Research graph
References from Neurovascular-metabolic coupling links hearing loss to cognitive impairment: Evidence from GABA and cerebral blood flow in presbycusis. Local targets link to admitted publications; unresolved targets remain external evidence.
Heschl gyrus and its included primary auditory cortex: structural MRI studies in healthy and diseased subjects
10.1002/jmri.21445 · 2008 · External reference
Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia
10.1002/mrm.25197 · 2015 · External reference
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
10.1038/nrn2044 · 2007 · External reference
Hippocampal synaptic plasticity, spatial memory, and neurotransmitter receptor expression are profoundly altered by gradual loss of hearing ability
10.1093/cercor/bhaa061 · 2020 · External reference
Central auditory aging: GABA changes in the inferior colliculus
10.1016/0531-5565(94)00052-5 · 1995 · External reference
Directed functional connectivity of the hippocampus in patients with presbycusis
10.1007/s11682-019-00162-z · 2020 · External reference
Cerebral blood flow pattern changes in unilateral sudden sensorineural hearing loss
2022 · External reference
Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: a 4-year longitudinal study
10.1002/jmri.25938 · 2018 · External reference
Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis
10.1371/journal.pone.0233224 · 2020 · External reference
Baseline GABA concentration and fMRI response
10.1016/j.neuroimage.2010.07.017 · 2010 · External reference
JuSpace: a tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps
10.1002/hbm.25244 · 2021 · External reference
Sex-specific cerebral blood flow alterations in youth operated for congenital heart disease
10.1161/jaha.122.028378 · 2023 · External reference
Auditory cortex signs of age-related hearing loss
10.1007/s10162-012-0332-5 · 2012 · External reference
Gannet: a batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra
10.1002/jmri.24478 · 2014 · External reference
Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy
10.1016/j.neuroimage.2014.11.023 · 2015 · External reference
Use of tissue water as a concentration reference for proton spectroscopic imaging
10.1002/mrm.20901 · 2006 · External reference
Reorganized brain functional network topology in presbycusis
10.3389/fnagi.2022.905487 · 2022 · External reference
Evidence of attentional impairments using virtual driving simulation in multiple sclerosis
10.1016/j.msard.2018.08.005 · 2018 · External reference
GABAergic mechanisms of hippocampal hyperactivity in schizophrenia
10.1016/j.schres.2014.09.041 · 2015 · External reference
Age-related hearing loss or presbycusis
10.1007/s00405-010-1270-7 · 2010 · External reference
Neural distinctiveness declines with age in auditory cortex and is associated with auditory GABA levels
10.1016/j.neuroimage.2019.116033 · 2019 · External reference
Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis
10.1016/j.neuroimage.2023.119861 · 2023 · External reference
Hearing loss and dementia - who is listening?
10.1080/13607863.2014.915924 · 2014 · External reference
Hearing loss and cognition in the Baltimore longitudinal study of aging
10.1037/a0024238 · 2011 · External reference
Hearing loss and incident dementia
10.1001/archneurol.2010.362 · 2011 · External reference
Hearing loss prevalence and risk factors among older adults in the United States
10.1093/gerona/glr002 · 2011 · External reference
Dementia prevention, intervention, and care: 2020 report of the lancet commission
10.1016/s0140-6736(20)30367-6 · 2020 · External reference
Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis
10.1001/jamaoto.2017.2513 · 2018 · External reference
Saliency, switching, attention and control: a network model of insula function
10.1007/s00429-010-0262-0 · 2010 · External reference
Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
10.1038/s41386-017-0004-6 · 2018 · External reference
Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA
10.1016/j.neuroimage.2012.12.004 · 2014 · External reference
The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment
10.1111/j.1532-5415.2005.53221.x · 2005 · External reference
Beyond the auditory system: cognitive implications of age-related hearing loss
10.3389/fnagi.2025.1736579 · 2026 · External reference
Hearing loss in older adults affects neural systems supporting speech comprehension
10.1523/jneurosci.2559-11.2011 · 2011 · External reference
Construct validity of the Stroop color-word test: influence of speed of visual search, verbal fluency, working memory, cognitive flexibility, and conflict monitoring
10.1093/arclin/acaa034 · 2021 · External reference
Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI
10.1002/hbm.24538 · 2019 · External reference
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy
10.1016/j.exger.2013.04.012 · 2013 · External reference
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
10.1002/mrm.1910300604 · 2005 · External reference
Alterations of cerebral blood flow and its connectivity patterns measured with arterial spin Labeling in mild cognitive impairment
10.2174/0115672050241163231017073139 · 2023 · External reference
Association between hearing ability and cortical morphology in the elderly: multiparametric mapping, cognitive relevance, and neurobiological underpinnings
10.1016/j.ebiom.2024.105160 · 2024 · External reference
