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References from Chronic hypertension and social isolation disrupt the blood-brain barrier and memory in a sex-dependent manner. Local targets link to admitted publications; unresolved targets remain external evidence.
Midlife ICAM-1 levels may predict cardiovascular disease and cognitive decline in latelife: insights from the HeartSCORE study
10.1016/j.athplu.2025.10.001 · 2025 · External reference
The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats
10.1016/j.biocel.2009.04.001 · 2009 · External reference
Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them
10.1186/s12974-021-02368-9 · 2022 · External reference
Alzheimer’s disease facts and figures
2022 · External reference
Sex differences in mixed neuropathologies in community-dwelling older adults
10.1016/j.brainres.2019.05.028 · 2019 · External reference
Loneliness around the world: age, gender, and cultural differences in loneliness
10.1016/j.paid.2020.110066 · 2021 · External reference
ABC transporters and the blood-brain barrier
10.2174/1381612043384844 · 2004 · External reference
Selective neuromicrovascular endothelial cell death by 8-Iso-prostaglandin F2alpha: possible role in ischemic brain injury
10.1161/01.str.0000055763.76479.e6 · 2003 · External reference
Object recognition memory and the rodent hippocampus
10.1101/lm.1650110 · 2010 · External reference
WHO’S global action plan on the public health response to dementia: some challenges and opportunities
10.1080/13607863.2018.1544213 · 2020 · External reference
Cognitive stimulation exerts long-lasting protective effects on the hippocampal vasculature and memory function in a rat model of vascular cognitive impairment
10.1038/s41514-025-00304-2 · 2025 · External reference
Vaginal cytology of the laboratory rat and mouse: review and criteria for the staging of the estrous cycle using stained vaginal smears
10.1177/0192623315570339 · 2015 · External reference
The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier
10.1016/s0165-5728(02)00114-5 · 2002 · External reference
Hypertension promotes neuroinflammation, brain injury and cognitive impairment
2025 · External reference
Sex differences in the blood-brain barrier: implications for mental health
10.1016/j.yfrne.2022.100989 · 2022 · External reference
Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia
10.1002/alz.70104 · 2025 · External reference
Incidence and risk factors of dementia in a defined elderly Japanese population: the Hisayama study
10.1111/j.1749-6632.2002.tb04793.x · 2002 · External reference
Angiotensin II-mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats
10.1002/alz.13491 · 2024 · External reference
Sex differences in hypertension: recent advances
10.1161/hypertensionaha.116.06602 · 2016 · External reference
Prostaglandin F2alpha FP receptor antagonist improves outcomes after experimental traumatic brain injury
10.1186/1742-2094-10-132 · 2013 · External reference
The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies
10.1002/bdrb.20106 · 2007 · External reference
Identifying living arrangements that heighten risk for loneliness in later life: evidence from the U.S. National Social Life, Health, and Aging Project
10.1177/0733464810364985 · 2010 · External reference
The impact of loneliness and social isolation on cognitive aging: a narrative review
10.3233/adr-230011 · 2023 · External reference
Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide
10.1124/mol.105.017954 · 2006 · External reference
17-beta-estradiol: a powerful modulator of blood-brain barrier BCRP activity
10.1038/jcbfm.2010.36 · 2010 · External reference
Vascular cognitive impairment and dementia: JACC scientific expert panel
10.1016/j.jacc.2019.04.034 · 2019 · External reference
Loneliness in midlife: historical increases and elevated levels in the United States compared with Europe
10.1037/amp0001322 · 2025 · External reference
Hippocampal vascular supply and its role in vascular cognitive impairment
10.1161/strokeaha.122.038263 · 2023 · External reference
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia
10.1371/journal.pone.0113670 · 2014 · External reference
Inhibition of blood-brain barrier efflux transporters promotes seizure in pregnant rats: role of circulating factors
10.1016/j.bbi.2017.07.017 · 2018 · External reference
Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia
