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References from New insights on microglial lysosomal acidification: A therapeutic target of neurodegenerative diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Ion Channels and Pumps in Autophagy: A Reciprocal Relationship
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Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages
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The Biology of Lysosomes: From Order to Disorder
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Neurofilament light: A candidate biomarker of presymptomatic amyotrophic lateral sclerosis and phenoconversion
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New tools for studying microglia in the mouse and human CNS
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Immunometabolism in the Brain: How Metabolism Shapes Microglial Function
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Lysosomal activity depends on TRPML1-mediated Ca2+ release coupled to incoming vesicle fusions
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Lysosomes as a therapeutic target
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Neuroinflammatory paradigms in lysosomal storage diseases
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Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression
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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
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Targeting lysosomes in human disease: from basic research to clinical applications
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Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
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Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer’s Disease via PPARα
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Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice
10.1080/15548627.2020.1719723 · 2020 · External reference
Unresolved reference
2020 · External reference
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH
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Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury
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Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity
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Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
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Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease
10.1016/j.arr.2016.05.004 · 2016 · External reference
TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities
10.1016/j.nbd.2018.05.012 · 2019 · External reference
Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice
10.3390/biology10010029 · 2021 · External reference
Lysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies
10.1007/s00018-024-05419-5 · 2024 · External reference
Pathogenic Lysosomal Depletion in Parkinson’s Disease
10.1523/jneurosci.1920-10.2010 · 2010 · External reference
Autophagy in infection, inflammation and immunity
10.1038/nri3532 · 2013 · External reference
Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
10.1038/s41467-021-22301-1 · 2021 · External reference
The First Frontier: Digital Biomarkers for Neurodegenerative Disorders
10.1159/000477383 · 2017 · External reference
The Role of Valosin-containing Protein in Organelle-specific Autophagy
2022 · External reference
Nigrostriatal dopamine transporter availability in early Parkinson’s disease
10.1002/mds.27316 · 2018 · External reference
Neuronal lysosomes
10.1016/j.neulet.2018.04.005 · 2019 · External reference
Lysosome quality control in health and neurodegenerative diseases
10.1186/s11658-024-00633-2 · 2024 · External reference
The Autophagy Lysosomal Pathway and Neurodegeneration
10.1101/cshperspect.a033993 · 2020 · External reference
The pathogenesis of lysosomal storage disorders: beyond the engorgement of lysosomes to abnormal development and neuroinflammation
10.1093/hmg/ddy155 · 2018 · External reference
Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders
10.15252/embj.201899553 · 2019 · External reference
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
10.1038/s41392-023-01588-0 · 2023 · External reference
Abnormal synaptic pruning during adolescence underlying the development of psychotic disorders
10.1097/yco.0000000000000696 · 2021 · External reference
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder
10.1016/j.cell.2025.12.012 · 2026 · External reference
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
10.1038/nn.3531 · 2013 · External reference
Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting
10.1109/access.2022.3156659 · 2022 · External reference
Combating apoptosis and multidrug resistant cancers by targeting lysosomes
10.1016/j.canlet.2010.05.021 · 2013 · External reference
A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation
10.1038/s41593-019-0539-4 · 2019 · External reference
Microglia-dependent remodeling of neuronal circuits
10.1111/jnc.15689 · 2022 · External reference
Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
10.1093/brain/awaa090 · 2020 · External reference
Development of digital voice biomarkers and associations with cognition, cerebrospinal biomarkers, and neural representation in early Alzheimer’s disease
2023 · External reference
Influence of lysosomal sequestration on multidrug resistance in cancer cells
2019 · External reference
Exosomes as drug delivery vehicles for Parkinson’s disease therapy
10.1016/j.jconrel.2015.03.033 · 2015 · External reference
Microglia in Alzheimer’s disease
10.1083/jcb.201709069 · 2018 · External reference
NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice
10.1038/nature11729 · 2013 · External reference
18F-FDG PET can effectively rule out conversion to dementia and the presence of CSF biomarker of neurodegeneration: a real-world data analysis
10.1186/s13195-024-01535-3 · 2024 · External reference
Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma
10.1073/pnas.1721434116 · 2019 · External reference
Dopamine Transporter Imaging in Parkinson Disease: Progressive Changes and Therapeutic Modification after Anti-parkinsonian Medications
10.2169/internalmedicine.2489-18 · 2019 · External reference
Theranostic F-SLOH mitigates Alzheimer’s disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer’s disease models
10.1016/j.redox.2022.102280 · 2022 · External reference
Recent advances in targeting autophagy in cancer
10.1016/j.tips.2023.02.003 · 2023 · External reference
Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies
10.1007/s11739-024-03700-w · 2024 · External reference
Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?