Gray matter atrophy is associated with cognitive impairment in patients with presbycusis: a comprehensive morphometric study
10.3389/fnins.2018.00744 · 2018 · External reference
Brain frequency-specific changes in the spontaneous neural activity are associated with cognitive impairment in patients with presbycusis
10.3389/fnagi.2021.649874 · 2021 · External reference
Identification of Pseudohypacusis using speech recognition thresholds
10.1097/00003446-199606000-00006 · 1996 · External reference
Cortical deafness of following bilateral temporal lobe stroke
10.1016/j.jstrokecerebrovasdis.2020.104827 · 2020 · External reference
The effects of age-related hearing loss on the brain and cognitive function
10.1016/j.tins.2020.07.005 · 2020 · External reference
Left and right superior parietal lobule in tactile object discrimination
10.1111/j.0953-816x.2004.03185.x · 2004 · External reference
Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
10.1038/mp.2011.171 · 2012 · External reference
Alterations of excitation–inhibition balance and brain network dynamics support sensory deprivation theory in presbycusis
10.1002/hbm.70067 · 2024 · External reference
More GABA, less distraction: a neurochemical predictor of motor decision speed
10.1038/nn.2559 · 2010 · External reference
Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment
10.1002/alz.13408 · 2023 · External reference
Changes of metabolism and functional connectivity in late-onset deafness: evidence from cerebral 18F-FDG-PET
10.1016/j.heares.2017.07.011 · 2017 · External reference
Genome-wide association study identified INSC gene associated with trail making test part a and Alzheimer’s disease related cognitive phenotypes
10.1016/j.pnpbp.2021.110393 · 2021 · External reference
Aberrant auditory metabolite levels and topological properties are associated with cognitive decline in presbycusis patients
10.1093/cercor/bhae181 · 2024 · External reference
Sensorineural hearing loss and cognitive impairments: contributions of thalamus using multiparametric MRI
10.1002/jmri.26665 · 2019 · External reference
Topological disruption of low- and high-order functional networks in presbycusis
10.1093/braincomms/fcae119 · 2024 · External reference
Short-term delayed recall of auditory verbal learning test is equivalent to long-term delayed recall for identifying amnestic mild cognitive impairment
10.1371/journal.pone.0051157 · 2012 · External reference
Altered coupling between resting-state cerebral blood flow and functional connectivity in schizophrenia
10.1093/schbul/sbx051 · 2017 · External reference
The hospital anxiety and depression scale
10.1111/j.1600-0447.1983.tb09716.x · 1983 · External reference
Hearing loss and incident dementia
10.1001/archneurol.2010.362 · ExternalCitation · doi-reference
Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis
10.1001/jamaoto.2017.2513 · ExternalCitation · doi-reference
Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment
10.1002/alz.13408 · ExternalCitation · doi-reference
Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI
10.1002/hbm.24538 · ExternalCitation · doi-reference
JuSpace: a tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps
10.1002/hbm.25244 · ExternalCitation · doi-reference
Alterations of excitation–inhibition balance and brain network dynamics support sensory deprivation theory in presbycusis
10.1002/hbm.70067 · ExternalCitation · doi-reference
Heschl gyrus and its included primary auditory cortex: structural MRI studies in healthy and diseased subjects
10.1002/jmri.21445 · ExternalCitation · doi-reference
Gannet: a batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra
10.1002/jmri.24478 · ExternalCitation · doi-reference
Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: a 4-year longitudinal study
10.1002/jmri.25938 · ExternalCitation · doi-reference
Sensorineural hearing loss and cognitive impairments: contributions of thalamus using multiparametric MRI
10.1002/jmri.26665 · ExternalCitation · doi-reference
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
10.1002/mrm.1910300604 · ExternalCitation · doi-reference
Use of tissue water as a concentration reference for proton spectroscopic imaging
10.1002/mrm.20901 · ExternalCitation · doi-reference
Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia
10.1002/mrm.25197 · ExternalCitation · doi-reference
Age-related hearing loss or presbycusis
10.1007/s00405-010-1270-7 · ExternalCitation · doi-reference
Saliency, switching, attention and control: a network model of insula function
10.1007/s00429-010-0262-0 · ExternalCitation · doi-reference
Auditory cortex signs of age-related hearing loss
10.1007/s10162-012-0332-5 · ExternalCitation · doi-reference
Directed functional connectivity of the hippocampus in patients with presbycusis
10.1007/s11682-019-00162-z · ExternalCitation · doi-reference
Central auditory aging: GABA changes in the inferior colliculus
10.1016/0531-5565(94)00052-5 · ExternalCitation · doi-reference
Association between hearing ability and cortical morphology in the elderly: multiparametric mapping, cognitive relevance, and neurobiological underpinnings
10.1016/j.ebiom.2024.105160 · ExternalCitation · doi-reference
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy
10.1016/j.exger.2013.04.012 · ExternalCitation · doi-reference
Changes of metabolism and functional connectivity in late-onset deafness: evidence from cerebral 18F-FDG-PET
