Research graph
References from Microglial CX3CR1 signaling mediates synaptic pruning in degenerative cervical myelopathy. Local targets link to admitted publications; unresolved targets remain external evidence.
Fractalkine signaling and microglia functions in the developing brain
10.1155/2015/689404 · 2015 · External reference
Degenerative cervical myelopathy - update and future directions
10.1038/s41582-019-0303-0 · 2020 · External reference
Microglia shape presynaptic properties at developing glutamatergic synapses
10.1002/glia.23508 · 2019 · External reference
A new class of membrane-bound chemokine with a CX3C motif
10.1038/385640a0 · 1997 · External reference
Role of CX3CR1 signaling on the maturation of GABAergic transmission and neuronal network activity in the neonate hippocampus
10.1016/j.neuroscience.2019.03.006 · 2019 · External reference
Microglia coordinate cellular interactions during spinal cord repair in mice
10.1038/s41467-022-31797-0 · 2022 · External reference
Compromised fractalkine signaling delays microglial occupancy of emerging modules in the multisensory midbrain
10.1002/glia.24134 · 2022 · External reference
Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system
10.1016/j.immuni.2015.06.012 · 2015 · External reference
Fractalkine/CX3CR1-dependent modulation of synaptic and network plasticity in health and disease
10.1155/2023/4637073 · 2023 · External reference
Unresolved reference
2023 · External reference
Control of microglial neurotoxicity by the fractalkine receptor
10.1038/nn1715 · 2006 · External reference
Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson’s disease
10.1002/glia.23338 · 2018 · External reference
Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage
10.1523/jneurosci.20-15-j0004.2000 · 2000 · External reference
A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis
2020 · External reference
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
10.1038/nature12776 · 2013 · External reference
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents
10.1523/jneurosci.3611-11.2011 · 2011 · External reference
Alterations of protein composition along the rostro-caudal axis after spinal cord injury: proteomic, in vitro and in vivo analyses
10.3389/fncel.2014.00105 · 2014 · External reference
Microglial signalling mechanisms: cathepsin S and fractalkine
10.1016/j.expneurol.2011.09.012 · 2012 · External reference
Fractalkine/CX3CR1 signaling during neuropathic pain
10.3389/fncel.2014.00121 · 2014 · External reference
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
10.1073/pnas.0610811104 · 2007 · External reference
ATP mediates rapid microglial response to local brain injury in vivo
10.1038/nn1472 · 2005 · External reference
Degenerative cervical myelopathy
2018 · External reference
Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse
10.1038/jcbfm.2008.64 · 2008 · External reference
The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy
10.1172/jci.insight.149227 · 2021 · External reference
Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats
10.1016/j.expneurol.2008.04.009 · 2008 · External reference
Methods used to evaluate pain behaviors in rodents
10.3389/fnmol.2017.00284 · 2017 · External reference
Microbiota restrict trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells
10.1038/nature11809 · 2013 · External reference
Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages
10.1523/jneurosci.2114-11.2011 · 2011 · External reference
A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury
10.1097/00007632-199812150-00012 · 1998 · External reference
Deletion of the fractalkine receptor, CX3CR1, improves endogenous repair, axon sprouting, and synaptogenesis after spinal cord injury in mice
10.1523/jneurosci.2841-16.2017 · 2017 · External reference
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer’s disease
10.1038/nn.2511 · 2010 · External reference
CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice
10.1002/glia.22474 · 2013 · External reference
Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury
10.1523/jneurosci.2823-08.2008 · 2008 · External reference
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
10.1074/jbc.m106434200 · 2001 · External reference
Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity
10.1016/j.celrep.2022.111209 · 2022 · External reference
V1 spinal neurons regulate the speed of vertebrate locomotor outputs
10.1038/nature04545 · 2006 · External reference
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
10.1038/s41593-019-0419-y · 2019 · External reference
Vascular expression of the chemokine CX3CL1 promotes osteoclast recruitment and exacerbates bone resorption in an irradiated murine model
10.1016/j.bone.2013.12.032 · 2014 · External reference
Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia
10.1073/pnas.95.18.10896 · 1998 · External reference
Fractalkine and fractalkine receptors in human neurons and glial cells
10.1002/jnr.10304 · 2002 · External reference
The prevalence and phenotype of activated microglia/macrophages within the spinal cord of the hyperostotic mouse (twy/twy) changes in response to chronic progressive spinal cord compression: implications for human cervical compressive myelopathy
10.1371/journal.pone.0064528 · 2013 · External reference
Complement and microglia mediate early synapse loss in Alzheimer mouse models
10.1126/science.aad8373 · 2016 · External reference
Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex
10.1523/jneurosci.1167-12.2012 · 2012 · External reference
Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts
2013 · External reference
