References

Traumatic spinal cord injury

10.1038/nrdp.2017.18 · 2017 · External reference

N1-acetylspermidine is a determinant of hair follicle stem cell fate

10.1242/jcs.252767 · 2021 · External reference

Polyamine synthesis as a target of MYC oncogenes

10.1074/jbc.tm118.003336 · 2018 · External reference

Origin of new glial cells in intact and injured adult spinal cord

10.1016/j.stem.2010.07.014 · 2010 · External reference

Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains

10.1089/neu.2006.23.635 · 2006 · External reference

Neuronal regeneration from ependymo-radial glial cells: cook, little pot, cook!

10.1016/j.devcel.2015.01.001 · 2015 · External reference

The spinal ependymal zone as a source of endogenous repair cells across vertebrates

10.1016/j.pneurobio.2018.04.002 · 2018 · External reference

Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools

10.1038/onc.2016.178 · 2017 · External reference

Moving beyond the glial scar for spinal cord repair

10.1038/s41467-019-11707-7 · 2019 · External reference

Reactive gliosis and the multicellular response to CNS damage and disease

10.1016/j.neuron.2013.12.034 · 2014 · External reference

The role of CD44 in fetal and adult hematopoietic stem cell regulation

10.3324/haematol.2015.135921 · 2016 · External reference

Polyamine metabolism and cancer: treatments, challenges and opportunities

10.1038/s41568-018-0050-3 · 2018 · External reference

Polyamine catabolism and disease

10.1042/bj20090598 · 2009 · External reference

Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer

10.1038/s41467-023-40486-5 · 2023 · External reference

Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation

10.1016/j.canlet.2023.216120 · 2023 · External reference

Effects of spermine synthase deficiency in mesenchymal stromal cells are rescued by upstream inhibition of ornithine decarboxylase

10.3390/ijms25052463 · 2024 · External reference

MYC, metabolism, cell growth, and tumorigenesis

10.1101/cshperspect.a014217 · 2013 · External reference

Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo

10.1523/jneurosci.1175-09.2009 · 2009 · External reference

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

10.1016/j.expneurol.2007.06.009 · 2008 · External reference

Metabolic plasticity in stem cell homeostasis and differentiation

10.1016/j.stem.2012.10.002 · 2012 · External reference

PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination

10.1002/neu.10158 · 2003 · External reference

Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway

10.1007/s11064-008-9748-z · 2009 · External reference

Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats

10.1371/journal.pone.0043152 · 2012 · External reference

Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness

10.1523/jneurosci.6005-11.2012 · 2012 · External reference

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

10.1126/scitranslmed.aau1099 · 2019 · External reference

Time-dependent effects of dexamethasone on glutamate binding, ornithine decarboxylase activity and polyamine levels in the transected spinal cord

10.1016/0960-0760(95)00160-2 · 1995 · External reference

Endogenous neural stem cell responses to stroke and spinal cord injury

10.1002/glia.22851 · 2015 · External reference

Subcutaneous administration of PDGF-AA improves the functional recovery after spinal cord injury

10.3389/fnins.2019.00006 · 2019 · External reference

Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery

10.1038/s41593-025-02044-8 · 2025 · External reference

TGF-β Signaling from receptors to Smads

10.1101/cshperspect.a022061 · 2016 · External reference

The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes

10.3109/10409238.2012.656843 · 2012 · External reference

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

10.1093/brain/awad392 · 2024 · External reference

Short-term post-fast refeeding enhances intestinal stemness via polyamines

10.1038/s41586-024-07840-z · 2024 · External reference

Metabolic requirements for the maintenance of self-renewing stem cells

10.1038/nrm3772 · 2014 · External reference

Metabolic regulation of the hallmarks of stem cell biology

10.1016/j.stem.2024.01.003 · 2024 · External reference

MINDY1 is a downstream target of the polyamines and promotes embryonic stem cell self-renewal

10.1002/stem.2830 · 2018 · External reference

Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing

10.1038/s42255-023-00955-z · 2024 · External reference

Translational implications of targeting annexin A2: from membrane repair to muscular dystrophy, cardiovascular disease and cancer

2023 · External reference

Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

10.7150/thno.84133 · 2023 · External reference

EGR1 promotes craniofacial bone regeneration via activation of ALPL+PDGFD+ periosteal stem cells