10.1016/j.heares.2017.07.011 · ExternalCitation · doi-reference
Cortical deafness of following bilateral temporal lobe stroke
10.1016/j.jstrokecerebrovasdis.2020.104827 · ExternalCitation · doi-reference
Evidence of attentional impairments using virtual driving simulation in multiple sclerosis
10.1016/j.msard.2018.08.005 · ExternalCitation · doi-reference
Baseline GABA concentration and fMRI response
10.1016/j.neuroimage.2010.07.017 · ExternalCitation · doi-reference
Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA
10.1016/j.neuroimage.2012.12.004 · ExternalCitation · doi-reference
Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy
10.1016/j.neuroimage.2014.11.023 · ExternalCitation · doi-reference
Neural distinctiveness declines with age in auditory cortex and is associated with auditory GABA levels
10.1016/j.neuroimage.2019.116033 · ExternalCitation · doi-reference
Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis
10.1016/j.neuroimage.2023.119861 · ExternalCitation · doi-reference
Genome-wide association study identified INSC gene associated with trail making test part a and Alzheimer’s disease related cognitive phenotypes
10.1016/j.pnpbp.2021.110393 · ExternalCitation · doi-reference
GABAergic mechanisms of hippocampal hyperactivity in schizophrenia
10.1016/j.schres.2014.09.041 · ExternalCitation · doi-reference
The effects of age-related hearing loss on the brain and cognitive function
10.1016/j.tins.2020.07.005 · ExternalCitation · doi-reference
Dementia prevention, intervention, and care: 2020 report of the lancet commission
10.1016/s0140-6736(20)30367-6 · ExternalCitation · doi-reference
Hearing loss and cognition in the Baltimore longitudinal study of aging
10.1037/a0024238 · ExternalCitation · doi-reference
Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
10.1038/mp.2011.171 · ExternalCitation · doi-reference
More GABA, less distraction: a neurochemical predictor of motor decision speed
10.1038/nn.2559 · ExternalCitation · doi-reference
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
10.1038/nrn2044 · ExternalCitation · doi-reference
Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
10.1038/s41386-017-0004-6 · ExternalCitation · doi-reference
Hearing loss and dementia - who is listening?
10.1080/13607863.2014.915924 · ExternalCitation · doi-reference
Construct validity of the Stroop color-word test: influence of speed of visual search, verbal fluency, working memory, cognitive flexibility, and conflict monitoring
10.1093/arclin/acaa034 · ExternalCitation · doi-reference
Topological disruption of low- and high-order functional networks in presbycusis
10.1093/braincomms/fcae119 · ExternalCitation · doi-reference
Hippocampal synaptic plasticity, spatial memory, and neurotransmitter receptor expression are profoundly altered by gradual loss of hearing ability
10.1093/cercor/bhaa061 · ExternalCitation · doi-reference
Aberrant auditory metabolite levels and topological properties are associated with cognitive decline in presbycusis patients
10.1093/cercor/bhae181 · ExternalCitation · doi-reference
Hearing loss prevalence and risk factors among older adults in the United States
10.1093/gerona/glr002 · ExternalCitation · doi-reference
Altered coupling between resting-state cerebral blood flow and functional connectivity in schizophrenia
10.1093/schbul/sbx051 · ExternalCitation · doi-reference
Identification of Pseudohypacusis using speech recognition thresholds
10.1097/00003446-199606000-00006 · ExternalCitation · doi-reference
Left and right superior parietal lobule in tactile object discrimination
10.1111/j.0953-816x.2004.03185.x · ExternalCitation · doi-reference
The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment
10.1111/j.1532-5415.2005.53221.x · ExternalCitation · doi-reference
The hospital anxiety and depression scale
10.1111/j.1600-0447.1983.tb09716.x · ExternalCitation · doi-reference
Sex-specific cerebral blood flow alterations in youth operated for congenital heart disease
10.1161/jaha.122.028378 · ExternalCitation · doi-reference
Short-term delayed recall of auditory verbal learning test is equivalent to long-term delayed recall for identifying amnestic mild cognitive impairment
10.1371/journal.pone.0051157 · ExternalCitation · doi-reference
Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis
10.1371/journal.pone.0233224 · ExternalCitation · doi-reference
Hearing loss in older adults affects neural systems supporting speech comprehension
10.1523/jneurosci.2559-11.2011 · ExternalCitation · doi-reference
Alterations of cerebral blood flow and its connectivity patterns measured with arterial spin Labeling in mild cognitive impairment
10.2174/0115672050241163231017073139 · ExternalCitation · doi-reference
Brain frequency-specific changes in the spontaneous neural activity are associated with cognitive impairment in patients with presbycusis
10.3389/fnagi.2021.649874 · ExternalCitation · doi-reference
Reorganized brain functional network topology in presbycusis
10.3389/fnagi.2022.905487 · ExternalCitation · doi-reference
Beyond the auditory system: cognitive implications of age-related hearing loss
10.3389/fnagi.2025.1736579 · ExternalCitation · doi-reference
Gray matter atrophy is associated with cognitive impairment in patients with presbycusis: a comprehensive morphometric study
10.3389/fnins.2018.00744 · ExternalCitation · doi-reference