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
10.1182/blood-2002-12-3775 · 2003 · External reference
Inflammatory osteoclasts prime TNFα-producing CD4+ T cells and express CX3 CR1
10.1002/jbmr.2868 · 2016 · External reference
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
10.1016/s0092-8674(00)80438-9 · 1997 · External reference
Tumor necrosis factor-alpha and its receptors contribute to apoptosis of oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy) sustaining chronic mechanical compression
10.1097/brs.0b013e3181b0d078 · 2009 · External reference
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
10.1128/mcb.20.11.4106-4114.2000 · 2000 · External reference
Cervical spondylotic myelopathy: the clinical phenomenon and the current pathobiology of an increasingly prevalent and devastating disorder
10.1177/1073858412467377 · 2013 · External reference
The role of oligodendrocytes in the molecular pathobiology and potential molecular treatment of cervical spondylotic myelopathy
10.2174/092986710790820598 · 2010 · External reference
A novel experimental model of cervical spondylotic myelopathy (CSM) to facilitate translational research
10.1016/j.nbd.2013.02.013 · 2013 · External reference
Pathobiology of cervical spondylotic myelopathy
10.1007/s00586-014-3264-4 · 2015 · External reference
Microglia: new roles for the synaptic stripper
10.1016/j.neuron.2012.12.023 · 2013 · External reference
New experimental rabbit animal model for cervical spondylotic myelopathy
10.1038/sc.2011.71 · 2011 · External reference
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption
10.4049/jimmunol.0803627 · 2009 · External reference
Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK
10.1016/j.ejpain.2009.10.017 · 2010 · External reference
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two alzheimer’s disease mouse models
10.2353/ajpath.2010.100265 · 2010 · External reference
Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis
10.1038/s41586-020-03060-3 · 2021 · External reference
Impairment of VGLUT2 but not VGLUT1 signaling reduces neuropathy-induced hypersensitivity
10.1016/j.ejpain.2008.12.001 · 2009 · External reference
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
10.1016/j.neuron.2010.09.008 · 2010 · External reference
Evidence for a protective role of the CX3CL1/CX3CR1 axis in a model of amyotrophic lateral sclerosis
10.1515/hsz-2018-0204 · 2019 · External reference
Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury
10.1093/stcltm/szae090 · 2025 · External reference
Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases
10.1016/j.brainresbull.2018.11.017 · 2019 · External reference
Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia
10.4049/jimmunol.163.3.1628 · 1999 · External reference
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1
10.7554/elife.54493 · 2020 · External reference
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
10.1097/00000542-200205000-00020 · 2002 · External reference
Involvement of CX3CL1 in the migration of osteoclast precursors across osteoblast layer stimulated by interleukin-1ß
10.1002/jcp.25577 · 2017 · External reference
Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice
10.1016/j.jneuroim.2013.02.008 · 2013 · External reference
Abnormal innate and learned behavior induced by neuron-microglia miscommunication is related to CA3 reconfiguration
10.1002/glia.24185 · 2022 · External reference
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival
10.1073/pnas.090017497 · 2000 · External reference
CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem
10.1002/cne.25150 · 2021 · External reference
Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats
10.1111/j.1460-9568.2004.03709.x · 2004 · External reference
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine
10.1111/j.1460-9568.2005.04470.x · 2005 · External reference
Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain
10.1523/jneurosci.2556-06.2006 · 2006 · External reference
Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration
10.1038/mt.2014.175 · 2015 · External reference
Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?
10.1016/s0014-5793(98)00583-3 · 1998 · External reference
Degenerative cervical myelopathy: epidemiology, genetics, and pathogenesis
10.1097/brs.0000000000000913 · 2015 · External reference
Osteoclasts derive predominantly from bone marrow-resident CX3CR1+ precursor cells in homeostasis while circulating CX3CR1+ cells contribute to osteoclast development during fracture repair
2020 · External reference
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
10.1038/42491 · 1997 · External reference
Synaptic pruning by microglia is necessary for normal brain development
10.1126/science.1202529 · 2011 · External reference
Astrocyte-dependent circuit remodeling by synapse phagocytosis
10.1016/j.conb.2023.102732 · 2023 · External reference
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
10.1016/j.cell.2013.11.030 · 2013 · External reference
The impact of the CX3CL1/CX3CR1 axis in neurological disorders
10.3390/cells9102277 · 2020 · External reference
CX3CR1 mediates motor dysfunction in mice through 5-HTR2a
10.1016/j.bbr.2023.114837 · 2024 · External reference
Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma
10.2353/ajpath.2006.060248 · 2006 · External reference
CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
10.1523/jneurosci.3667-11.2011 · 2011 · External reference
Lamina-specific membrane and discharge properties of rat spinal dorsal horn neurones in vitro
10.1113/jphysiol.2002.017756 · 2002 · External reference
