Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Mechanisms of CD4+T tolerance to a corneal epithelial neoantigen. Local targets link to admitted publications; unresolved targets remain external evidence.
Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface
10.1016/j.celrep.2022.110852 · 2022 · External reference
Redefining the human corneal immune compartment using dynamic intravital imaging
10.1073/pnas.2217795120 · 2023 · External reference
Single cell analysis of short-term dry eye induced changes in cornea immune cell populations
2024 · External reference
CLEAR - anatomy and physiology of the anterior eye
10.1016/j.clae.2021.02.009 · 2021 · External reference
Mucosal immune tolerance at the ocular surface in health and disease
10.1111/imm.12716 · 2017 · External reference
TFOS DEWS II definition and classification report
10.1016/j.jtos.2017.05.008 · 2017 · External reference
TFOS DEWS II epidemiology report
10.1016/j.jtos.2017.05.003 · 2017 · External reference
Desiccating stress induces T cell-mediated Sjogren’s syndrome-like lacrimal keratoconjunctivitis
10.4049/jimmunol.176.7.3950 · 2006 · External reference
Chronic dry eye disease is principally mediated by effector memory Th17 cells
10.1038/mi.2013.20 · 2014 · External reference
CD4(+) T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model
10.1073/pnas.2407648121 · 2024 · External reference
Intravital imaging of the human cornea reveals the differential effects of season on innate and adaptive immune cell Morphodynamics
10.1016/j.ophtha.2024.04.020 · 2024 · External reference
When clarity is crucial: regulating ocular surface immunity
10.1016/j.it.2017.11.007 · 2017 · External reference
Conjunctival T-cell subpopulations in Sjogren’s and non-Sjogren’s patients with dry eye
2002 · External reference
TFOS DEWS II pathophysiology report
10.1016/j.jtos.2017.05.011 · 2017 · External reference
Defining dry eye from a clinical perspective
10.3390/ijms21239271 · 2020 · External reference
Immunological mechanisms of tolerance: central, peripheral and the role of T and B cells
10.5415/apallergy.0000000000000128 · 2023 · External reference
Breakdown of T-cell ignorance: the tolerance failure responsible for mainstream autoimmune diseases?
10.1016/j.jtauto.2020.100070 · 2020 · External reference
Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells
10.1186/s13059-016-1079-9 · 2016 · External reference
CD4+ T cell tolerance to tissue-restricted self antigens is mediated by antigen-specific regulatory T cells rather than deletion
10.1016/j.immuni.2015.10.011 · 2015 · External reference
Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns
10.1038/ni.3327 · 2016 · External reference
Age-related changes in ocular mucosal tolerance: lessons learned from gut and respiratory tract immunity
10.1111/imm.13338 · 2021 · External reference
Cellular and molecular mechanisms of anterior chamber-associated immune deviation (ACAID): what we have learned from knockout mice
10.3389/fimmu.2017.01686 · 2017 · External reference
Ocular immune privilege and transplantation
10.3389/fimmu.2016.00037 · 2016 · External reference
Immune regulation of the ocular surface
10.1016/j.exer.2022.109007 · 2022 · External reference
Immune privilege in corneal transplantation
10.1016/j.preteyeres.2019.04.002 · 2019 · External reference
Restoring conjunctival tolerance by topical nuclear factor-kappaB inhibitors reduces preservative-facilitated allergic conjunctivitis in mice
10.1167/iovs.14-14075 · 2014 · External reference
Sjögren disease, not Sjögren's: comment on the article by Baer and Hammitt
10.1002/art.41952 · 2022 · External reference
Deregulation of the kallikrein protease family in the salivary glands of the Sjögren’s syndrome ERdj5 knockout mouse model
10.3389/fimmu.2021.693911 · 2021 · External reference
Transient tear hyperosmolarity disrupts the neuroimmune homeostasis of the ocular surface and facilitates dry eye onset
10.1111/imm.13243 · 2020 · External reference
Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye
10.1016/j.exer.2016.07.004 · 2016 · External reference
Flow-cytometric analysis of rare antigen-specific T cells
10.1002/cyto.a.22317 · 2013 · External reference
Unresolved reference
External reference
CpG-ODN facilitates effective intratracheal immunization and recall of memory against neoantigen-expressing alveolar cells
10.3389/fimmu.2017.01201 · 2017 · External reference
An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells
10.1371/journal.pone.0068720 · 2013 · External reference
Characterization of tetracycline-inducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice
10.1167/iovs.04-1464 · 2005 · External reference
Cornea-specific expression of K12 keratin during mouse development
10.3109/02713689309029222 · 1993 · External reference
Keratin 12-deficient mice have fragile corneal epithelia
1996 · External reference
Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces
10.1167/iovs.06-0574 · 2006 · External reference
An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy
10.1186/s12974-023-02800-2 · 2023 · External reference
Cathepsin S is a novel target for age-related dry eye
10.1016/j.exer.2021.108895 · 2022 · External reference
Aging and dry eye alter corneal sensitivity to mechanical and chemical stimulation
2025 · External reference
