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References from Precise modulation of pathological networks in myocardial ischemia-reperfusion injury: Advances in multi-target nanomedicine strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Therapeutic peptides to treat myocardial ischemia-reperfusion injury
10.3389/fcvm.2022.792885 · 2022 · External reference
Myocardial ischemia-reperfusion injury; molecular mechanisms and prevention
10.1016/j.mvr.2023.104565 · 2023 · External reference
Molecular and cellular mechanisms of cardioplegic protection in surgical myocardial revascularization
10.3390/cells15020173 · 2026 · External reference
Molecular and cellular mechanisms of myocardial ischemia and reperfusion injury: a narrative review
10.3390/cells15030265 · 2026 · External reference
Mitochondrial redox regulation and myocardial ischemia-reperfusion injury
2022 · External reference
Resorcimoline protects against myocardial ischemia-reperfusion injury via suppression of oxidative stress
10.1253/circj.cj-25-0926 · 2026 · External reference
Effect of inhibition of Na+/Ca2+ exchanger at the time of myocardial reperfusion on hypercontracture and cell death
10.1016/s0008-6363(02)00461-3 · 2002 · External reference
Levistolide a alleviates myocardial ischemia-reperfusion injury partly by improving calcium homeostasis via the ADORA2B/cAMP/PKA/PLB/SERCA2α signaling axis
10.3390/cimb48020125 · 2026 · External reference
Calpain: the regulatory point of myocardial ischemia-reperfusion injury
2023 · External reference
Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury
10.1096/fj.202301040rr · 2024 · External reference
Dantrolene induces mitigation of myocardial ischemia-reperfusion injury by ryanodine receptor inhibition
10.1053/j.semtcvs.2021.01.004 · 2022 · External reference
2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway
10.1038/s41598-025-14822-2 · 2025 · External reference
The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis
10.1016/j.gene.2013.05.041 · 2013 · External reference
Inflammation in myocardial ischemia/reperfusion injury: underlying mechanisms and therapeutic potential
2023 · External reference
Myeloid cells in myocardial ischemic injury: the role of the macrophage migration inhibitory factor
2024 · External reference
Ozone protects from myocardial ischemia-reperfusion injury via inhibition of the NLRP3 inflammasome
10.1016/j.ejphar.2025.177631 · 2025 · External reference
Macrophage polarization in myocardial ischemia–reperfusion injury: pathophysiology and therapeutic targets
10.2147/dddt.s516001 · 2025 · External reference
Regulated cell death in myocardial ischemia-reperfusion injury
10.1016/j.tem.2023.10.010 · 2024 · External reference
Targeting programmed cell death in myocardial ischemia-reperfusion injury: potential mechanisms and natural medicine treatments
10.1002/ptr.70269 · 2026 · External reference
Iguratimod alleviates myocardial ischemia/reperfusion injury through inhibiting inflammatory response induced by cardiac fibroblast Pyroptosis via COX2/NLRP3 signaling pathway
2021 · External reference
PIM3 regulates myocardial ischemia/reperfusion injury via ferroptosis
10.1007/s13258-023-01475-6 · 2024 · External reference
Carnosic acid protects against mitochondrial dysfunction and ferroptosis in myocardial ischemia/reperfusion injury through mediating Mfn2
10.1016/j.ejphar.2026.178690 · 2026 · External reference
Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis
10.1016/j.redox.2024.103471 · 2025 · External reference
The myocardial ischemic cascade network and multi-target synergistic interventions: from molecular mechanisms to therapeutic innovations
10.1016/j.bcp.2026.117704 · 2026 · External reference
Myocardial ischemia-reperfusion injury-mechanistic insights and novel therapeutics
10.3390/ijms27052106 · 2026 · External reference
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective
10.1080/10717544.2023.2298514 · 2024 · External reference
Nanodrug targeting for myocardial ischemia-reperfusion injury: mechanisms, therapeutic strategies, and challenges in clinical translation
10.1016/j.ijpharm.2025.126153 · 2025 · External reference
Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury
10.1016/j.jconrel.2022.11.057 · 2023 · External reference
CIRKIL exacerbates cardiac ischemia/reperfusion injury by interacting with Ku70
10.1161/circresaha.121.318992 · 2022 · External reference
Ubiquitin-specific protease 11 aggravates ischemia-reperfusion-induced cardiomyocyte Pyroptosis and injury by promoting TRAF3 Deubiquitination
10.4274/balkanmedj.galenos.2023.2022-12-15 · 2023 · External reference
SerpinA3 promotes myocardial infarction in rat and cell-based models
10.1007/s12033-023-00982-x · 2025 · External reference
Luteolin modulates SERCA2a via Sp1 upregulation to attenuate myocardial ischemia/reperfusion injury in mice
