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References from Limiting intestinal iron absorption rescues glial defects and extends lifespan in a Drosophila model of Friedreich's ataxia. Local targets link to admitted publications; unresolved targets remain external evidence.
RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila
10.1093/hmg/ddi367 · 2005 · External reference
Triple therapy with deferiprone, idebenone and riboflavin in Friedreich’s ataxia - open-label trial
10.1111/ane.12141 · 2014 · External reference
Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase
10.1242/jeb.051664 · 2011 · External reference
Iron-sulfur cluster biogenesis and trafficking in mitochondria
10.1074/jbc.r117.787101 · 2017 · External reference
Friedreich’s ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion
10.1126/science.271.5254.1423 · 1996 · External reference
Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration
10.7554/elife.16043 · 2016 · External reference
ShinyR-DAM: a program analyzing Drosophila activity, sleep and circadian rhythms
10.1038/s42003-018-0031-9 · 2018 · External reference
Ferroptosis as a novel therapeutic target for Friedreich’s Ataxia
10.1124/jpet.118.252759 · 2019 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Identification of Frataxin as a regulator of ferroptosis
10.1016/j.redox.2020.101483 · 2020 · External reference
Clinical and genetic abnormalities in patients with Friedreich’s ataxia
10.1056/nejm199610173351601 · 1996 · External reference
Clinical experience with Deferiprone treatment for Friedreich Ataxia
10.1177/0883073816636087 · 2016 · External reference
Iron chelators in treatment of iron overload
10.1155/2022/4911205 · 2022 · External reference
Immunolocalisation of the D. Melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous
10.1242/jeb.02193 · 2006 · External reference
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin
10.1038/s41467-019-11470-9 · 2019 · External reference
Safety monitoring of Omaveloxolone in Friedreich Ataxia: results from one year of clinical treatment
10.1007/s40120-025-00749-3 · 2025 · External reference
Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features
10.1093/brain/104.3.589 · 1981 · External reference
In situ detection of ferric reductase activity in the intestinal lumen of an insect
10.1007/s00775-024-02080-y · 2024 · External reference
Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila
10.1016/j.biochi.2024.05.003 · 2024 · External reference
Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation
10.1182/blood-2008-06-161919 · 2008 · External reference
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation
10.1186/s40478-016-0288-5 · 2016 · External reference
Ferroptosis in Friedreich’s Ataxia: a metal-induced neurodegenerative disease
10.3390/biom10111551 · 2020 · External reference
The Nrf2 induction prevents ferroptosis in Friedreich’s Ataxia
10.1016/j.redox.2020.101791 · 2021 · External reference
The role of Iron in Friedreich’s Ataxia: insights from studies in human tissues and cellular and animal models
10.3389/fnins.2019.00075 · 2019 · External reference
Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity
10.1016/j.nbd.2014.12.017 · 2015 · External reference
Frataxin deficiency induces Schwann cell inflammation and death
10.1016/j.bbadis.2009.07.011 · 2009 · External reference
Safety and efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe study)
10.1002/ana.25934 · 2021 · External reference
Iron absorption in Drosophila melanogaster
10.3390/nu5051622 · 2013 · External reference
Ferritin accumulation under iron scarcity in Drosophila iron cells
10.1016/j.biochi.2009.05.003 · 2009 · External reference
Characterization of mitochondrial ferritin in Drosophila
10.1073/pnas.0601471103 · 2006 · External reference
dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila
10.1371/journal.pgen.1003081 · 2012 · External reference
Altered lipid metabolism in a Drosophila model of Friedreich’s ataxia
10.1093/hmg/ddq183 · 2010 · External reference
Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich’s ataxia
10.1016/j.freeradbiomed.2015.03.014 · 2015 · External reference
Friedreich ataxia: the clinical picture
10.1007/s00415-009-1002-3 · 2009 · External reference
Deferiprone for the treatment of Friedreich’s ataxia
10.1111/jnc.12300 · 2013 · External reference
Deferiprone in Friedreich ataxia: a 6-month randomized controlled trial
10.1002/ana.24248 · 2014 · External reference
Pathological frataxin deficiency in mice causes tissue-specific alterations in iron homeostasis
10.1016/j.isci.2025.114625 · 2026 · External reference
Targeting frataxin deficiency in DRG neurons and fibroblasts: omaveloxolone restores metabolic and iron balance to reduce ferroptosis
10.1016/j.biopha.2026.119031 · 2026 · External reference
Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits
10.1038/84818 · 2001 · External reference
Iron concentrations in neurons and glial cells with estimates on ferritin concentrations
10.1186/s12868-019-0507-7 · 2019 · External reference
Lack of miRNA Misregulation at early pathological stages in Drosophila neurodegenerative disease models
10.3389/fgene.2012.00226 · 2012 · External reference
A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine
10.1093/hmg/ddaa170 · 2020 · External reference
Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3beta in the impairment of the NRF2 response
10.1016/j.redox.2024.103339 · 2024 · External reference
Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications
10.1182/blood-2007-07-102335 · 2008 · External reference
Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich’s ataxia
10.1016/j.gene.2013.02.049 · 2013 · External reference
Metal homeostasis regulators suppress FRDA phenotypes in a Drosophila model of the disease
10.1371/journal.pone.0159209 · 2016 · External reference
Oxidative stress and altered lipid metabolism in Friedreich ataxia
10.1016/j.freeradbiomed.2016.06.007 · 2016 · External reference
Mortality in Friedreich ataxia
10.1016/j.jns.2011.05.023 · 2011 · External reference
Cross-regulation of [2Fe-2S] cluster synthesis by ferredoxin-2 and frataxin
10.1038/s41586-025-09822-1 · 2026 · External reference
The MCK mouse heart model of Friedreich’s ataxia: alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation
10.1073/pnas.0804261105 · 2008 · External reference
Comparative efficacy and safety of deferoxamine, deferiprone and deferasirox on severe thalassemia: a meta-analysis of 16 randomized controlled trials
10.1371/journal.pone.0082662 · 2013 · External reference
Transferrin 1 functions in iron trafficking and genetically interacts with ferritin in Drosophila melanogaster
10.1016/j.celrep.2018.12.053 · 2019 · External reference
Ferroptosis: process and function
10.1038/cdd.2015.158 · 2016 · External reference