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells
10.1038/s41385-018-0127-z · 2019 · External reference
Modulation of oxidative stress and inflammation in the aged lacrimal gland
10.1016/j.ajpath.2020.10.013 · 2021 · External reference
Unveiling the power of high-dimensional cytometry data with cyCONDOR
10.1038/s41467-024-55179-w · 2024 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Goblet cells contribute to ocular surface immune tolerance-implications for dry eye disease
10.3390/ijms18050978 · 2017 · External reference
Goblet cell loss abrogates ocular surface immune tolerance
10.1172/jci.insight.98222 · 2018 · External reference
Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection
10.1046/j.1600-6135.2003.00246.x · 2003 · External reference
Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report
10.1111/imm.13153 · 2020 · External reference
The melting pot of the MHC II peptidome
10.1016/j.coi.2016.03.004 · 2016 · External reference
New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease
2022 · External reference
Effects of cathepsin S inhibition in the age-related dry eye phenotype
10.1167/iovs.64.11.7 · 2023 · External reference
Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline
10.1167/iovs.05-1281 · 2006 · External reference
Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice
10.1016/j.exer.2018.01.024 · 2018 · External reference
Age-related differences in the mouse corneal epithelial transcriptome and their impact on corneal wound healing
10.1167/iovs.65.5.21 · 2024 · External reference
Ocular surface disease and dacryoadenitis in aging C57BL/6 mice
10.1016/j.ajpath.2013.11.019 · 2014 · External reference
IFN-gamma-expressing Th17 cells are required for development of severe ocular surface autoimmunity
10.4049/jimmunol.1602144 · 2017 · External reference
Transient receptor potential vanilloid-1 channels facilitate axonal degeneration of corneal sensory nerves in dry eye
10.1016/j.ajpath.2024.01.015 · 2024 · External reference
A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy
10.1038/s12276-026-01653-y · 2026 · External reference
Conversion of anergic T cells into Foxp3(−) IL-10(+) regulatory T cells by a second antigen stimulus in vivo
10.3389/fimmu.2021.704578 · 2021 · External reference
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression
10.4049/jimmunol.182.3.1247 · 2009 · External reference
Characterization of effector T cells in dry eye disease
10.1167/iovs.08-2417 · 2009 · External reference
Correlation of transferrin receptor (CD71) with Ki67 expression on stimulated human and mouse T cells: the kinetics of expression of T cell activation markers
10.1016/j.jim.2016.08.002 · 2016 · External reference
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus
10.1126/sciimmunol.abq0178 · 2023 · External reference
Antigen-driven EGR2 expression is required for exhausted CD8(+) T cell stability and maintenance
10.1038/s41467-021-23044-9 · 2021 · External reference
CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors
10.1038/ni.3331 · 2016 · External reference
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells
10.4049/jimmunol.1101311 · 2012 · External reference
The endogenous antigen-specific CD8(+) T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments
10.1016/j.immuni.2025.02.001 · 2025 · External reference
Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response
10.4049/jimmunol.178.1.539 · 2007 · External reference
Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site
10.1016/j.immuni.2015.07.014 · 2015 · External reference
Immunology in corneal transplantation-from homeostasis to graft rejection
10.1016/j.trre.2025.100909 · 2025 · External reference
Immunology of corneal allografts: insights from animal models
10.4172/2155-9570.1000429 · 2015 · External reference
Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
10.1073/pnas.1120607109 · 2012 · External reference
Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model
10.1038/mi.2012.44 · 2013 · External reference
Immune privilege of corneal allografts
10.3109/09273948.2010.486100 · 2010 · External reference
The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking
2007 · External reference
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
10.1084/jem.20042307 · 2005 · External reference
Tuning microenvironments: induction of regulatory T cells by dendritic cells
10.1016/j.immuni.2008.08.005 · 2008 · External reference
Mechanisms maintaining peripheral tolerance
2010 · External reference
Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg
10.1002/eji.200839073 · 2009 · External reference
CAR T(reg) cells mediate linked suppression and infectious tolerance in islet transplantation in mice
10.1126/scitranslmed.adp6519 · 2025 · External reference
Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity
10.1016/j.ebiom.2021.103496 · 2021 · External reference
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren’s syndrome-like keratoconjunctivitis sicca in CD25KO mice
10.1093/rheumatology/kep357 · 2010 · External reference
Spontaneous autoimmune dacryoadenitis in aged CD25KO mice
10.2353/ajpath.2010.091116 · 2010 · External reference
The mucosal surfaces of both eyes are immunologically linked by a neurogenic inflammatory reflex involving TRPV1 and substance P
10.1038/s41385-018-0040-5 · 2018 · External reference
