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References from The role of PANoptosis regulatory networks in acute neurological injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Calycosin inhibit PANoptosis and alleviate brain damage: a bioinformatics and experimental verification approach
10.1021/acschemneuro.5c00072 · 2025 · External reference
Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway
10.1016/j.freeradbiomed.2024.05.037 · 2024 · External reference
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
10.1038/s41423-020-00630-3 · 2021 · External reference
Extracellular vesicles: mediators of intercellular communication in tissue injury and disease
10.1186/s12964-021-00787-y · 2021 · External reference
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
10.1074/jbc.270.14.7795 · 1995 · External reference
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis
10.1186/s12915-024-01901-5 · 2024 · External reference
Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model
10.1007/s12031-013-0132-3 · 2014 · External reference
The role of cGAS-STING signaling in ischemic stroke: from immune response to therapeutic targeting
10.1016/j.drudis.2023.103792 · 2023 · External reference
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
10.1038/nature09413 · 2010 · External reference
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly
10.15252/embj.2019101638 · 2019 · External reference
VX-765 reduces neuroinflammation after spinal cord injury in mice
10.4103/1673-5374.306096 · 2021 · External reference
Inhibition of TLR4 alleviates heat stroke-induced cardiomyocyte injury by down-regulating inflammation and ferroptosis
10.3390/molecules28052297 · 2023 · External reference
Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)
10.3389/fcimb.2020.00237 · 2020 · External reference
Spontaneous subarachnoid haemorrhage
10.1016/s0140-6736(22)00938-2 · 2022 · External reference
Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury
10.1096/fasebj.13.8.813 · 1999 · External reference
Immune exosomes loading self-assembled nanomicelles traverse the blood-brain barrier for chemo-immunotherapy against glioblastoma
10.1021/acsnano.2c10219 · 2023 · External reference
DL-3-n-Butylphthalide ameliorates post-stroke emotional disorders by suppressing neuroinflammation and PANoptosis
10.1007/s11064-024-04171-3 · 2024 · External reference
Gasdermins and pyroptosis in the kidney
10.1038/s41581-022-00662-0 · 2023 · External reference
Histologic studies of the brain following head trauma; post-traumatic petechial and massive intracerebral hemorrhage
10.3171/jns.1946.3.2.0101 · 1946 · External reference
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
10.1186/s12974-020-01973-4 · 2020 · External reference
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
10.1371/journal.ppat.1009220 · 2021 · External reference
Neuronal cell death
10.1152/physrev.00011.2017 · 2018 · External reference
Safety, pharmacokinetics and target engagement of a novel brain penetrant RIPK1 inhibitor (SIR9900) in healthy adults and elderly participants
10.1111/cts.70151 · 2025 · External reference
Drug repurposing for spinal cord injury: progress towards therapeutic intervention for primary factors and secondary complications
10.1007/s40290-023-00499-3 · 2023 · External reference
It’s all in the PAN: crosstalk, plasticity, redundancies, switches, and interconnectedness encompassed by PANoptosis underlying the totality of cell death-associated biological effects
10.3390/cells11091495 · 2022 · External reference
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress
10.1038/s41467-024-45466-x · 2024 · External reference
Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis
10.1186/s12974-022-02602-y · 2022 · External reference
PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats
10.1016/j.expneurol.2024.115072 · 2025 · External reference
Traumatic brain injury in China
10.1016/s1474-4422(18)30469-1 · 2019 · External reference
ADAR1 and ZBP1 in innate immunity, cell death, and disease
10.1016/j.it.2023.01.001 · 2023 · External reference
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer
10.1172/jci.insight.136720 · 2020 · External reference
NINJ1 mediates plasma membrane rupture during lytic cell death
10.1038/s41586-021-03218-7 · 2021 · External reference
Autophagy in major human diseases
10.15252/embj.2021108863 · 2021 · External reference
The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies
10.1186/1742-2094-11-2 · 2014 · External reference
Severe traumatic brain injury induces early changes in the physical properties and protein composition of intracranial extracellular vesicles
10.1089/neu.2017.5515 · 2019 · External reference
Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the global burden of disease study 2016
10.1016/s1474-4422(19)30034-1 · 2019 · External reference
10.1016/s1474-4422(18)30415-0