10.1016/j.pneurobio.2020.101938 · 2021 · External reference
Stroke injury, cognitive impairment and vascular dementia
10.1016/j.bbadis.2016.01.015 · 2016 · External reference
Editorial: Sex differences in cerebrovascular diseases
2022 · External reference
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET
10.1007/s00259-009-1332-5 · 2010 · External reference
Compromised cortical-hippocampal network function from transient hypertension: linking mid-life hypertension to late life dementia risk
10.3389/fnins.2022.897206 · 2022 · External reference
Loneliness, cerebrovascular and Alzheimer’s disease pathology, and cognition
10.1002/alz.14196 · 2024 · External reference
Lowering midlife levels of systolic blood pressure as a public health strategy to reduce late-life dementia: perspective from the Honolulu Heart Program/Honolulu Asia Aging Study
10.1161/hypertensionaha.109.147389 · 2010 · External reference
NF-kappaB/ICAM-1 signaling regulates vascular dysfunction in depressive hypertension rats
10.1038/s41598-025-27188-2 · 2025 · External reference
Directional hippocampal-prefrontal interactions during working memory
10.1016/j.bbr.2017.10.003 · 2018 · External reference
Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking
10.1016/j.bbi.2015.08.020 · 2016 · External reference
Estrogen, menopause, and Alzheimer’s disease: understanding the link to cognitive decline in women
10.3389/fmolb.2025.1634302 · 2025 · External reference
Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
10.1124/pr.107.07109 · 2008 · External reference
Blood-brain barrier breakdown in the aging human hippocampus
10.1016/j.neuron.2014.12.032 · 2015 · External reference
Isoprostanes: markers and mediators of oxidative stress
10.1096/fj.04-2330rev · 2004 · External reference
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction
10.1038/s41591-018-0297-y · 2019 · External reference
Hypertension, neurodegeneration, and cognitive decline
10.1161/hypertensionaha.123.21356 · 2024 · External reference
Heart disease and stroke statistics: a report of US and global data from the American Heart Association
10.1161/cir.0000000000001412 · 2026 · External reference
Combined neuropathological pathways account for age-related risk of dementia
10.1002/ana.25246 · 2018 · External reference
Contributors to age inequalities in loneliness among older adults: a decomposition analysis of 29 countries
10.1080/13607863.2025.2473634 · 2025 · External reference
ICAM-1 deletion using CRISPR/Cas9 protects the brain from traumatic brain injury-induced inflammatory leukocyte adhesion and transmigration cascades by attenuating the Paxillin/FAK-dependent rho GTPase pathway
10.1523/jneurosci.1742-23.2024 · 2024 · External reference
The pathobiology of neurovascular aging
10.1016/j.neuron.2024.12.014 · 2025 · External reference
Hypertension, neurovascular dysfunction, and cognitive impairment
10.1161/hypertensionaha.122.18085 · 2023 · External reference
Brain-to-blood transport of fluorescein in vitro
10.1038/s41598-024-77040-2 · 2024 · External reference
Hippocampal-prefrontal input supports spatial encoding in working memory
10.1038/nature14445 · 2015 · External reference
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease
10.1093/brain/awab099 · 2021 · External reference
Sex differences in the inflammatory response to stroke
10.1007/s00281-022-00969-x · 2023 · External reference
Molecular anatomy of the brain endothelial barrier: an overview of the distributional features
10.2174/092986707780597943 · 2007 · External reference
Gender differences in the correlates of loneliness among Japanese persons aged 50-70
10.1111/ajag.12448 · 2017 · External reference
The blood-brain barrier in systemic inflammation
10.1016/j.bbi.2016.03.010 · 2017 · External reference
Unresolved reference
2018 · External reference
Social isolation and the brain: effects and mechanisms
10.1038/s41380-022-01835-w · 2023 · External reference
Prevalence and risks of dementia in the Japanese population: RERF’s adult health study Hiroshima subjects. Radiation effects research foundation
10.1111/j.1532-5415.1999.tb04577.x · 1999 · External reference
Rodent models of vascular cognitive impairment
10.1007/s12975-016-0486-2 · 2016 · External reference
Role of FPR2 antagonism in alleviating social isolation-induced depression and protecting blood-brain barrier integrity
10.1186/s12974-025-03408-4 · 2025 · External reference