2025 · External reference

Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair

10.1080/15548627.2023.2281156 · 2024 · External reference

Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: a systematic analysis for the global burden of disease 2021 study

10.1016/j.arr.2024.102598 · 2025 · External reference

10.1186/scrt48 · 2011 · Admitted local publication

Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D

10.1038/s41598-019-50543-z · 2019 · External reference

The effect of tissue inhibitor of metalloproteinases on scar formation after spinal cord injury

10.3390/cells13181547 · 2024 · External reference

Bone morphogenetic protein receptors and signal transduction

10.1093/jb/mvp148 · 2010 · External reference

Regenerative medicine for spinal cord injury using induced pluripotent stem cells: from animals to humans

10.1097/j.pain.0000000000003306 · 2024 · External reference

Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

10.1158/1078-0432.ccr-24-1778 · 2025 · External reference

Adult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury

10.3389/fphys.2013.00340 · 2013 · External reference

Mammalian polyamine metabolism and function

10.1002/iub.230 · 2009 · External reference

Functions of polyamines in mammals

10.1074/jbc.r116.731661 · 2016 · External reference

Challenges in studying stem cell metabolism

10.1016/j.stem.2021.02.016 · 2021 · External reference

Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

10.1126/sciadv.add5220 · 2023 · External reference

Current states of endogenous stem cells in adult spinal cord

10.1002/jnr.23480 · 2015 · External reference

An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury

10.1016/j.devcel.2023.01.003 · 2023 · External reference

The activation of dormant ependymal cells following spinal cord injury

10.1186/s13287-023-03395-4 · 2023 · External reference

Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice

10.1126/science.1242576 · 2013 · External reference

The role of polyamine metabolism in cellular function and physiology

10.1152/ajpcell.00074.2024 · 2024 · External reference

Role of endogenous neural stem cells in spinal cord injury and repair

10.1001/jamaneurol.2014.2927 · 2015 · External reference

Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties

10.1016/j.celrep.2022.110440 · 2022 · External reference

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin

10.1126/sciimmunol.abb6444 · 2021 · External reference

Glial progenitor heterogeneity and plasticity in the adult spinal cord

10.4103/nrr.nrr-d-23-01988 · 2024 · External reference

Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8(+) T cells

10.1016/j.devcel.2025.10.017 · 2026 · External reference

Polyamines: their significance for maintaining health and contributing to diseases

10.1186/s12964-023-01373-0 · 2023 · External reference

Metabolic and proteostatic differences in quiescent and active neural stem cells

10.4103/1673-5374.375306 · 2024 · External reference

Endogenous opioid signalling regulates spinal ependymal cell proliferation

10.1038/s41586-024-07889-w · 2024 · External reference

Metabolism in pluripotent stem cells and early mammalian development

10.1016/j.cmet.2018.01.008 · 2018 · External reference

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

10.1038/s41586-018-0694-x · 2018 · External reference

N-myc downstream-regulated gene 2 controls astrocyte morphology via rho-GTPase signaling

10.1002/jcp.28689 · 2019 · External reference

Deciphering glial scar after spinal cord injury

10.1093/burnst/tkab035 · 2021 · External reference

Inhibition of TANK-binding kinase1 attenuates the astrocyte-mediated neuroinflammatory response through YAP signaling after spinal cord injury

10.1111/cns.14170 · 2023 · External reference

CD74 is a functional MIF receptor on activated CD4(+) T cells

10.1007/s00018-024-05338-5 · 2024 · External reference

Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice

10.1016/j.nbd.2024.106746 · 2024 · External reference

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control

10.1038/s41421-024-00712-w · 2024 · External reference

Characterizing progenitor cells in developing and injured spinal cord: insights from single-nucleus transcriptomics and lineage tracing

10.1073/pnas.2413140122 · 2025 · External reference

A role for polyamine regulators in ESC self-renewal

10.4161/cc.22772 · 2012 · External reference

Metabolic remodelling during early mouse embryo development

10.1038/s42255-021-00464-x · 2021 · External reference

Regulation of axonal regeneration after mammalian spinal cord injury

10.1038/s41580-022-00562-y · 2023 · External reference

Fibroblast growth factors in the management of spinal cord injury

10.1111/jcmm.13353 · 2018 · External reference