Research graph
References from Sex-specific contribution of endothelial AT1aRs to avoidance behaviors and BBB changes in a mouse model of PTSD. Local targets link to admitted publications; unresolved targets remain external evidence.
Activation patterns of cells in selected brain stem nuclei of more and less stress responsive rats in two animal models of PTSD - predator exposure and submersion stress
10.1016/j.neuropharm.2010.11.018 · 2012 · External reference
Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier
10.1161/hypertensionaha.113.01743 · 2014 · External reference
Posttraumatic stress disorder and comorbidity: recognizing the many faces of PTSD
1997 · External reference
Gene networks specific for innate immunity define post-traumatic stress disorder
10.1038/mp.2015.9 · 2015 · External reference
PTSD blood transcriptome mega-analysis: shared inflammatory pathways across biological sex and modes of trauma
10.1038/npp.2017.220 · 2018 · External reference
Traumatic stress: effects on the brain
10.31887/dcns.2006.8.4/jbremner · 2006 · External reference
Post-traumatic stress disorder: a state-of-the-art review of evidence and challenges
2019 · External reference
The blood-brain barrier
10.1101/cshperspect.a020412 · 2015 · External reference
Effects of LPS-induced immune activation prior to trauma exposure on PTSD-like symptoms in mice
10.1016/j.bbr.2017.01.048 · 2017 · External reference
Current status of animal models of posttraumatic stress disorder: behavioral and biological phenotypes, and future challenges in improving translation
10.1016/j.biopsych.2017.11.019 · 2018 · External reference
Heritable differences in catecholamine signaling modulate susceptibility to trauma and response to methylphenidate treatment: relevance for PTSD
10.3389/fnbeh.2019.00111 · 2019 · External reference
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue
10.1038/s41467-021-27604-x · 2022 · External reference
Chronic perfusion of angiotensin II causes cognitive dysfunctions and anxiety in mice
10.1016/j.physbeh.2012.10.005 · 2013 · External reference
Post-traumatic stress disorder and cardiovascular disease
10.1016/s2215-0366(16)30377-7 · 2017 · External reference
Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk
10.1001/jamapsychiatry.2013.4374 · 2014 · External reference
Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells
10.1038/jcbfm.2008.158 · 2009 · External reference
Sex differences in post-traumatic stress disorder risk: autonomic control and inflammation
10.1007/s10286-020-00729-7 · 2020 · External reference
Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress
10.1186/s12974-021-02322-9 · 2021 · External reference
AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure
10.1016/j.cmet.2011.03.001 · 2011 · External reference
Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear1
10.1111/gbb.12235 · 2015 · External reference
Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice
10.1186/s12974-018-1090-z · 2018 · External reference
The renin-angiotensin pathway in posttraumatic stress disorder: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are associated with fewer traumatic stress symptoms
10.4088/jcp.11m07316 · 2012 · External reference
Hypertension in relation to posttraumatic stress disorder and depression in the US National Comorbidity Survey
10.3200/bmed.34.4.125-132 · 2009 · External reference
Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress
10.1523/jneurosci.0892-11.2011 · 2011 · External reference
Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?
10.1016/j.comppsych.2004.03.015 · 2004 · External reference
Sex differences in peritraumatic inflammatory cytokines and steroid hormones contribute to prospective risk for nonremitting posttraumatic stress disorder
10.1177/24705470211032208 · 2021 · External reference
Sex-specific immune mechanisms in PTSD symptomatology and risk: a translational overview and perspectives
10.1016/j.brainresbull.2023.02.013 · 2023 · External reference
Type 1 angiotensin receptors on CD11c-expressing cells protect against hypertension by regulating dendritic cell-mediated T cell activation
10.1161/hypertensionaha.121.18734 · 2022 · External reference
Sex differences in cardiovascular actions of the renin-angiotensin system
10.1007/s10286-020-00720-2 · 2020 · External reference
Social stress induces neurovascular pathology promoting depression
10.1038/s41593-017-0010-3 · 2017 · External reference
Oxidative stress, inflammation, and neuroprogression in chronic PTSD
10.1097/hrp.0000000000000167 · 2018 · External reference
Estrogen modulates AT1 receptor gene expression in vitro and in vivo
10.1161/01.cir.97.22.2197 · 1998 · External reference
A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities
10.1016/j.bbi.2010.10.003 · 2011 · External reference
Renin-angiotensin-aldosterone (RAAS): the ubiquitous system for homeostasis and pathologies
10.1016/j.biopha.2017.07.091 · 2017 · External reference
Endothelial-specific Cre mouse models: is your Cre CREdibile?
10.1161/atvbaha.118.309669 · 2018 · External reference
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain
10.1111/j.1460-9568.2005.04225.x · 2005 · External reference
Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production
10.1002/1521-4141(2000)30:8<2344::aid-immu2344>3.0.co;2-7 · 2000 · External reference
Angiotensin receptor blockers are not just for hypertension anymore
10.1152/physiol.00036.2020 · 2021 · External reference
Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: therapeutic implications
10.1016/j.psyneuen.2010.10.001 · 2011 · External reference
A review of PTSD and current treatment strategies
2021 · External reference
Use of the open field maze to measure locomotor and anxiety-like behavior in mice
10.3791/52434-v · 2015 · External reference
The renin-angiotensin system in PTSD: a replication and extension
10.1038/s41386-020-00923-1 · 2021 · External reference
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat
10.1161/hypertensionaha.111.00156 · 2013 · External reference
Brain microglial cytokines in neurogenic hypertension
10.1161/hypertensionaha.110.150409 · 2010 · External reference
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
10.1196/annals.1364.007 · 2006 · External reference
Randomized, placebo-controlled trial of the angiotensin receptor antagonist losartan for posttraumatic stress disorder
10.1016/j.biopsych.2021.05.012 · 2021 · External reference
Inflammation, anti-inflammatory interventions, and post-stroke cognitive impairment: a systematic review and meta-analysis of human and animal studies
10.1007/s12975-023-01218-5 · 2025 · External reference
Light/dark transition test for mice
10.3791/104 · 2006 · External reference
Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation
10.1002/1521-4141(200111)31:11<3228::aid-immu3228>3.0.co;2-7 · 2001 · External reference
Failure of losartan in a clinical trial for posttraumatic stress disorder: lack of efficacy or spotlight on the power of placebo?
10.1016/j.biopsych.2021.07.009 · 2021 · External reference
Overexpression of forebrain CRH during early life increases trauma susceptibility in adulthood
10.1038/npp.2015.338 · 2016 · External reference
Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice
10.1152/physiolgenomics.00029.2016 · 2016 · External reference
Cellular mechanisms and molecular signaling pathways in stress-induced anxiety, depression, and blood-brain barrier inflammation and leakage
10.1007/s10787-020-00712-8 · 2020 · External reference
Tail-cuff technique and its influence on central blood pressure in the mouse
10.1161/jaha.116.005204 · 2017 · External reference
Interleukin-5 is a potential mediator of angiotensin II-induced aneurysm formation in apolipoprotein E knockout mice
10.1016/j.jss.2011.12.016 · 2012 · External reference
Angiotensin-II, the brain, and hypertension
10.1161/hypertensionaha.115.03624 · 2015 · External reference
A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice
10.1016/j.psyneuen.2018.05.012 · 2018 · External reference
Central amygdala angiotensin type 1 receptor (Agtr1) expressing neurons contribute to fear extinction
10.1016/j.neuropharm.2023.109460 · 2023 · External reference