Research graph
References from Single-cell spatial transcriptomics reveals rewiring of RPE and Müller glia signaling toward photoreceptors following outer segment disruption in Prph2C213Y mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Regulation of stem cell properties of Müller glia by JAK/STAT and MAPK signaling in the mammalian retina
10.1155/2017/1610691 · 2017 · External reference
Retina-directed gene therapy: achievements and remaining challenges
10.1016/j.pharmthera.2025.108862 · 2025 · External reference
The spectrum of retinal dystrophies caused by mutations in the peripherin/RDS gene
10.1016/j.preteyeres.2008.01.002 · 2008 · External reference
Müller cells in the healthy and diseased retina
10.1016/j.preteyeres.2006.05.003 · 2006 · External reference
Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
10.1016/j.preteyeres.2009.07.001 · 2009 · External reference
A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration
10.1093/hmg/ddae128 · 2024 · External reference
Novel molecular mechanisms for Prph2-associated pattern dystrophy
10.1096/fj.201901888r · 2020 · External reference
Effect of ciliary neurotrophic factor on retinal neurodegeneration in patients with macular telangiectasia type 2
10.1016/j.ophtha.2018.09.041 · 2019 · External reference
Spatial organization of the mouse retina at single cell resolution by MERFISH
10.1038/s41467-023-40674-3 · 2023 · External reference
Genetic treatment for autosomal dominant inherited retinal dystrophies: approaches, challenges and targeted genotypes
10.1136/bjo-2022-321903 · 2023 · External reference
FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells
2001 · External reference
Nuclear factor one transcription factors: divergent functions in developmental versus adult stem cell populations
10.1002/dvdy.24182 · 2015 · External reference
Retinitis pigmentosa
10.1016/s0140-6736(06)69740-7 · 2006 · External reference
Inherited retinal diseases are the most common cause of blindness in the working-age population in Australia
10.1080/13816810.2021.1913610 · 2021 · External reference
Retinal dystrophies associated with Peripherin-2: genetic spectrum and novel clinical observations in 241 patients
10.1167/iovs.65.5.22 · 2024 · External reference
Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials
10.1016/s0140-6736(23)01520-9 · 2023 · External reference
Revakinagene Taroretcel: first approval
10.1007/s40291-025-00787-5 · 2025 · External reference
Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones
10.1007/s00018-023-04851-3 · 2023 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Microglia activation and inflammation during the death of mammalian photoreceptors
10.1146/annurev-vision-121219-081730 · 2020 · External reference
Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial
10.1016/s0140-6736(23)01583-0 · 2023 · External reference
Protection of mouse photoreceptors by survival factors in retinal degenerations
1998 · External reference
Photoreceptor disc enclosure is tightly controlled by Peripherin-2 oligomerization
10.1523/jneurosci.0041-21.2021 · 2021 · External reference
High prevalence of PRPH2 in autosomal dominant retinitis pigmentosa in France and characterization of biochemical and clinical features
10.1016/j.ajo.2014.10.033 · 2015 · External reference
Follistatin-like 1 in development and human diseases
10.1007/s00018-018-2805-0 · 2018 · External reference
Cell-type-specific complement expression in the healthy and diseased retina
10.1016/j.celrep.2019.10.084 · 2019 · External reference
Tenascins in retinal and optic nerve neurodegeneration
10.3389/fnint.2017.00030 · 2017 · External reference
Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation
10.1038/s41419-023-06243-8 · 2023 · External reference
Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders
10.1038/s41467-024-48846-5 · 2024 · External reference
EMT and EndMT: emerging roles in age-related macular degeneration
10.3390/ijms21124271 · 2020 · External reference
The expression of Follistatin-like 1 protein is associated with the activation of the EMT program in Sjögren’s syndrome
10.3390/jcm11185368 · 2022 · External reference
ROM1 contributes to phenotypic heterogeneity in PRPH2-associated retinal disease
10.1093/hmg/ddaa160 · 2020 · External reference
The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse
10.1093/hmg/ddu345 · 2014 · External reference
Retinal injury activates complement expression in Müller cells leading to neuroinflammation and photoreceptor cell death
10.3390/cells12131754 · 2023 · External reference
Prph2 disease mutations lead to structural and functional defects in the RPE
10.1096/fj.202101562rr · 2022 · External reference
Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa
10.1038/s12276-021-00693-w · 2021 · External reference
STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage
10.1111/j.1471-4159.2007.05180.x · 2008 · External reference
Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration
10.1038/labinvest.2014.60 · 2014 · External reference
Single-cell RNA sequencing reveals the Müller subtypes and inner blood–retinal barrier regulatory network in early diabetic retinopathy
10.3389/fnmol.2022.1048634 · 2022 · External reference
Butterfly-shaped pattern dystrophy: a genetic, clinical, and histopathological report
10.1001/archopht.120.4.485 · 2002 · External reference
Role of epithelial-mesenchymal transition in retinal pigment epithelium dysfunction
10.3389/fcell.2020.00501 · 2020 · External reference