10.1038/s41598-020-72325-8 · 2020 · External reference
Mitochondrial disorder and treatment of ischemic cardiomyopathy: potential and advantages of Chinese herbal medicine
10.1016/j.biopha.2022.114171 · 2023 · External reference
TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia/reperfusion injury
10.1016/j.metabol.2022.155239 · 2022 · External reference
Cellular mechanisms and pathways in myocardial reperfusion injury
10.1097/mca.0000000000000997 · 2021 · External reference
The roles of neutrophils in cardiovascular diseases
10.3389/fcvm.2025.1526170 · 2025 · External reference
SOX4 promotes Ferroptosis to aggravate myocardial ischemia/reperfusion injury through elevating DAPK1 expression
10.1007/s12012-025-10072-w · 2025 · External reference
Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target
10.1186/s43556-026-00420-9 · 2026 · External reference
CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly
10.1007/s00395-020-0790-6 · 2020 · External reference
Suppression of OTUD4 protects against myocardial ischemia-reperfusion injury by increasing autophagic flux and inhibiting apoptosis in cardiomyocytes
10.1007/s00109-025-02605-1 · 2025 · External reference
Shionone attenuates endoplasmic reticulum stress-associated ferroptosis in cardiomyocytes by reducing LCN2 and regulating PI3K/Akt signaling
10.1007/s10863-026-10092-3 · 2026 · External reference
Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: involvement of redox signalling
10.1016/j.freeradbiomed.2021.04.034 · 2021 · External reference
Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT
10.1186/s12929-023-00927-1 · 2023 · External reference
Non-coding RNAs modulate pyroptosis in myocardial ischemia-reperfusion injury: a comprehensive review
2024 · External reference
Different types of cell death and their interactions in myocardial ischemia-reperfusion injury
10.1038/s41420-025-02372-5 · 2025 · External reference
Role of dysregulated ferroptosis-related genes in cardiomyocyte ischemia-reperfusion injury: experimental verification and bioinformatics analysis
10.3892/etm.2023.12233 · 2023 · External reference
Spatial metabolomics reveals GLA-mediated imbalance of Gal2Cer/GalCer as a therapeutic target in myocardial ischemia-reperfusion injury
10.1096/fj.202502961rr · 2026 · External reference
Spatial multiplexed protein profiling of cardiac ischemia-reperfusion injury
10.1161/circresaha.123.322620 · 2023 · External reference
Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo
10.1007/s00395-012-0270-8 · 2012 · External reference
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis
10.1038/nm.4017 · 2016 · External reference
The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression
10.1038/s41418-021-00872-2 · 2022 · External reference
Multi-stage cooperative ROS-responsive hydrogel platform for drug delivery in myocardial ischemia-reperfusion injury repair
2025 · External reference
Thrombus-specific/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia/reperfusion injury
10.1186/s12951-022-01686-1 · 2022 · External reference
Lipid-based nanoparticles as drug delivery carriers for cancer therapy
10.3389/fonc.2024.1296091 · 2024 · External reference
Stealth PEGylated chitosan polyelectrolyte complex nanoparticles as drug delivery carrier
10.1080/09205063.2021.1918043 · 2021 · External reference
To assess drug delivery system Nanocarrier at industrial production: establishment of liposomal surface using physicochemical properties
10.1248/yakushi.23-00129 · 2024 · External reference
Cardiotropic ligand-guided liposomes for myocardial delivery of atorvastatin in a mouse model of myocardial infarction
10.1016/j.ijpharm.2025.125841 · 2025 · External reference
Recent advances on PEO-PCL block and graft copolymers as nanocarriers for drug delivery applications
10.3390/ma16062298 · 2023 · External reference
PLGA-based nanoparticles: an overview of biomedical applications
10.1016/j.jconrel.2012.01.043 · 2012 · External reference
Targeted delivery of curcumin based on nanocarriers: potential therapeutic strategies for noninfectious arthritis
10.1007/s10787-026-02161-1 · 2026 · External reference
Advances in nanocarrier-mediated delivery of chrysin: enhancing solubility, bioavailability, and anticancer efficacy
2025 · External reference
Effect of quercetin-loaded mesoporous silica nanoparticles on myocardial ischemia-reperfusion injury in rats and its mechanism
10.2147/ijn.s277377 · 2021 · External reference
Platelet membrane-encapsulated MSNs loaded with SS31 peptide alleviate myocardial ischemia-reperfusion injury
10.3390/jfb13040181 · 2022 · External reference
Angiotensin 1 peptide-conjugated CdSe/ZnS quantum dots for cardiac-specific hydrogen sulfide targeted therapy in myocardial ischemia-reperfusion injury
2024 · External reference
