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References from Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes. Local targets link to admitted publications; unresolved targets remain external evidence.
Cell-based ligand discovery for the ENL YEATS domain
10.1021/acschembio.0c00124 · 2020 · External reference
The neuronal activity-driven transcriptome
10.1007/s12035-014-8772-z · 2015 · External reference
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
10.1242/dev.118.2.401 · 1993 · External reference
Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis
10.1038/s41419-020-2601-2 · 2020 · External reference
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2alpha phosphorylation
10.1038/s41467-017-02495-z · 2018 · External reference
A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
10.1038/s41467-018-05273-7 · 2018 · External reference
Autophagy in polyglutamine disease: imposing order on disorder or contributing to the chaos?
10.1016/j.mcn.2015.03.010 · 2015 · External reference
GAL4 system in Drosophila: a fly geneticist’s Swiss army knife
10.1002/gene.10150 · 2002 · External reference
Diverse activities of histone Acylations connect metabolism to chromatin function
10.1016/j.molcel.2016.06.038 · 2016 · External reference
Small-molecule tools for YEATS domain proteins
10.1016/j.cbpa.2023.102404 · 2023 · External reference
Transcription control by the ENL YEATS domain in acute leukaemia
10.1038/nature21688 · 2017 · External reference
Chromatin regulation of neuronal maturation and plasticity
10.1016/j.tins.2018.02.009 · 2018 · External reference
Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia
10.1021/acscentsci.0c01550 · 2021 · External reference
Activation-induced chromatin reorganization in neurons depends on HDAC1 activity
10.1016/j.celrep.2022.110352 · 2022 · External reference
Chronic oxidative stress and stress granule formation in UBQLN2 ALS neurons: insights into neuronal degeneration and potential therapeutic targets
10.3390/ijms252413448 · 2024 · External reference
Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress
10.1007/s00018-019-03394-w · 2020 · External reference
Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition
10.7554/elife.63512 · 2021 · External reference
Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly
10.1016/j.bbadis.2018.06.017 · 2018 · External reference
Unresolved reference
2025 · External reference
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation
10.1038/s12276-020-00539-x · 2020 · External reference
The intrinsically disordered proteins MLLT3 (AF9) and MLLT1 (ENL) - multimodal transcriptional switches with roles in Normal hematopoiesis, MLL fusion leukemia, and kidney Cancer
10.1016/j.jmb.2021.167117 · 2022 · External reference
Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS
10.1093/hmg/ddx403 · 2018 · External reference
Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2
10.7554/elife.84382 · 2023 · External reference
A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth
10.1186/s13045-022-01258-8 · 2022 · External reference
YEATS domains as novel epigenetic readers: structures, functions, and inhibitor development
10.1021/acschembio.1c00945 · 2023 · External reference
YEATS domain: linking histone crotonylation to gene regulation
10.1080/21541264.2016.1239602 · 2017 · External reference
Chromatin organization and function in Drosophila
10.3390/cells10092362 · 2021 · External reference
FAME4-associating YEATS2 knockdown impairs dopaminergic synaptic integrity and leads to seizure-like behaviours in Drosophila melanogaster
10.1016/j.pneurobio.2023.102558 · 2024 · External reference
Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
10.1016/j.isci.2026.115855 · 2026 · External reference
Rotenone inhibits autophagic flux prior to inducing cell death
10.1021/cn300145z · 2012 · External reference
YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
10.1038/s41467-017-01173-4 · 2017 · External reference
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
10.1101/gad.1898410 · 2010 · External reference
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism
10.15252/embr.202152774 · 2021 · External reference
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
10.1007/s00401-015-1487-z · 2015 · External reference
Metabolic regulation of gene expression through histone acylations
10.1038/nrm.2016.140 · 2017 · External reference
The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
10.1007/s00401-015-1462-8 · 2015 · External reference
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
10.7554/elife.07314 · 2015 · External reference
The super elongation complex (SEC) and MLL in development and disease
10.1101/gad.2015411 · 2011 · External reference
The little elongation complex regulates small nuclear RNA transcription
10.1016/j.molcel.2011.12.008 · 2011 · External reference
Polyglutamine (PolyQ) diseases: navigating the landscape of neurodegeneration
10.1021/acschemneuro.4c00184 · 2024 · External reference
Molecular chaperones: a double-edged sword in neurodegenerative diseases
10.3389/fnagi.2020.581374 · 2020 · External reference
ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia
10.1038/nature21687 · 2017 · External reference
A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression
10.1126/sciadv.ado1432 · 2024 · External reference
Activity-regulated transcription: bridging the gap between neural activity and behavior
10.1016/j.neuron.2018.10.013 · 2018 · External reference
Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases
10.1007/s00018-022-04218-0 · 2022 · External reference
The histone acylation reader ENL/AF9 regulates aging in Drosophila melanogaster
10.1016/j.neurobiolaging.2024.10.002 · 2024 · External reference
ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2(ALS) phenotypes in Drosophila melanogaster
10.1016/j.pneurobio.2024.102674 · 2024 · External reference
Diesel exhaust particles induce lasting and age-dependent damage to the brain in Drosophila melanogaster
10.1016/j.neuro.2026.103464 · 2026 · External reference
YEATS2 O-GlcNAcylation promotes chromatin association of the ATAC complex and lung cancer tumorigenesis
10.1016/j.jbc.2025.110388 · 2025 · External reference
Mitochondrial dysfunction: mechanisms and advances in therapy
10.1038/s41392-024-01839-8 · 2024 · External reference
