Research graph
References from Multiple system atrophy-derived α-synuclein fibrils are more potent and display oligodendrocyte cell tropism compared to Parkinson's disease-derived fibrils. Local targets link to admitted publications; unresolved targets remain external evidence.
Selective vulnerability in α-synucleinopathies
10.1007/s00401-019-02010-2 · 2019 · External reference
The secondary structural difference between Lewy body and glial cytoplasmic inclusion in autopsy brain with synchrotron FTIR micro-spectroscopy
10.1038/s41598-020-76565-6 · 2020 · External reference
QuPath: open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
10.1007/s00401-009-0538-8 · 2009 · External reference
Structural and functional characterization of two alpha-synuclein strains
10.1038/ncomms3575 · 2013 · External reference
Staging of brain pathology related to sporadic Parkinson’s disease
10.1016/s0197-4580(02)00065-9 · 2003 · External reference
Prying into the prion hypothesis for Parkinson’s disease
10.1523/jneurosci.1788-16.2017 · 2017 · External reference
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
10.1038/s41586-025-09698-1 · 2025 · External reference
Expanding the spectrum of neuronal pathology in multiple system atrophy
10.1093/brain/awv114 · 2015 · External reference
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
10.1126/sciadv.abc4364 · 2020 · External reference
Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
10.1186/s40035-019-0164-x · 2019 · External reference
Oligodendrocytes prune axons containing α-synuclein aggregates in vivo: Lewy neurites as precursors of glial cytoplasmic inclusions in multiple system atrophy?
10.3390/biom13020269 · 2023 · External reference
The interplay between α-synuclein and microglia in α-Synucleinopathies
10.3390/ijms24032477 · 2023 · External reference
Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity
10.1371/journal.pone.0090659 · 2014 · External reference
Yet another polymorph of α-synuclein: solid-state sequential assignments
10.1007/s12104-013-9526-y · 2014 · External reference
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
10.1212/01.wnl.0000078192.95645.e6 · 2003 · External reference
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson’s disease
10.1016/j.nbd.2005.08.002 · 2006 · External reference
Characterization of pSer129-αSyn pathology and neurofilament light-chain release across in vivo, ex vivo, and in vitro models of pre-formed-fibril-induced αSyn aggregation
10.3390/cells13030253 · 2024 · External reference
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson’s disease brains
10.1007/s00401-003-0766-2 · 2003 · External reference
A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
10.1186/s13041-024-01104-7 · 2024 · External reference
Glia imaging differentiates multiple system atrophy from Parkinson’s disease: a positron emission tomography study with [11C]PBR28 and machine learning analysis
10.1002/mds.28814 · 2022 · External reference
Overview of general and discriminating markers of differential microglia phenotypes
10.3389/fncel.2020.00198 · 2020 · External reference
Immunohistochemical and molecular investigations show alteration in the inflammatory profile of multiple system atrophy brain
10.1093/jnen/nly035 · 2018 · External reference
Neuropathology and molecular diagnosis of Synucleinopathies
10.1186/s13024-021-00501-z · 2021 · External reference
Transplanted dopaminergic neurons develop PD pathologic changes: a second case report
10.1002/mds.22369 · 2008 · External reference
Widespread microglial activation in multiple system atrophy
10.1002/mds.27620 · 2019 · External reference
Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
10.1038/s41531-021-00264-w · 2022 · External reference
α-Synuclein overexpression increases the tropism of pre-formed fibrils and MSA-patient derived seeds towards oligodendroglia
10.1186/s40478-026-02346-3 · 2026 · External reference
Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging
10.1016/j.parkreldis.2020.11.011 · 2021 · External reference
Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation
10.1038/nm1746 · 2008 · External reference
Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study
10.1186/s12974-022-02574-z · 2022 · External reference
Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice
10.1007/s00401-022-02425-4 · 2022 · External reference
Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy
10.1002/2211-5463.13110 · 2021 · External reference
Molecular and biological compatibility with host alpha-synuclein influences fibril pathogenicity
10.1016/j.celrep.2016.08.053 · 2016 · External reference
Prion-like spreading of pathological α-synuclein in brain
10.1093/brain/awt037 · 2013 · External reference
Microglia in neuroinflammation and neurodegeneration: from understanding to therapy
10.3389/fnins.2021.742065 · 2021 · External reference
⍺-synuclein structural diversity and the cellular environment in ⍺-synuclein transmission models and humans
10.1007/s13311-023-01365-5 · 2023 · External reference
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
10.1038/nature14547 · 2015 · External reference
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
10.1038/s41586-018-0104-4 · 2018 · External reference
Multiple system atrophy
10.1038/s41572-022-00382-6 · 2022 · External reference
MDS clinical diagnostic criteria for Parkinson’s disease
10.1002/mds.26424 · 2015 · External reference
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
10.1073/pnas.1514475112 · 2015 · External reference
Neocortical neuronal loss in patients with multiple system atrophy: a stereological study
2017 · External reference
The amyloid packing difference: a pairwise comparison metric for amyloid structures
10.1016/j.str.2026.04.014 · 2026 · External reference
Structures of α-synuclein filaments from multiple system atrophy
10.1038/s41586-020-2317-6 · 2020 · External reference
Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
10.1038/s44320-026-00199-5 · 2026 · External reference
Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
10.1038/s41586-020-1984-7 · 2020 · External reference
Stochastic misfolding drives the emergence of distinct α-synuclein strains
10.1016/j.neuron.2026.01.014 · 2026 · External reference
Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
10.1038/s41467-021-23682-z · 2021 · External reference
Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy
10.1093/brain/awac061 · 2023 · External reference
Fibril-seeded animal models of synucleinopathies: pathological mechanisms, disease modeling, and therapeutic implications
10.1016/j.neures.2025.04.008 · 2025 · External reference
Slow progressive accumulation of oligodendroglial alpha-synuclein (a-syn) pathology in synthetic a-syn fibril-induced mouse models of synucleinopathy
10.1093/jnen/nlz070 · 2019 · External reference
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
10.1007/s00401-020-02157-3 · 2020 · External reference
Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph
10.1007/s12104-015-9628-9 · 2016 · External reference
Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates
2025 · External reference
The Allen mouse brain common coordinate framework: a 3D reference atlas
10.1016/j.cell.2020.04.007 · 2020 · External reference
The Movement Disorder Society criteria for the diagnosis of multiple system atrophy
10.1002/mds.29005 · 2022 · External reference
Refining α-synuclein seed amplification assays to distinguish Parkinson’s disease from multiple system atrophy
10.1186/s40035-025-00469-6 · 2025 · External reference
Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines
10.1007/s00401-019-01959-4 · 2019 · External reference
Beyond strains: molecular diversity in alpha-synuclein at the Center of Disease Heterogeneity
10.3390/ijms241713199 · 2023 · External reference
Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics
10.1074/jbc.ra118.004471 · 2019 · External reference
Structures of α-synuclein filaments from human brains with Lewy pathology
10.1038/s41586-022-05319-3 · 2022 · External reference
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson’s disease patient brain spread after intracerebral injection into mouse brain
10.1111/bpa.13196 · 2023 · External reference