Research graph
References from PERK deficiency amplifies molecular, structural, and network vulnerability to repetitive mild traumatic brain injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
10.1523/jneurosci.5397-12.2013 · 2013 · External reference
Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson’s disease
10.1002/jcp.24830 · 2015 · External reference
Diffusion tensor MR imaging in diffuse axonal injury
2002 · External reference
MW151 inhibited IL-1beta levels after traumatic brain injury with no effect on microglia physiological responses
10.1371/journal.pone.0149451 · 2016 · External reference
PERK-opathies: an endoplasmic reticulum stress mechanism underlying neurodegeneration
10.2174/1567205013666151218145431 · 2016 · External reference
Loss of consciousness and righting reflex following traumatic brain injury: predictors of post-injury symptom development (a narrative review)
10.3390/brainsci13050750 · 2023 · External reference
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
10.1038/35014014 · 2000 · External reference
Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury
10.1007/s00414-021-02606-y · 2021 · External reference
Network topology changes in chronic mild traumatic brain injury (mTBI)
10.1016/j.nicl.2021.102691 · 2021 · External reference
Activation of the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway of the unfolded protein response after experimental traumatic brain injury and treatment with a PERK inhibitor
10.1089/neur.2021.0001 · 2021 · External reference
PERK activation mitigates tau pathology in vitro and in vivo
10.15252/emmm.201606664 · 2017 · External reference
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
10.1006/cbmr.1996.0014 · 1996 · External reference
Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries in mice
10.1016/j.neuroimage.2024.120764 · 2024 · External reference
PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK/p-eIF2a/ATF4/CHOP signaling
10.1007/s11011-023-01183-w · 2023 · External reference
Regulated translation initiation controls stress-induced gene expression in mammalian cells
10.1016/s1097-2765(00)00108-8 · 2000 · External reference
MerTK is a functional regulator of myelin phagocytosis by human myeloid cells
10.4049/jimmunol.1502562 · 2016 · External reference
The unfolded protein response is activated in pretangle neurons in Alzheimer’s disease hippocampus
10.2353/ajpath.2009.080814 · 2009 · External reference
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway
10.1111/febs.14422 · 2019 · External reference
Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination
10.1002/glia.22634 · 2014 · External reference
Broad kinase inhibition mitigates early neuronal dysfunction in tauopathy
10.3390/ijms22031186 · 2021 · External reference
Chronic PERK induction promotes Alzheimer-like neuropathology in down syndrome: insights for therapeutic intervention
10.1016/j.pneurobio.2020.101892 · 2021 · External reference
Unresolved reference
2026 · External reference
Biological functions of autophagy genes: a disease perspective
10.1016/j.cell.2018.09.048 · 2019 · External reference
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: a longitudinal study
10.1016/j.neurobiolaging.2023.11.002 · 2024 · External reference
Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis
10.1523/jneurosci.1636-12.2013 · 2013 · External reference
Vimentin and p53 immunoreactivity in cases of traumatic brain injury
10.3390/jpm15040135 · 2025 · External reference
PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation
10.1128/mcb.00980-14 · 2014 · External reference
Pathological tau promotes neuronal damage by impairing ribosomal function and decreasing protein synthesis
10.1523/jneurosci.3029-15.2016 · 2016 · External reference
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson’s disease
10.1016/j.nbd.2018.01.004 · 2018 · External reference
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies
10.1002/path.3969 · 2012 · External reference
Structure of the human ATG12∼ATG5 conjugate required for LC3 lipidation in autophagy
10.1038/nsmb.2431 · 2013 · External reference
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
10.1007/s00401-015-1487-z · 2015 · External reference
Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment
10.1007/s003359900551 · 1997 · External reference
The PERK-dependent molecular mechanisms as a novel therapeutic target for neurodegenerative diseases
10.3390/ijms21062108 · 2020 · External reference
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson’s disease
10.1523/jneurosci.22-24-10690.2002 · 2002 · External reference
White matter aging drives microglial diversity
10.1016/j.neuron.2021.01.027 · 2021 · External reference
Fixed time-point analysis reveals repetitive mild traumatic brain injury effects on resting state functional magnetic resonance imaging connectivity and neuro-spatial protein profiles
10.1089/neu.2022.0464 · 2023 · External reference
The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
10.1007/s00401-015-1462-8 · 2015 · External reference
Endoplasmic reticulum stress responses
10.1007/s00018-007-7383-5 · 2008 · External reference
Activation of PERK elicits memory impairment through inactivation of CREB and downregulation of PSD95 after traumatic brain injury
10.1523/jneurosci.2343-16.2017 · 2017 · External reference
Aberrant ER stress induced neuronal-IFNbeta elicits white matter injury due to microglial activation and T-cell infiltration after TBI
10.1523/jneurosci.0718-19.2019 · 2020 · External reference
TFEB links autophagy to lysosomal biogenesis
10.1126/science.1204592 · 2011 · External reference
Advances in functional and structural MR image analysis and implementation as FSL
10.1016/j.neuroimage.2004.07.051 · 2004 · External reference
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease
2014 · External reference
Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury
10.7554/elife.55827 · 2020 · External reference
The Allen mouse brain common coordinate framework: a 3D reference atlas
10.1016/j.cell.2020.04.007 · 2020 · External reference
The integrated UPR and ERAD in oligodendrocytes maintain myelin thickness in adults by regulating myelin protein translation
10.1523/jneurosci.0604-20.2020 · 2020 · External reference
Possible mechanisms of the PERK pathway on neuronal apoptosis in a rat model of surgical brain injury
2021 · External reference
Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury
10.1038/s41419-024-06515-x · 2024 · External reference
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress
2018 · External reference
User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability
10.1016/j.neuroimage.2006.01.015 · 2006 · External reference
Small world properties changes in mild traumatic brain injury
10.1002/jmri.25548 · 2017 · External reference