10.1016/s1474-4422(18)30415-0 · 2019 · External reference
10.1016/s1474-4422(21)00252-0
10.1016/s1474-4422(21)00252-0 · 2021 · External reference
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
10.1038/s41586-021-03875-8 · 2021 · External reference
Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis
10.1186/s12943-023-01741-x · 2023 · External reference
PANoptosis in neurological disorders: mechanisms, implications, and therapeutic potential
2025 · External reference
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10.1016/s0092-8674(00)80434-1 · 1997 · External reference
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis [J]
10.1080/14728222.2023.2239495 · 2023 · External reference
Extracellular histones exacerbate heat stroke-induced liver injury by triggering hepatocyte pyroptosis and liver injury via the TLR9-NLRP3 pathway
10.1016/j.intimp.2023.111305 · 2024 · External reference
Machine learning and experiments revealed key genes related to PANoptosis linked to drug prediction and immune landscape in spinal cord injury
10.1007/s12035-025-04717-8 · 2025 · External reference
The challenge of cell death switching in inflammasome-targeted therapies for bacterial and viral infections
10.1038/s42003-026-10475-7 · 2026 · External reference
RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: dependent on AMPK pathway
10.1016/j.bbrc.2018.02.150 · 2018 · External reference
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion
10.1186/s12974-021-02216-w · 2021 · External reference
RIPK1 in the inflammatory response and sepsis: recent advances, drug discovery and beyond
2023 · External reference
TRIM56 modulates YBX1 degradation to ameliorate ZBP1-mediated neuronal PANoptosis in spinal cord injury
2024 · External reference
RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk
10.1016/j.bcp.2019.113751 · 2020 · External reference
Label-free cholesteric liquid crystal biosensing chips for heme oxygenase-1 detection within cerebrospinal fluid as an effective outcome indicator for spontaneous subarachnoid hemorrhage
2022 · External reference
Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice
10.1186/s12974-022-02501-2 · 2022 · External reference
ZBP1 and TAK1: master regulators of NLRP3 inflammasome/Pyroptosis, apoptosis, and necroptosis (PAN-optosis)
10.3389/fcimb.2019.00406 · 2019 · External reference
RIPK1 distinctly regulates Yersinia-induced inflammatory cell death, PANoptosis
10.4049/immunohorizons.2000097 · 2020 · External reference
ZBP1 drives IAV-induced NLRP3 inflammasome activation and lytic cell death, PANoptosis, independent of the necroptosis executioner MLKL
10.3390/v15112141 · 2023 · External reference
Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis
10.1016/j.isci.2023.106938 · 2023 · External reference
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
10.1038/ni.3118 · 2015 · External reference
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
10.1111/imr.12534 · 2017 · External reference
Spinal-cord injury
10.1016/s0140-6736(02)07603-1 · 2002 · External reference
Caspase 8 inhibits programmed necrosis by processing CYLD
10.1038/ncb2362 · 2011 · External reference
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death
10.1126/science.aau2818 · 2018 · External reference
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
10.1016/j.molmed.2023.10.001 · 2024 · External reference
HMGB1: a common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction
10.3389/fnins.2018.00628 · 2018 · External reference
Heat stroke
10.1001/jama.2017.18780 · 2017 · External reference
PANoptosis in microbial infection
10.1016/j.mib.2020.07.012 · 2021 · External reference
Pathophysiology of long non-coding RNAs in ischemic stroke
10.3389/fnmol.2018.00096 · 2018 · External reference
HMGB1: a double-edged sword and therapeutic target in the female reproductive system
10.3389/fimmu.2023.1238785 · 2023 · External reference
Neurovascular unit-derived extracellular vesicles: from their physiopathological roles to their clinical applications in acute brain injuries
10.3390/biomedicines10092147 · 2022 · External reference
Neuroprotection by a bile acid in an acute stroke model in the rat
10.1097/00004647-200204000-00010 · 2002 · External reference
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats
10.1073/pnas.1031632100 · 2003 · External reference
Targeting of TAK1 in inflammatory disorders and cancer
10.1016/j.tips.2012.06.007 · 2012 · External reference
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
10.1073/pnas.1809548115 · 2018 · External reference
Essential function for the kinase TAK1 in innate and adaptive immune responses
10.1038/ni1255 · 2005 · External reference
Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)
10.1016/j.jbc.2023.105141 · 2023 · External reference
Neuroinflammation across neurological diseases
10.1126/science.adx0043 · 2025 · External reference