10.3389/fnmol.2018.00144 · 2018 · External reference
Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation
2019 · External reference
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)
10.1523/jneurosci.0578-19.2019 · 2019 · External reference
The autophagy–lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease
10.4103/nrr.nrr-d-23-01195 · 2024 · External reference
Tmem119-EGFP and Tmem119-CreERT2 Transgenic Mice for Labeling and Manipulating Microglia
10.1523/eneuro.0448-18.2019 · 2019 · External reference
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes
10.1002/hep4.1785 · 2021 · External reference
Regulatory Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer’s Disease
10.7150/ijbs.103028 · 2025 · External reference
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
10.1038/s41582-018-0070-3 · 2018 · External reference
Stress-induced microautophagy is coordinated with lysosome biogenesis and regulated by PIKfyve
10.1091/mbc.e23-08-0332 · 2024 · External reference
Lysosomal Functions in Glia Associated with Neurodegeneration
10.3390/biom11030400 · 2021 · External reference
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics
10.3390/ijms23031851 · 2022 · External reference
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
10.1016/j.celrep.2020.107530 · 2020 · External reference
Hematological Findings in Lysosomal Storage Disorders: A Perspective from the Medical Laboratory
2022 · External reference
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo
10.1080/15548627.2018.1528812 · 2019 · External reference
β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7
10.1016/j.jmb.2020.02.021 · 2020 · External reference
Autophagy mediates an amplification loop during ferroptosis
10.1038/s41419-023-05978-8 · 2023 · External reference
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
10.1038/s41582-020-00435-y · 2021 · External reference
Lysosome trafficking and signaling in health and neurodegenerative diseases
10.1016/j.nbd.2018.05.015 · 2019 · External reference
Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
10.1186/s40035-023-00362-0 · 2023 · External reference
Preclinical Alzheimer’s disease biomarkers accurately predict cognitive and neuropathological outcomes
10.1093/brain/awac250 · 2022 · External reference
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading
10.1007/s00401-017-1746-2 · 2017 · External reference
Autophagy in health and disease: From molecular mechanisms to therapeutic target
10.1002/mco2.150 · 2022 · External reference
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
10.1371/journal.pone.0025416 · 2011 · External reference
Targeting Aggrephagy for the Treatment of Alzheimer’s Disease
10.3390/cells9020311 · 2020 · External reference
Neurodegenerative Diseases: A Multidisciplinary Approach
10.2174/1381612827666210608152745 · 2021 · External reference
Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases
10.1242/jcs.221739 · 2019 · External reference
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
10.1080/15548627.2019.1637200 · 2020 · External reference
Neuroimaging Biomarkers for Alzheimer’s Disease
10.1186/s13024-019-0325-5 · 2019 · External reference
The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
10.1016/j.tins.2016.02.002 · 2016 · External reference
Gene Therapy for Lysosomal Storage Disorders: Ongoing Studies and Clinical Development
10.3390/biom11040611 · 2021 · External reference
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
10.1038/s41586-019-0924-x · 2019 · External reference
Microglia Heterogeneity in the Single-Cell Era
10.1016/j.celrep.2020.01.010 · 2020 · External reference
A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester
10.1016/j.jim.2008.11.019 · 2009 · External reference
Lysosomal acidification mechanisms
10.1146/annurev-physiol-012110-142317 · 2012 · External reference
mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a
10.4049/jimmunol.1701712 · 2018 · External reference
Autophagic lysosome reformation in health and disease
10.1080/15548627.2022.2128019 · 2023 · External reference
TFEB at a glance
10.1242/jcs.146365 · 2016 · External reference
Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
10.1038/s12276-024-01161-x · 2024 · External reference
Deciphering host lysosome-mediated elimination of Plasmodium berghei liver stage parasites
10.1038/s41598-019-44449-z · 2019 · External reference
18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging
10.1007/s12149-018-1240-5 · 2018 · External reference
The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases
10.1016/j.bbapap.2020.140443 · 2020 · External reference
Autophagy-lysosomal-associated neuronal death in neurodegenerative disease
10.1007/s00401-024-02799-7 · 2024 · External reference
Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration
10.3389/fnins.2020.00048 · 2020 · External reference
Lysosomal storage diseases: from pathophysiology to therapy
10.1146/annurev-med-122313-085916 · 2015 · External reference
The rapidly evolving view of lysosomal storage diseases
10.15252/emmm.202012836 · 2021 · External reference
Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
2019 · External reference
The Lysosome as a Regulatory Hub
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Targeting the lysosome in cancer
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Lysosomal storage diseases
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Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
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CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
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Defective mitophagy in Alzheimer’s disease