An injectable mitochondria-targeted nanodrug loaded-hydrogel for restoring mitochondrial function and hierarchically attenuating oxidative stress to reduce myocardial ischemia-reperfusion injury
10.1016/j.biomaterials.2022.121656 · 2022 · External reference
Biodegradable redox-responsive AIEgen-based-covalent organic framework nanocarriers for long-term treatment of myocardial ischemia/reperfusion injury
10.1002/smll.202205062 · 2022 · External reference
ROS-responsive Prussian blue nanoplatform for synergistic myocardial ischemia/reperfusion injury therapy via EGCG delivery and DJ-1 pathway regulation
10.1016/j.ijpharm.2026.126620 · 2026 · External reference
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties
10.1186/s12951-025-03810-3 · 2025 · External reference
Mitochondrial targeted astaxanthin liposomes for myocardial ischemia-reperfusion injury based on oxidative stress
10.1177/08853282221087102 · 2022 · External reference
An injectable dual-function hydrogel protects against myocardial ischemia/reperfusion injury by modulating ROS/NO disequilibrium
10.1002/advs.202105408 · 2022 · External reference
Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models
10.1186/s12951-025-03197-1 · 2025 · External reference
Homotransplantation of engineered macrophages with surface-modified nanomedicines for mitigating myocardial ischemia-reperfusion injury
10.1021/acsnano.5c05068 · 2025 · External reference
Engineered macrophage membrane-coated S100A9-siRNA for ameliorating myocardial ischemia-reperfusion injury
2024 · External reference
Engineering extracellular vesicles with platelet membranes fusion enhanced targeted therapeutic angiogenesis in a mouse model of myocardial ischemia reperfusion
10.7150/thno.52496 · 2021 · External reference
Organic nano-quantum dots of salvianolic acid B modified with photosensitive cypate for the diagnosis and treatment of myocardial ischemia-reperfusion injury
10.1016/j.colsurfb.2026.115414 · 2026 · External reference
Theranostic contribution of extracellular matrix metalloprotease inducer-paramagnetic nanoparticles against acute myocardial infarction in a pig model of coronary ischemia-reperfusion
10.1161/circimaging.121.013379 · 2022 · External reference
VEGF mimetic peptide-modified bifunctional Nanosystem for targeted drug delivery in myocardial infarction
10.1021/acsabm.5c01922 · 2026 · External reference
VEGF mimetic peptide-conjugated nanoparticles for magnetic resonance imaging and therapy of myocardial infarction
10.1016/j.jconrel.2023.06.017 · 2023 · External reference
Targeted neutrophil-mimetic liposomes promote cardiac repair by adsorbing proinflammatory cytokines and regulating the immune microenvironment
2022 · External reference
Self-assembling antioxidants for ischemia-reperfusion injuries
10.1089/ars.2021.0103 · 2022 · External reference
Activation of sphingosine-1-phosphate receptors can relieve myocardial ischemia-reperfusion injury by mitigating oxidative stress and ferroptosis in cardiomyocytes
10.7150/ijbs.107402 · 2025 · External reference
Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies
10.1186/s12967-025-06262-3 · 2025 · External reference
CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection
10.1126/sciadv.abo1244 · 2022 · External reference
FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis
10.1038/s41420-025-02575-w · 2025 · External reference
The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
10.3389/fphys.2022.1013817 · 2022 · External reference
Targeting mitochondrial shape: at the heart of cardioprotection
10.1007/s00395-023-01019-9 · 2023 · External reference
Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts
10.1016/j.celrep.2025.115380 · 2025 · External reference
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching
10.1038/s41401-023-01222-3 · 2024 · External reference
Comparative optimization of polysaccharide-based nanoformulations for cardiac RNAi therapy
2024 · External reference
Identification of splenic IRF7 as a nanotherapy target for tele-conditioning myocardial reperfusion injury
10.1038/s41467-025-57048-6 · 2025 · External reference
Modified bFGF targeting connective tissue growth factor in the injured microenvironment improved cardiac repair after chronic myocardial ischemia
10.1016/j.reth.2025.01.006 · 2025 · External reference
Injectable BMSC-based extracellular matrix-mimicking microtissue for myocardial infarction repair
2026 · External reference
Ultrasound-targeted microbubble destruction-mediated Galectin-7-siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats
10.3892/ijmm.2020.4830 · 2021 · External reference
Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury
10.1007/s10495-020-01602-8 · 2020 · External reference
Intelligent responsive PVA hydrogel loaded with composite MXene nanozyme enables efficient myocardial infarction repair by disrupting the oxidative stress-inflammation cascade
