inducing intrinsic complement C3 expression in immune cells
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A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins
10.1038/s41385-022-00534-7 · 2022 · External reference
Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury
10.1126/sciimmunol.abp9547 · 2023 · External reference
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
10.1016/j.cell.2023.04.031 · 2023 · External reference
Gut complement induced by the microbiota combats pathogens and spares commensals
10.1016/j.cell.2023.12.036 · 2024 · External reference
The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure
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Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia
10.1165/rcmb.2002-0145oc · 2003 · External reference
The alternative activation pathway and complement component C3 are critical for a protective immune response against Pseudomonas aeruginosa in a murine model of pneumonia
10.1128/iai.72.5.2899-2906.2004 · 2004 · External reference
Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza a(H1N1) 2009 virus infection
10.1371/journal.ppat.1006248 · 2017 · External reference
Emerging roles of the complement system in host-pathogen interactions
10.1016/j.tim.2021.09.002 · 2022 · External reference
Local complement activation and modulation in mucosal immunity
10.1016/j.mucimm.2024.05.006 · 2024 · External reference
Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes
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Patrolling alveolar macrophages conceal Bacteria from the immune system to maintain homeostasis
10.1016/j.cell.2020.08.020 · 2020 · External reference
Complement levels and activity in the normal and LPS-injured lung
10.1152/ajplung.00127.2006 · 2007 · External reference
Serum complement after orthotopic transplantation of the human liver
1972 · External reference
Intracellular C3 protects human airway epithelial cells from stress-associated cell death
10.1165/rcmb.2017-0405oc · 2019 · External reference
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm
10.1161/circulationaha.108.832972 · 2009 · External reference
Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
10.1073/pnas.0907996106 · 2009 · External reference
Diverse novel functions of neutrophils in immunity, inflammation, and beyond
10.1084/jem.20122220 · 2013 · External reference
More friend than foe: the emerging role of neutrophils in tissue repair
10.1172/jci124616 · 2019 · External reference
Leukocyte migration into inflamed tissues
10.1016/j.immuni.2014.10.008 · 2014 · External reference
Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation
10.1016/j.chom.2021.04.004 · 2021 · External reference
Distinct gene expression signatures comparing latent tuberculosis infection with different routes of Bacillus Calmette-Guérin vaccination
10.1038/s41467-023-44136-8 · 2023 · External reference
A C3(H2O) recycling pathway is a component of the intracellular complement system
10.1172/jci89412 · 2017 · External reference
Development and optimization of an ELISA to quantitate C3(H2O) as a marker of human disease
10.3389/fimmu.2019.00703 · 2019 · External reference
Assessment of the role of C3(H2O) in the alternative pathway
10.3389/fimmu.2020.00530 · 2020 · External reference
Kallikrein cleaves C3 and activates complement
10.1159/000484257 · 2018 · External reference
Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease
10.1007/s00441-017-2753-2 · 2018 · External reference
Neutrophils enhance their own influx to sites of bacterial infection via endosomal TLR-dependent Cxcl2 production
10.4049/jimmunol.1901039 · 2020 · External reference
C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion
10.4049/jimmunol.178.3.1819 · 2007 · External reference
Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling
10.1073/pnas.1213797109 · 2012 · External reference
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis
10.1007/978-1-4614-0106-3_9 · 2012 · External reference
Intracellular complement: Evidence, definitions, controversies, and solutions
10.1111/imr.13135 · 2023 · External reference
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2
10.1126/sciimmunol.aba7350 · 2020 · External reference
Role of apoptosis in Pseudomonas aeruginosa pneumonia
10.1126/science.294.5548.1783a · 2001 · External reference
FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa
10.1084/jem.20102041 · 2011 · External reference
Therapeutic effects of high molecular weight hyaluronic acid in severe Pseudomonas aeruginosa pneumonia in ex vivo perfused human lungs
10.1152/ajplung.00626.2020 · 2021 · External reference
Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice
10.1128/iai.70.9.5322-5327.2002 · 2002 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics
10.1038/s41596-024-01045-4 · 2025 · External reference