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity
10.1073/pnas.1013413108 · 2010 · External reference
Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole
10.1016/s0079-6123(02)37016-x · 2002 · External reference
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
10.1038/s41593-018-0334-7 · 2019 · External reference
PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements
10.1038/s41467-022-30168-z · 2022 · External reference
Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take Centre stage
10.1098/rsob.130181 · 2013 · External reference
Fractalkine is a “find-me” signal released by neurons undergoing ethanol-induced apoptosis
10.3389/fncel.2014.00360 · 2014 · External reference
Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury
10.1016/s0165-5728(02)00033-4 · 2002 · External reference
Spinal inhibitory interneurons: gatekeepers of sensorimotor pathways
10.3390/ijms22052667 · 2021 · External reference
Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice
10.1111/j.1471-4159.2010.06837.x · 2010 · External reference
Inflammatory cascades mediate synapse elimination in spinal cord compression
10.1186/1742-2094-11-40 · 2014 · External reference
Synaptic pathways and inhibitory gates in the spinal cord dorsal horn
10.1111/j.1749-6632.2010.05501.x · 2010 · External reference
Inhibition mediated by glycinergic and GABAergic receptors on excitatory neurons in mouse superficial dorsal horn is location-specific but modified by inflammation
10.1523/jneurosci.2354-16.2017 · 2017 · External reference
Expression of apoptosis signal-regulating kinase 1 in mouse spinal cord under chronic mechanical compression: possible involvement of the stress-activated mitogen-activated protein kinase pathways in spinal cord cell apoptosis
10.1097/brs.0b013e3181822ed7 · 2008 · External reference
CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke
10.1186/1742-2094-11-26 · 2014 · External reference
Spinal inhibitory neurotransmission in neuropathic pain
10.1007/s11916-009-0035-8 · 2009 · External reference
Degenerative cervical myelopathy: a spectrum of related disorders affecting the aging spine
10.1227/neu.0000000000000951 · 2015 · External reference
Cervical spondylotic myelopathy
10.1097/nrl.0b013e3181da3a29 · 2010 · External reference
Microglial interactions with synapses are modulated by visual experience
10.1371/journal.pbio.1000527 · 2010 · External reference
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
10.1182/blood-2008-06-162404 · 2008 · External reference
Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine
10.1074/jbc.m107327200 · 2001 · External reference
Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function
10.1101/cshperspect.a005736 · 2012 · External reference
Novel composites materials from functionalized polymers and silver coated titanium oxide capable for calcium phosphate induction, control of orthopedic biofilm infections: an “in vitro” study
10.1007/s10856-010-4086-5 · 2010 · External reference
Design and evaluation of a chronic EMG multichannel detection system for long-term recordings of hindlimb muscles in behaving mice
10.1016/j.jelekin.2012.11.014 · 2013 · External reference
Layer V cortical neurons require microglial support for survival during postnatal development
10.1038/nn.3358 · 2013 · External reference
Acute systemic white blood cell changes following degenerative cervical myelopathy (DCM) in a mouse model
10.3390/ijms231911496 · 2022 · External reference
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
10.1038/s41590-023-01468-3 · 2023 · External reference
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
10.1111/j.1460-9568.2004.03593.x · 2004 · External reference
Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy
10.1172/jci.insight.92512 · 2017 · External reference
Homeostasis of microglia in the adult brain: review of novel microglia depletion systems
10.1016/j.it.2015.08.005 · 2015 · External reference
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
10.1523/jneurosci.4363-08.2009 · 2009 · External reference
Changes in VGLUT1 and VGLUT2 expression in rat dorsal root ganglia and spinal cord following spared nerve injury
10.1016/j.neuint.2016.05.008 · 2016 · External reference
Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons
10.1111/jnc.14588 · 2018 · External reference
Ischemia-induced neuronal cell death is mediated by chemokine receptor CX3CR1
10.1038/s41598-017-18774-0 · 2018 · External reference
Microglia, seen from the CX3CR1 angle
10.3389/fncel.2013.00026 · 2013 · External reference
ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents
10.1002/glia.20500 · 2007 · External reference
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
10.1016/j.immuni.2012.12.001 · 2013 · External reference
Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy
10.1016/j.nbd.2008.09.024 · 2009 · External reference
Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy
10.1093/brain/awr054 · 2011 · External reference
An examination of the role of CX3CR1 in the pathobiology of degenerative cervical myelopathy: evidence from human and mouse tissue
2026 · External reference
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
10.1038/nn.3641 · 2014 · External reference
Wnt1/β-catenin signaling upregulates spinal VGLUT2 expression to control neuropathic pain in mice
10.1016/j.neuropharm.2019.107869 · 2020 · External reference
Spinal interneurons as gatekeepers to neuroplasticity after injury or disease
10.1523/jneurosci.1654-20.2020 · 2021 · External reference
Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
10.1016/j.bbi.2006.11.003 · 2007 · External reference