2025 · External reference
Design of a Zn-based nanozyme injectable multifunctional hydrogel with ROS scavenging activity for myocardial infarction therapy
10.1016/j.actbio.2024.01.015 · 2024 · External reference
Time-released black phosphorus hydrogel accelerates myocardial repairing through antioxidant and motivates macrophage polarization properties
10.34133/bmr.0029 · 2024 · External reference
Hierarchical structures of protein-Fiber-infused Aminoglycan hydrogels to promote myocardial repair
10.1021/acsnano.5c07064 · 2025 · External reference
Engineered mesenchymal stem cells for targeted delivery of H2S to suppress cGAS-STING inflammation and enhance cardioprotection in myocardial ischemia-reperfusion
10.1016/j.jconrel.2025.114484 · 2026 · External reference
Mesenchymal stem cell-originated Exosomal Lnc A2M-AS1 alleviates hypoxia/reperfusion-induced apoptosis and oxidative stress in cardiomyocytes
10.1007/s10557-022-07339-7 · 2023 · External reference
MicroRNA-204 carried by exosomes of human umbilical cord-derived mesenchymal stem cells regulates the polarization of macrophages in a mouse model of myocardial ischemia-reperfusion injury
2022 · External reference
Tumor microenvironment responsive drug delivery systems
2020 · External reference
Single functional group platform for multistimuli responsivities: tertiary amine for CO2/pH/ROS-triggered cargo release in Nanocarriers
10.1021/acs.biomac.3c00434 · 2023 · External reference
Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration
2026 · External reference
Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer therapy
10.1021/acsami.1c13634 · 2021 · External reference
Biomimetic targeted Nanoplatform exerts a combined effect of alleviating calcium overload and scavenging ROS to attenuate the inflammatory response in myocardial ischemia-reperfusion injury
10.1021/acsami.5c08306 · 2025 · External reference
Anti-tumor metastasis via platelet inhibitor combined with Photothermal therapy under Activatable fluorescence/magnetic resonance bimodal imaging guidance
10.1021/acsami.1c02302 · 2021 · External reference
Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery
10.1126/sciadv.abo6163 · 2022 · External reference
A shear-responsive nanosystem engineered from fucoidan targets endothelial for atherosclerosis therapy
10.1016/j.biomaterials.2025.123931 · 2026 · External reference
Advances in stimuli-responsive gold nanorods for drug-delivery and targeted therapy systems
10.1016/j.biopha.2024.117493 · 2024 · External reference
Stimuli-responsive carbon nanotubes for on-demand cancer therapy: a review
10.1208/s12249-026-03391-w · 2026 · External reference
PDT-sensitized ROS-responsive dextran nanosystem for maximizing antitumor potency of multi-target drugs
10.1016/j.ijpharm.2022.122567 · 2023 · External reference
Single doping for triple functions: integrated theranostic nanoplatforms for multimodal image-guided tumor therapy
10.1002/adhm.202301435 · 2023 · External reference
Camptothecin-loaded and manganese dioxide-coated polydopamine nanomedicine used for magnetic resonance imaging diagnosis and chemo-photothermal therapy for lung cancer
10.2147/ijn.s359300 · 2022 · External reference
Integrated organosilica nanomedicine enables sonoimaging, sonochemistry and antitumor sonodynamic therapy
10.1177/08853282241258555 · 2024 · External reference
A TME-responsive polysaccharide nanoplatform integrating synergetic therapy for cancer
2025 · External reference
Current hurdles to the translation of nanomedicines from bench to the clinic
10.1007/s13346-021-01024-2 · 2022 · External reference
To PEGylate or not to PEGylate: immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives
10.1016/j.addr.2021.114079 · 2022 · External reference
Regulatory considerations, challenges and risk-based approach in nanomedicine development
10.2174/0929867328666210406115529 · 2021 · External reference
Roadmap for commercial nanomedicine development: integrating quality by design principles with pharmaceutical nanotechnology
10.1021/acs.molpharmaceut.5c00056 · 2025 · External reference
Current and near-future technologies to quantify nanoparticle therapeutic loading efficiency and surface coating efficiency with targeted moieties
2025 · External reference
Nanoscale reference and test materials for the validation of characterization methods for engineered nanomaterials - current state, limitations, and needs
10.1007/s00216-024-05719-6 · 2025 · External reference
Microfluidic manufacture of lipid-based nanomedicines
10.3390/pharmaceutics14091940 · 2022 · External reference
Spatiotemporal reprogramming of cardiac lipid metabolism by platelet-engineered RNA therapy epigenetically modulate heart repair and regeneration
2026 · External reference