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Microglia Biology: One Century of Evolving Concepts
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Artificial General Intelligence for the Detection of Neurodegenerative Disorders
10.3390/s24206658 · 2024 · External reference
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
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Microglia-Mediated Synapse Loss in Alzheimer’s Disease
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Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects
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Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes
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Automatic speech-based assessment to discriminate Parkinson’s disease from essential tremor with a cross-language approach
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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
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Novel Microglia Cell Line Expressing the Human EP2 Receptor
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Chronic acidosis rewires cancer cell metabolism through PPARα signaling
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Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment: A Systematic Review and Meta-analysis
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HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons
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Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
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Quantity and quality of gait and turning in people with multiple sclerosis, Parkinson’s disease and matched controls during daily living
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Selective Autophagy and Xenophagy in Infection and Disease
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Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction-associated diseases
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Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages
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The identity and function of microglia in neurodegeneration
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The impact of amyloid-beta and tau on prospective cognitive decline in older individuals
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Microglia-mediated neuroinflammation in neurodegenerative diseases
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Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies
10.3390/biom14070833 · 2024 · External reference
Early Diagnosis of Alzheimer’s Disease: Moving Toward a Blood-Based Biomarkers Era
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When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy. Matrix Biol
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Lysosomal Biology and Function: Modern View of Cellular Debris Bin
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Lysosomal dysfunction in neurodegeneration: emerging concepts and methods
10.1016/j.tins.2021.12.004 · 2022 · External reference
TREM2 - a key player in microglial biology and Alzheimer disease
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Using the Alzheimer’s Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer’s disease
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Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration
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Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease
10.1111/febs.14323 · 2018 · External reference
Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer’s disease
2022 · External reference
Challenges in the development and establishment of exosome-based drug delivery systems
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Dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: Involvement of CX3CR1 signaling
2023 · External reference
Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
10.3390/ph16040601 · 2023 · External reference
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation
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Lysosomal storage disorders: diagnostic dilemmas and prospects for therapy
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Emerging Roles for Microglial Phagocytic Signaling in Epilepsy
10.1177/1535759719890336 · 2020 · External reference
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
10.7554/elife.51031 · 2019 · External reference
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles
10.1080/15548627.2020.1725377 · 2021 · External reference
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10.1038/s41421-020-0141-7 · 2020 · External reference
Modulating lysosomal pH: a molecular and nanoscale materials design perspective
2020 · External reference
Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
10.1038/s41467-023-38165-6 · 2023 · External reference
Lysosomal acidification impairment in astrocyte-mediated neuroinflammation
10.1186/s12974-025-03410-w · 2025 · External reference
New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
10.3389/fnagi.2018.00370 · 2018 · External reference
Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
2022 · External reference
Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
10.1080/15548627.2022.2108252 · 2023 · External reference
Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
10.1038/s41419-018-1227-0 · 2018 · External reference
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
10.1038/cr.2013.11 · 2013 · External reference
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease
10.3390/ijms20030728 · 2019 · External reference