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury
10.1186/s12974-023-02903-w · 2023 · External reference
PANoptosis: a cell death characterized by pyroptosis, apoptosis, and necroptosis
10.2147/jir.s403819 · 2023 · External reference
Neuronal LAMP2A-mediated reduction of adenylyl cyclases induces acute neurodegenerative responses and neuroinflammation after ischemic stroke
10.1038/s41418-024-01389-0 · 2025 · External reference
VX765 attenuates pyroptosis and HMGB1/TLR4/NF-κB pathways to improve functional outcomes in TBI mice
10.1155/2020/7879629 · 2020 · External reference
The mechanisms behind heatstroke-induced intestinal damage
10.1038/s41420-024-02210-0 · 2024 · External reference
PANoptosis: mechanisms, biology, and role in disease
10.1111/imr.13279 · 2024 · External reference
NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
10.1016/j.cell.2023.05.005 · 2023 · External reference
Autophagy: a double-edged sword in ischemia-reperfusion injury
10.1186/s11658-025-00713-x · 2025 · External reference
TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases
10.1098/rsob.200099 · 2020 · External reference
Wiring and rewiring PANoptosis: molecular vulnerabilities for targeting inflammatory cell death in human disease
10.1016/j.cytogfr.2025.09.003 · 2025 · External reference
Challenges and directions in studying cell-cell communication by extracellular vesicles
10.1038/s41580-022-00460-3 · 2022 · External reference
Molecular mechanisms of necroptosis: an ordered cellular explosion
10.1038/nrm2970 · 2010 · External reference
Adeno-associated virus vector as a platform for gene therapy delivery
10.1038/s41573-019-0012-9 · 2019 · External reference
The repression of the HMGB1-TLR4-NF-κB signaling pathway by safflower yellow may improve spinal cord injury
10.3389/fnins.2021.803885 · 2021 · External reference
The pathogenesis and therapeutic strategies of heat stroke-induced liver injury
10.1186/s13054-022-04273-w · 2022 · External reference
Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
10.1038/s41419-023-06370-2 · 2023 · External reference
The significant mechanism and treatments of cell death in heatstroke
10.1007/s10495-024-01979-w · 2024 · External reference
Response to inhibition of receptor-interacting protein kinase 1 (RIPK1) in active plaque psoriasis: a randomized placebo-controlled study
10.1002/cpt.1852 · 2020 · External reference
Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury
10.1038/s41418-024-01408-0 · 2025 · External reference
Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage
10.1016/j.expneurol.2024.114705 · 2024 · External reference
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia–reperfusion injury
10.1186/s12964-023-01457-x · 2024 · External reference
Melatonin exerts an anti-Panoptoic role in spinal cord ischemia-reperfusion injured rats
2024 · External reference
Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis
10.18632/aging.203221 · 2021 · External reference
Ripks and neuroinflammation
10.1007/s12035-024-03981-4 · 2024 · External reference
Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury
10.1080/15548627.2025.2471633 · 2025 · External reference
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies
10.4103/1673-5374.331539 · 2022 · External reference
Caspase-11 requires the Pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock
10.1016/j.immuni.2015.10.009 · 2015 · External reference
Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy
10.1016/j.jconrel.2023.07.021 · 2023 · External reference
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
10.1038/jcbfm.2008.44 · 2008 · External reference
Pseudorabies virus infection induces IRF1-dependent PANoptosis to provoke the excessive release of HMGB1 and IL-1β
10.1038/s42003-026-10435-1 · 2026 · External reference
Z-DNA binding protein 1 promotes heatstroke-induced cell death
10.1126/science.abg5251 · 2022 · External reference
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
10.1016/j.celrep.2021.109112 · 2021 · External reference
Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury
10.1126/sciadv.adj4260 · 2024 · External reference
Heat stroke: pathogenesis, diagnosis, and current treatment
10.1016/j.arr.2024.102409 · 2024 · External reference
Esculentoside H reduces the PANoptosis and protects the blood-brain barrier after cerebral ischemia/reperfusion through the TLE1/PI3K/AKT signaling pathway
10.1016/j.expneurol.2024.114850 · 2024 · External reference
Pathogenesis and therapeutic strategy of heat stroke-induced acute kidney injury
10.1016/j.intimp.2025.114969 · 2025 · External reference
Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
10.1186/s12974-022-02633-5 · 2022 · External reference
The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K
10.3389/fphar.2023.1157054 · 2023 · External reference
Advances in mechanism and regulation of PANoptosis: prospects in disease treatment
2023 · External reference